检索结果-南通市图书馆

Association between heat shock factor protein 4 methylation and colorectal cancer risk and potential molecular mechanisms:A bioinformatics study

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2023年第12期15卷 2150-2168页

作者： wen-jing zhang Ke-Lin Yue jing-Zhai Wang Yu zhang Department of Medical Oncology The First People’s Hospital of Yunnan ProvinceAffiliated Hospital of Kunming University of Science and TechnologyKunming 650032Yunnan ProvinceChina Department of Gastroenterology The First People’s Hospital of Yunnan ProvinceAffiliated Hospital of Kunming University of Science and TechnologyKunming 650032Yunnan ProvinceChina

BACKGROUND We previously demonstrated that heat shock factor protein 4(HSF4)facilitates colorectal cancer(CRC)*** methylation,a major modifier of gene expression and stability,is involved in CRC development and *** To investigate the correlation between HSF4 methylation and CRC risk,and to uncover the underlying molecular *** Differences in β values of HSF4 methylation loci in multiple malignancies and their correlation with HSF4 mRNA expression were analyzed based on Shiny Methylation Analysis Resource ***4 methylation-related genes were identified by LinkedOmics in CRC,and Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were ***-protein interaction network of HSF4 methylation-related genes was constructed by String database and MCODE *** A total of 19 CpG methylation loci were identified in HSF4,and their β values were significantly increased in CRC tissues and exhibited a positive correlation with HSF4 mRNA ***,the prognostic and diagnostic performance of these CpG loci in CRC patients was *** CRC,there were 1694 HSF4 methylation-related genes;1468 of which displayed positive and 226 negative associations,and they were involved in regulating phenotypes such as immune,inflammatory,and metabolic ***,RELA,STAT3,FCGR3A,POLR2K,and AXIN1 are hub genes among the HSF4 methylation-related *** HSF4 is highly methylated in CRC,but there is no significant correlation between it and the prognosis and diagnosis of ***4 methylation may serve as one of the ways in which HSF4 mediates the CRC process.

关键词： Colorectal cancer DNA methylation Prognosis Diagnosis Bioinformatics Heat shock factor protein 4

Analytic solutions for generalized PT-symmetric Rabi models

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics B 2019年第11期28卷 161-167页

作者： Yuanhao Dong wen-jing zhang jing Liu Xiao-Tao Xie School of Physics and Information Technology Shaanxi Normal UniversityXi’an 710119China School of Physics Northwest UniversityXi’an 710069China

We theoretically investigate the exact solutions for generalized parity–time(PT)-reversal-symmetric Rabi models driven by external fields with monochromatic periodic, linear, and parabolic forms, respectively. The corresponding exact solutions are presented in terms of the confluent Heun equations without any approximation. In principle, the analytic solutions derived here are valid in the whole parameter space. Such a kind of study may offer potential coherent control schemes of the PT-symmetric two-level systems.

关键词： Rabi model PT symmetry population dynamics

Microstructure and tensile properties of Ti-62421S alloy plate with different annealing treatments

在线全文

学校读者我要写书评

暂无评论

Rare Metals 2018年第7期37卷 568-573页

作者： Yong-Ling Wang Xiao-Yun Song wen Ma wen-jing zhang wen-Jun Ye Song-Xiao Hui State Key Laboratory of Nonferrous Metals and Processes General Research Institute for Nonferrous Metals Division of Science and Technology Information General Research Institute for Nonferrous Metals

Ti-62421S （Ti-6A1-2Sn-4Zr-2Nb-lMo-0.2Si） is a novel short-time using high-temperature titanium alloy. The effects of annealing on microstructure and tensile properties of Ti-62421S alloy plate were studied through optical microscopy （OM）, electron probe microanalysis （EPMA）, transmission electron microscopy （TEM）, and tensile tests. The results show that, with annealing tem- perature increasing, the volume fraction of primary α（αp）- phase decreases while that of transformed β（βt）-structure and secondary α （αs）-phase increases. The room-temperature strength and plasticity are insensitive to annealing temperature. However, with annealing temperature increasing, the tensile strength decreases at 550℃, while increases at 600 and 650℃ instead. It is suggested that, at 550℃, the strengthening mechanism is mainly boundary strengthening and the biggest contributor is ap-phase by providing αp/β-boundary area. Above 600 ℃, the strengthening mechanism is grain strengthening, where αs-phase strengthens the β-phase.

