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life cycle assessment and economic analysis of HFC-134a production from natural gas compared with oil-based and coal-based production

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Frontiers of Chemical Science and Engineering 2022年第12期16卷 1713-1725页

作者： Suisui Zhang Gang li Boyang Bai Luyao Qiang Xiaoxun Ma jingying li School of Chemical Engineering Northwest UniversityXi’an 710069China Chemical Engineering Research Center of the Ministry of Education(MOE)for Advanced Use Technology of Shanbei Energy Xi’an 710069China Shaanxi Research Center of Engineering Technology for Clean Coal Conversion Xi’an 710069China Collaborative Innovation Center for Development of Energy and Chemical Industry in Northern Shaanxi Xi’an 710069China International Scientific and Technological Cooperation Base of the Ministry of Science and Technology(MOST)for Clean Utilization of Hydrocarbon Resources Xi’an 710069China Longdong University Qingyang 745000China

China is the largest producer and consumer of HFC-134a(1,1,1,2-tetrafluoroethane)in the ***-based route is mainly adopted to produce HFC-134a,which suffers from large waste and CO_(2) *** gas is a low-carbon and clean energy resource,and no research has been found on the environment and economy of producing HFC-134a from natural *** this study,CML 2001 method was used to carry out the life cycle assessment of natural gas(partial oxidation)-based and natural gas(plasma cracking)-based routes(abbreviated as gas(O)-based and gas(P)-based routes,respectively),and their environmental performances were compared with coal-based and oil-based ***,considering that China is vigorously promoting the transformation of energy structure,and the application of electric heating equipment to replace fossil-based heating equipment in industrial field,which has a great impact on the environmental performance of the production processes,the authors conducted a scenario *** results showed that the gas(O)-based route had the most favourable environmental ***,the gas(P)-based route had the highest potential for reducing environmental burdens,and its environmental benefit was the most favourable in scenario ***,the economic performance of the gas(P)-based route was significantly better than that of gas(O)-based and coal-based routes.

关键词： life cycle assessment economic performance HFC-134a natural gas oil coal

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Base editing in plants: Current status and challenges

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The Crop Journal 2020年第3期8卷 384-395页

作者： Sutar Suhas Bharat Shaoya li jingying li Lei Yan Lanqin Xia Institute of Crop Sciences Chinese Academy of Agricultural SciencesBeijing 100081China

Genome editing technologies have revolutionized the field of plant science by enabling targeted modification of plant genomes and are emerging as powerful tools for both plant gene functional analyses and crop improvement. Although homology-directed repair(HDR)is a feasible approach to achieve precise gene replacement and base substitution in some plant species, the dominance of the non-homologous end joining pathway and low efficiency of HDR in plant cells have limited its application. Base editing has emerged as an alternative tool to HDR-mediated replacement, facilitating precise editing of plant genome by converting one single base to another in a programmable manner without a doublestranded break and a donor repair template. In this review, we summarize the latest developments in base-editing technologies as well as their underlying mechanisms. We review current applications of these technologies in plant species. Finally, we address the challenges and future perspectives of this emerging technology in plants.

关键词： Base editing in plants Current status and challenges

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Increasing yield potential through manipulating of an ARE1 ortholog related to nitrogen use efficiency in wheat by CRISPR/Cas9

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Journal of Integrative Plant Biology 2021年第9期63卷 1649-1663页

作者： Jiahui Zhang Huating Zhang Shaoya li jingying li Lei Yan Lanqin Xia Institute of Crop Sciences Chinese Academy of Agricultural SciencesBeijing 100081China School of Agricultural Sciences Zhengzhou UniversityZhengzhou 450001China

