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β-catenin、Smad3及TGF-β1在宫腔粘连患者子宫内膜组织中的表达及意义

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中国妇幼健康研究 2017年第7期28卷 793-796,831页

作者：路静王玉平张霆郝友瑛乌鲁木齐市妇幼保健院妇科新疆乌鲁木齐830001 新疆佳音医院妇科新疆乌鲁木齐830000 新疆医科大学第二附属医院新疆乌鲁木齐830063

目的研究β-catenin、Smad3及TGF-β1在宫腔粘连(IUA)患者粘连组织中的表达水平,探讨其在IUA中的作用机制。方法选择2014年5月至2016年5月在乌鲁木齐市妇幼保健院行宫腔镜下宫腔粘连松解术的IUA患者60例为实验组,常规行宫腔镜检查患者6... 详细信息

目的研究β-catenin、Smad3及TGF-β1在宫腔粘连(IUA)患者粘连组织中的表达水平,探讨其在IUA中的作用机制。方法选择2014年5月至2016年5月在乌鲁木齐市妇幼保健院行宫腔镜下宫腔粘连松解术的IUA患者60例为实验组,常规行宫腔镜检查患者60例为对照组。采用实时荧光定量聚合酶链反应(RT-PCR)方法检测实验组IUA患者的粘连组织、靠近粘连的子宫内膜和对照组的正常子宫内膜组织中β-catenin m RNA、Smad3m RNA及TGF-β1 m RNA的表达水平。结果对照组患者正常子宫内膜组织中与实验组轻度、中度、重度IUA患者粘连组织中的β-catenin m RNA、Smad3 m RNA、TGF-β1 m RNA的表达比较,从低到高依次排序:对照组<实验组轻度粘连<实验组中度粘连<实验组重度粘连,对比差异有统计学意义(F值分别为20.35、19.62、22.32,均P<0.05),β-catenin m RNA、Smad3 m RNA、TGF-β1 m RNA在实验组IUA患者粘连组织、靠近粘连的子宫内膜中的表达均高于对照组正常子宫内膜,差异有统计学意义(P值分别为0.038、0.003、0.004);β-catenin m RNA、Smad3m RNA、TGF-β1 m RNA在粘连组织中的表达高于靠近粘连的子宫内膜,差异有统计学意义(P值分别为0.016、0.001、0.008)。在IUA患者粘连组织中TGF-β1与Smad3的表达呈正相关(rs=0.44,P=0.01);TGF-β1与β-catenin的表达亦呈正相关(rs=0.42,P=0.02);Smad3与β-catenin的达无相关性(rs=0.037,P=0.85)。结论在IUA中β-catenin、TGF-β1及Smad3的高表达可能与宫腔粘连的发生有密切相关;β-catenin和TGF-β1/Smad通路可能协同参与子宫内膜纤维化及促进宫腔粘连的形成。

关键词：宫腔粘连 β-连环蛋白 TGF-β1/Smad 纤维化

Studies on Structure and Properties of Water Soluble Polysaccharide from Fruiting Body of Cordyceps Militarvs(L.) Link

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Chemical Research in Chinese Universities 2003年第1期19卷 37-40页

作者： WANG Bai jing WEI Min zhang Li ping School of Life Science Northeast Normal UniversityChangchun 130024P.R.China

A water soluble crude polysaccharide has been isolated from the fruiting body of cultivated Cordyceps militarvs(L.) Link. The GC analysis indicated that it contained the monosaccharides of Gal, Man, Glc and GlcA. Their molar ratio is 1 00∶1 58∶7 89∶0 19. The crude polysaccharide was fractionated with ethanol to get three fractions, which were CM Ⅰ, CM Ⅱ and CM Ⅲ. CM Ⅱ was further purified to get one homogeneous fraction named CMB. The molecular weight was estimated to be 60000 by means of gel filtration. CMB is a greyish white powder. The GC analysis indicated that it was composed of Gal, Man, Glc and the molar ratio is 1 00∶1 38∶5 10. Partial hydrolysis with an acid, periodate oxidation, Smith degradation, IR, GC and methylation analyses, GC/MS analyses were used for the structure analyses of CMB. The results reveal that CMB is of a lower branched structure. The main chain is composed of (1→6) linked Man, (1→6) linked Glc, (1→4) linked Glc and (1→4) linked Gal. Some of (1→4) linked Glc and all (1→4) linked Gal residues are substituted at 3 O and 6 O respectively. (1→4) Linked Glc residues without branch probably exist with other monosaccharides alternately. On an average, there is one branch every ten hexose residues. The side chain is composed of major (1→4) linked Glc and minor (1→6) linked Glc. The nonreduced end is composed of Gal and Glc. The main glycosidic link of CMB is α configuration.

