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3D bio-printed living nerve-like fibers refine the ecological niche for long-distance spinal cord injury regeneration

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Bioactive Materials 2023年第7期25卷 160-175页

作者： Jia Yang Kaiyuan Yang Weitao Man jingchuan zheng zheng Cao Chun-Yi Yang Kunkoo Kim Shuhui Yang Zhaohui Hou Guihuai Wang Xiumei Wang State Key Laboratory of New Ceramics and Fine Processing Key Laboratory of Advanced MaterialsSchool of Materials Science and EngineeringTsinghua UniversityBeijing100084China Department of Neurosurgery Beijing Tsinghua Changgung HospitalSchool of Clinical MedicineTsinghua UniversityBeijing102218China School of Materials Science and Engineering Zhejiang-Mauritius Joint Research Center for BiomaterialsTissue Engineering Zhejiang Sci-Tech UniversityHangzhou310018China

3D bioprinting holds great promise toward fabricating biomimetic living constructs in a bottom-up assembly *** date,various emergences of living constructs have been bioprinted for in vitro applications,while the conspicuous potential serving for in vivo implantable therapies in spinal cord injury(SCI)has been relatively ***,living nerve-like fibers are prepared via extrusion-based 3D bioprinting for SCI *** living nerve-like fibers are comprised of neural stem cells(NSCs)embedded within a designed hydrogel that mimics the extracellular matrix(ECM),assembled into a highly spatial ordered architecture,similar to densely arranged bundles of the nerve *** pro-neurogenesis ability of these living nerve-like fibers is tested in a 4 mm-long complete transected SCI rat *** shows that living nerve-like fibers refine the ecological niche of the defect site by immune modulation,angiogenesis,neurogenesis,neural relay formations,and neural circuit remodeling,leading to outstanding functional reconstruction,revealing an evolution process of this living construct after *** effective strategy,based on biomimetic living constructs,opens a new perspective on SCI therapies.

关键词： Neural stem cells Hydrogels 3D bioprinting Living constructs Spinal cord injury

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Hierarchically electrospraying a PLGA@chitosan sphere-in-sphere composite microsphere for multi-drug-controlled release

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Regenerative Biomaterials 2020年第4期7卷 381-390页

作者： Zhu Liu Weilong Ye jingchuan zheng Qindong Wang Guowu Ma Huiying Liu Xiumei Wang State Key Laboratory of New Ceramic&Fine Processing School of Materials Science and EngineeringTsinghua UniversityNo.1 QinghuayuanBeijing 100084China Department of Prosthodontics School of StomatologyDalian Medical UniversityNo.9 west sectionLvshunnan RoadDalian 116044China

Sequential administration and controlled release of different drugs are of vital importance for regulating cellular behaviors and tissue regeneration,which usually demands appropriate carriers like microspheres(MS)to control drugs *** has been proven an effective technique to prepare MS with uniform particle size and high drug-loading *** this study,we applied electrospray to simply and hierarchically fabricate sphere-in-sphere composite microspheres,with smaller poly(lactic-co-glycolic acid)MS(~8-10 lm in diameter)embedded in a larger chitosan MS(~250-300 lm in diameter).The scanning electron microscopy images revealed highly uniform MS that can be accurately controlled by adjusting the nozzle diameter or *** kinds of model drugs,bovine serum albumin and chlorhexidine acetate,were encapsulated in the *** fluorescence-labeled rhodamine-fluoresceine isothiocyanate(Rho-FITC)and ultraviolet(UV)spectrophotometry results suggested that loaded drugs got excellent distribution in microspheres,as well as sustained,slow release in *** addition,far-UV circular dichroism and matrixassisted laser desorption/ionization time-of-flight mass spectrometry(MALDI-TOF-MS)results indicated original secondary structure and molecular weight of drugs after *** speaking,our research proposed a modified hierarchically electrospraying technique to prepare sphere-in-sphere composite MS with two different drugs loaded,which could be applied in sequential,multi-modality therapy.