Wheat(Triticum aestivum L.)is a staple food crop consumed by more than 30%of world ***(N)fertilizer has been applied broadly in agriculture practice to improve wheat yield to meet the growing demands for food ***,undue N fertilizer application and the low N use efficiency(NUE)of modern wheat varieties are aggravating environmental pollution and ecological *** nitrogen-limiting conditions,the rice(Oryza sativa)abnormal cytokinin response1 repressor1(are1)mutant exhibits increased NUE,delayed senescence and consequently,increased grain ***,the function of ARE1 ortholog in wheat remains ***,we isolated and characterized three TaARE1 homoeologs from the elite Chinese winter wheat cultivar ZhengMai *** then used CRISPR/Cas9-mediated targeted mutagenesis to generate a series of transgene-free mutant lines either with partial or triple-null taare1 *** transgene-free mutant lines showed enhanced tolerance to N starvation,and showed delayed senescence and increased grain yield in field *** particular,the AABBdd and aabbDD mutant lines exhibited delayed senescence and significantly increased grain yield without growth defects compared to the wild-type ***,our results underscore the potential to manipulate ARE1 orthologs through gene editing for breeding of high-yield wheat as well as other cereal crops with improved NUE.

关键词： CRISPR Increasing yield potential through manipulating of an ARE1 ortholog related to nitrogen use efficiency in wheat by CRISPR/Cas9

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Thiol-mediated transportation pathway:an approach for improving tumor penetration of nanomedicines in vivo

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Science China Chemistry 2024年第1期67卷 383-389页

作者： Junjie Zhang Weican Sun Xing Wang Senyan Chen jingying li Huanghao Yang New Cornerstone Science Laboratory Key Laboratory for Analytical Science of Food Safety and Biology(Ministry of Education)College of ChemistryFuzhou UniversityFuzhou 350116China Department of Chemistry and College of Biological Science and Engineering Fuzhou UniversityFuzhou 350116China

Abnormal tumor microenvironment imposes barriers to tumor penetration of nanomedicine,which remains a major challenge for effective ***,we present disulfide-based nanoparticles that actively penetrate deep tumors in vivo through a thiol-mediated transportation *** achieve active tumor accumulation in vivo,disulfide-based nanoparticles are modified with folic acid units(FA-DBNPs).It is gratifying that FA-DBNPs still enter cells via the thiol-mediated pathway,which facilitates transcellular transportation and tumor penetration both in vitro and in ***,FA-DBNPs exhibit GSH concentration-dependent depolymerization characterization,indicating that the GSH level in tumor tissues regulates the penetration depth of *** from these advantages,FA-DBNPs showed potent anti-tumor activity in mouse models,leading to the significant regression of *** current study lays a foundation that thiol-mediated transportation is a promising approach in nanomedicine design for solid tumor therapy.

关键词： deep penetration thiol-mediated pathway transcellular transportation solid tumor

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Toward Precision Genome Editing in Crop Plants

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Molecular Plant 2020年第6期13卷 811-813页

作者： jingying li Huiyuan li Jilin Chen Lei Yan Lanqin Xia Institute of Crop Sciences(ICS) Chinese Academy of Agricultural Sciences(CAAS)Beijing 100081China

Precision genome editing through homology-directed repair(HDR)in plants remains very challenging due to the innately low occurrence of HDR and obstacles in the delivery of sufficient donor repair template(DRT)into plant *** single-base substitution,cytidine or adenine base editors have been used successfully in crop plants in recent ***,base editing is constrained by the distance between the targeted base and PAM motif and cannot install predefined transversion mutations or insertions and deletions(indels).Here,we briefly summarize the strategies reported so far for precision genome editing in *** on the recently developed prime editing strategy,which enables gene replacement without double-strand breaks(DSBs)or DRT in both human cells and plants,we provide our perspectives on exploiting diverse strategies to achieve precise targeted gene/allele replacement toward crop improvement and resilience for sustainable agricultural development.

关键词： base install template

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Precise Modifications of Both Exogenous and Endogenous Genes in Rice by Prime Editing

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Molecular Plant 2020年第5期13卷 671-674页

作者： Huiyuan li jingying li Jilin Chen Lei Yan Lanqin Xia Institute of Crop Sciences(ICS) Chinese Academy of Agricultural Sciences(CAAS)Beijing 100081China

Dear Editor,Harnessing genetic diversity and the introduction of elite alleles from wild relatives or landraces into commercial cultivars has been a major goal in crop breeding *** modification of the plant genome through clustered regularly interspaced short palindromic repeat(CRISPR)/CRISPR-associated protein(Cas)(CRISPR/Cas)-mediated homology-directed repair(HDR)offers a great promise to introduce elite alleles from wild relatives or landraces into commercialized cultivars in the short term.

