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基于超高效液相色谱-串联质谱技术快速测定果梅中化学成分

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食品与发酵工业 2022年第20期48卷 260-264,271页

作者：夏梦秋王星晨杨兰香岳婧怡王瑞曹侃程旺开芜湖职业技术学院安徽芜湖241000 芜湖生命健康工程技术研究中心安徽芜湖241000

采用超高效液相色谱-串联质谱技术对果梅的化学成分进行快速测定。采用ZORBAX SB-C18(3.0 mm×100 mm,3.5μm)色谱柱,流动相为水(含体积分数0.2%甲酸)(A)和乙腈(含体积分数0.2%甲酸)(B),采用梯度洗脱方式,柱温30℃,流速为0.2 m/min,进... 详细信息

采用超高效液相色谱-串联质谱技术对果梅的化学成分进行快速测定。采用ZORBAX SB-C18(3.0 mm×100 mm,3.5μm)色谱柱,流动相为水(含体积分数0.2%甲酸)(A)和乙腈(含体积分数0.2%甲酸)(B),采用梯度洗脱方式,柱温30℃,流速为0.2 m/min,进样量为1μL。从果梅中成功测定了16种化学成分,主要包括10种有机酸、4种黄酮类、5-羟甲基糠醛和苦杏仁苷。该文成功快速测定了果梅中主要的化学成分,为进一步研究果梅的药效基础和作用机制提供理论基础。

关键词：果梅超高效液相色谱-串联质谱法化学成分

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人参实时荧光定量PCR快速鉴别方法

山西大学学报(自然科学版) 2021年第3期44卷 609-616页

作者：李忠华杨宝马宁岳静怡郝娟赵丽红太原市食品药品检验所山西国新晋药集团有限公司

采用实时荧光定量PCR法,建立了人参的快速鉴别方法。基于ITS片段序列特征,用Snapgene软件、Oligov7.0.1和NCBI的Primer-Blast等软件设计了人参的特异性引物和TaqMan探针,并用人参及常见的易混品和伪品对引物和TaqMan探针的物种特异性、... 详细信息

采用实时荧光定量PCR法,建立了人参的快速鉴别方法。基于ITS片段序列特征,用Snapgene软件、Oligov7.0.1和NCBI的Primer-Blast等软件设计了人参的特异性引物和TaqMan探针,并用人参及常见的易混品和伪品对引物和TaqMan探针的物种特异性、检测灵敏度进行了验证。结果表明:引物和探针对人参检测特异性良好,与其他植物DNA无非目标扩增,与其他PCR方法比较所用设备少、污染小,仅需2 h～3 h出结果;检测结果在1×10-3ng/反应～100 ng/反应范围内线性关系良好(R2=0.993);灵敏度高,检测限1×10-3ng/反应。该方法具有准确、快捷、灵敏的特点,可应用于人参检测。

关键词：人参实时荧光定量PCR 快速鉴别

Numerical Simulation Investigation on Split Sleeve Cold Expansion of Ti-Al Stacked Structure

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Journal of Wuhan University of Technology(Materials Science) 2023年第5期38卷 1147-1154页

作者： GAo yue LU Shihong FU jingyi College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China

Split sleeve cold expansion(SSCX)can efiectively enhance fatigue life of holes by improving the field of residual *** simulations were conducted to investigate the parameter influence mechanism and obtain higher compressive residual stress(CRS).Expansion method,degree of cold expansion(DCE),friction coefficient between laminations and depth-diameter ratio were *** Ti-Al stacked joint holes,two expansion methods are proposed,namely aluminum alloy first followed titanium alloy(Al first)and titanium alloy first followed aluminum alloy(Ti first).The results show that expansion method and DCE have significant efiects on the field of circumferential residual stress,and the friction has a negligible influence.A higher value of CRS and a wider layer of plastic deformation are induced with Ti *** DCE of TiAl stacked structure is 5.2%-5.6%.As the depth-diameter ratio is in the range of 0.5-1.25,a positive linear correlation between the maximum compressive residual stress(CRS_(max))and depth-diameter ratio is shown.

