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Journal of Genetics and Genomics 2023年第9期50卷 641-651页

作者： Wenbo Guo Yining Hu jingyang qian Lidan Zhu Junyun Cheng Jie Liao Xiaohui Fan Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang UniversityHangzhouZhejiang 310058China National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang UniversityJiaxingZhejiang 314100China

Spatial omics technologies have become powerful methods to provide valuable insights into cells and tissues within a complex context,significantly enhancing our understanding of the intricate and multifaceted biological *** an increasing focus on spatial heterogeneity,there is a growing need for unbiased,spatially resolved omics *** capture microdissection(LCM)is a cutting-edge method for acquiring spatial information that can quickly collect regions of interest(ROIs)from heterogeneous tissues,with resolutions ranging from single cells to cell ***,LCM has been widely used for studying the cellular and molecular mechanisms of *** review focuses on the differences among four types of commonly used LCM technologies and their applications in omics and disease *** attributes of application cases are also highlighted,such as throughput and spatial *** addition,we comprehensively discuss the existing challenges and the great potential of LCM in biomedical research,disease diagnosis,and targeted therapy from the perspective of high-throughput,multi-omics,and single-cell resolution.

关键词： Laser capture microdissection Spatial omics Single-cell resolution Multiplexed barcoding Disease microenvironment

Single-cell RNA sequencing reveals the dynamics of hepatic non-parenchymal cells in autoprotection against acetaminophen-induced hepatotoxicity

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药物分析学报:英文版 2023年第8期13卷 926-941页

作者： Lingqi Yu Jun Yan Yingqi Zhan Anyao Li Lidan Zhu jingyang qian Fanfan Zhou Xiaoyan Lu Xiaohui Fan Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang UniversityHangzhou310058China Future Health Laboratory Innovation Center of Yangtze River DeltaZhejiang UniversityJiaxingZhejiang314100China Innovation Center in Zhejiang University State Key Laboratory of Component-Based Chinese MedicineHangzhou 310058China School of Pharmacy The University of SydneySydney2006Australia Jinhua Institute of Zhejiang University JinhuaZhejiang321016China Hangzhou Institute of Innovative Medicine Zhejiang UniversityHangzhou310058China Engineering Research Center of Innovative Anticancer Drugs Ministry of EducationHarbin150023China

Gaining a better understanding of autoprotection against drug-induced liver injury(DILI)may provide new strategies for its prevention and ***,little is known about the underlying mechanisms of this *** used single-cell RNA sequencing to characterize the dynamics and functions of hepatic non-parenchymal cells(NPCs)in autoprotection against DILI,using acetaminophen(APAP)as a model *** was modeled through pretreatment with a mildly hepatotoxic dose of APAP in mice,followed by a higher dose in a secondary *** subsets and dynamic changes were identified in the APAP(hepatotoxicity-sensitive)and APAP-resistant(hepatotoxicity-resistant)groups.A chemokine(C-C motif)ligand 2^(+)endothelial cell subset almost disappeared in the APAP-resistant group,and an R-spondin 3^(+)endothelial cell subset promoted hepatocyte proliferation and played an important role in APAP ***,the dendritic cell subset DC-3 may protect the liver from APAP hepatotoxicity by inducing low reactivity and suppressing the autoimmune response and occurrence of ***-3 cells also promoted angiogenesis through crosstalk with endothelial cells via vascular endothelial growth factor-associated ligand-receptor pairs and facilitated liver tissue repair in the APAP-resistant *** addition,the natural killer cell subsets NK-3 and NK-4 and the Sca-1^(-)CD62L^(+)natural killer T cell subset may promote autoprotection through interferon-γ-dependent ***,macrophage and neutrophil subpopulations with anti-inflammatory phenotypes promoted tolerance to APAP ***,this study reveals the dynamics of NPCs in the resistance to APAP hepatotoxicity and provides novel insights into the mechanism of autoprotection against DILI at a high resolution.

关键词： Single-cell RNA sequencing Drug-induced liver injury Autoprotection against APAP hepatotoxicity Endothelial cells Dendritic cells

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不同芍药品种侧枝性状的多样性分析

浙江农业科学 2024年第2期65卷 362-370页

作者：钱景扬李芹卢莉莉孟家松陶俊赵大球扬州大学园艺园林学院江苏扬州225009

芍药是近些年国际市场上新兴的高档切花,有无侧枝是衡量芍药切花品质的重要标准之一。本研究基于单株侧枝总数将188个芍药品种分为多侧枝、中等侧枝、少侧枝和无侧枝4个类型,各侧枝类型品种分别占品种总数的4.79%、28.72%、26.60%和39.8... 详细信息

