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Chinese Journal of Aeronautics 2025年第1期38卷 365-379页

作者： jingwen hu Xun CHEN Yashun WANG Chen YANG College of Intelligence Science and Technology National University of Defense TechnologyChangsha 410073China Laboratory of Science and Technology on Integrated Logistics Support National University of Defense TechnologyChangsha 410073China

This paper investigates the uniaxial tensile mechanical properties and flow behavior of Ti-6Al-4V alloys with equiaxed microstructure at cryogenic temperatures ranging from 77 K to298 K and strain rates from 10^(-4)/s to 10^(-2)/*** electron microscopy is utilized to analyze the fracture morphology,aiming to reveal the fracture behavior at various *** applicability of the Zener-Hollomon parameter and the Johnson-Cook model in describing the flow stress of Ti-6Al-4V at cryogenic temperatures is ***,a constitutive relationship modeling method based on the variational recurrent networks is *** test results show a significant increase in the strength of equiaxed Ti-6Al-4V alloy under cryogenic conditions while the plastic deformation process is ***,the fracture analysis indicates that even at 77 K,the fracture process is still dominated by ductile fracture,and brittle fracture does not occur within the range of 77 K to 298 *** fitting results validate the performance of the Zener-Hollomon parameter and the Johnson-Cook model in describing the deformation flow stress of Ti-6Al-4V alloy at cryogenic *** results also indicate that the proposed constitutive relationship modeling method based on the variational recurrent network performs better,making it a potential method for widespread applications.

关键词： Titanium alloys Mechanical properties Cryogenics Fracture testing Flow behavior

Mechanical properties and flow stress constitutive relationship of Ti–6Al–4V alloy with equiaxed microstructure at cryogenic temperatures

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Chinese Journal of Aeronautics 2025年第1期 370-384页

作者： jingwen hu Xun CHEN Yashun WANG Chen YANG College of Intelligence Science and Technology National University of Defense Technology Laboratory of Science and Technology on Integrated Logistics Support National University of Defense Technology

This paper investigates the uniaxial tensile mechanical properties and flow behavior of Ti-6Al-4V alloys with equiaxed microstructure at cryogenic temperatures ranging from 77 K to298 K and strain rates from 10-4/s to 10-2/s. Scanning electron microscopy is utilized to analyze the fracture morphology, aiming to reveal the fracture behavior at various temperatures. The applicability of the Zener-Hollomon parameter and the Johnson-Cook model in describing the flow stress of Ti-6Al-4V at cryogenic temperatures is analyzed. Moreover, a constitutive relationship modeling method based on the variational recurrent networks is proposed. Mechanical test results show a significant increase in the strength of equiaxed Ti-6Al-4V alloy under cryogenic conditions while the plastic deformation process is shortened. However, the fracture analysis indicates that even at 77 K, the fracture process is still dominated by ductile fracture, and brittle fracture does not occur within the range of 77 K to 298 K. The fitting results validate the performance of the Zener-Hollomon parameter and the Johnson-Cook model in describing the deformation flow stress of Ti-6Al-4V alloy at cryogenic temperatures. The results also indicate that the proposed constitutive relationship modeling method based on the variational recurrent network performs better,making it a potential method for widespread applications.

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以中国服饰文化为核心的服装表演课程教学实践与探索

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湖北成人教育学院学报 2025年第1期31卷 64-69页

作者：扈静雯广东海洋大学广东湛江524088

服装表演课程是服装表演专业核心课程之一,旨在通过深入讲解中国服饰文化的理论精髓、赏析中国绘画中女性形象所呈现的空间视觉艺术,以及聆听富有中国主题的音乐作品,引领学生重返中国服饰文化的语境。课程设计不仅帮助学生探究不同朝... 详细信息

服装表演课程是服装表演专业核心课程之一,旨在通过深入讲解中国服饰文化的理论精髓、赏析中国绘画中女性形象所呈现的空间视觉艺术,以及聆听富有中国主题的音乐作品,引领学生重返中国服饰文化的语境。课程设计不仅帮助学生探究不同朝代的服装表演风格,而且鼓励他们从多元角度审视服装表演艺术。我们期望通过这一课程,丰富学生的服装表演理论知识,激发其专业潜能,并助力于中国服饰文化的传承与推广。

