检索结果-南通市图书馆

Cold-Induced Reprogramming of Subcutaneous White Adipose Tissue Assessed by Single-Cell and Single-Nucleus RNA Sequencing

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Research 2024年第1期2023卷 763-778页

作者： Qing Liu Qiaoyun Long Jiayu Zhao Wenjie Wu Zexin Lin Wei Sun Ping Gu Tuo Deng Kerry Martin Loomes Donghai Wu Alice P.S.Kong jingying zhou Alfred S.Cheng Hannah Xiaoyan Hui School of Biomedical Sciences The Chinese University of Hong KongHong KongChina Department of Pharmacology and Pharmacy The University of Hong KongHong KongChina Guangzhou Institute of Biomedicine and Health Chinese Academy of SciencesGuangzhouChina China-New Zealand Joint Laboratory on Biomedicine and Health Chinese Academy of SciencesGuangzhouChina Department of Endocrinology Jinling HospitalNanjing UniversitySchool of MedicineNanjingChina National Clinical Research Center for Metabolic Diseases and Department of Metabolism and EndocrinologyThe Second Xiangya Hospital of Central South UniversityChangshaChina Key Laboratory of Diabetes Immunology Ministry of Educationand Metabolic Syndrome Research CenterThe Second Xiangya Hospital of Central South UniversityChangshaChina Clinical Immunology Center The Second Xiangya Hospital of Central South UniversityChangshaChina School of Biological Sciences and Maurice Wilkins Centre University of AucklandAucklandNew Zealand Department of Medicine and Therapeutics The Chinese University of Hong KongHong KongChina Hong Kong Institute of Diabetes and Obesity The Chinese University of Hong KongPrince of Wales HospitalShatinHong KongChina Li Ka Shing Institute of Health Sciences The Chinese University of Hong KongPrince of Wales HospitalShatinHong KongChina

Adipose browning has demonstrated therapeutic potentials in several ***,by conducting transcriptomic profiling at the single-cell and single-nucleus resolution,we reconstituted the cellular atlas in mouse inguinal subcutaneous white adipose tissue(iWAT)at thermoneutrality or chronic cold *** major nonimmune cells within the iWAT,including adipose stem and progenitor cells(ASPCs),mature adipocytes,endothelial cells,Schwann cells,and smooth muscle cells,were recovered,allowing us to uncover an overall and detailed blueprint for transcriptomes and intercellular cross-talks and the dynamics during white adipose tissue brown *** findings also unravel the existence of subpopulations in mature adipocytes,ASPCs,and endothelial cells,as well as new insights on their interconversion and reprogramming in response to *** adipocyte subpopulation competent of major histocompatibility complex class Ⅱ(MHCⅡ)antigen presentation is ***,a subcluster of ASPC with CD74 expression was identified as the precursor of this MHCⅡ^(+)*** adipocytes are transdifferented from preexisting lipid generating adipocytes,which exhibit developmental trajectory from de novo differentiation of amphiregulin cells(Aregs).Two distinct immune-like endothelial subpopulations are present in iWAT and are responsive to *** data reveal fundamental changes during cold-evoked adipose browning.

关键词： evoked programming generating

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

以问题意识审视调查与研究

重庆大学学报（社会科学版） 2015年第1期21卷 106-119页

作者：周靖祥周靖英湘潭大学商学院湖南湘潭411105 重庆大学城市科技学院经济管理学院重庆402167

随着各类微观数据的可得性增强,盛行拿来主义的社会科学经验研究发展趋向理应受到重视。鉴于中国式经验或实证研究遭遇了"可信性"的质疑,我们试图用具体事例解答如何通过调查"搞对问题"和"识辨数据"。借此强化社会经济问题调查研究的重... 详细信息

随着各类微观数据的可得性增强,盛行拿来主义的社会科学经验研究发展趋向理应受到重视。鉴于中国式经验或实证研究遭遇了"可信性"的质疑,我们试图用具体事例解答如何通过调查"搞对问题"和"识辨数据"。借此强化社会经济问题调查研究的重要性认识:开展调查有助于抽取学术问题,依据观察检验经验或实证研究"发现"的存在性,更能够达到对机构数据"纠错"的目的。为避免研究陷入"庸俗和肤浅"的泥潭,方法论建构需要坚守"和而不同、殊途同归"的包容理念,极有必要将调查嵌入社会科学研究的"价值理性"和"责任理性"认知体系中。

关键词：调查研究拿来主义微观数据问题主义

The Generalized Inverse Computing Method of a Class of Block Matrix from Models for Flow in Porous Materials

在线全文

学校读者我要写书评

暂无评论

The Generalized Inverse Computing Method of a Class of Block...