关键词： Cordyceps militarvs(L.) Link Polysaccharide Structure Property

Poor outcomes of delirium in the intensive care units are amplified by increasing age: A retrospective cohort study

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World Journal of Emergency Medicine 2021年第2期12卷 117-123页

作者： Wen Gao Yu-ping zhang jing-fen Jin Nursing Department School of MedicineZhejiang UniversityHangzhou 310058China Nursing Department the Second Affi liated Hospital of Zhejiang University School of MedicineHangzhou 310009China

BACKGROUND: Delirium in patients in intensive care units(ICUs) is an acute disturbance and fluctuation of cognition and consciousness. Though increasing age has been found to be related to ICU delirium, there is limited evidence of the effect of age on delirium outcomes. The aim of this study is to investigate the relationship between age categories and outcomes among ICU delirium ***: Data were extracted from the electronic ICU(e ICU) Collaborative Research Database with records from 3,931 patients with delirium. Patients were classified into non-aged(<65 years), youngold(65–74 years), middle-old(75–84 years), and very-old(≥85 years) groups. A Cox regression model was built to examine the role of age in death in ICU and in hospital after controlling covariates. RESULTS: The sample included 1,667(42.4%) non-aged, 891(22.7%) young-old, 848(21.6%) middle-old, and 525(13.3%) very-old patients. The ICU mortality rate was 8.3% and the hospital mortality rate was 15.4%. Compared with the non-aged group, the elderly patients(≥65 yeras) had higher mortality at ICU discharge(χ2=13.726, P=0.001) and hospital discharge(χ2=56.347, P<0.001). The Cox regression analysis showed that age was an independent risk factor for death at ICU discharge(hazard ratio [HR]=1.502, 1.675, 1.840, 95% confidence interval [CI] 1.138–1.983, 1.250–2.244, 1.260–2.687;P=0.004, 0.001, 0.002 for the young-, middle-and very-old group, respectively) as well as death at hospital discharge(HR=1.801, 2.036, 2.642, 95% CI 1.454–2.230, 1.638–2.530, 2.047–3.409;all P<0.001).CONCLUSIONS: The risks of death in the ICU and hospital increase with age among delirious patients.

关键词： Intensive care Delirium Aging Mortality

Bifunctional bridging capping layer enables 24.5% efficiency of perovskite solar cells with polymer-based hole transport materials

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Science China Chemistry 2025年第1期 350-359页

作者： Can Zhu Yiyang Wang Lei Meng Beibei Qiu jing Li Shucheng Qin Ke Hu Xin Jiang Wenbin Lai Minchao Liu Zhe Liu Chenxing Lu Jinyuan zhang Yongfang Li Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Organic Solids Institute of Chemistry Chinese Academy of Sciences School of Chemical Science University of Chinese Academy of Sciences Key Laboratory of Solid State Optoelectronic Devices of Zhejiang Province College of Physics and Electronic Information Engineering Zhejiang Normal University Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and ChemistryChinese Academy of Sciences Laboratory of Advanced Optoelectronic Materials College of Chemistry Chemical Engineering and Materials ScienceSoochow University

Developing a bridge capping layer between perovskite and hole transport layer materials（HTMs） in the n-i-p perovskite solar cells（pero-SCs） is an effective approach to modify the morphology of HTMs and passivate the perovskite ***, we select the quinoxaline-based bifunctional passivation agent, quinoxalin-6-yl-methylamine hydrochloride（Qx MACl）,as the bridging layer, and a D-A copolymer PBQ12 containing the same quinoxaline unit as an HTM for the n-i-p pero-SCs. Due to the π-π stacking among the common quinoxaline units in the bridge layer and HTM, Qx MACl induces the π-π stacking of the PBQ12 film and improves the film morphology of HTMs with better conductivity. Additionally, Qx MACl can effectively passivate the perovskite surface, and PBQ12 possesses appropriate energy levels and high hole mobility. The pero-SCs based on FAPbI3with PBQ12/Qx MACl treatment showed a higher power conversion efficiency（PCE） of 24.05% and outstanding stability, maintaining 95.4% and 92.1% of its initial PCE after 750 h of storage and after over 800 h of thermal annealing at 85 °C, respectively. To further enhance the PCE of the PBQ12/Qx MACl-based devices, we developed a non-metal ion dopant for the PBQ12 HTM. Through trace doping of PBQ12 HTM by the non-metal ion dopant, the PCE of the PBQ12/Qx MACl-based devices reached 25.24%（the calibrated PCE of 24.55% by the National Institute of Metrology, China）.