关键词： cultivar elite CRISPR/Cas

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Plant base editing and prime editing:The current status and future perspectives

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Journal of Integrative Plant Biology 2023年第2期65卷 444-467页

作者： jingying li Chen Zhang Yubing He Shaoya li Lei Yan Yucai li Ziwei Zhu Lanqin Xia Institute of Crop Sciences(ICS) Chinese Academy of Agricultural Sciences(CAAS)Beijing 100081China National Nanfan Research Institute(Sanya) Chinese Academy of Agricultural Sciences/Hainan Yazhou Bay Seed LaboratorySanya 572024China

Precise replacement of an allele with an elite allele controlling an important agronomic trait in a predefined manner by gene editing technologies is highly desirable in crop *** editing and prime editing are two newly developed precision gene editing systems which can introduce the substitution of a single base and install the desired short indels to the target loci in the absence of double-strand breaks and donor repair templates,*** their discoveries,various strategies have been attempted to optimize both base editor(BE)and prime editor(PE)in order to improve the precise editing efficacy,specificity,and expand the targeting ***,we summarize the latest development of various BEs and PEs,as well as their applications in *** on these progresses,we recommend the appropriate BEs and PEs for both basic plant research and crop ***,we propose the perspectives for further optimization of these two *** envision that both BEs and PEs will become the routine and customized precise gene editing tools for both plant biological research and crop improvement in the near future.

关键词： base editing CRISPR/Cas plants precision genome editing prime editing

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life cycle assessment of HFC-134a production by calcium carbide acetylene route in China

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Chinese Journal of Chemical Engineering 2022年第2期35卷 236-244页

作者： Suisui Zhang jingying li Yan Nie Luyao Qiang Boyang Bai Zhiwei Peng Xiaoxun Ma School of Chemical Engineering Northwest UniversityXi’an 710069China Chemical Engineering Research Center of the Ministry of Education(MOE)for Advanced Use Technology of Shanbei Energy Xi’an 710069China Shaanxi Research Center of Engineering Technology for Clean Coal Conversion Xi’an 710069China Collaborative Innovation Center for Development of Energy and Chemical Industry in Northern Shaanxi Xi’an 710069China International Scientific and Technological Cooperation Base of the Ministry of Science and Technology(MOST)for Clean Utilization of Hydrocarbon Resources Xi’an 710069China

HFC-134a is a widely used environment-friendly *** present,China is the largest producer of HFC-134a in the *** production of HFC-134a in China mainly adopts the calcium carbide acetylene ***,the production route has high resource and energy consumption and large waste emission,and few of the studies addressed on the environmental performance of its production *** study quantified the environmental performance of HFC-134a production by calcium carbide route via carrying out a life cycle assessment(LCA)using the CML 2001 *** uncertainty analysis by Monte-Carlo simulation was also carried *** results showed that electricity had the most impact on the environment,followed by steam,hydrogen fluoride and chlorine,and the impact of direct CO_(2) emissions in calcium carbide production stage on the global warming effect also could not be ***,the clean energy(e.g.,wind,solar,biomass,and natural gas)was used to replace coal-based electricity and coal-fired steam in this study,showing considerable environmental *** the same time,the use of advanced production technologies could also improve environmental benefits,and the environmental impact of the global warming category could be reduced by 4.1%via using CO_(2) capture and purification *** Chinese database of HFC-134a production established in this study provides convenience for the relevant study of *** the production of HFC-134a,this study helps to better identify the specific environmental hotspots and proposes useful ways to improve the environmental benefits.

