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Genes & Diseases 2024年第3期11卷 136-139页

作者： Yuchao Yang Shutong Wu Rongmei Qu Congrong Wang Jinyang Wang Asmat Ullah Khan You Pan Wenqing Liu Jinhui Zhu Muhammad Akram Khan Chujiang Xu jingxing dai Jun Ouyang Guangdong Provincial Key Laboratory of Medical Biomechanics&National Key Discipline of Human Anatomy Schoolof BasicMedical SciencesSouthern Medical UniversityGuangzhouGuangdong 510515China Department of Laboratory Medicine Nanfang Hospital of Southern Medical UniversityGuangzhouGuangdong 510515China Department of Pathology Guangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhouGuangdong 510080China Department of Breast Surgery Guangxi Medical University Cancer HospitalNanningGuangxi 530000China Department of Veterinary Pathology Faculty of Veterinary and Animal SciencesPMAS Arid Agriculture UniversityRawalpindi 46300Pakistan Department of Orthopedics TCM-Integrated HospitalSouthern Medical UniversityGuangzhouGuangdong 510000China

Bone regeneration is a multifaceted,abstract,and wellcoordinated physiological progression of bone formation that participates in continuous regeneration and remodeling throughout life.However,when it comes to complex clinical situations requiring extensive bone regeneration,such as massive bone defects caused by injuries,infection,or tumor removal,traditional methods do not often yield good treatment strategies or protocols due to their limitations.

关键词： alterations injuries massive

Lipid rafts participate in aberrant degradative autophagic-lysosomal pathway of amyloid-beta peptide in Alzheimer's disease

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Neural Regeneration Research 2014年第1期9卷 92-100页

作者： Xin Zhou Chun Yang Yufeng Liu Peng Li Huiying Yang jingxing dai Rongmei Qu Lin Yuan Department of Human Anatomy Histology and EmbryologySchool of Basic Medical SciencesSouthern Medical University

Amyloid-beta peptide is the main component of amyloid plaques, which are found in Alzhei- mer＇s disease. The generation and deposition of amyloid-beta is one of the crucial factors for the onset and progression of Alzheimer＇s disease. Lipid rafts are glycolipid-rich liquid domains of the plasma membrane, where certain types of protein tend to aggregate and intercalate. Lipid rafts are involved in the generation of amyloid-beta oligomers and the formation of amyloid-beta peptides. In this paper, we review the mechanism by which lipid rafts disturb the aberrant deg- radative autophagic-lysosomal pathway of amyloid-beta, which plays an important role in the pathological process of Alzheimer＇s disease. Moreover, we describe this mechanism from the view of the Two-system Theory of fasciology and thus, suggest that lipid rafts may be a new target of Alzheimer＇s disease treatment.

关键词： nerve regeneration lipid rafts amyloid precursor protein autophagy lysosome Alzhei-mer＇s disease Two-system Theory amyloid beta peptide autophagosome National Financial MajorProject of China neural regeneration

Paravertebral fascial massage promotes brain development of neonatal rats via the insulin-like growth factor 1 pathway

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Neural Regeneration Research 2012年第15期7卷 1185-1191页

作者： Zhongqiu Wen Wenqin Zeng jingxing dai Xin Zhou Chun Yang Fuhua Duan Yufeng Liu Huiying Yang Lin Yuan Key Laboratory of Tissue Construction and Detection of Guangdong Province Department of AnatomySouthem Medical UniversityGuangzhou 510515Guangdong ProvinceChina

Massage in traditional Chinese medicine can promote body and brain development of premature and normal newborn infants. In the present study, neonatal rats （1 day old） underwent paravertebral fascial massage （15 consecutive days）, followed by subcutaneous injection of insulin-like growth factor 1 receptor antagonist, JB1 （9 consecutive days）. Paravertebral fascial massage significantly increased insulin-like growth factor 1 expression and cell proliferation in the subventricular zone of the lateral ventricle and dentate gyrus of the hippocampus. However, JB1 inhibited this increase. Results suggest that paravertebral fascial massage can promote brain development of neonatal rats via the insulin-like growth factor I pathway.