关键词： PLGA chitosan electrospray composite microsphere

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Biphasic mineralized collagen-based composite scaffold for cranial bone regeneration in developing sheep

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Regenerative Biomaterials 2022年第1期9卷 280-293页

作者： jingchuan zheng Zhijun Zhao Yongdong Yang Shuo Wang Yonggang Zhao Yang Xiong Shuhui Yang Zhiye Qiu Tianxi Song Chunyang Zhang Xiumei Wang State Key Laboratory of New Ceramics and Fine Processing Key Laboratory of Advanced Materials of Ministry of EducationSchool of Materials Science and EngineeringTsinghua UniversityBeijing 100084China Department of Neurosurgery The First Affiliated Hospital of Baotou Medical SchoolBaotou 014010China Dongzhimen Hospital Affiliated Beijing University of Chinese Medicine Beijing 100700China Beijing Allgens Medical Science and Technology Co. Ltd.Beijing 100176China

Appropriate mechanical support and excellent osteogenic capability are two essential prerequisites of customized implants for regenerating large-sized cranial bone *** porous bone scaffolds have been widely proven to promote bone regeneration,their weak mechanical properties limit the clinical applications in ***,we applied two previously developed mineralized collagen-based bone scaffolds(MC),porous MC(pMC)and compact MC(cMC)to construct a biphasic MC composite bone scaffold(bMC)to repair the large-sized cranial bone defect in developing sheep.A supporting frame composed of cMC phase in the shape of tic–tac–toe structure was fabricated first and then embedded in pMC *** two phases had good interfacial bond,attributing to the formation of an interfacial *** in vivo performance of the bMC scaffold was evaluated by using a cranial bone defect model in 1-month-old *** computed tomography imaging,X-ray scanning and histological evaluation showed that the pMC phase in the bMC scaffold,similar to the pMC scaffold,was gradually replaced by the regenerative bone tissues with comprehensively increased bone mineral density and complete connection of bone bridge in the whole *** cMC frame promoted new bone formation beneath the frame without obvious degradation,thus providing appropriate mechanical protection and ensuring the structural integrity of the *** general,the sheep with bMC implantation exhibited the best status of survival,growth and the repair *** biphasic structural design may be a prospective strategy for developing new generation of cranioplasty materials to regenerate cranial bone defect in clinic.

关键词： mineralized collagen cranial bone defect biphasic composite scaffold,developing sheep

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Weakened interlayer coupling in two-dimensional MoSe2 flakes with screw dislocations

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Nano Research 2019年第8期12卷 1900-1905页

作者： Xiangzhuo Wang Huixia Yang Rong Yang Qinsheng Wang jingchuan zheng Lu Qiao Xianglin Peng Yongkai Li Dongyun Chen Xiaolu Xiong Junxi Duan Guangyu Zhang Jie Ma Junfeng Han Wende Xiao Yugui Yao Key Lab of Advanced Optoelectronic Quantum Architecture and Measurement (MOE) Beijing Key Lab of Nanophotonics & Ultrafine Optoelectronic Systemsand School of PhysicsBeijing Institute of TechnologyBeijing 100081China Micronano Center Beijing Institute of TechnologyBeijing 100081China Institute of Physics Chinese Academy of SciencesBeijing 100190China

The screw dislocations are intriguing defects that are often observed in natural and artificial materials. The dislocation spirals break the reflection and inversion symmetries of the lattices and modify the interlayer coupling in layer-structured materials, inducing additional complexity in layer stacking and thus novel properties in materials. Here, we report on the interlayer coupling of two-dimensional (2D) MoSe2 flakes with screw dislocations by atomic force microscopy (AFM), Raman spectra and photoluminescence (PL) spectra. By controlling the supersaturation conditions, 2D MoSe2 flakes with screw dislocations are grown on amorphous SiO2 substrates by chemical vapor deposition (CVD). AFM measurements reveal that the interlayer spacing in such 2D MoSe2 flakes with screw dislocation is slightly widened with respect to the normal AA- or AB-stacked ones due to the presence of the screw dislocations. Raman and PL spectra show that the interlayer coupling is weaker and thus the band gap is wider than that in the normal AA- or AB-stacked ones. Our work demonstrates that the interlayer coupling of 2D transition metal dichalcogenides (TMDCs) flakes can be tuned by the induction of screw dislocations, which is very helpful for developing novel catalysts and electronic devices.

