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ligand density-dependent influence of arginine-glycine- aspartate functionalized gold nanoparticles on osteogenic and adipogenic differentiation of mesenchymal stem cells

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Nano Research 2018年第3期11卷 1247-1261页

作者： jingchao li Ying Chen Naoki Kawazoe Guoping Chen Intemational Center for Materials Nanoarchitectonics National lnstitute for Materials Science 1-1 Namiki Tsukuba Ibaraki 305-0044Japan Department of Materials Science and Engineering Graduate School of Pure and Applied Sciences University of Tsukuba 1-1-1 Tennodai Tsukuba Ibaraki 305-8577 Japan Research Center for Functional Materials National Institute for Materials Science 1- 1 Namiki Tsukuba Ibaraki 305-0044 Japan

Extracellular matrix （ECM） plays a very important role in regulating cell function and fate. It is highly desirable to fabricate biomimetic models to investigate the role of ECM in stem cell differentiation. In this study, arginine- glycine--aspartate （RGD）-modified gold nanoparticles （Au NPs） with tunable surface ligand density were prepared to mimic the ECM microenvironment. Their effect on osteogenic and adipogenic differentiation of human mesenchymal stem cells （MSCs） was investigated. The biomimetic Au NPs were taken up by MSCs in a ligand density-dependent manner. The biomimetic NPs with a high RGD density had an inhibitive effect on the alkaline phosphatase （ALP） activity, calcium deposition, and osteogenic marker gene expression of MSCs. Their effect on oil droplet formation and adipogenic marker gene expression was negative when RGD density was low, while their effect was promotive when RGD density was high. The biomimetic Au NPs regulated the osteogenic and adipogenic differentiation of MSCs mainly through affecting the focal adhesion and cytoskeleton. This study highlights the roles of biomimetic NPs on stem cell differentiation that could provide a meaningful strategy in fabricating functional biomaterials for tissue engineering and biomedical applications.

关键词： arginine-glycine--aspartate(RGD) density biomimetic goldnanopartides (Au NPs) osteogenic differentiation adipogenic differentiation mesenchymal stem cells

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Research Progress of Soybean Protein Adhesive:A Review

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Journal of Renewable Materials 2022年第10期10卷 2519-2541页

作者： Yantao Xu Yufei Han Jianzhang li Jing Luo Sheldon QShi jingchao li Qiang Gao An Mao MOE Key Laboratory of Wooden Material Science and Application&Beijing Key Laboratory of Wood Science and Engineering Beijing Forestry UniversityBeijing100083China College of Materials Science and Engineering Nanjing Forestry UniversityNanjing210037China College of Engineering Department of Mechanical and Energy Engineering University of North TexasDenton76203USA State Forestry and Grassland Administration Key Laboratory of Silviculture in Downstream Areas of the Yellow River College of ForestryShandong Agricultural UniversityTai’an271000China

Traditional formaldehyde-based adhesives rely excessively on petrochemical resources,release toxic gases,and pollute the ***-derived soybean protein adhesives are eco-friendly materials that have the potential to replace the formaldehyde-based adhesives used to fabricate wood-based ***,the poor water resistance,high brittleness,and poor mildew resistance of soybean protein adhesives limit their industrial *** article reviews recent research progress in the modification of soybean protein adhesives for improving the bonding performance of adhesives used for wood-based panel *** methods were summarized in terms of water resistance,solid content,and mildew *** modification mechanisms and remaining problems were also ***,the current industrial applications and the future research direction of soybean protein adhesives are discussed.

