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surrogate modeling for unsaturated infiltration via the physics and equality-constrained artificial neural networks

Journal of Rock Mechanics and Geotechnical Engineering 2024年第6期16卷 2282-2295页

作者： Peng Lan jingjing su Sheng Zhang School of Civil Engineering Central South UniversityChangsha410075China Discipline of Civil Surveying and Environmental EngineeringPriority Research Centre for Geotechnical Science and EngineeringThe University of NewcastleCallaghanNSW2308Australia Qinghai University Qinghai810016China

Machine learning(ML)provides a new surrogate method for investigating groundwater flow dynamics in unsaturated *** pure data-driven methods(*** neural network,DNN)can provide rapid predictions,but they do require sufficient on-site data for accurate training,and lack interpretability to the physical processes within the *** this paper,we provide a physics and equalityconstrained artificial neural network(PECANN),to derive unsaturated infiltration solutions with a small amount of initial and boundary *** takes the physics-informed neural network(PINN)as a foundation,encodes the unsaturated infiltration physical laws(*** equation,RE)into the loss function,and uses the augmented Lagrangian method to constrain the learning process of the solutions of RE by adding stronger penalty for the initial and boundary *** unsaturated infiltration cases are designed to test the training performance of PECANN,***-dimensional(1D)steady-state unsaturated infiltration,1D transient-state infiltration,two-dimensional(2D)transient-state infiltration,and 1D coupled unsaturated infiltration and *** predicted results of PECANN are compared with the finite difference solutions or analytical *** results indicate that PECANN can accurately capture the variations of pressure head during the unsaturated infiltration,and present higher precision and robustness than DNN and *** is also revealed that PECANN can achieve the same accuracy as the finite difference method with fewer initial and boundary training ***,we investigate the effect of the hyperparameters of PECANN on solving RE *** provides an effective tool for simulating unsaturated infiltration.

关键词： Richards equation(RE) Unsaturated infiltration Data-driven solutions Numerical modeling Machine learning(ML)

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Bombyx mori U-shaped regulates the melanization cascade and immune response via binding with the Lozenge protein

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Insect Science 2022年第3期29卷 704-716页

作者： Kui Zhang Juan Tan Xiangwei Hao Houyi Tang Muhammad Nadeem Abbas jingjing su Yongyue su Hongjuan Cui State Key Laboratory of Silkworm Genome Biology College of SericultureTextile and Biomass SciencesSouthwest UniversityChongqing400716China Chongqing Reproductive and Genetics Institute Chongqing Obstetrics and Gynecology HospitalChongqing400013China Department of Orthopaedic 920th Hospital of Joint Logistics Support Force of Chinese People’s Liberation ArmyKunming650032China Cancer Center Reproductive Medicine CenterMedical Research InstituteSouthwest UniversityChongqing400716China

Zinc finger protein,an important transcription factor,regulates gene expression associated with various physiological and pathological processes.U-shaped,belong to the Friend of GATA(FOG)transcription factor,plays a crucial role in hematopoiesis by interacting with the GATA transcription factor as a ***,little is known about its functions in *** the present study,a U-shaped cDNA was identified and characterized from the silkworm Bombyx mori and its potential roles in innate immunity *** predicted silkworm U-shaped amino acid sequence contained a classical nuclear localization signal(NLS)motif“GESSPKRRRR”at position 45CU459,and arginine residues at position 456 and 478 are the critical sites of the NLS.U-shaped mRNA was detected in all tested tissues of the ***;however,the highest levels were found in the hemocytes.U-shaped mRNA expression levels were upregulated in the hemocyte after the Escherichia coli and Staphylococcus aureus ***,U-shaped knockdown significantly reduced the melanization process and suppressed the expression of melanization-associated genes,including PPO1,PPO2,PPAE and *** addition,U-shaped interacts with Lozenge protein to regulate the innate immune response of the *** results revealed that U-shaped binds directly to Lozenge protein to modulate the melanization process and innate immune responses in silkworm.

关键词： Bombyx mori Lozenge melanization response silkworm U-shaped

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Liver-specific deficiency of TMEM30A develops spontaneous hepatocellular carcinoma

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Gastroenterology Report 2023年第1期11卷 536-538页

作者： Leiming Liu Zhiqing Xia Yongming Zhang jingjing su Leimin sun Lingling Zhang International Institutes of Medicine The Fourth Affiliated HospitalZhejiang University School of MedicineYiwuZhejiangP.R.China Laboratory of Applied Pharmacology and Department of Pharmacology College of PharmacyWeifang Medical UniversityWeifangShandongP.R.China Department of Gastroenterology Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhouZhejiangP.R.China

Introduction Hepatocellular carcinoma is the third leading cause of cancer deaths worldwide and mainly originates from chronic liver diseases[1].It is essential to establish a stable and effective model for studying hepatocellular *** present,chemical induction is the most common method to establish liver cancer models in mice,in which diethylnitrosamine(DEN)and carbon tetrachloride(CCl4)are the main inducers[2].It simulates well the natural formation process of liver cancer,but the induction time is *** primary liver cancer organoids retain livertissue function and genetic stability[3].