关键词： paravertebral fascial massage insulin-like growth factor 1 neurogenesis immunohistochemistry neural regeneration

In situ staining of the primo vascular system in the ventricles and subarachnoid space of the brain by trypan blue injection into the lateral ventricle

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Neural Regeneration Research 2011年第28期6卷 2171-2175页

作者： jingxing dai Byung-Cheon Lee Ping An Zhendong Su Rongmei Qu Ki Hoon Eom Kwang-Sup Soh Department of Human Anatomy Southern Medical University Guangzhou 510515 Guangdong Province China Nano Primo Research Center Advanced Institute of Convergence Technology Seoul National University Seou1443-270 Korea Pharmacupuncture Medical Research Institute Korean Pharmacupuncture Institute Seoul Korea

We examined a new method for visualization of the primo vascular system in the rat brain involving lateral ventricle injection of trypan blue. Results showed that the primo vascular system in the lateral ventricles and arachnoid mater of the brain were preferentially stained relative to blood vessels and fascia. The primo-vessels along blood vessels in the brain were clearly exhibited. In addition, the primo vascular system was evident between the fourth ventricle and the quadrigeminal cistern. Our experimental findings indicate that this new technique of lateral ventricle injection of trypan blue can visualize the primo vascular system in lateral ventricles and arachnoid mater of rats in situ.

关键词： trypan blue primo vascular system fascia cerebral ventricles choroid plexus neuroanatomy neural regeneration

Transplanted adipose-derived stem cells delay D-galactose-induced aging in rats

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Neural Regeneration Research 2011年第34期6卷 2673-2680页

作者： Chun Yang Dongfei Li Zhongqiu Wen Huiying Yang Meichun Yu Hui Tao Rongmei Qu Yikuan Du Yong Huang Ou Sha jingxing dai Lin Yuan Department of Anatomy Southem Medical University Guangzhou 510515 Guangdong Province China Department of Orthopaedics Linyi Traditional Chinese Medical Hospital Linyi 276000 Shandong Province China Department of Traditional Chinese Medicine Southern Medical University Guangzhou 510515 Guangdong Province China School of Biomedical Sciences Chinese University of Hong Kong Hong Kong Special Administrative Region 999077 China

To investigate the effects of allogeneically transplanted, adipose-derived stem cells in aging rats, in the present study, we established a rat model of subacute aging using continuous subcutaneous injections of D-galactose. Two weeks after the adipose-derived stem cells transplantations, serum superoxide dismutase activity was significantly increased, malondialdehyde content was significantly reduced, hJppocampal neuronal degeneration was ameliorated, the apoptotic index of hippocampal neurons was decreased, and leaming and memory function was significantly improved in the aging rats. These results indicate that allogeneic transplantation of adipose-derived stem cells may effectively delay D-galactose-induced aging.

关键词： adipose-derived stem cell transplantation stem cells fasciology fascial anatomy anti-aging

Cognitive improvement following transvenous adipose-derived mesenchymal stem cell transplantation in a rat model of traumatic brain injury

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Neural Regeneration Research 2011年第10期6卷 732-737页

作者： Dongfei Li Chun Yang Rongmei Qu Huiying Yang Meichun Yu Hui Tao jingxing dai Lin Yuan Key Laboratory of Tissue Construction and Detection of Guangdong Province Department of Anatomy Southern Medical UniversityGuangzhou 510515 Guangdong Province China

The effects of adipose-derived mesenchymal stem cell (ADMSC) transplantation for the repair of traumatic brain injury remain poorly understood. The present study observed neurological functional changes in a rat model of traumatic brain injury following ADMSC transplantation via the tail vein. Cell transplants were observed in injured cerebral cortex, and expression of brain-derived nerve growth factor was significantly increased in the injured hippocampus following transplantation. Results demonstrated that transvenous ADMSC transplants migrated to the injured cerebral cortex and significantly improved cognitive function.