关键词： Soybean protein adhesive bonding performance water resistance solid content mildew resistance

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Pd@Ir-LOD multienzyme utilizing endogenous lactate consumption cooperates with photothermal for tumor therapy

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Nano Research 2024年第1期17卷 270-281页

作者： Zichen Ye Yun li jingchao li Xinyan Hu Jinyang Zheng Gongxin Zhang Sijin Xiang Tianbao Zhu Zhide Guo Xiaolan Chen State Key Laboratory for Physical Chemistry of Solid Surfaces Collaborative Innovation Center of Chemistry for Energy Materials and Engineering Research Center for Nano-Preparation Technology of Fujian ProvinceCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics&Center for Molecular Imaging and Translational Medicine School of Public Health Xiamen UniversityXiamen 361102China The High Educational Key Laboratory for Biomedical Engineering&Key Laboratory of Fire Retardant Materials of Fujian Province Department of BiomaterialsCollege of MaterialsXiamen UniversityXiamen 361102China

Lactic acid(LA)plays a major role in the occurrence,development,and spread of *** by its high accumulation in tumor site,a novel lactate oxidase(LOD)conjugated two-dimensional Pd@Ir nanoplatform(Pd@Ir-LOD,PIL)was fabricated to combine cascade reaction with photothermal for tumor *** detail,the overexpressed LA in tumor microenvironment(TME)was a key factor to activate the PIL-based cascade reaction:(1)Plenty of H_(2)O_(2)could be generated from LA by the catalysis of LOD with O_(2);(2)potent·OH was produced from H_(2)O_(2)due to the peroxidase(POD)-like activity of PIL;(3)meantime,PIL’s catalase(CAT)-like activity could decompose part H_(2)O_(2)into O_(2)to achieve the purpose of LA cyclic ***,the reduced glutathione(GSH)scavenging capability of PIL might protect the produced reactive oxygen species(ROS)from being cleared to further improve the cascade therapeutic *** importantly,PIL had excellent photothermal conversion efficiency(37.35%)and manifested a surprising temperature rising effect in *** together,the decreasing LA concentration,accumulation of high-toxic ROS,the depletion of GSH together with the higher intra-tumoral temperature potently enhanced in vivo antitumor ***,a promising therapeutic tactic based on PIL integrating endogenous LA consumption,chemodynamic therapy(CDT),and photothermal therapy(PTT)has been put forward.

关键词： lactate oxidase chemodynamic therapy photothermal therapy cascade reaction tumor microenvironment

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Palladium nanoplates scotch breast cancer lung metastasis by constraining epithelial-mesenchymal transition

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National Science Review 2021年第7期8卷 124-136页

作者： Shunhao Wang jingchao li Mei Chen liting Ren Wenya Feng lining Xu Xiaolan Chen Tian Xia Nanfeng Zheng Sijin liu State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences University of Chinese Academy of Sciences State Key Laboratory for Physical Chemistry of Solid Surfaces Collaborative Innovation Center of Chemistry for Energy Materials Department of Chemistry Xiamen University College of Materials Science and Engineering Hunan University Division of Nanomedicine Department of Medicine California Nano Systems Institute University of CaliforniaLos Angeles

Metastasis accounts for the majority of cancer deaths in many tumor types including breast ***-mesenchymal transition(EMT) is the driving force for the occurrence and progression of metastasis, however, no targeted strategies to block the EMT program are currently available to combat metastasis. Diverse engineered nanomaterials(ENMs) have been reported to exert promising anti-cancer effects, however, no ENMs have been designed to target EMT. Palladium(Pd) nanomaterials, a type of ENM, have received substantial attention in nanomedicine due to their favorable photothermal performance for cancer therapeutics. Herein, Pd nanoplates(Pd PL) were found to be preferentially biodistributed to both primary tumors and metastatic tumors. Importantly, Pd PL showed a significant inhibition of lung metastasis with and without near-infrared(NIR) irradiation. Mechanistic investigations revealed that EMT was significantly compromised in breast cancer cells upon the Pd PL treatment, which was partially due to the inhibition of the transforming growth factor-beta(TGF-β) signaling. Strikingly, the Pd PL was found to directly interact with TGF-β proteins to diminish TGF-β functions in activating its downstream signaling, as evidenced by the reduced phosphorylation of Smad2. Notably,TGF-β-independent pathways were also involved in undermining EMT and other important biological processes that are necessary for metastasis. Additionally, NIR irradiation elicited synergistic effects on PdPL-induced inhibition of primary tumors and metastasis. In summary, these results revealed that the Pd PL remarkably curbed metastasis by inhibiting EMT signaling, thereby indicating the promising potential of Pd PL as a therapeutic agent for treating breast cancer metastasis.