关键词： transition-metal dichalcogenides molybdenum selenide screw dislocations interlayer coupling band gap

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针对大连金州天然气管道火灾爆炸事故的调查分析

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今日消防 2023年第1期8卷 97-99页

作者：敖卓谦郑景川深圳市消防救援支队广东深圳518000 深圳市城市公共安全技术研究院有限公司广东深圳518000

通过对大连金州天然气管道火灾爆炸事故发生地点、时间、主要致灾因素等具体环节开展针对性地调查分析,结合我国城市燃气的主要理化性质对本起事故的发展过程及事故后果实施逐一认定,以此为依据对我国城市天然气管道泄漏爆炸事故产生的... 详细信息

通过对大连金州天然气管道火灾爆炸事故发生地点、时间、主要致灾因素等具体环节开展针对性地调查分析,结合我国城市燃气的主要理化性质对本起事故的发展过程及事故后果实施逐一认定,以此为依据对我国城市天然气管道泄漏爆炸事故产生的主要原因以及事故可能造成的相应后果开展系统性的归纳总结,最终结合我国现行的相关法律法规,对我国城市燃气火灾爆炸事故的有效预防提出了建议。

关键词：天然气管道泄漏事故火灾爆炸事故分析

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硫酸依替米星治疗呼吸系统感染的临床研究

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中国抗生素杂志 2000年第B05期25卷 28-29页

作者：余春艳郑经川陈亚岗浙江大学附属第一医院杭州310003

为评价硫酸依替米星粉针剂治疗呼吸系统感染的疗效与安全性 ,对 10 3例呼吸道感染病人采用硫酸依替米星粉针剂 0 .2 g溶于 5 %葡萄糖中 ,静脉滴注 ,每天 1次 ,疗程 5～ 14d。治疗结果 :总有效率为80 .5 8% ,细菌清除率 89.6 6 % ,不良... 详细信息

为评价硫酸依替米星粉针剂治疗呼吸系统感染的疗效与安全性 ,对 10 3例呼吸道感染病人采用硫酸依替米星粉针剂 0 .2 g溶于 5 %葡萄糖中 ,静脉滴注 ,每天 1次 ,疗程 5～ 14d。治疗结果 :总有效率为80 .5 8% ,细菌清除率 89.6 6 % ,不良反应发生率 3.88%。提示硫酸依替米星粉针剂治疗呼吸系统感染安全有效。

关键词：硫酸依替米星呼吸系统感染药物疗法安全性

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社会单位消防安全信用评价

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中国人民警察大学学报 2024年第2期40卷 45-50页

作者：廖亚峰曾铮谭双源周亮蒋慧灵王菁川衡阳市消防救援支队湖南衡阳421001 北京科技大学北京100083 上海意静信息科技有限公司上海200120

介绍国外消防安全管理现状和国内消防信用体系与信用评价方法研究进展,分析我国消防领域信用评价发展现状和存在问题,提出消防领域信用评价建设目标。研究社会单位消防安全信用评价指标体系建立原则与分级架构,确立消防安全信用评价指... 详细信息

介绍国外消防安全管理现状和国内消防信用体系与信用评价方法研究进展,分析我国消防领域信用评价发展现状和存在问题,提出消防领域信用评价建设目标。研究社会单位消防安全信用评价指标体系建立原则与分级架构,确立消防安全信用评价指标体系信息采集与评价方法,确定社会单位消防安全信用等级情况与分级依据,基于并借助消防物联网技术,实现消防安全信用动态化评价,并阐明信用评价结果应用方法。建立健全社会单位消防安全信用评价体系,能有效激励社会单位自主提升消防安全水平。

关键词：消防安全信用指标体系信用等级动态评价消防物联网

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Corrigendum to:Hierarchically electrospraying a PLGA@chitosan sphere-in-sphere composite microsphere for multi-drug-controlled release

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Regenerative Biomaterials 2020年第4期7卷 441-441页

[This corrects the article DOI: 10.1093/rb/rbaa009.][This corrects the article DOI: 10.1093/rb/rbaa009.].