关键词： hepatocellular cancer diseases

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Reducing oxidative stress and hepatoprotective effect of water extracts from Pu-erh tea on rats with high-fat diet

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Food Science and Human Wellness 2016年第4期5卷 199-206页

作者： jingjing su Xueqing Wang Wenjun Song Xiaoli Bai Changwen Li Tianjin Key Laboratory of Food Biotechnology College of Biotechnology and Food ScienceTianjin University of CommerceTianjin 300134China Yunnan Tasly Deepure Biological Tea Group Company Limited Pu ErhYunnan 665100China

Reducing oxidative stress and hepatoprotective effect of Pu-erh tea water extracts on rats fed with high-fat diet were researched for explaining health care of Pu-erh *** SD rats were divided into five *** body weight was measured once a *** malondialdehyde(MDA)and glucose(Glu)levels and the activities of alanine aminotransferase(ALT),aspartate aminotransferase(AST),nitric oxide synthase(NOS),and pyruvate kinase(PK)in serum were ***,the hepatic glycogen level(HGL)and the activities of hepatic total superoxide dismutase(T-SOD),catalase(CAT),and glutathione peroxidase(GSH-Px)were also measured after continuous administration for 12 *** result demonstrated that Pu-erh extract caused the decreases in body weight,fat index,MDA and NOS levels,and the increases in hepatic T-SOD,CAT and GSH-Px activities,indicating that the extract may be due to inhibiting the increases of body weight and fat index,reducing oxidant stress state and inhibiting lipid peroxidation,thus decreasing the activities of ALT and AST,and protecting the liver in ***,the extracts could increase the production of hepatic glycogen and the activity of PK,and reduce glucose level,protecting the liver from the diseases associated with type II diabetes.

关键词： Pu-erh tea extracts Oxidative stress Hepatoprotective effect

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Genomic variation of 363 diverse tea accessions unveils the genetic diversity, domestication, and structural variations associated with tea adaptation

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Journal of Integrative Plant Biology 2024年第10期66卷 2175-2190页

作者： Wei Tong Yanli Wang Fangdong Li Fei Zhai jingjing su Didi Wu Lianghui Yi Qijuan Gao Qiong Wu Enhua Xia State Key Laboratory of Tea Plant Biology and Utilization Anhui Agricultural UniversityHefei 230036China School of Information and Artificial Intelligence Anhui Agricultural UniversityHefei 230036China School of Computer and Artificial Intelligence Hefei Normal UniversityHefei 230061China Tea Research Institute Anhui Academy of Agricultural SciencesHefei 230031China

Domestication has shaped the population structure and agronomic traits of tea plants, yet the complexity of tea population structure and genetic variation that determines these traits remains *** here investigated the resequencing data of 363 diverse tea accessions collected extensively from almost all tea distributions and found that the population structure of tea plants was divided into eight subgroups, which were basically consistent with their geographical distributions. The genetic diversity of tea plants in China decreased from southwest to east as latitude increased. Results also indicated that Camellia sinensis var. assamica(CSA) illustrated divergent selection signatures with Camellia sinensis var. sinensis(CSS). The domesticated genes of CSA were mainly involved in leaf development, flavonoid and alkaloid biosynthesis, while the domesticated genes in CSS mainly participated in amino acid metabolism, aroma compounds biosynthesis,and cold stress. Comparative population genomics further identified ~730 Mb novel sequences, generating 6,058 full-length protein-encoding genes,significantly expanding the gene pool of tea *** also discovered 217,376 large-scale structural variations and 56,583 presence and absence variations(PAVs) across diverse tea accessions, some of which were associated with tea quality and stress resistance. Functional experiments demonstrated that two PAV genes(CSS0049975 and CSS0006599)were likely to drive trait diversification in cold tolerance between CSA and CSS tea plants. The overall findings not only revealed the genetic diversity and domestication of tea plants, but also underscored the vital role of structural variations in the diversification of tea plant traits.