关键词： palladium nanoplates tumor targeting lung metastasis epithelial-mesenchymal transition TGF-β

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Molecular imaging of advanced atherosclerotic plaques with folate receptor-targeted 2D nanoprobes

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Nano Research 2020年第1期13卷 173-182页

作者： Zhide Guo liu Yang Mei Chen Xuejun Wen Huanhuan liu jingchao li Duo Xu Yuanyuan An Changrong Shi Jindian li Xinhui Su Zijing li Ting liu Rongqiang Zhuang Nanfeng Zheng Haibo Zhu Xianzhong Zhang State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics&Center for Molecular Imaging and Translational Medicine School of Public HealthXiamen UniversityXiamen361102China State Key Laboratory for Bioactive Substances and Functions of Natural Medicines Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation StudyInstitute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing100050China College of Materials Science and Engineering Hunan UniversityChangsha410082China The State Key Laboratory for Physical Chemistry of Solid Surfaces Collaborative Innovation Center of Chemistry for Energy MaterialsDepartment of ChemistryXiamen UniversityXiamen361005China Zhongshan Hospital Affiliated to Xiamen University Xiamen361004China

Vulnerable atherosclerotic plaques are responsible for most cardiovascular diseases(CVDs).Folate receptor(FR)positive activated macrophages were thought to be a prominent component in the development of vulnerable *** objective of this study is to develop folate conjugated two-dimensional(2D)Pd@Au nanomaterials(Pd@Au-PEG-FA)for targeted multimodal imaging of the FRs in advanced atherosclerotic *** and imaging studies(single photon emission computed tomography(SPECT),computed tomography(CT)and photoacoustic(PA)imaging)were performed to confirm the prolonged blood half-life and enrichment of radioactivity in atherosclerotic *** signals were detected in vivo with SPECT,CT and PA imaging in heavy atherosclerotic plaques,which were significantly higher than those of the normal aortas after injection of Pd@*** studies with preinjection of excess FA could effectively reduce the targeting ability of Pd@Au-PEG-FA in atherosclerotic plaques,further demonstrating the specific binding of Pd@Au-PEG-FA for plaque *** characterization revealed that the signal of probe was in accordance with the high-risk *** summary,the Pd@Au-PEG-FA has favorable pharmacokinetic properties and provides a valuable approach for detecting high-risk plaques in the presence of FRs in atherosclerotic plaques.

关键词： 2D material folate receptor multifunctional imaging activated macrophages atherosclerosis

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木材胶黏剂仿生改性研究进展

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材料导报 2024年第8期38卷 270-276页

作者：崔政李京超李建章高强北京林业大学木质材料科学与应用教育部重点实验室木材科学与工程北京市重点实验室北京100083

目前,利用无醛胶黏剂替代醛类树脂胶黏剂制备人造板产品成为木材胶黏剂研究热点,符合国家可持续发展和“双碳”战略。生物仿生为木材胶黏剂的改性和性能提升提供了设计灵感,是一种新兴且有效的改性策略。通过仿生设计与改性,无醛木材胶... 详细信息

目前,利用无醛胶黏剂替代醛类树脂胶黏剂制备人造板产品成为木材胶黏剂研究热点,符合国家可持续发展和“双碳”战略。生物仿生为木材胶黏剂的改性和性能提升提供了设计灵感,是一种新兴且有效的改性策略。通过仿生设计与改性,无醛木材胶黏剂的耐水性、防霉性、涂布预压性等得到显著提升的同时可以赋予胶黏剂功能性,是木材工业研究热点之一。本文综述了无醛木材胶黏剂仿生改性研究进展,按照仿生原理分为生物化学仿生木材胶黏剂(包括灵感来源于贻贝湿态黏附或模拟生物矿化、细胞壁构筑和重组键合网络过程等)以及结构仿生木材胶黏剂(包括灵感来源于壁虎脚趾微纳刷状结构、蜘蛛丝微相分离结构、珍珠层“砖和砂浆”结构、墨鱼骨多孔结构、弹簧螺旋结构等)。重点介绍了仿生原理、配方设计、胶黏剂性能和潜在应用价值,以期为木材胶黏剂的开发与高附加值利用提供参考。

关键词：无醛木材胶黏剂仿生性能功能性

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Polymer-Assisted Synthesis and Functionalization of Fe3O4/Au Composite Nanoparticles for Precision Tumor Imaging and Photothermal Therapy

Polymer-Assisted Synthesis and Functionalization of Fe3O4/Au...

