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Morphological comparison and molecular marker screening of three Skeletonema species found in Changjiang(Yangtze)River Basin

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Journal of Oceanology and Limnology 2024年第3期42卷 923-942页

作者： jingwen hu Yuxin YI Zhengxin YANG John Patrick KOCIOLEK Pan YU Quanxi WANG Qingmin YOU College of Life Sciences Shanghai Normal UniversityShanghai 200235China Museum of Natural History University of ColoradoBoulder 80309USA College of Environmental and Geographical Sciences Shanghai Normal UniversityShanghai 200235China

In our recent investigations of diatom diversity,we studied three species,namely,Skeletonema costatum,Skeletonema subsalsum,and Skeletonema *** they have been found frequently in Changjiang(Yangtze)River Basin,their morphological and molecular identification is difficult in ***,to integrate morphological and molecular biological approaches,we compared systematically their morphological characters and performed phylogenetic *** strains of Skeletonema were collected and isolated from Shanghai and Jiangsu,China,and their morphological characteristics were examined by light microscopy(LM)and the scanning electron microscopy(SEM).Based on morphological comparison,we determined that *** is easy to distinguish from the other two *** heavily silicified areolae,undulated or cleft distal ends of terminal fultoportula processes(TFPPs),absence of basal pores of fultoportula processes(FPPs),the rootlike protrusions of FPPs,and no interlocking connection are the stable characteristics that can be used to identify ***,there are only two features that can distinguish *** from ***,namely the location of terminal rimoportulae(TRPs)and the distal shape of *** addition,we amplified and sequenced nine common genetic markers from the strains,from which 101 sequences were obtained,constructed phylogenetic trees based on the nine genes and evaluated that seven genes can be used to identify ***,and revealed that *** is the closest known relative of ***,and only ATP synthetase beta-subunit gene(atp B)is able to distinguish them from each other,which strongly support that it is an effective molecular marker for *** work provided a theoretical basis for the taxonomic study of Skeletonema.

关键词： Skeletonema Changjiang River morphological change distinguishing morphological characteristics molecular marker

Hypofibrinogenemia Caused by Hemocoagulase Injection:A Retrospective Study on Clinical Laboratory Findings

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Chinese Medical Sciences Journal 2020年第2期35卷 151-156页

作者： jingwen hu Xiaosong Qin Department of Laboratory Medicine Shengjing Hospital of China Medical UniversityShenyang 110004China

Objective Hemocoagulase injection based on the venom of Agkistrodon halys Pallas is widely used in the treatment of hemorrhagic *** study aimed to characterize the clinical laboratory findings of hemocoagulase-induced hypofibrinogenemia as the associated adverse reaction of hemocoagulase *** Wie retrospectively enrolled 27 in-patients who were treated with hemocoagulase injection for hemoptysis and developed hypofibrinogenemia during the period of January 1,2015 to March 31,*** data were collected and investigated,including clinical manifestations,hemostatic and fibrinolytic parameters,dosage of hemocoagulase,the medication time,and the cryoprecipitate blood product *** in fibrinogen,D-dimer,and fibrin/fibrinogen degradation products(FDP)before,during,and after the application of hemocoagulase injection were analyzed *** Plasma fibrinogen level during medication of hemocoagulase injection decreased significantly compared to that before the treatment(F=1.80,P<0.001),with the average decrease of 2.28 g/L(0.63-3.9 g/L).After withdrawal,fibrinogen level increased significantly compared to that during the medication(F=l.20,P<0.001),but was still lower than that before the medication(F=0.59,P=0.03).The D-dimer level and the FDP level after withdrawal decreased significantly compared to the levels during the medication(F=0.83,P=0.002;Wilcoxon-test,Z=-4.54,P<0.001).Spearman's correlation analyses did not find either fibrinogen change during-before the administration or FDP change after-during the administration was associated with the dosage of hemo coagulase(r=-0.17,P=0.40;r=-0.28,P=0.15;respectively)and the time of recovery from hypofibrinogenemia(r=-0.45,P=0.05;r=0.13,P=0.61;respectively).Conclusion Monitoring both clotting and fibrinolysis parameters is essential in the management of hemoptysis patients treated with hemocoagulase *** should be aware of hypofibrinogenemia and consider