关键词： High temperature titanium alloy Ti-62421S Heat treatment Microstructure Tensile properties

Phase precipitation behavior and tensile property of a Ti-Al-Sn-Zr-Mo-Nb-W-Si titanium alloy

在线全文

学校读者我要写书评

暂无评论

Rare Metals 2018年第12期37卷 1064-1069页

作者： wen-jing zhang Xiao-Yun Song Song-Xiao Hui wen-Jun Ye Wei-Qi Wang State Key Laboratory for Fabrication and Processing of Nonferrous Metals General Research Institute for Nonferrous Metals School of Materials and Metallurgy Northeastern University Baoti Group Co. Ltd.

The characteristic of precipitation behavior of a2 phase and silicide, and the tensile properties at room temperature and 650℃after heat treatments in anovel TiAl-Sn-Zr-Mo-Nb-W-Si titanium alloy（BTi-6431 S） were investigated by microstructure analysis and mechanics performance testing. The results show that no second phase precipitates after solution treatment(980 ℃/2 h, air cooling（AC）). However, when the solution-treated specimens are aged at 600 ℃（600 ℃/2 h,AC）,α;phase precipitates in the primary α phase, and the size of α;phase increases with the aging temperature increasing to 750 ℃. Meanwhile, 50-100-nm S2-type silicide particles precipitate along lamellar phase boundaries of transformed β phase after aging at 750 ℃. BTi-6431 S alloy shows the best650 ℃ ultimate tensile strength（UTS） and yield strength（YS） when treated in solution treatment. However, aging treatment results in a decline in 650 ℃ ultimate tensile strength. This may be attributed to the loss of solution strengthening due to the depletion of Al, Si and Zr of the matrix caused by the precipitation of Ti;Al and（TiZr）;Si;.Silicide is a brittle phase; therefore, its precipitation causes a sharp decrease in the room-temperature ductility of BTi-6431 S alloy.

关键词： High-temperature titanium alloy Precipitation behavior α_2 phase Silicide Tensile properties

α_(2) phase precipitation behavior and tensile properties at room temperature and 650℃ in an(α+β) titanium alloy

在线全文

学校读者我要写书评

暂无评论

Rare Metals 2021年第11期40卷 3261-3268页

作者： wen-jing zhang Xiao-Yun Song Song-Xiao Hui wen-Jun Ye Yang Yu Yan-Feng Li State Key Laboratory of Nonferrous Metals and Processes GRIMAT Engineering Institute Co.Ltd.Beijing 100088China

The microstructure,room temperature and 650℃ tensile properties of an(α+β) titanium alloy were investigated after aging over a temperature range of 600-750℃ following solution *** results exhibit that both aging temperature and aging time influence the precipitation behavior of α_(2) phase,and the size ofα_(2) phase affects the tensile *** growth speed ofα_(2) phase gets quicker with the aging temperature increasing under the same aging *** a given aging temperature,the size of α_(2) phase gets larger when prolonging the aging *** are significant improvements in yield and ultimate tensile strength at room temperature and 650 ℃ after aging at 600℃ for 2 h,but these values decrease with the size of α_(2) phase *** is found that α_(2) phase,less than 7 nm,does not impair the roomtemperature ***,when the size of α_(2) phase grows up from 7 to 15 nm,ductility decreases *** 650 ℃ tensile process,with the particle size increasing from 3 to 15 nm,the interaction between moving dislocations and coherent particles changes from cutting mechanism to bypass mechanism.

关键词： Aging treatment α_(2)phase Tensile properties Interaction mechanism

Top Quark Flavor Changing Decay t→ cH^0 in Little Higgs Model

在线全文

学校读者我要写书评

暂无评论

Communications in Theoretical Physics 2005年第4X期44卷 651-658页

作者： Farshid Tabbakh LIU jing-jing MA wen-Gan zhang Ren-You HOU Hong-Sheng Department of Modern Physics University of Science and Technology of China Hefei 230027 China

We study theoretically the quantum effects of the littlest Higgs model (LH) mediated by flavor changing one-loop Feynman diagrams on the rare decay process t → cH0. The comparison of the decay width in the LH model with that in the standard model (SM) is made. We find that the decay branch ratio of t → cH0 in the LH model is at most of the order ～ 10-12, which is two order larger than in the SM. The numerical results show that the difference between the branch ratios in the LH model and the SM is generally sensitive to the LH model parameters, such as symmetry breaking scale f, Higgs boson mass mH0, and x = v'4f /v2 in our chosen parameter space, but relatively insensitive to the value choice of the cosine of the mixing angle c and the ratio λ1/λ2.