关键词：服装表演中国服饰文化教学改革

Evolution of Surface Cold Patches in the North Yellow Sea Based on Satellite SST Data

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Journal of Ocean University of China 2016年第6期15卷 936-946页

作者： hu jingwen SHI Maochong ZHANG Tinglu CHEN Shuguo WU Lunyu Department of Marine Technology Ocean University of China Qingdao 266100 P. R. China The First Institute of Oceanography SOA Qingdao 266061 PI R. China

Ten years （from 2005 to 2014） of satellite sea surface temperature （SST） data from the Advanced Very High Resolution Radiometer （AVHRR） are analyzed to reveal the monthly changes in surface cold patches （SCPs） in the main areas of the Northern Yellow Sea （NYS）. The Canny edge detection algorithm is used to identify the edges of the patches. The monthly changes are de- scribed in terms of location, temperature and area. The inter-annual variations, including changes in the location and area of the SCPs from 2010 to 2014, are briefly discussed. The formation mechanisms of the SCPs in different periods are systematically analyzed using both in situ data and numerical simulation. The results show that from May to October, the location and area of the SCPs re- main stable, with a north-south orientation. The SCPs altogether cover about I° of longitude （124°E-125°E） in width and 2° of lati- tude （37.5°N-39.5°N） in length. In November, the SCP separates from the Jangsan Cape and forms a closed, isolated, and approxi- mately circular cold patch in the central NYS. From May to October, the upweUing that leads to the formation of the SCP is mainly triggered by the headland residual current, wind field, climbing movement of the current and secondary circulation at the tide front. In November, cyclonic circulation in the NYS is primarily responsible for generating the upwelling that leads to the formation of the closed and isolated SCE

关键词： surface cold patch monthly evolutions upwelling the North Yellow Sea

从“肠-肝对话”角度探究植物来源细胞外囊泡样颗粒防治肠肝疾病的研究进展

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中草药 2025年第2期56卷 709-720页

作者：黄志远胡静雯卢倩马洁贺欣雨代薪钰杨珅珅于海洋天津中医药大学中药学院

植物来源的细胞外囊泡（plant-derived extracellular vesicles,PDEVs）是植物细胞释放的纳米级囊泡，内含蛋白质、脂质、核酸等生物活性物质，不仅参与机体生理病理过程的调控，如跨界通讯、细胞增殖分化、免疫调节和炎症反应等，还可... 详细信息

植物来源的细胞外囊泡（plant-derived extracellular vesicles,PDEVs）是植物细胞释放的纳米级囊泡，内含蛋白质、脂质、核酸等生物活性物质，不仅参与机体生理病理过程的调控，如跨界通讯、细胞增殖分化、免疫调节和炎症反应等，还可克服生物屏障作为药物载体靶向病变部位，对疾病的转归起到关键作用。随着对PDEVs研究的深入，其在肠肝疾病防治的应用潜力逐渐显现。然而关于PDEVs如何通过肠-肝轴发挥治疗作用的潜在机制尚未明确，鉴于PDEVs具备良好的自然靶向性、生物相容性等突出优势，从肠-肝轴的角度切入，在肠道、肝脏及二者之间相互调节和通信层面上对PDEVs防治肠肝疾病的分子作用机制进行总结探讨，为PDEVs治疗肠肝疾病的研究提供新的思路与方法。

关键词：植物源EVs样颗粒肠-肝轴肠道疾病肝脏疾病肠道菌群药物载体

Morphological comparison and molecular marker screening of three Skeletonema species found in Changjiang(Yangtze)River Basin

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Journal of Oceanology and Limnology 2024年第3期42卷 923-942页

作者： jingwen hu Yuxin YI Zhengxin YANG John Patrick KOCIOLEK Pan YU Quanxi WANG Qingmin YOU College of Life Sciences Shanghai Normal UniversityShanghai 200235China Museum of Natural History University of ColoradoBoulder 80309USA College of Environmental and Geographical Sciences Shanghai Normal UniversityShanghai 200235China