关键词： HFC-134a Calcium carbide life cycle assessment Environmental impact Carbon capture

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Present and future prospects for wheat improvement through genome editing and advanced technologies

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Plant Communications 2021年第4期2卷 100-115页

作者： Shaoya li Chen Zhang jingying li Lei Yan Ning Wang Lanqin Xia Institute of Crop Sciences(ICS) Chinese Academy of Agricultural Sciences(CAAS)Beijing 100081China

Wheat(Triticum aestivum,2n=6x=42,AABBDD)is one of the most important staple food crops in the *** the fact that wheat production has significantly increased over the past decades,future wheat production will face unprecedented challenges from global climate change,increasing world population,and water shortages in arid and semi-arid ***,excessive applications of diverse fertilizers and pesticides are exacerbating environmental pollution and ecological *** ensure global food and ecosystem security,it is essential to enhance the resilience of wheat production while minimizing environmental pollution through the use of cutting-edge ***,the hexaploid genome and gene redundancy complicate advances in genetic research and precision gene modifications for wheat improvement,thus impeding the breeding of elite wheat *** this review,we first introduce state-of-the-art genome-editing technologies in crop plants,especially wheat,for both functional genomics and genetic *** then outline applications of other technologies,such as GWAS,high-throughput genotyping and phenotyping,speed breeding,and synthetic biology,in ***,we discuss existing challenges in wheat genome editing and future prospects for precision gene modifications using advanced genome-editing *** conclude that the combination of genome editing and other molecular breeding strategies will greatly facilitate genetic improvement ofwheat for sustainable global production.

关键词： CRISPR/Cas genome editing GWAS speed breeding wheat(Triticum aestivum L.)

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Fusion of a rice endogenous N-methylpurine DNA glycosylase to a plant adenine base transition editor ABE8e enables A-toK base editing in rice plants

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aBIOTECH 2024年第2期5卷 127-139页

作者： Yucai li Shaoya li Chenfei li Chen Zhang Lei Yan jingying li Yubing He Yan Guo Lanqin Xia Institute of Crop Sciences(ICS) Chinese Academy of Agricultural Sciences(CAAS)Beijing 100081China State Key Laboratory of Plant Physiology and Biochemistry College of Biological SciencesChina Agricultural UniversityBeijing 100193China Hainan Yazhou Bay Seed Laboratory/National Nanfan Research Institute(Sanya) CAASSanya 572024China

Engineering of a new type of plant base editor for simultaneous adenine transition and transversion within the editing window will greatly expand the scope and potential of base editing in directed evolution and crop ***,we isolated a rice endogenous hypoxanthine excision protein,N-methylpurine DNA glycosylase(OsMPG),and engineered two plant A-to-K(K=G or T)base editors,rAKBE01 and rAKBE02,for simultaneous adenine transition and transversion base editing in rice by fusing OsMPG or its mutant mOsMPG to a plant adenine transition base editor,*** further coupled either OsMPG or mOsMPG with a transactivation factor VP64 to generate rAKBE03 and rAKBE04,*** these four rAKBEs,at five endogenous loci in rice protoplasts,indicated that rAKBE03 and rAKBE04 enabled higher levels of A-to-G base transitions when compared to ABE8e and ***,whereas rAKBE01 only enabled A-to-C/T editing at one endogenous locus,in comparison with rAKBE02 and rAKBE03,rAKBE04 could significantly improve the A-to-C/T base transversion efficiencies by up to 6.57-and 1.75-fold in the rice protoplasts,***,although no stable lines with A-to-C transversion were induced by rAKBE01 and rAKBE04,rAKBE04 could enable simultaneous A-to-G and A-to-T transition and transversion base editing,at all the five target loci,with the efficiencies of A-to-G transition and A-to-T transversion editing ranging from 70.97 to 92.31%and 1.67 to 4.84%in rice stable lines,***,these rAKBEs enable different portfolios of editing products and,thus,now expands the potential of base editing in diverse application scenario for crop improvement.

关键词： Rice(Oryza sativa L) Rice N-methylpurine DNA glycosylase(OsMPG) A-to-K base editor(AKBE) Transactivation module VP64

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