关键词： Ti-Al stacked structure SSCX residual stress expansion method DCE

Assessment and simulation of evacuation in large railway stations

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Building Simulation 2021年第5期14卷 1553-1566页

作者： yue Wu Jian Kang jingyi Mu Key Laboratory of Cold Region Urban and Rural Human Settlement Environment Science and Technology School of ArchitectureHarbin Institute ofTechnologyNo.66 WestDazhi StreetHarbin 150001China UCL Institute for Environmental Design and Engineering The BartlettUniversity College LondonLondonUK

Evacuation systems in buildings are frequently assessed to improve emergency response *** paper proposes a method to evaluate the performance of different evacuation modes,and determine a rational mode for large railway *** developed a simulation for the evaluation of fire safety in large buildings based on an analytic hierarchy process(AHP)*** approach includes AHP-based exploration and simulation-based *** considered a typical railway station for validation,conducted a field survey to collect the data,and calculated the influencing factors based on expert *** influencing factors were further processed based on the principles of a hierarchical *** relative weights of the influencing factors were calculated through a series of pairwise comparisons using the ***,we applied factor refinement based on the evacuation simulations to determine the degree and status of influence of each *** influence of external factors was generally stronger than that of the internal *** them,the building component characteristics and people's physiological capabilities were the core of the evacuation assessment in large railway ***,the exit width,seat layout,visibility,speed,and reaction capabilities were crucial to the evacuation *** proposed method is practical as it demands limited computations to provide useful information,such as a priority ranking of each influencing factor,for the evaluation process.

关键词： analytic hierarchy process risk analysis large railway station evacuation simulation

减刑、假释案件实质化审理存在的矛盾及解决路径

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河南司法警官职业学院学报 2023年第3期21卷 28-32页

作者：楼伟君冯德艮岳静怡浙江省十里丰监狱浙江衢州324016 河南省郑州女子监狱河南郑州450000

近年,在以习近平同志为核心的党中央领导下,监狱认真贯彻执行党中央决策部署,依法履行监督职责,为推动社会主义法治进程作出了巨大贡献。但近几年,监狱一些徇私舞弊、滥用职权等司法腐败的案件屡屡发生,严重损害了司法的权威和公信力。... 详细信息

近年,在以习近平同志为核心的党中央领导下,监狱认真贯彻执行党中央决策部署,依法履行监督职责,为推动社会主义法治进程作出了巨大贡献。但近几年,监狱一些徇私舞弊、滥用职权等司法腐败的案件屡屡发生,严重损害了司法的权威和公信力。党的十八届四中全会提出了“推进以审判为中心的诉讼制度改革”,对我国司法改革和刑事诉讼制度的完善、杜绝司法腐败有着重要的指导意义。监狱如何适应减刑、假释案件的实质化审理新形式、新要求,以确保案件质量,保障社会的公平正义,值得监狱有关部门深思。

关键词：减刑假释实质化审理监狱法治

绿萼梅的化学成分、药理作用及其质量标志物预测分析

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中华中医药学刊 2024年第7期42卷 243-250页

作者：夏梦秋王瑞王星晨杨兰香岳婧怡程旺开芜湖职业技术学院食品与生物工程学院芜湖市生命健康工程技术研究中心安徽芜湖241000

绿萼梅为蔷薇科植物梅的干燥花蕾,产地广阔,民间应用历史悠久,主要含有黄酮类、苯丙素类、花青素类、挥发性成分、有机酸成分等化学成分,具有疏肝解郁及开胃生津的功效,主治胁肋胀痛,脘闷胀气,纳食不香,咽中似有物作梗等。药理研究表明... 详细信息

绿萼梅为蔷薇科植物梅的干燥花蕾,产地广阔,民间应用历史悠久,主要含有黄酮类、苯丙素类、花青素类、挥发性成分、有机酸成分等化学成分,具有疏肝解郁及开胃生津的功效,主治胁肋胀痛,脘闷胀气,纳食不香,咽中似有物作梗等。药理研究表明,绿萼梅提取物有抗抑郁、抗氧化、抑菌、抗血小板聚集等作用,临床上主要用于治疗抑郁症,胃病,癔球症,淋巴结核等症状。就近年来有关绿萼梅的相关化学成分及其药理作用进行综述,并在此基础上结合质量标志物(Q-Marker)的核心概念,从传统药性、拓展功效性、化学成分可测性等方面进行绿萼梅质量标志物的预测分析。结果发现与其传统功效及拓展功效相关药理作用的活性成分主要为苯丙素类及黄酮类成分,并初步预测出绿原酸、金丝桃苷、异槲皮苷、槲皮素、芦丁、异鼠李素、柚皮素、山柰酚和咖啡酸等成分可作为绿萼梅质量标志物的候选化合物,为建立和完善绿萼梅质量标准提供依据,以期为绿萼梅药材质量的深入研究及综合利用提供参考。