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石墨烯褶皱结构对双电层储能性能的理论研究

原子与分子物理学报 2025年第6期42卷 89-100页

作者：张倩蒋更平武汉科技大学理学院应用物理系武汉430081

石墨烯因其出色的比表面积和单层结构而被广泛认为是一种理想的电极材料.然而,实验制备的石墨烯常因官能团、缺陷和位错的引入而出现褶皱和变形.针对这一问题,本文构建了一系列具有不同幅度褶皱(a=0~6.6?)的石墨烯片,并运用分子动力学... 详细信息

石墨烯因其出色的比表面积和单层结构而被广泛认为是一种理想的电极材料.然而,实验制备的石墨烯常因官能团、缺陷和位错的引入而出现褶皱和变形.针对这一问题,本文构建了一系列具有不同幅度褶皱(a=0~6.6?)的石墨烯片,并运用分子动力学模拟来研究这些褶皱石墨烯表面的双电层结构.本研究旨在探讨不同褶皱高度和充电状态下双电层的变化规律,及其与超级电容器储能性能之间的关系.研究发现,褶皱石墨烯模型内部的离子浓度随电压的增加呈现多峰层状分布,而表面离子浓度与施加的电压正相关.此外,石墨烯的褶皱结构能够减少离子和水对电极电压响应的敏感性.在不同电压条件下,褶皱型石墨烯结构的面积比电容(C_A)始终高于其平面对应区域,突出了其在提升双电层储能性能上的优势.本研究揭示了石墨烯褶皱结构在调节离子分布、降低电压敏感性,以及增强电化学储能性能方面的特有作用机制.

关键词：双电层石墨烯褶皱恒电势模拟方法

Using non-destructive sampling to evaluate the population genomic status of captive Brown Eared Pheasants

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Avian Research 2023年第2期14卷 291-297页

作者： Pengcheng Wang ping Hu Jinping zhang Lixia zhang jing zhang Zhengwang zhang Jiangsu Key Laboratory for Biodiversity and Biotechnology College of Life SciencesNanjing Normal UniversityNanjing210023China Taiyuan Zoo Taiyuan030009China Beijing Zoo Management Office Beijing Key Laboratory of Captive Wildlife Technologies of Beijing ZooBeijing100044China Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering College of Life SciencesBeijing Normal UniversityBeijing100875China

Evaluating the genetic status of threatened species is an essential task in conservation ***,the genetic status of threatened species has been mostly evaluated through techniques that fail to estimate genetic diversity at the whole genomic *** generation sequencing can meet this demand,but high quality samples such as blood or muscle tissues are ***,it is difficult to collect such samples from threatened species because sampling work may impact their ***,it is essential to design a workflow to evaluate the whole genomic status of threatened species using non-destructive *** though non-destructive sampling has been used in traditional barcoding technique,the barcoding technique cannot evaluate the whole genomic *** Eared Pheasant(Crossoptilon mantchuricum)is an endangered species,with captive populations maintained in Taiyuan Zoo,China,and ***,the genetic diversity,inbreeding pattern,and mutation load of these two populations are *** uncover the genetic status of these two captive populations,we applied 2b-RAD technology to evaluate the genomic status of these populations using feathers as *** feathers could be collected by non-destructive *** results indicate that the Taiyuan Zoo population has a lower genetic diversity and higher inbreeding coefficient than the European *** Taiyuan Zoo population has lethal mutations when *** current project uses a non-destructive sampling technique to evaluate the whole genomic status of the two captive populations,providing a paradigm for conservation genetics,which will facilitate the development of conservation biology.