关键词： Camellia sinensis cold tolerance novel genes population structure presence-absence variation structural variation

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Integrin β2 and β3:Two plasmatocyte markers deepen our understanding of the development of plasmatocytes in the silkworm Bombyx mori

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Insect Science 2022年第6期29卷 1659-1671页

作者： Kui Zhang jingjing su Xin Hu Xiaomin Yan Siyuan Chen Chongyang Li Guangzhao Pan Hongbo Chang Wenli Tian Muhammad Nadeem Abbas Hongjuan Cui State Key Laboratory of Silkworm Genome Biology College of SericultureTextile and Biomass SciencesSouthwest UniversityChongqingChina Chongqing iCELL Biotechnology Co.Ltd ChongqingChina Department of Gastroenterology The Second Affliated Hospital of Chongqing Medical UniversityChongqingChina Institute of Apicultural Research Chinese Academy of Agricultural SciencesBejingChina Cancer Center Reproductive Medicine CenterMedical Research InstituteSouthwest UniversityChongqing.China

Insect hemocytes play important biological roles at developmental stages,metamorphosis,and innate *** one of the most abundant cell types,plasmatocytes can participate in various innate immune responses,especially in encapsulation and node ***,2 molecular markers of plasmatocytes,consisting of integrinβ2 andβ3,were identified and used to understand the development of *** are widely distributed in the hematopoietic system,including circulating hemolymph and hematopoietic organs(HPOs).HPOs constantly release plasmatocytes with high proliferative activity in vitro;removal of HPOs leads to a dramatic reduction in the circulating plasmatocytes,and the remaining plasmatocytes gradually lose their ability to proliferate in *** results demonstrated that the release of plasmatocytes from HPOs is regulated by insulin-mediated signals and their downstream pathways,including PI3K/Akt and MAPK/Erk *** insulin/PI3K/Akt signaling pathway can significantly irritate the hematopoiesis,and its inhibitor LY294002 could inhibit the hemocytes discharged from *** the insulin/MAPK/Erk signaling pathway plays a negative regulatory role,inhibiting its activity with U0126 can markedly promote the discharge of plasmatocytes from *** results indicate that the circulating plasmatocytes are mainly generated and discharged by *** process is co-regulated by the PI3K/Akt and MAPK/Erk signals in an antagonistic manner to adjust the dynamic balance of the *** findings can enhance our understanding of insect hematopoiesis.

关键词： Bombyx mori hematopoiesis MAPK/Erk PI3K/Akt plasmatocytes

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Particulate matter pollution in Kunshan High-Tech zone： Source apportionment with trace elements, plume evolution and its monitoring

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Journal of Environmental Sciences 2018年第9期30卷 119-126页

作者： suwei Zhang Qijie Zhang Armand Albergel Didier Buty Liangmin Yu Haiting Wang Wuxia Bi Peng Cheng Fu Chen Jun Fang Ruirui Hou Xudong Luan Changgan Shu jingjing su Jiangsu Skyray Instrument Co. Ltd. Kunshan 215300 China ARIA Technologies SA Boulogne-Billancourt 92100 France Kunshan Environment Monitoring Station Kunshan 215300 China State Environmental Protection Key Laboratory of Urban Ambient Air Particulate Matter Pollution Prevention and Control College of Environmental Science and Engineering Nankai University Tianjin 300000 China Center for Urban Transport Emission Research College of Environmental Science and Engineering Nankai University Tianjin 300000 China Ecole Nationale superieure des Mines de Douai Douai France Kinton Environmental Technology Co. Ltd. Nanjing 210000 China Chengdu University of Information Science and Technology Chengdu 610000 China Hohai Uniuersity Nanjing 210000 China

Particulate matter （PM} in the Kunshan High-Tech zone is studied during a three-month campaign. PM and trace elements are measured by the online pollution monitoring, forecast-warning and source term retrieval system AS3. Hourly measured concentrations of PM10, PM2.5 and 16 trace elements in the PM2.5 section （Ca, Pb, Cu, C1, V, Cr, Fe, Ti, Mn, Ni, Zn, Ga, As, Se, Sr, Ba） are focused. Source apportionment of trace elements by Positive Matrix Factorization modeling indicates that there are five major sources, including dust, industrial processing, traffic, combustion, and sea salt with contribution rate of 23.68%, 21.66%, 14.30%, 22.03%, and 6.89%, respectively. Prediction ofptume dispersion from concrete plant and traffic emissions shows that PM20 pollution of concrete plant is three orders of magnitude more than that of the traffic. The influence range can extend to more than 3 km in 1 hr. Because the footprint of the industrial plumes is constantly moving according to the local meteorological conditions, the fixed monitoring sites scattered in a few hundred meters haven＇t captured the heaviest pollution plume at the local scale of a few km2. As a more intensive monitoring network is not operationally possible, the use of online modeling gives accurate and quantitative information of plume location, which increases the spatial pollution monitoring capacity and improves the understanding of measurement data. These results indicate that the development of the AS3 system, which combines monitoring equipment and air pollution modeling systems, is beneficial to the real-time pollution monitoring in the industrial zone.