芍药是近些年国际市场上新兴的高档切花,有无侧枝是衡量芍药切花品质的重要标准之一。本研究基于单株侧枝总数将188个芍药品种分为多侧枝、中等侧枝、少侧枝和无侧枝4个类型,各侧枝类型品种分别占品种总数的4.79%、28.72%、26.60%和39.89%,其中多侧枝、中等侧枝和少侧枝类型品种的侧枝总数变异范围分别为9.00~20.00、3.00~7.00和1.00~2.00。进一步的侧枝性状多样性分析显示,所有供试品种和3个侧枝类型品种的侧枝性状差异明显,遗传多样性水平较高。有侧枝的主枝条数和单个主枝条上平均侧枝数与侧枝总数关系密切,是影响侧枝分类的两个主要因素。本研究结果可为我国芍药切花生产提供品种资源储备。

关键词：芍药侧枝性状聚类分析遗传多样性

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Security-constrained Transmission Maintenance Optimization Considering Generation and Operational Risk Costs

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Journal of Modern Power Systems and Clean Energy 2024年第3期12卷 767-781页

作者： Dan Xu Zhi Cai qian Cheng Guodong Huang jingyang Zhou Junjie Tang Beijing Key Laboratory of Research and System Evaluation of Power Dispatching Automation Technology China Electric Power Research InstituteBeijing 100192China State Key Laboratory of Power Transmission Equipment&System Security and New Technology Chongqing UniversityChongqing 400044China

With the large-scale integration of renewable energy,the traditional maintenance arrangement during the load valley period cannot satisfy the transmission demand of renewable energy ***,in a market-oriented operation mode,the power dispatching control center aims to reduce the overall power purchase cost while ensuring the security of the power ***,a security-constrained transmission maintenance optimization model considering generation and operational risk costs is proposed *** model is built on double-layer optimization framework,where the upper-layer model is used for maintenance and generation planning,and the lowerlayer model is primarily used to address the operational security risk arising from the random prediction error and N-1 transmission ***,a generation-maintenance iterative algorithm based on a defined cost feedback is included to increase solution *** cost is determined using long-term security-constrained unit commitment,and the operational risk cost is obtained using a double-layer N-1 risk assessment *** electrical correlation coupling coefficient is proposed for the solution process to avoid maintenance of associated equipment simultaneously,thereby improving model convergence *** IEEE 118-bus system is used as a test case for illustration,and test results suggest that the proposed model and algorithm can reduce the total cost of transmission maintenance and system operation while effectively improving the solution efficiency of the joint optimization model.

关键词： Transmission maintenance security-constrained unit commitment iterative algorithm cost feedback N−1 risk assessment

A historical review of hybrid rice breeding

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Journal of Integrative Plant Biology 2024年第3期66卷 532-545页

作者： Xiaoming Zheng Fei Wei Cheng Cheng qian qian State Key Laboratory of Crop Gene Resources and Breeding Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China Yazhouwan National Laboratory Sanya City 572024China

The development of germplasm resources and advances in breeding methods have led to steady increases in yield and quality of rice (Oryza sativa L.). Three milestones in the recent history of rice breeding have contributed to these increases: dwarf rice breeding, hybrid rice breeding, and super rice breeding. On the 50th anniversary of the success of three-line hybrid rice,we highlight important scientific discoveries in rice breeding that were made by Chinese scientists and summarize the broader history of the field. We discuss the strategies that could be used in the future to optimize rice breeding further in the hope that China will continue to play a leading role in international rice breeding.

关键词： Chinese experience dwarf breeding hybrid rice breeding super rice breeding

Molecular Mechanism of Rice Necrotic Lesion for Optimized Yield and Disease Resistance

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Rice science 2024年第3期31卷 285-299页

作者： HOU Xinyue WANG Yuping qian qian REN Deyong State Key Laboratory of Rice Biology and Breeding China National Rice Research InstituteHangzhou 310006China State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China Rice Research InstituteSichuan Agricultural UniversityChengdu 611130China

How to balance rice resistance and yield is an important issue in rice *** with mutated necrotic lesion genes often have persistent broad-spectrum resistance,but this broad-spectrum resistance usually comes at the expense of ***,many necrotic lesion mutants in rice have been identified,and these genes are involved in disease resistance *** review provides a detailed introduction to the characteristics,classification,and molecular mechanisms of necrotic lesion ***,we review the molecular regulatory pathways of genes involved in rice disease ***,we summarize the relationship between resistance and yield in rice using newly developed gene editing *** discuss a rational and precise breeding strategy to better utilize molecular design technology for breeding disease-resistant and high-yield rice varieties.

关键词： rice necrotic lesion regulation mechanism high yield high resistance

Localizing vitamin-C through nanoconfinement enables high-rate CO_(2) electrolysis to ethylene

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Science China Materials 2024年第3期67卷 1006-1008页

作者： Zhengyi qian Shaojun Guo School of Materials Science and Engineering Peking UniversityBeijing 100871China

The electrosynthesis of value-added fuels and chemicals from carbon dioxide reduction reaction(CO_(2)RR)is a promising approach for realizing the objectives of carbon neutrality[1].Nevertheless,the current production of desirable multicarbon(C_(2+))chemicals,such as ethylene(C_(2)H_(4)),still encounters challenges related to low selectivity,low current density,and the requirement for high-purity feeding gas[2].