关键词： hypofibrinogenemia hemocoagulase fibrinogen fibrinolysis

Rapidly separating dissolving microneedles with sustained-release colchicine and stabilized uricase for simplified long-term gout management

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Acta Pharmaceutica Sinica B 2023年第8期13卷 3454-3470页

作者： Yao Yang Zimu Li Ping huang Jiachan Lin Jinyuan Li Kexin Shi Jiahui Lin jingwen hu Zhuoxian Zhao Yongkang Yu Hongzhong Chen Xiaowei Zeng Lin Mei Institute of Pharmaceutics School of Pharmaceutical Sciences(Shenzhen)Sun Yat-sen UniversityShenzhen 518107China State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yatsen University Cancer CenterGuangzhou 510060China Tianjin Key Laboratory of Biomedical Materials Key Laboratory of Biomaterials and Nanotechnology for Cancer ImmunotherapyInstitute of Biomedical EngineeringChinese Academy of Medical SciencesPeking Union Medical CollegeTianjin300192China

Despite growing prevalence and incidence,the management of gout remains *** intermittent nature of the gout makes the long-term urate-lowering therapy(ULT)particularly important for gout ***,patients are reluctant to take medication day after day to manage incurable occasional gout flares,and suffer from possible long-term ***,a safe and easy-tooperate drug delivery system with simple preparation for the long-term management of gout is very ***,a chitosan-containing sustained-release microneedle system co-loaded with colchicine and uricase liposomes were fabricated to achieve this *** microneedle system was confirmed to successfully deliver the drug to the skin and maintain a one-week drug ***,its powerful therapeutic potency to manage gout was investigated in both acute gouty and chronic gouty ***,the drug co-delivery system could help avoid long-term daily oral colchicine,a drug with a narrow therapeutic *** system also avoids mass injection of uricase by improving its stability,enhancing the clinical application value of *** general,this two-drug system reduces the dosage of uricase and colchicine and improves the patient’s compliance,which has a strong clinical translation.

关键词： Microneedles Colchicine Sustained-release Uricase Liposome Transdermal administration Gout management Long-term urate-lowering therapy

Meiotic nuclear divisions 1(MND1)fuels cell cycle progression by activating a KLF6/E2F1 positive feedback loop in lung adenocarcinoma

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Cancer Communications 2021年第6期41卷 492-510页

作者： Quanli Zhang Run Shi Yongkang Bai Lijuan Meng jingwen hu Hongyu Zhu Tongyan Liu Xiaomeng De Siwei Wang Jie Wang Lin Xu Guoren Zhou Rong Yin Department of Thoracic Surgery the Affiliated Cancer Hospital of Nanjing Medical University&Jiangsu Cancer Hospital&Jiangsu Institute of Cancer ResearchJiangsu Key Laboratory of Molecular and Translational Cancer ResearchCollaborative Innovation Center for Cancer Personalized MedicineNanjingJiangsu 210009P.R.China Department of Scientific Research Jiangsu Cancer Hospital&the Affiliated Cancer Hospital of Nanjing Medical University&Jiangsu Institute of Cancer ResearchJiangsu Key Laboratory of Molecular and Translational Cancer ResearchNanjingJiangsu 210009P.R.China The Fourth Clinical College of Nanjing Medical University NanjingJiangsu 210009P.R.China Jiangsu Biobank of Clinical Resources NanjingJiangsu 210009P.R.China Faculty of Medicine Ludwig-Maximilians-Universität(LMU)MünchenMünchenBayern D-80539Germany Department of Oncology Jiangsu Cancer Hospital&the Affiliated Cancer Hospital of Nanjing Medical University&Jiangsu Institute of Cancer ResearchNanjingJiangsu 210009P.R.China Department of Geriatric Oncology The First Affiliated Hospital with Nanjing Medical UniversityNanjingJiangsu 210009P.R.China

