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Solution-Processed Hybrid Europium (Ⅱ) lodide Scintillator for Sensitive X-Ray Detection

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Research 2024年第1期2024卷 49-57页

作者： Xue Zhao Pengfei Fu Pan li Hainan Du Jinsong Zhu Ciyu Ge Longbo Yang Boxiang Song Haodi Wu Tong Jin Qingxun Guo liang Wang jinghui li Zewen Xiao Jingjing Chang Guangda Niu Jiajun Luo Jiang Tang School of Microelectronics Xidian UniversityXi'an 710071China Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan 430074China China Optics Valley Laboratory Wuhan 430074China School of Optical and Electronic Information Huazhong University of Science and TechnologyWuhan 430074China

Lead halide perovskite nanocrystals have recently demonstrated great potential as x-ray scintillators,yet they stll suffer toxicity issues,inferior light yield(LY)caused by severe self-absorption.Nontoxic bivalent europium ions(Eu^(2+))with intrinsically efficient and self-absorption-free d-f transition are a prospective replacement for the toxic Pb^(2+).Here,we demonstrated solution-processed organic-inorganic hybrid halide BA_(10)Eul_(12)(BA denotes C_(4)H_(9)NH_(4)^(+))single crystals for the first time.

关键词： absorption halide perovskite

The enhanced genomic 6mA metabolism contributes to the proliferation and migration of TSCC cells

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International Journal of Oral Science 2022年第1期14卷 100-112页

作者： Lei Xi Ying Yang Ying Xu Fangming Zhang jinghui li Xiyang liu Zhenxi Zhang Quan Du State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijingChina Department of Stomatology Beijing Friendship HospitalCapital Medical UniversityBeijingChina

In contrast to the well-established genomic 5-methylcytosine(5mC),the existence of N^(6)-methyladenine(6 mA)in eukaryotic genomes was discovered only recently.Initial studies found that it was actively regulated in cancer cells,suggesting its involvement in the process of carcinogenesis.However,the contribution of 6 mA in tongue squamous cell carcinoma(TSCC)still remains uncharacterized.In this study,a pan-cancer type analysis was first performed,which revealed enhanced 6mA metabolism in diverse cancer types.The study was then focused on the regulation of 6 mA metabolism,as well as its effects on TSCC cells.To these aspects,genome 6mA level was found greatly increased in TSCC tissues and cultured cells.By knocking down 6mA methylases N6AMT1 and METTL4,the level of genomic 6mA was decreased in TSCC cells.This led to suppressed colony formation and cell migration.By contrast,knockdown of 6mA demethylase ALKBH1 resulted in an increased 6 mA level,enhanced colony formation,and cell migration.Further study suggested that regulation of the NF-κB pathway might contribute to the enhanced migration of TSCC cells.Therefore,in the case of TSCC,we have shown that genomic 6mA modification is involved in the proliferation and migration of cancer cells.

关键词： metabolism involvement cancer

Optimal Motion Planning of the Space Manipulator for Minimum Reaction Torque to Satellite

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Journal of Harbin Institute of Technology(New Series) 2022年第2期29卷 81-91页

作者： Zhiqiang Xu Xiangxin Zeng jinghui li Zhaoyan Jia Norinco Group Air Ammunition Research Institute Co. Ltd.Harbin 150030China

For the problem of free⁃floating space robot(FFSR)that the motion of manipulator will cause a large disturbance to the attitude of satellite,a path planning method based on hp⁃adaptive Gauss pseudospectral method(hp⁃AGPM)is proposed in this paper.In this method,the minimum reaction torque acting on satellite is taken as the objective function,and the number of segments and the order of polynomial in each segment are determined adaptively to improve the accuracy and the efficiency of the solution.At the same time,the theoretical convergence of the designed method is innovatively proved to ensure that the solution of the discretized nonlinear programming(NLP)problem is the optimal solution to the original optimal problem.The simulation results of a planar two degree⁃of⁃freedom(2⁃DOF)space manipulator show that the proposed path planning method is more effective than the resolved acceleration control(RAC)method and the control variable parameterization(CVP)method,and is better than other pseudospectral methods both in computation speed and the number of collocation points.

关键词： free⁃floating space robot hp-adaptive Gauss pseudospectral method path planning nonlinear programming

Tributyrin administration improves intestinal development and health in pre-weaned dairy calves fed milk replacer

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Animal Nutrition 2022年第3期10卷 399-411页

作者： Shuai liu Junda Wu Zhaohai Wu Gibson Maswayi Alugongo Muhammad Zahoor Khan jinghui li Jianxin Xiao Zhiyuan He Yulin Ma Shengli li Zhijun Cao State Key Laboratory of Animal Nutrition College of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China Institute of Animal Husbandry and Veterinary Guizhou Academy of Agricultural SciencesGuizhou 550005China State Key Laboratory of Animal Nutrition Institute of Animal ScienceChinese Academy of Agricultural SciencesBeijing 100193China Department of Animal Science University of CaliforniaDavisCA 95616USA Faculty of Veterinary and Animal Sciences University of AgricultureDera Ismail Khan29220Pakistan