Associations between LMO1 gene polymorphisms and central nervous system tumor susceptibility

作者： Tangwei Liu jingying zhou Kangxiu Hu Shuo Chen Jinfeng Lai School of Science East China University of Technology

The generalized inverse method of block matrix plays an effective and important role during the computing procedure of certain mathematical models. Some numerical methods for flow models in porous materials are discussed in this paper. Firstly, some partial differential equation models of flow in porous materials are given. Then a class of block matrix from the discrete systems of mathematic models by the multiscale finite element methods are analyzed. Finally, the generalized inverse of the two-by-two block matrix are obtained and the algorithm for computing the minus inverse is presented. The presented methods have an advantage of concise computing procedure for the simulation of models.

关键词： porous materials partial difference equation model inverse computing method block matrix

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Pediatric Investigation 2021年第4期5卷 281-287页

作者： Huiran Lin Huitong Chen Ao Lin Xiaoping Liu Xiaokai Huang jingying zhou Li Yuan Zhenjian Zhuo Department of Pediatric Surgery Guangzhou Institute of PediatricsGuangdong Provincial Key Laboratory of Research in Structural Birth Defect DiseaseGuangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangzhouGuangdongChina Faculty of Medicine Macao University of Science and TechnologyMacaoChina Laboratory Animal Management Office Public Technology Service PlatformShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdongChina Department of Hematology Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangzhouGuangdongChina Department of Hematology The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhouZhejiangChina Department of Pathology Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangzhouGuangdongChina

Importance:LIM domain only 1(LMO1)gene polymorphisms were previously found to be implicated in the risk of several *** available studies were performed regarding the predisposing effect of LMO1 gene single nucleotide polymorphisms(SNPs)on central nervous system(CNS)tumor ***:We aimed to determine whether the LMO1 gene SNPs were associated with the risk of CNS tumor by applying a case-control study with 191 cases and 248 controls in ***:The contributions of LMO1 gene SNPs to the risk of CNS tumor was evaluated by multinomial logistic ***:Based on the calculations of odds ratio(OR)and 95%confidence interval(CI),we failed to detect a significant relationship between each LMO1 gene SNP(rs110419 A>G,rs4758051 G>A,rs10840002 A>G,rs204938 A>G,and rs2168101 G>T)and CNS tumor risk,respectively.A negative association was also found in the combined effects on these five SNPs and CNS tumor *** stratification analysis further demonstrated the individuals with rs204938 AG/GG genotype confer to increased risk of CNS tumor compared with those with an AA genotype in males(OR:1.74,95%CI:1.01-2.98,P=0.046).Interpretation:We concluded that LMO1 gene SNPs may not strong enough to influence the risk of CNS tumor in Chinese *** studies are required to verify this association.

关键词： LMO1 SNPs CNS tumor Chinese

Association of ERCC1 and XPF polymorphisms with pediatric glioma susceptibility

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2023年第6期136卷 746-748页

作者： Yongping Chen Yuxiang Liao Xingyu Jia Huiran Lin Lei Miao Li Yuan Xiaokai Huang jingying zhou Jun Bian Zhenjian Zhuo Department of Pediatric Surgery Guangzhou Institute of PediatricsGuangdong Provincial Key Laboratory of Research in Structural Birth Defect DiseaseGuangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangzhouGuangdong 510623China Department of Neurosurgery Xiangya HospitalCentral South UniversityChangshaHunan 410008China School of Medicine Jinan UniversityGuangzhouGuangdong 510632China Faculty of Medicine Macao University of Science and TechnologyMacao 999078China Department of Hematology The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhouZhejiang 325027China Department of General Surgery Xi’an Children’s HospitalXi’an Jiaotong University Affiliated Children’s HospitalXi’anShaanxi 710003China Laboratory Animal Center School of Chemical Biology and BiotechnologyPeking University Shenzhen Graduate SchoolShenzhenGuangdong 518055China

To the Editor:Glioma is a highly invasive and lethal heterogeneous disease caused by glial or precursor cell *** accounts for about 50%of tumors in children and 80%of malignant tumors.[1]The nucleotide excision repair(NER)pathway is a process that involves the sequential assembly of many proteins,including excision repair cross complementation group 1(ERCC1)and xeroderma pigmentosum complementation group F(XPF,also known as ERCC4).