Background:Considering the increase in the proportion of lung adenocarcinoma(LUAD)cases among all lung cancers and its considerable contribution to cancer-related deaths worldwide,we sought to identify novel oncogenes to provide potential targets and facilitate a better understanding of the malignant progression of ***:The results from the screening of transcriptome and survival analyses according to the integrated Gene Expression Omnibus(GEO)datasets and The Cancer Genome Atlas(TCGA)data were combined,and a promising risk biomarker called meiotic nuclear divisions 1(MND1)was selectively *** viability assays and subcutaneous xenograftmodelswere used to validate the oncogenic role ofMND1 in LUADcell proliferation and tumor *** of assays,including mass spectrometry,co-immunoprecipitation(Co-IP),and chromatin immunoprecipitation(ChIP),were performed to explore the underlying ***:MND1 up-regulation was identified to be an independent risk factor for overall survival in LUAD patients evaluated by both tissue microarray staining and third party data *** vivo and in vitro assays showed that MND1 promoted LUAD cell proliferation by regulating cell *** results of the Co-IP,ChIP and dual-luciferase reporter assays validated that MND1 competitively bound to tumor suppressor Kruppel-like factor 6(KLF6),and thereby protecting E2F transcription factor 1(E2F1)from KLF6-induced transcriptional *** reporter and ChIP assays found that E2F1 activated MND1 transcription by binding to its promoter in a feedback ***:MND1,KLF6,and E2F1 form a positive feedback loop to regulate cell cycle and confer DDP resistance in ***1 is crucial for malignant progression and may be a potential therapeutic target in LUAD patients.

关键词： cell cycle cisplatin resistance E2F transcription factor 1(E2F1) Kruppel-like factor 6(KLF6) lung adenocarcinoma meiotic nuclear divisions 1(MND1) positive feedback loop

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仿射构形的可约性

北京化工大学学报（自然科学版） 2008年第6期35卷 107-112页

作者：胡婧雯牛兴文北京化工大学理学院北京100029

用矩阵方法讨论仿射超平面构形的可约性。通过证明仿射构形可约等价于对应的中心构形可约,把仿射构形因子分解存在惟一性归结为中心构形相应的已知结论,得到仿射超平面构形因子分解的存在惟一性。

关键词：仿射构形可约矩阵分解

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“可沟通城市”建构中新兴出版的意义及实践

出版发行研究 2020年第11期 26-31页

作者：佘世红胡婧雯华南理工大学新闻与传播学院

本文将城市信息流通互动、意见自由表达、文化共识达成置于“可沟通城市”的理论框架中,针对后现代社会的沟通问题,探讨了新兴出版在“可沟通城市”建构中的意义与实践,认为新兴出版在城市时空关系重塑、拓展城市文化空间,构建平等、开... 详细信息

本文将城市信息流通互动、意见自由表达、文化共识达成置于“可沟通城市”的理论框架中,针对后现代社会的沟通问题,探讨了新兴出版在“可沟通城市”建构中的意义与实践,认为新兴出版在城市时空关系重塑、拓展城市文化空间,构建平等、开放、互动的城市公共传播网络,弥合社会鸿沟及形成文化认同的城市共同体等方面具有重要意义。实践方面,从强调新兴出版内容选择的文化取向、利用大数据AI技术增强城市文化传播的精准性、基于用户场景感知的个性化出版、利用AR和VR技术促进体验性城市文化传播、加强新兴出版与传统出版的深度融合的五个层面来探讨,以此实现城市文化传播系统流动性和稳定性的统一,为实现“可沟通城市”创造文化沟通共识。

关键词：可沟通城市新兴出版城市文化意义共享

Beyond Lambertian light trapping for large-area silicon solar cells:fabrication methods

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Opto-Electronic Advances 2022年第9期5卷 14-25页

作者： Jovan Maksimovic jingwen hu Soon Hock Ng Tomas Katkus Gediminas Seniutinas Tatiana Pinedo Rivera Michael Stuiber Yoshiaki Nishijima Sajeev John Saulius Juodkazis Optical Sciences Centre and ARC Training Centre in Surface Engineering for Advanced Materials(SEAM) School of ScienceSwinburne University of TechnologyHawthorn Vic 3122Australia Melbourne Centre for Nanofabrication ANFF Victoria151 Wellington Rd.Clayton Vic 3168 Australia Department of Electrical and Computer Engineering Graduate School of EngineeringYokohama National University79-5 TokiwadaiHodogaya-kuYokohama 240-8501Japan Institute of Advanced Sciences Yokohama National University79-5 TokiwadaiHodogaya-kuYokohama 240-8501Japan Department of Physics University of Toronto60 St.George StreetTorontoONM5S 1A7Canada World Research hub Initiative(WRHI) School of Materials and Chemical TechnologyTokyo Institute of Technology2-12-1OokayamaMeguro-kuTokyo 152-8550Japan