Butyrate and its derivatives possess various nutritional and biological benefits for mammals,whereas its effects on dairy calves have not been well characterized.This study evaluated the effects of tributyrin administration on blood immune,intestinal immune and barrier functions,and microbial composition of pre-weaned dairy calves.Twenty newborn Holstein bull calves were randomly assigned into a control group(no tributyrin supplementation,CON;n=10)or a treatment group(supplemented with tributyrin at 2 g/L of milk,TRB;n=10).The results showed that diarrhea frequency was decreased significantly by tributyrin administration from d 29 to 56(Plites,tributyrin administration significantly reduced the concentration of interleukin-1b(IL-1b)on d 28(P=0.001)and tended to reduce the concentration of serum amyloid A on d 56(P=0.079),whereas serum oxidative status parameters were not affected.For intestinal development,tributyrin administration increased the villus height(Plike receptor 2(TRL2,P=0.045)and IL-1b(P=0.088)gene expressions were downregulated,while claudin-4(P=0.022)gene expression was upregulated in the jejunum following tributyrin administration.In the ileum,claudin-4(P=0.029)and G-protein coupled receptor 41(P=0.019)gene expressions were upregulated in the TRB group compared to CON.No significantly higher abundances of microbiota were found in the jejunum or ileum of calves in the CON group.In the TRB group,supplementing tributyrin significantly increased the abundance of shortchain fatty acid(SCFA)-producing bacteria,including Ruminococcaceae,Lachnospiraceae,Prevotella and Rikenellaceae(LDA>3.5,P<0.05),which was negatively associated with inflammatory gene expression(TLR2 and IL-1b)but positively associated with intestinal barrier genes(claudin-4)and

关键词： Dairy calves Tributyrin Gut microbiota Inflammation Barrier function

粮食产能安全责任的制定与层级政府分配——基于产能约束性指标的文本分析

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农村经济 2024年第5期 66-76页

作者：李宁李婧慧南京财经大学粮食安全与战略研究中心江苏南京210023 江西省粮油科技创新和物资储备中心江西南昌330046

粮食产能安全约束性指标的首次确立,成为国家保障粮食安全、压实地方政府粮食安全主体责任的又一重大举措。本文从治理风险的交易成本角度入手,并借助对“十四五”规划和粮食产能约束性指标文本的收集和手工整理,系统考察了粮食产能安... 详细信息

粮食产能安全约束性指标的首次确立,成为国家保障粮食安全、压实地方政府粮食安全主体责任的又一重大举措。本文从治理风险的交易成本角度入手,并借助对“十四五”规划和粮食产能约束性指标文本的收集和手工整理,系统考察了粮食产能安全政府责任的产生缘由、制度内涵与具体运行机制。研究发现:(1)粮食供给的风险治理构成了政府承担粮食产能安全主体责任的重要缘由;(2)在现有的农地产权制度架构下,地方政府承担粮食产能安全责任的制度内涵,并非是要求各级政府强制干预农户自主的种植经营权利,而是主要通过约束政府占用耕地和强调提高种粮综合收益的政府行为,以达到遏制农地非农化和预防耕地非粮化的风险治理目的;(3)责任运行的指标体系上,从中央到地方各级政府主要将粮食产能约束性指标细分为粮食面积和粮食产量两类指标体系,其中粮食面积较之粮食产量在采用地区数量上占比更高,且指标用词也更显约束性;(4)责任指标在层级政府间的纵向与横向配置上,各级地方政府均严格落实并分解了上级政府的粮食产能指标,加码特征并不显著,但呈现出分布不平衡和集中化特征。

关键词：粮食产能安全政府主体责任约束性指标层级分配

Development of localized interictal epileptiform discharges following vagus nerve stimulation for lennox-gastaut syndrome: a case report

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Acta Epileptologica 2022年第4期5卷 286-291页

作者： Renli Qi Wei Wang Yaoduan Xu Zongling Shen Xin Geng Na li jinghui li Hualin Yu Second Department of Neurosurgery First Affiliated Hospital of Kunming Medical UniversityKunming650032China Department of Neurosurgery The Third People’s Hospital of Honghe PrefectureGejiu661000China Department of Psychiatry First Affiliated Hospital of Kunming Medical UniversityKunming650032China Yunnan Provincial Clinical Research Center for Neurological Disease Kunming650032China

Background Lennox-gastaut syndrome(LGS)is an epileptic encephalopathy often associated with behavioral and psychiatric disorders.Vagus nerve stimulation(VNS)has been approved effective for LGS treatment.Surgical resection is also an option for LGS patients with focal pathology,offering a high probability of seizure control.However,it is challenging to accurately localize the seizure focus.Case presentation The case presented here is a 19-year-old male with a 16-year history of epilepsy with comorbid severe cognitive and psychiatric disorders.He was diagnosed with LGS due to generalized slow spike-wave discharges and multiple seizure types.He was treated with VNS in 2017 at the age of 15.After that,the frequency of the short tonic seizures decreased from 4–5 times per day to 2–5 times per year,and the generalized tonic–clonic seizure pattern did not recur,which had a frequency of 2–4 times per month before the surgery.In 2019,the generalized abnormal interictal epileptiform discharges changed to be localized in the right frontal–temporal lobe at the age of 17 years(2019).Conclusions This case report suggested that the generalized epileptiform discharges evolve into localized discharges after VNS treatment,which may help reveal the primary seizure focus for resection surgery in patients with LGS.