关键词： ERCC1 XPF excision

Vaccine-elicited CD8+ T cells in HIV/AIDS control

在线全文

学校读者我要写书评

暂无评论

Vaccine-elicited CD8+ T cells in HIV/AIDS control

中华民族现代文明与中华民族共同体的协同建设理路

第九届全国免疫学学术大会

作者： Zhiwu Tan jingying zhou Allen K.L.Cheung Zhe Yu Zhiwei Chen AIDS Institute and Department of Microbiology LKS Faculty of MedicineThe University of Hong Kong

Eradicating HIV/AIDS by vaccine-elicited host immunity remains a major medical *** date,correlates of immune protection remain unknown for HIV/*** this study,we demonstrated that antigen-specific CD8+T cell immune response correlates with the elimination of HIVp24-expressing cells by a model PD-1-based DNA vaccine.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

吉林省社会主义学院学报 2024年第2期 38-46页

作者：周晶莹同济大学马克思主义学院

中华民族现代文明与中华民族共同体的生成和发展具有共同的历史脉络和文化渊源,有着一致的现实依据、实践基础和目标导向。二者皆于波澜壮阔的中华文明史中汲取了中华优秀传统文化的丰厚滋养,皆是实现伟大复兴民族梦与建设社会主义现代... 详细信息

中华民族现代文明与中华民族共同体的生成和发展具有共同的历史脉络和文化渊源,有着一致的现实依据、实践基础和目标导向。二者皆于波澜壮阔的中华文明史中汲取了中华优秀传统文化的丰厚滋养,皆是实现伟大复兴民族梦与建设社会主义现代化强国梦的必要举措。同时,建设中华民族现代文明和中华民族共同体的进程具有内在的紧密关联,是相互作用、相得益彰、互嵌互构的关系。为此,要坚持“两个结合”、坚持以经济建设为中心、着力推进中国式现代化,传承创新中华优秀传统文化、建设社会主义文化,坚持中国共产党的领导、坚持中国特色社会主义政治制度,构筑起协同建设中华民族现代文明和中华民族共同体的现实路径。

关键词：中华民族现代文明中华民族共同体中国式现代化

小剂量泼尼松联合他克莫司治疗特发性膜性肾病的临床价值

在线全文

学校读者我要写书评

暂无评论

中国继续医学教育 2018年第16期10卷 117-119页

作者：周晶瀛广西梧州市红十字会医院肾脏病科广西梧州543000

目的探讨小剂量泼尼松联合他克莫司对特发性膜性肾病的临床价值。方法选取本院2015年2月—2017年6月肾穿刺活检提示膜性肾病(PLA2R+Ig G4荧光免疫染色为阳性)患者102例,肾功能正常,24小时尿蛋白定量均大于4 g,且经过6个月保守治疗后,未... 详细信息

目的探讨小剂量泼尼松联合他克莫司对特发性膜性肾病的临床价值。方法选取本院2015年2月—2017年6月肾穿刺活检提示膜性肾病(PLA2R+Ig G4荧光免疫染色为阳性)患者102例,肾功能正常,24小时尿蛋白定量均大于4 g,且经过6个月保守治疗后,未见自发缓解。采用随机数字表法分为两组,对照组患者(51例)采用改良Ponticelli方案(第1、3、5个月初给予甲泼尼龙0.5 g,每日1次,连用3天,随后隔日口服泼尼松0.5 mg/kg,并于第2、4、6个月开始,每月静脉滴注环磷酰胺0.8~1.0 g,总量6~8 g)。观察组患者(51例)采用小剂量泼尼松0.15 mg/(kg·d)联合他克莫司0.05mg/(kg·d)治疗,血药浓度保持在5~10 ng/ml。比较两组患者临床指标改善情况、临床疗效、用药安全性。结果治疗后,两组患者尿蛋白、血肌酐、甘油三酯、总胆固醇降低,血清白蛋白、内生肌酐清除率增加,差异具有统计学意义(P<0.05)。观察组患者尿蛋白、血肌酐、甘油三酯、总胆固醇、不良反应发生率低于对照组,清白蛋白、内生肌酐清除率、总有效率高于对照组,差异具有统计学意义(P<0.05)。结论小剂量泼尼松联合他克莫司治疗特发性膜性肾病的疗效显著且安全高。

关键词：泼尼松他克莫司特发性膜性肾病环磷酰胺临床疗效用药安全性

在线全文

学校读者我要写书评

暂无评论

基于最小二乘的视野区域运动方向分析

无线互联科技 2016年第13期13卷 20-21页

作者：周晶莹南京农业大学工学院江苏南京210031

文章利用最小二乘法、迭代法、遍历法,结合MATLAB编程解决了如何在客观环境限制条件下判断当前视野区域运动方向的问题,得到了一系列从一维到三维运动方向的判断方法。首先利用MATLAB得到所选图像的灰度值矩阵,然后根据一定原则选取5个... 详细信息

文章利用最小二乘法、迭代法、遍历法,结合MATLAB编程解决了如何在客观环境限制条件下判断当前视野区域运动方向的问题,得到了一系列从一维到三维运动方向的判断方法。首先利用MATLAB得到所选图像的灰度值矩阵,然后根据一定原则选取5个特征域,再比较前后两张图像的位置对应关系,最终通过迭代法推断出视野区域的运动方向。

关键词：最小二乘迭代特征域