关键词： Genetic diversity Inbreeding coefficient Kinship Mutation load Threatened species

Metastable seed-crystals: epitaxial growth of branched-array organic heterostructure nanowires

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Science China Chemistry 2025年

作者： Jin Feng Zhen-Yu Geng Ting-Yao Song Ying-Xin Ma Chuan-Zeng Wang Wei zhang Hong-Tao Lin Jin Zhou Shu-ping Zhuo Shu-Hai Chen Xue-Dong Wang School of Chemistry and Chemical Engineering Shandong University of Technology Institute of Functional Nano & Soft Materials (FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials & DevicesSoochow University College of Chemistry and Chemical Engineering Hunan Normal University

Tunable light–matter interactions are exhibited by organic low-dimensional crystals, making these crystals a promising platform for organic photonics. However, the precise synthesis of organic low-dimensional crystals remains challenging due to the stochastic nature of molecular nucleation processes. Herein, the directed nucleation process is driven by the introduction of metastable seed-crystals as the trunk, which ultimately leads to branched-array organic heterostructures. The successful formation of organic heterostructures with high-density branched arrays is attributed to the highest attachment energy (Eatt（023）=-104.25 kcal mol-1) of the exposed （023） crystal plane during the seed-crystal growth route. Significantly, these as-prepared heterostructures inherently have an ultralow lattice mismatch ratio η of 0.7%between trunk and branch, which contributes to the multi-channel photon transportation. Therefore, this work provides valuable insights into a versatile synthetic strategy for accessing low-dimensional heterostructures for integrated optoelectronics.

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Studies on the preparation of active oxygen-deficient copper ferrite and its application for hydrogen production through thermal chemical water splitting

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Science China Chemistry 2008年第9期51卷 878-886页

作者： YU Bo zhang ping zhang Lei CHEN jing XU jingMing Institute of Nuclear and New Energy Technology Tsinghua UniversityBeijing 102201China

Hydrogen generation through thermal chemical water splitting technology has recently received in- creasingly international interest in the nuclear hydrogen production field. Besides the main known sulfur-iodine (S-I) cycle developed by the General Atomics Company and the UT3 cycle (iron, calcium, and bromine) developed at the University of Tokyo, the thermal cycle based on metal oxide two-step water splitting methods is also receiving research and development attention worldwide. In this work, copper ferrite was prepared by the co-precipitation method and oxygen-deficient copper ferrite was synthesized through first and second calcination steps for the application of hydrogen production by a two-step water splitting process. The crystal structure, properties, chemical composition and δ were investigated in detail by utilizing X-ray diffraction (XRD), thermogravimetry (TG) and differential thermal analysis (DTA), atomic absorption spectrometer (AAS), ultraviolet spectrophotometry (UV), gas chro- matography (GC), and so on. The experimental two-step thermal chemical cycle reactor for hydrogen generation was designed and developed in this lab. The hydrogen generation process of water splitting through CuFe2O4-δ and the cycle performance of copper ferrite regeneration were firstly studied and discussed.

关键词： copper ferrite oxygen deficient thermal chemical water splitting hydrogen production

Is it possible to foot reflexology for infants with sensorineural hearing loss?

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World Journal of Clinical Cases 2025年第2期13卷 1-4页

作者： Min Ai Hang-Hang zhang Jun-Bang Feng Chuan-Ming Li Wen-jing Wang Meng-Die Hu Department of Anesthesiology Nanan District People's Hospital of ChongqingChongqing 400060China Department of Breast and Thyroid Surgery Chongqing Bishan District Maternal and Child Health Care HospitalChongqing 402760China Department of Medical Imaging Chongqing University Central HospitalChongqing 400014China

Foot reflexology is a non-invasive and safe complementary therapy that works by massaging the reflex zones of the feet and exerts systemic or whole-body regulation through meridian nerve *** therapy is commonly used in the treatment of various conditions such as autism and Parkinson's ***,there is limited reporting on the use of foot reflexology therapy for infants with sensorineural hearing loss(SNHL).Currently,there is no definitive conclusion on how foot reflexology therapy can influence *** editorial holds some guiding significance regarding this clinical *** aim is to present physiological evidence of how foot reflexology therapy can impact infants with SNHL,thereby enhancing clinician’s awareness of foot reflexology in treating infants with SNHL.

关键词： Foot reflexology Sensorineural Hearing Loss Future perspectives Limitations Neural conduction