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第二届海峡两岸功能材料科技与产业峰会（2015）

作者： jingchao li Hongdong Cai Yong Hu Mingwu Shen Xiangyang Shi College of Chemistry Chemical Engineering and BiotechnologyDonghua University State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringDonghua University

Development of functionalized Fe3O4/Au composite nanoparticles(NPs)having a controllable size,narrow size distribution,and featured optical property has offered many opportunities in the filed of cancer imaging and th...

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经典风险模型中破产变量的联合分布

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深圳大学学报（理工版） 2019年第4期36卷 419-423页

作者：苏必豪李婧超深圳大学数学与统计学院

破产理论对风险衡量和风险调控至关重要,破产索赔作为破产理论的一大重点问题,通过研究总索赔额随时间的分布,可以对风险进行较好描述,根据其分布的特征,可采取注资及保费再调整等方式进行风险调控.在经典风险模型中,优先考虑的4个破产... 详细信息

破产理论对风险衡量和风险调控至关重要,破产索赔作为破产理论的一大重点问题,通过研究总索赔额随时间的分布,可以对风险进行较好描述,根据其分布的特征,可采取注资及保费再调整等方式进行风险调控.在经典风险模型中,优先考虑的4个破产相关变量为:破产时间、截止至破产时的总索赔额、截止至破产时的总索赔次数及破产时的赤字.本研究考虑截止至破产时的总索赔额与其他破产变量的联合概率密度函数,给出当个体索赔为指数分布时,不同联合概率密度函数的表达式.指出当个体索赔分布服从某一类特定分解形式时,联合概率密度函数的表达式也可以分解并求出。

关键词：概率论经典风险模型破产时间破产时赤字破产时的总索赔额破产时的总索赔次数联合概率密度函数

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Hydrogen and oxygen isotopes geochemistry of the Qixiashan Pb-Zn-Ag polymetallic deposit in Nanjing

Hydrogen and oxygen isotopes geochemistry of the Qixiashan P...

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第三届全国青年地质大会

作者： Mingchao Zhang Renyi Chen jingchao li Zhicheng L Lei Yao Hui Chen Development and Research Center China Geological Survey Faculty of Geosciences and Resources China University of Geosciences Oil & Gas Survey China Geological Survey

1 Introduction Qixiashan deposit is the largest Pb-Zn-Ag polymetallic deposit in East China,which is located in the eastern outskirts of Nanjing,Jiangsu *** present,there are mainly two viewpoints on the genesis of the deposit.1)magmatic hydrothermal fluid dominated,including post-magmatic hydrothermal fluid as the main part accompanied with meteoric water activities(Zhen,1986),post-magmatic hydrothermal solu-

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Regional Geochemical Division—A Tool for Delineating Geochemical Block

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Journal of Earth Science 2000年第2期19卷 58-61页

作者： Chen Ming Yan Guangsheng Department of Geology, China University of Geosciences, Beijing 100083 Fan Jizhang li jingchao Geomathematics Institute, Changchun University of Science and Technology, Changchun 130026

Regional geochemical division is a mapping technique to divide an area into slices where the associations between geochemical elements are relatively simple and uniform. The result of division is expressed on a 2 D map. The scheme of regional geochemical division includes non supervised pattern recognition, elementary statistics and factor analysis. A practical example in a gold prospecting area in Jilin, China, and the corresponding explanation are presented. Regional geochemical division is a basic approach to the delineation of the geochemical blocks as well.

关键词： regional geochemical exploration regional geochemical division C transformation pattern recognition geochemical block association of elements.

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