In our recent investigations of diatom diversity,we studied three species,namely,Skeletonema costatum,Skeletonema subsalsum,and Skeletonema *** they have been found frequently in Changjiang(Yangtze)River Basin,their morphological and molecular identification is difficult in ***,to integrate morphological and molecular biological approaches,we compared systematically their morphological characters and performed phylogenetic *** strains of Skeletonema were collected and isolated from Shanghai and Jiangsu,China,and their morphological characteristics were examined by light microscopy(LM)and the scanning electron microscopy(SEM).Based on morphological comparison,we determined that *** is easy to distinguish from the other two *** heavily silicified areolae,undulated or cleft distal ends of terminal fultoportula processes(TFPPs),absence of basal pores of fultoportula processes(FPPs),the rootlike protrusions of FPPs,and no interlocking connection are the stable characteristics that can be used to identify ***,there are only two features that can distinguish *** from ***,namely the location of terminal rimoportulae(TRPs)and the distal shape of *** addition,we amplified and sequenced nine common genetic markers from the strains,from which 101 sequences were obtained,constructed phylogenetic trees based on the nine genes and evaluated that seven genes can be used to identify ***,and revealed that *** is the closest known relative of ***,and only ATP synthetase beta-subunit gene(atp B)is able to distinguish them from each other,which strongly support that it is an effective molecular marker for *** work provided a theoretical basis for the taxonomic study of Skeletonema.

关键词： Skeletonema Changjiang River morphological change distinguishing morphological characteristics molecular marker

研究生教育立德树人成效评价工具初探——基于学生过程体验的视角

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西北工业大学学报(社会科学版) 2025年第1期 56-65页

作者：彭湃党宇胡静雯梁媛媛赵红艳华中科技大学教育科学研究院华中科技大学计算机科学与技术学院华中科技大学学生工作部研究生工作办公室事务管理科共青团华中科技大学委员会研究生团建工作部

立德树人成效是检验研究生教育工作的根本标准。研究生教育的立德树人在育人目标、育人价值及育人途径上具备特殊性,其成效可从学生体验的教育过程要素对其学习和发展的促进作用中得到评价。本文基于严格的量表设计程序,从过程体验视角... 详细信息

立德树人成效是检验研究生教育工作的根本标准。研究生教育的立德树人在育人目标、育人价值及育人途径上具备特殊性,其成效可从学生体验的教育过程要素对其学习和发展的促进作用中得到评价。本文基于严格的量表设计程序,从过程体验视角开发出包含导师育人、课程育人、管理服务育人三个分量表的研究生教育立德树人成效综合评价工具,并通过了系列检验程序。建议科学使用本评价工具,并服务于形成性和诊断性评价的目的。

关键词：研究生教育立德树人成效评价过程体验

Hypofibrinogenemia Caused by Hemocoagulase Injection:A Retrospective Study on Clinical Laboratory Findings

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Chinese Medical Sciences Journal 2020年第2期35卷 151-156页

作者： jingwen hu Xiaosong Qin Department of Laboratory Medicine Shengjing Hospital of China Medical UniversityShenyang 110004China

Objective Hemocoagulase injection based on the venom of Agkistrodon halys Pallas is widely used in the treatment of hemorrhagic *** study aimed to characterize the clinical laboratory findings of hemocoagulase-induced hypofibrinogenemia as the associated adverse reaction of hemocoagulase *** Wie retrospectively enrolled 27 in-patients who were treated with hemocoagulase injection for hemoptysis and developed hypofibrinogenemia during the period of January 1,2015 to March 31,*** data were collected and investigated,including clinical manifestations,hemostatic and fibrinolytic parameters,dosage of hemocoagulase,the medication time,and the cryoprecipitate blood product *** in fibrinogen,D-dimer,and fibrin/fibrinogen degradation products(FDP)before,during,and after the application of hemocoagulase injection were analyzed *** Plasma fibrinogen level during medication of hemocoagulase injection decreased significantly compared to that before the treatment(F=1.80,P<0.001),with the average decrease of 2.28 g/L(0.63-3.9 g/L).After withdrawal,fibrinogen level increased significantly compared to that during the medication(F=l.20,P<0.001),but was still lower than that before the medication(F=0.59,P=0.03).The D-dimer level and the FDP level after withdrawal decreased significantly compared to the levels during the medication(F=0.83,P=0.002;Wilcoxon-test,Z=-4.54,P<0.001).Spearman's correlation analyses did not find either fibrinogen change during-before the administration or FDP change after-during the administration was associated with the dosage of hemo coagulase(r=-0.17,P=0.40;r=-0.28,P=0.15;respectively)and the time of recovery from hypofibrinogenemia(r=-0.45,P=0.05;r=0.13,P=0.61;respectively).Conclusion Monitoring both clotting and fibrinolysis parameters is essential in the management of hemoptysis patients treated with hemocoagulase *** should be aware of hypofibrinogenemia and consider