关键词： littlest Higgs model top quark rare decay flavor changing neutral current

Bone cement implantation syndrome during hip replacement in a patient with pemphigus and Parkinson’s disease: A case report

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2021年第14期9卷 3342-3349页

作者： Wei Zhou wen-jing zhang Guo-Qing Zhao Kai Li Department of Anesthesiology Tongde Hospital of Zhejiang ProvinceHangzhou 310012Zhejiang ProvinceChina Department of Anesthesiology China Japan Union Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina

BACKGROUND Bone cement implantation syndrome(BCIS)is characterized by hypotension,arrhythmia,diffuse pulmonary microvascular embolism,shock,cardiac arrest,any combination of these factors,or even death following bone cement *** SUMMARY An 80-year-old patient with pemphigus and Parkinson’s disease underwent total hip replacement under spinal subarachnoid block and developed acute pulmonary embolism after bone cement *** patient received mask mechanical ventilation with a continuous intravenous infusion of adrenaline(2μg/mL)at a rate of 30 mL/***,the symptoms of BCIS were markedly alleviated,and the infusion rate of adrenaline was gradually reduced until the infusion was completely stopped 45 min *** patient was then transferred to the Department of Orthopedics,and anticoagulation therapy began at 12 h *** other complications were *** This is a rare case of BCIS in a high-risk patient with pemphigus and Parkinson’s disease.

关键词： Bone cement implantation syndrome Pemphigus Parkinson’s disease Pulmonary embolism Case report

Ocular diseases: immunological and molecular mechanisms

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2016年第5期9卷 780-788页

作者： jing Song Yi-Fei Huang wen-jing zhang Xiao-Fei Chen Yu-Mian Guo Department of Ophthalmology Affiliated Hospital of Logistics University of People's Armed Police Force Department of Ophthalmology General Hospital of PLA

Many factors, such as environmental, microbial and endogenous stress, antigen localization, can trigger the immunological events that affect the ending of the diverse spectrum of ocular disorders. Significant advances in understanding of immunological and molecular mechanisms have been researched to improve the diagnosis and therapy for patients with ocular inflammatory diseases. Some kinds of ocular diseases are inadequately responsive to current medications;therefore, immunotherapy may be a potential choice as an alternative or adjunctive treatment, even in the prophylactic setting. This article first provides an overview of the immunological and molecular mechanisms concerning several typical and common ocular diseases; second, the functions of immunological roles in some of systemic autoimmunity will be discussed; third, we will provide a summary of the mechanisms that dictate immune cell trafficking to ocular local microenvironment in response to inflammation.

关键词： immunological mechanism ocular diseases systemic autoimmunity immune response chemokines

Hyperhomocysteinemia induces injury in olfactory bulb neurons by downregulating Hes1 and Hes5 expression

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2018年第2期13卷 272-279页

作者： jing-wen zhang Bo Pang Qi Zhao Yue Chang Yi-li Wang Yi-deng Jiang Li jing School of Basic Medical Science Ningxia Key Laboratory of Cerebrocranial Diseases-Incubation Base of National Key LaboratoryNingxiaMedical UniversityYinchuanNingxia Hui Autonomous RegionChina Institute of Immunopathology Medical SchoolKey Laboratory of Biomedical Information Engineering of Ministry of EducationXi'an JiaotongUniversityXi'anShaanxi ProvinceChina

Hyperhomocysteinemia has been shown to be associated with neurodegenerative diseases; however, lesions or histological changes and mechanisms underlying homocysteine-induced injury in olfactory bulb neurons remain unclear. In this study, hyperhomocysteinemia was induced in apolipoprotein E-deficient mice with 1.7% methionine. Pathological changes in the olfactory bulb were observed through hematoxylin-eosin and Pischingert staining. Cell apoptosis in the olfactory bulb was determined through terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling （TUNEL） staining. Transmission electron microscopy revealed an abnormal ultrastructure of neurons. Furthermore, immunoreactivity and expression of the hairy enhancer of the split 1 （Hesl） and Hess were measured using immunohistochemistry, immunofluorescence, and western blot assay. Our results revealed no significant structural abnormality in the ol- factory bulb of hyperhomocysteinemic mice. However, the number of TUNEL-positive cells increased in the olfactory bulb, lipofuscin and vacuolization were visible in mitochondria, and the expression of Hes1 and Hes5 decreased. These findings confirm that hyperhomocyste- inemia induces injury in olfactory bulb neurons by downregulating Hes1 and Hes5 expression.

关键词： nerve regeneration olfactory bulb apoptosis neurons Nissl body homocysteine hairy enhancer of split 1 hairy enhancer of split 5 neural regeneration