关键词：绿萼梅化学成分药理作用质量标志物

Optimal Decoupling Control Method and Its Application to a Ball Mill Coal-pulverizing System

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IEEE/CAA Journal of Automatica Sinica 2018年第6期5卷 1035-1043页

作者： yue Fu Chengwen Hong jingyi Li State Key Laboratory of Synthetical Automation for Process Industries Northeastern University

Abstract-The conventional optimal tracking control method cannot realize decoupling control of linear systems with a strong coupling property. To solve this problem, in this paper, an optimal decoupling control method is proposed, which can simultaneousiy provide optimal performance. The optimal decoupling controller is composed of an inner-loop decoupling controller and an outer-loop optimal tracking controller. First, by introducing one virtual control variable, the original differential equation on state is converted to a generalized system on output. Then, by introducing the other virtual control variable, and viewing the coupling terms as the measurable disturbances, the generalized system is open-loop decoupled. Finally, for the decoupled system, the optimal tracking control method is used. It is proved that the decoupling control is optimal for a certain performance index. Simulations on a ball mill coal-pulverizing system are conducted. The results show the effectiveness and superiority of the proposed method as compared with the conventional optimal quadratic tracking （LQT） control method.

关键词： Ball mill coal-pulverizing system linear system,optimal decoupling control optimal quadratic tracking (LQT)control.

Targeting capabilities of engineered extracellular vesicles for the treatment of neurological diseases

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Neural Regeneration Research 2025年第11期20卷 3076-3094页

作者： Xinyu Yang Xiangyu Gao Xiaofan Jiang Kangyi yue Peng Luo Department of Neurosurgery Xijing HospitalFourth Military Medical UniversityXi’anShaanxi ProvinceChina

Recent advances in research on extracellular vesicles have significantly enhanced their potential as therapeutic agents for neurological *** to their therapeutic properties and ability to cross the blood–brain barrier,extracellular vesicles are recognized as promising drug delivery vehicles for various neurological conditions,including ischemic stroke,traumatic brain injury,neurodegenerative diseases,glioma,and ***,the clinical application of natural extracellular vesicles is hindered by their limited targeting ability and short clearance from the *** address these limitations,multiple engineering strategies have been developed to enhance the targeting capabilities of extracellular vesicles,thereby enabling the delivery of therapeutic contents to specific tissues or ***,this review aims to highlight the latest advancements in natural and targeting-engineered extracellular vesicles,exploring their applications in treating traumatic brain injury,ischemic stroke,Parkinson's disease,Alzheimer's disease,amyotrophic lateral sclerosis,glioma,and ***,we summarized recent clinical trials involving extracellular vesicles and discussed the challenges and future prospects of using targeting-engineered extracellular vesicles for drug delivery in treating neurological *** review offers new insights for developing highly targeted therapies in this field.

关键词： Alzheimer's disease amyotrophic lateral sclerosis engineered extracellular vesicles glioma ischemic stroke neurological diseases Parkinson's disease psychosis targeted drug delivery traumatic brain injury

精品在线开放课程建设的探讨与应用——以药品生物检定技术课程为例

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西昌学院学报（自然科学版） 2022年第2期36卷 119-124页

作者：岳婧怡熊冉张冬冬王巨龙芜湖职业技术学院食品与生物工程学院安徽芜湖241003

[目的]更好地提高药品生物检定技术课程的教学质量,提高授课教师的教学能力,充分发挥优质教学资源的共享功能。[方法]从该课程建设的意义出发,将其内容颗粒化为37个知识点,并以其中“无菌检查法”为案例,讨论并分析该课程的教学方法、... 详细信息

[目的]更好地提高药品生物检定技术课程的教学质量,提高授课教师的教学能力,充分发挥优质教学资源的共享功能。[方法]从该课程建设的意义出发,将其内容颗粒化为37个知识点,并以其中“无菌检查法”为案例,讨论并分析该课程的教学方法、内容及考核评价。[结果]在线开放课程的建立提供了药品类专业学生网络学习和互动的载体,丰富了该课程的学习途径。[结论]通过重构该课程教学内容、优化教学手段、改革考评方式,能有效地提高学生学习兴趣、提升学习效果,可为相关教学改革提供参考。

关键词：药品生物检定技术药品质量与安全精品在线开放课程建设