关键词： Particulate matter pollution Trace elements Online pollution monitoring in a industrial zone Source apportionment Plume evolution

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Chinese investment in Greenland

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Advances in Polar Science 2016年第3期27卷 192-199页

作者： Bent Ole Gram Mortensen jingjing su Lone Wandahl Mouyal University of Southern Denmark Campusvej 55DK-5230Odense MDenmark Bech-Bruun&University of Copenhagen Langelinie All6 35CopenhagenDenmark University of Copenhagen Karen Blixens Plads 16CopenhagenDenmark

In 2009 Greenland moved to a more extensive degree of self-government in relation to the Kingdom of Denmark （the Realm）, and most policy areas related to business activities and investment are now under the control of Greenland. Under the Self-Government Act, Greenland has issued legislation within several business sectors and other business-related policy areas, including the mineral resources sector. Today, Greenland is highly dependent on fishing and fish exports; however, the government is quite ambi-tious in its desire to develop new business sectors and attract foreign investment, including investment from China, especially to develop its mineral resources. China is now the second largest economy in the world, and outbound investments by Chinese companies present unprecedented opportunities for both the Chinese companies and their global partners. However, Chinese outbound investment faces many hurdles, both at home and elsewhere. It is highly advisable for Chinese companies to evaluate the regulatory, political, environmental, labor, and financial conditions and under-stand what remedies may mitigate the risks they identify before investing in Green land. This paper investigates and analyzes the hurdles faced by Chinese investors in both Greenland and the Danish Realm. The paper focuses on but is not limited to investments in the mining industry.

关键词： Arctic Greenland mineral resources Chinese investment investment incentives and barriers,investment in the Arctic

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电弧故障保护电器动作特性测试分析系统

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电力自动化设备 2019年第10期39卷 194-200页

作者：苏晶晶许志红福州大学电气工程与自动化学院福建省新能源发电与电能变换重点实验室

针对电弧故障保护电器动作特性测试项目多、操作复杂、试验效率低等问题,研究了一种电弧故障保护电器动作特性测试分析系统。利用电磁开关设计综合试验电路,以开关的状态作为控制和观测量,实现综合试验电路的自动化控制及其状态监测;采... 详细信息

针对电弧故障保护电器动作特性测试项目多、操作复杂、试验效率低等问题,研究了一种电弧故障保护电器动作特性测试分析系统。利用电磁开关设计综合试验电路,以开关的状态作为控制和观测量,实现综合试验电路的自动化控制及其状态监测;采用基于电压和机械位移量的机电耦合反馈控制策略,改善电弧故障模拟装置的运行性能,提高电弧故障模拟的成功率;同时,上位机平台对下位机硬件设备的运行状态进行控制和监测,并实时采集电弧电压和电流波形。测试系统不仅能够实现对电弧故障保护电器动作特性的自动测试,还具有波形采集与存储、测试报告自动生成等功能,大幅度提高试验的自动化水平和试验效率,减少测试过程中人为因素的干扰,为进一步研究故障电弧的形成机理与故障电弧检测技术奠定基础。

关键词：特性测试电弧故障保护电器故障电弧功能配置反馈控制

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基于EMD和PNN的故障电弧多变量判据诊断方法

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电力自动化设备 2019年第4期39卷 106-113页

作者：苏晶晶许志红福州大学电气工程与自动化学院福建省新能源发电与电能变换重点实验室福建福州350116

故障电弧单变量判据诊断法受不确定因素影响大、特征量提取困难,针对此提出一种基于经验模态分解(EMD)和概率神经网络(PNN)的故障电弧多变量判据的诊断方法。利用经验模态分解分析法对电弧电流进行时频分解,并借助信号相关性理论自动提... 详细信息

故障电弧单变量判据诊断法受不确定因素影响大、特征量提取困难,针对此提出一种基于经验模态分解(EMD)和概率神经网络(PNN)的故障电弧多变量判据的诊断方法。利用经验模态分解分析法对电弧电流进行时频分解,并借助信号相关性理论自动提取故障特征信号;同时,通过分析故障特征信号的无量纲指标,形成多变量特征向量集。在此基础上,构建基于概率神经网络的故障电弧诊断模型。通过分析燃弧前后烧水壶、吸尘器、卤素灯、电钻、荧光灯、计算机的电流波形,验证故障诊断模型的准确性。结果表明,所提方法解决了单变量判据故障诊断中出现的特征量提取困难、交叉重复等问题,准确率超过90%。

关键词：电弧特征信号提取经验模态分解概率神经网络无量纲指标多变量判据模型

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