Development of localized interictal epileptiform discharges following vagus nerve stimulation for lennox-gastaut syndrome: a case report
作者机构：Second Department of NeurosurgeryFirst Affiliated Hospital of Kunming Medical UniversityKunming650032China Department of NeurosurgeryThe Third People’s Hospital of Honghe PrefectureGejiu661000China Department of PsychiatryFirst Affiliated Hospital of Kunming Medical UniversityKunming650032China Yunnan Provincial Clinical Research Center for Neurological DiseaseKunming650032China
出 版 物：《Acta Epileptologica》 (癫痫学报（英文）)
年 卷 期：2022年第5卷第4期
页 面：286-291页
基 金：Natural Science Foundation of Yunnan Province(202105AC160029,KYRLMY20200026 and YNGXCXTD2018012) Major Science and Technology Special Project of Yunnan Province(202002AA100204)
主 题：Vagus nerve stimulation Lennox-gastaut syndrome Epileptiform discharges
摘 要：Background Lennox-gastaut syndrome(LGS)is an epileptic encephalopathy often associated with behavioral and psychiatric *** nerve stimulation(VNS)has been approved effective for LGS *** resection is also an option for LGS patients with focal pathology,offering a high probability of seizure ***,it is challenging to accurately localize the seizure *** presentation The case presented here is a 19-year-old male with a 16-year history of epilepsy with comorbid severe cognitive and psychiatric *** was diagnosed with LGS due to generalized slow spike-wave discharges and multiple seizure *** was treated with VNS in 2017 at the age of *** that,the frequency of the short tonic seizures decreased from 4–5 times per day to 2–5 times per year,and the generalized tonic–clonic seizure pattern did not recur,which had a frequency of 2–4 times per month before the *** 2019,the generalized abnormal interictal epileptiform discharges changed to be localized in the right frontal–temporal lobe at the age of 17 years(2019).Conclusions This case report suggested that the generalized epileptiform discharges evolve into localized discharges after VNS treatment,which may help reveal the primary seizure focus for resection surgery in patients with LGS.
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