Light trapping photonic crystal(PhC)patterns on the surface of Si solar cells provides a novel opportunity to approach the theoretical efficiency limit of 32.3%,for light-to-electrical power conversion with a single junction *** is beyond the efficiency limit implied by the Lambertian limit of ray trapping~29%.The interference and slow light effects are harnessed for collecting light even at the long wavelengths near the Si *** compare two different methods for surface patterning,that can be extended to large area surface patterning:1)laser direct write and 2)step-&-repeat 5×reduction projection *** area throughput limitations of these methods are compared with the established elec-tron beam lithography(EBL)route,which is conventionally utilised but much slower than the presented ***-tral characterisation of the PhC light trapping is compared for samples fabricated by different *** of Si etched via laser patterned mask was~7%at visible wavelengths and was comparable with Si patterned via EBL made *** later pattern showed a stronger absorbance than the Lambertian limit6.

关键词： silicon solar cells laser ablation light trapping Lambertian limit

The Measurements of Highly Stripped Bromine Atom Spectra

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原子与分子物理学报 1998年第S1期15卷 85-86页

作者： Zeng Xiantang Li jingwen hu Aidong Jiang Liyang Du ShubinDepartment of Nuclear Physics, CLAE, Beijing 102413Wang Youde Liu huiping Ma XinwenInstitute of Moden Physics, Academia sinica, Lanzhou 730000

Ｓｐｅｃｔｒａｏｆｈｉｇｈｌｙｉｏｎｉｚｅｄｂｒｏｍｉｎｅａｔｏｍｗｅｒｅｍｅａｓｕｒｅｄｂｙｍｅａｎｓｏｆｂｅａｍ－ｆｏｉｌｍｅｔｈｏｄｉｎｔｈｅＨＩ－１３ｔａｎｄｅｍａｃｅｌｅｒａｔｏｒｌａｂｏｒａｔｏｒｙａｔＣ... 详细信息

Ｓｐｅｃｔｒａｏｆｈｉｇｈｌｙｉｏｎｉｚｅｄｂｒｏｍｉｎｅａｔｏｍｗｅｒｅｍｅａｓｕｒｅｄｂｙｍｅａｎｓｏｆｂｅａｍ－ｆｏｉｌｍｅｔｈｏｄｉｎｔｈｅＨＩ－１３ｔａｎｄｅｍａｃｅｌｅｒａｔｏｒｌａｂｏｒａｔｏｒｙａｔＣｈｉｎａＩｎｓｔｉｔｕｔｅＡｔｏｍ...

关键词： Atom Stripped Highly Measurements Spectra Bromine

细菌纤维素/聚乳酸互穿网络复合材料的结晶与熔融

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复合材料学报 2015年第5期32卷 1294-1300页

作者：李红月卢秀萍杨华胡静雯天津科技大学材料科学与化学工程学院天津300457

为了研究细菌纤维素(BC)网络结构对聚乳酸(PLA)结晶与熔融过程的影响,以PLA为基体,BC为增强体,通过PLA-三氯甲烷溶液与BC-无水乙醇分散液的共混扩散制备了具有互穿网络结构的BC/PLA生物复合材料。采用SEM、偏光显微镜(POM)、DSC和莫志深... 详细信息

为了研究细菌纤维素(BC)网络结构对聚乳酸(PLA)结晶与熔融过程的影响,以PLA为基体,BC为增强体,通过PLA-三氯甲烷溶液与BC-无水乙醇分散液的共混扩散制备了具有互穿网络结构的BC/PLA生物复合材料。采用SEM、偏光显微镜(POM)、DSC和莫志深(MO)模型研究了复合材料的微观形态、球晶形貌、非等温结晶动力学和熔融行为。结果表明:采用溶液共混扩散法可得到以BC为骨架、PLA缠绕其表面的互穿网络结构的复合材料。随降温速率增加,BC/PLA复合材料的结晶温度、熔融温度和相对结晶度均下降。BC可作为异相成核剂,适量添加可同时提高BC/PLA复合材料的结晶速率和相对结晶度,细化球晶尺寸。MO模型可较好地描述BC/PLA复合材料的非等温结晶动力学行为。

关键词：细菌纤维素聚乳酸互穿网络复合材料形态熔融结晶动力学