关键词： hypofibrinogenemia hemocoagulase fibrinogen fibrinolysis

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薇甘菊驱蚊活性成分筛选及配比优化

中华卫生杀虫药械 2025年第1期31卷 12-16,35页

作者：胡静雯程倩倩吕斌刘宏振王振华杜勤广州中医药大学中药学院广东广州510000 广州中医药大学青蒿研究中心广东广州510000

目的探究薇甘菊驱蚊活性成分,获得高效驱蚊组合物,为植物源驱蚊剂的开发提供基础。方法首先通过Y型嗅觉仪法对不同薇甘菊粗提物进行驱蚊活性初筛;采用气相色谱-质谱联用技术(GC-MS)对活性粗提物进行定性分析,复筛驱蚊活性成分;通过各... 详细信息

目的探究薇甘菊驱蚊活性成分,获得高效驱蚊组合物,为植物源驱蚊剂的开发提供基础。方法首先通过Y型嗅觉仪法对不同薇甘菊粗提物进行驱蚊活性初筛;采用气相色谱-质谱联用技术(GC-MS)对活性粗提物进行定性分析,复筛驱蚊活性成分;通过各成分配伍组合后的驱蚊效果,利用均匀试验设计建立高效驱蚊组合物。结果挥发油为薇甘菊主要驱蚊活性物质,对白蚊伊蚊的驱避率可达63.80%,其中含有氧化石竹烯、桉叶油醇等活性成分;均匀试验设计筛选获得的适宜驱蚊组合配比为:9.8%氧化石竹烯+9.9%桉叶油醇+8.6%芳樟醇+7.9%α-松油醇+7.8%δ-杜松烯,该组合物对白蚊伊蚊的平均驱避率为83.20%,驱蚊效果良好。结论薇甘菊挥发油具有驱蚊活性,其中含有多种驱蚊活性成分,可制备成高效驱蚊组合物,进一步开发为驱蚊产品,为植物源驱蚊剂提供新资源。

关键词：薇甘菊驱蚊组合物活性组分挥发油均匀实验设计

Rapidly separating dissolving microneedles with sustained-release colchicine and stabilized uricase for simplified long-term gout management

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Acta Pharmaceutica Sinica B 2023年第8期13卷 3454-3470页

作者： Yao Yang Zimu Li Ping huang Jiachan Lin Jinyuan Li Kexin Shi Jiahui Lin jingwen hu Zhuoxian Zhao Yongkang Yu Hongzhong Chen Xiaowei Zeng Lin Mei Institute of Pharmaceutics School of Pharmaceutical Sciences(Shenzhen)Sun Yat-sen UniversityShenzhen 518107China State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yatsen University Cancer CenterGuangzhou 510060China Tianjin Key Laboratory of Biomedical Materials Key Laboratory of Biomaterials and Nanotechnology for Cancer ImmunotherapyInstitute of Biomedical EngineeringChinese Academy of Medical SciencesPeking Union Medical CollegeTianjin300192China

Despite growing prevalence and incidence,the management of gout remains *** intermittent nature of the gout makes the long-term urate-lowering therapy(ULT)particularly important for gout ***,patients are reluctant to take medication day after day to manage incurable occasional gout flares,and suffer from possible long-term ***,a safe and easy-tooperate drug delivery system with simple preparation for the long-term management of gout is very ***,a chitosan-containing sustained-release microneedle system co-loaded with colchicine and uricase liposomes were fabricated to achieve this *** microneedle system was confirmed to successfully deliver the drug to the skin and maintain a one-week drug ***,its powerful therapeutic potency to manage gout was investigated in both acute gouty and chronic gouty ***,the drug co-delivery system could help avoid long-term daily oral colchicine,a drug with a narrow therapeutic *** system also avoids mass injection of uricase by improving its stability,enhancing the clinical application value of *** general,this two-drug system reduces the dosage of uricase and colchicine and improves the patient’s compliance,which has a strong clinical translation.

关键词： Microneedles Colchicine Sustained-release Uricase Liposome Transdermal administration Gout management Long-term urate-lowering therapy