关键词： Vagus nerve stimulation Lennox-gastaut syndrome Epileptiform discharges

Traumatic brain injury induced by exposure to blast overpressure via ear canal

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Neural Regeneration Research 2022年第1期17卷 115-121页

作者： Yang Ou Brad AClifton jinghui li David Sandlin Na li li Wu Chunming Zhang Tianwen Chen Jun Huang Yue Yu Jerome Allison Fan Fan Richard JRoman James Shaffery Wu Zhou Yi Pang Hong Zhu Departmant of Otolaryngology and Head Neck Surgery Department of Neurobiology and Anatomical Sciences MD Program School of Medicine Graduate Program in Neuroscience Department of Pediatrics Department of Pharmacology and Toxicology Department of Psychiatry and Human Behavior University of Mississippi Medical CenterJacksonMSUSA Kunming Medical University KunmingYunnan ProvinceChina Department of Otolaryngology First Affiliated HospitalShanxi Medical UniversityTaiyuanShanxi ProvinceChina

Exposure to explosive shockwave often leads to blast-induced traumatic brain injury in military and civilian populations.Unprotected ears are most often damaged following exposure to blasts.Although there is an association between tympanic membrane perforation and TBI in blast exposure victims,little is known about how and to what extent blast energy is transmitted to the central nervous system via the external ear canal.The present study investigated whether exposure to blasts directed through the ear canal causes brain injury in LongEvans rats.Animals were exposed to a single blast(0–30 pounds per square inch(psi))through the ear canal,and brain injury was evaluated by histological and behavioral outcomes at multiple time-points.Blast exposure not only caused tympanic membrane perforation but also produced substantial neuropathological changes in the brain,including increased expression of c-Fos,induction of a profound chronic neuroinflammatory response,and apoptosis of neurons.The blast-induced injury was not limited only to the brainstem most proximal to the source of the blast,but also affected the forebrain including the hippocampus,amygdala and the habenula,which are all involved in cognitive functions.Indeed,the animals exhibited long-term neurological deficits,including signs of anxiety in open field tests 2 months following blast exposure,and impaired learning and memory in an 8-arm maze 12 months following blast exposure.These results suggest that the unprotected ear canal provides a locus for blast waves to cause TBI.This study was approved by the Institutional Animal Care and Use Committee at the University of Mississippi Medical Center(Animal protocol#0932 E,approval date:September 30,2016 and 0932 F,approval date:September 27,2019).

关键词： anxiety blast ear ear protection learning memory microglia neuroinflammation neuron rat traumatic brain injury

Simulation and uniform design-based automatic generation of risk scenarios

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Journal of Systems Engineering and Electronics 2011年第6期22卷 1015-1022页

作者： jinghui li Rui Kang Ali Mosleh Xing Pan School of Reliability and Systems Engineering Beihang UniversityBeijing 100191P.R.China Center for Risk and Reliability University of MarylandCollege ParkMD 20742USA

This paper presents a methodology for automatically generating risk scenarios for dynamic reliability applications in which some dynamic characteristics(e.g.,the order,timing and magnitude of events,the value of relevant process parameters and initial conditions) have a significant influence on the evolution of the system.The main idea of the methodology is:(i) making the system model "express itself" through simulation by having the model driven by an elaborated simulation engine;(ii) exploiting uniform design to pick out a small subset of representative design points from the space of relevant dynamic characteristics;(iii) for each selected design point,employing a depth-first systematic exploration strategy to cover all possible scenario branches at each branch point.A highly dynamic example adapted from the literature(a chemical batch reactor) is studied to test the effectiveness of the proposed methodology.

关键词： risk scenarios automatic generation simulation uniform design dynamic reliability.

Simulation-based automatic generation of risk scenarios

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Journal of Systems Engineering and Electronics 2011年第3期22卷 437-444页

A methodology for automatically generating risk scenarios is presented.Its main idea is to let the system model ＂express itself＂ through simulation.This is achieved by having the simulation model driven by an elaborated simulation engine,which：（i） manipulates the generation of branch points,i.***.event occurrence times;（ii） employs a depth-first systematic exploration strategy to cover all possible branch paths at each branch point.In addition,a backtracking technique,as an extension,is implemented to recover some missed risk scenarios.A widely discussed dynamic reliability example（a holdup tank） is used to aid in the explanation of and to demonstrate the effectiveness of the proposed methodology.

关键词： risk scenario automatic generation simulation risk assessment dynamic reliability.