关键词：创伤性脑损伤干细胞移植大鼠模型尾静脉脂肪脑源性神经生长因子间充质干细胞神经功能

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人工椎体的结构和界面之生物力学设计

生物医学工程学杂志 1999年第S1期16卷 29-30页

作者：原林戴景兴第一军医大学人体解剖学教研室广州510515

设计一种新型的弹性活动式人工椎体 ,以切口弹簧为主体。用三种不同的界面处理再现椎体与椎间盘间界面的生物相容性。脊柱功能单位是包括椎间盘及其周围韧带的椎体间连接。椎间盘具有吸收振荡、减缓冲击和传导应力的能力 ,其运动方式是... 详细信息

设计一种新型的弹性活动式人工椎体 ,以切口弹簧为主体。用三种不同的界面处理再现椎体与椎间盘间界面的生物相容性。脊柱功能单位是包括椎间盘及其周围韧带的椎体间连接。椎间盘具有吸收振荡、减缓冲击和传导应力的能力 ,其运动方式是压缩、弯曲和扭转的组合。弹性活动式人工椎体整体的切口弹簧设计能够与正常脊柱的生物力学性能相近。

关键词：人工椎体力学性能界面生物相容性

术前低白蛋白血症与后路腰椎融合术后不良结局发生率的相关性

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中国临床解剖学杂志 2022年第4期40卷 485-490页

作者：李鑫张国炜万江涛仇显帅张福戴景兴闵少雄南方医科大学珠江医院脊柱外科广州510280 中山大学第七附属医院骨科深圳518107 南方医科大学人体解剖学教研室广州510515 北京大学深圳医院脊柱外科深圳518036

目的探讨术前低白蛋白血症与后路腰椎融合术(posterior lumbar interbody fusion,PLIF)后不良结局发生率的相关性。方法选取珠江医院2017年1月~2019年12月接受后路腰椎融合术治疗的腰椎退行性疾病患者1372例,男597例,女775例,平均年龄(5... 详细信息

目的探讨术前低白蛋白血症与后路腰椎融合术(posterior lumbar interbody fusion,PLIF)后不良结局发生率的相关性。方法选取珠江医院2017年1月~2019年12月接受后路腰椎融合术治疗的腰椎退行性疾病患者1372例,男597例,女775例,平均年龄(58.11±12.56)岁,根据术前血清白蛋白(albumin,ALB)水平,分为低白蛋白组(ALB<35 g/L,n=91)和正常白蛋白组(ALB≥35 g/L,n=1281),比较两组患者术后3个月内发生的不良结局(术后转ICU监护、术后特定并发症、再次入院、切口感染、愈合不良等),通过logistic多元回归分析模型及混杂因素调整来评估术前血清白蛋白水平与术后不良结局之间的关系及术前低白蛋白血症与术后不良结局发生率的相关性。结果术前白蛋白水平与术后不良结局的发生密切相关(OR=0.94;95%CI:0.90~0.98;P<0.05),术前低白蛋白组患者发生术后不良结局的风险是术前正常白蛋白组的2.15倍(OR=2.15;95%CI:1.21~3.79;P<0.05)。结论术前低白蛋白血症患者会显著增加PLIF术后不良结局的发生率,术前血清白蛋白水平可作为预测PLIF术后不良结局发生的重要参考指标。

关键词：腰椎退行性疾病低白蛋白血症后路腰椎融合术不良结局

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miRNA调控脂肪干细胞分化的研究进展

中国修复重建外科杂志 2017年第12期31卷 1506-1511页

作者：周兰庭冯雁婷戴景兴欧阳钧湖北文理学院医学院湖北襄阳441053 南方医科大学人体解剖学教研室广州510515

目的总结近年来miRNA在调控脂肪干细胞(adipose-derived stem cells,ADSCs)分化中的研究进展。方法查阅近年来与miRNA和ADSCs分化调控相关的文献,详细分析其调节机制,并进行综述。结果在ADSCs分化过程中,miRNA的表达会改变,并且miRNA可... 详细信息

目的总结近年来miRNA在调控脂肪干细胞(adipose-derived stem cells,ADSCs)分化中的研究进展。方法查阅近年来与miRNA和ADSCs分化调控相关的文献,详细分析其调节机制,并进行综述。结果在ADSCs分化过程中,miRNA的表达会改变,并且miRNA可通过调节细胞分化相关的信号通路,调控ADSCs定向分化为脂肪细胞、成骨细胞、软骨细胞、神经细胞、肝细胞等。结论利用miRNA对ADSCs分化的调控作用,构建出符合需求的组织工程种子细胞,用于临床分子靶向治疗和干细胞治疗。

关键词： miRNA 脂肪干细胞多向分化

The osteogenic effect of aligned porous poly(ethylene glycol)/silk fibroin/hydroxyapatite scaffold in different stiffness

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The osteogenic effect of aligned porous poly(ethylene glycol...