关键词： enable purity dioxide

The tangential k-Cauchy-Fueter type operator and Penrose type integral formula on the generalized complex Heisenberg group

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Applied Mathematics(A Journal of Chinese Universities) 2024年第1期39卷 181-190页

作者： REN Guang-zhen SHI Yun KANG qian-qian Department of Mathematics Zhejiang International Studies UniversityHangzhou 310023China Department of Mathematics Zhejiang University of Science and TechnologyHangzhou 310023China

The tangential k-Cauchy-Fueter operator and k-CF functions are counterparts of the tangential Cauchy–Riemann operator and CR functions on the Heisenberg group in the theory of several complex variables,*** this paper,we introduce a Lie group that the Heisenberg group can be imbedded into and call it generalized complex *** investigate quaternionic analysis on the generalized complex *** also give the Penrose integral formula for k-CF functions and construct the tangential k-Cauchy-Fueter complex.

关键词： the generalized complex Heisenberg group the tangential k-Cauchy-Fueter type operator Penrose-type integral formula

Unveiling a half-century mystery of molecular bases for three-line hybrid rice breeding system

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Journal of Integrative Plant Biology 2024年第1期66卷 3-6页

作者： Xiaoming Zheng qian qian State Key Laboratory of Crop Gene Resources and Breeding Chinese Academy of Agricultural SciencesBeijing 100081China Yazhouwan National Laboratory No.8 Huanjin RoadYazhou DistrictSanya 572024China

Rice(Oryza sativa L.)isa staplecropforhalf theworld's Ipopulation and an important contributor to world food *** discovery and application of cytoplasmic male sterility(CMS)and fertility restoration(Rf)genetic materials have allowed the production of three-line hybrid rice(Kim and Zhang,2018),successfully harnessing heterosis in *** major CMS and/or Rf systems are commonly used to produce three-line hybrid rice:Wild Abortive(CMS-WA),Boroll(CMS-BT),and Honglian(CMS-HL).Among these,the CMS-WA system is the most widely employed(Sattari et al.,2007;Chen and Liu,2014;Huang et al.,2014).Several Rf genes from different CMS systems have been cloned in rice,including Rf4 for CMS-WA(Tang et al.,2014),Rf1a and Rf1b for CMS-BT(Wang et al.,2006),Rf5,and Rf6 for CMS-HL(Huet al.,2012;Huang et al.,2015),and Rf19for CMS-FA(Jiang et al.,2022).A molecular mechanism and evolutionary model for the CMS-WA gene WA352c have also been reported(Luo et al.,2013;Tang et al.,2017).

关键词： breeding fertility Wild

Spatial Distribution Pattern and Influencing Factors of Bed-and-breakfasts(B&Bs)from the Perspective of Urban-rural Differences:A Case Study of Jiaodong Peninsula,China

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Chinese Geographical Science 2024年第4期34卷 752-763页

作者： WANG Xinyue MA qian Management College Ocean University of ChinaQingdao 266100China

There are significant differences between urban and rural bed-and-breakfasts(B&Bs)in terms of customer positioning,economic strength and spatial *** identifying the differences in spatial characteristics and influencing factors of each type,is essential for creating urban and rural B&B agglomeration *** study used density-based spatial clustering of applications with noise(DBSCAN)and the multi-scale geographically weighted regression(MGWR)model to explore similarities and differences in the spatial distribution patterns and influencing factors for urban and rural B&Bs on the Jiaodong Peninsula of China from 2010 to *** results showed that:1)both urban and rural B&Bs in Jiaodong Peninsula went through three stages:a slow start from 2010 to 2015,rapid development from 2015 to 2019,and hindered development from 2019 to ***,urban B&Bs demonstrated a higher development speed and agglomeration intensity,leading to an increasingly evident trend of uneven development between the two sectors.2)The clustering scale of both urban and rural B&Bs continued to expand in terms of quantity and *** B&B clusters characterized by a limited number,but a higher likelihood of transitioning from low-level to high-level *** the number of rural B&B clusters steadily increased over time,their clustering scale was comparatively lower than that of urban B&Bs,and they lacked the presence of high-level clustering.3)In terms of development direction,urban B&B clusters exhibited a relatively stable pattern and evolved into high-level clustering centers within the main urban ***,rural B&Bs exhibited a more pronounced spatial diffusion effect,with clusters showing a trend of multi-center development along the coastline.4)Transport emerged as a common influencing factor for both urban and rural B&Bs,with the density of road network having the strongest explanatory power for their spatial *** terms of differences,populati

关键词： urban-rural bed-and-breakfasts(B&Bs) spatiotemporal evolution density-based spatial clustering of applications with noise(DBSCAN)model multi-scale geographically weighted regression(MGWR) Jiaodong Peninsula China