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分级电纺复合载药微球辅助牙槽骨增量

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口腔医学研究 2021年第5期37卷 458-461页

作者：叶伟龙郑靖川黄佳倩赵鹏程刘柱马国武大连医科大学口腔医学院辽宁大连116044 大连医科大学口腔医学院附属口腔医院辽宁大连116023

目的:分级电纺法制备PLGArhBMP2@CSPac525复合微球,研究其抗菌与成骨活性。方法:分级电纺法制备双载药PLGA@CS复合微球,扫描电镜检测微观结构,紫外分光光度计和Elisa检测包封效率。抑菌环试验与碱性磷酸酶染色测试抗菌与成骨的活性。结... 详细信息

目的:分级电纺法制备PLGArhBMP2@CSPac525复合微球,研究其抗菌与成骨活性。方法:分级电纺法制备双载药PLGA@CS复合微球,扫描电镜检测微观结构,紫外分光光度计和Elisa检测包封效率。抑菌环试验与碱性磷酸酶染色测试抗菌与成骨的活性。结果:复合微球呈理想的球包球结构,粒径均一约280~290μm,rhBMP与Pac525包封率均大于90%。在30 d时释放的Pac525仍可形成超过10 mm的抑菌圈,碱性磷酸酶染色证实第20、40、60天时释放的rhBMP2在诱导第7天时即有明显的成骨表现。结论:本研究为口腔种植前骨增量治疗提出了一种可靠而高效的生物多功能支架方案。

关键词：分级电纺复合微球抗菌成骨

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量子自旋霍尔绝缘体Bi_(4)Br_(4)体与边缘的可区分的光学性质研究

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Science Bulletin 2023年第4期68卷 417-423,M0004页

作者：韩俊峰毛鹏程陈海龙殷嘉鑫王茂原陈东云李永恺郑靖川张旭马大帅马琼余智明周金健刘铖铖王业亮贾爽翁羽翔 M.Zahid Hasan 肖文德姚裕贵 Centre for Quantum Physics Key Laboratory of Advanced Optoelectronic Quantum Architecture and Measurement(Ministry of Education)School of PhysicsBeijing Institute of TechnologyBeijing 100081China Yangtze Delta Region Academy of Beijing Institute of Technology Jiaxing 314000China Beijing Key Laboratory of Nanophotonics&Ultrafine Optoelectronic Systems Beijing Institute of TechnologyBeijing 100081China Analysis&Testing Center Beijing Institute of TechnologyBeijing 100081China Beijing National Laboratory for Condensed Matter Physics and Institute of Physics Chinese Academy of SciencesBeijing 100190China Songshan Lake Materials Laboratory Dongguan 523808China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100190China Laboratory for Topological Quantum Matter and Advanced Spectroscopy(B7) Department of PhysicsPrinceton UniversityPrinceton NJ 08544USA Department of Physics Xiamen UniversityXiamen 361005China Department of Physics Boston CollegeChestnut Hill MA 02467USA School of Integrated Circuits and Electronics MIIT Key Laboratory for Low-Dimensional Quantum Structure and DevicesBeijing Institute of TechnologyBeijing 100081China International Center for Quantum Materials School of PhysicsPeking UniversityBeijing 100871China Department of Physics Chongqing UniversityChongqing 400044China

量子自旋霍尔绝缘体拥有具有带隙的体态和无能隙的一维拓扑边缘态.然而,由于拓扑边缘态局域在纳米尺度,所以很难用光学手段直接观测并区分体态和边缘态,这就限制了对拓扑边缘态独特的光学特性和光电响应等方面的研究和应用.Bi_(4)Br_(4... 详细信息

量子自旋霍尔绝缘体拥有具有带隙的体态和无能隙的一维拓扑边缘态.然而,由于拓扑边缘态局域在纳米尺度,所以很难用光学手段直接观测并区分体态和边缘态,这就限制了对拓扑边缘态独特的光学特性和光电响应等方面的研究和应用.Bi_(4)Br_(4)体材料的台阶存在一维非平庸的边缘态,多个台阶累加的效应使得通过较为宏观的光学和光电分析手段来研究一维边缘态成为可能.该工作利用中远红外显微吸收光谱和泵浦探测光谱,对比研究了Bi_(4)Br_(4)体和边缘的光学响应行为.研究发现Bi_(4)Br_(4)的边缘在小于带隙(约0.22 eV)的波段存在明显的强于体内的红外吸收,且该吸收呈现较强的各向异性.室温下的红外泵浦探测首次观察到边缘处载流子激发态超长的弛豫时间(1.5 ns),该激发态载流子寿命要比体内载流子寿命长两个量级.该工作证实体态和拓扑边缘态具有明显不同的光学和光电响应行为,为未来设计新型红外探测器提供了材料和物理基础.

关键词： Topological insulator Quantum spin Hall effect Bi_(4)Br_(4) Edge states Mid-infrared absorption microspectroscopy Pump-probe micro-spectroscopy

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