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Facile electrochemical surface-alloying and etching of Au wires to enable high-performance substrates for surface enhanced Raman scattering

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nano Materials Science 2024年第3期6卷 305-311页

作者： Yawen Zhan Guobin Zhang Junda Shen Binbin zhou Chenghao Zhao Junmei Guo Ming Wen Zhilong Tan Lirong Zheng Jian Lu Yang Yang Li Center of Super-Diamond and Advanced Films(COSDAF) City University of Hong Kong83 Tat Chee AvenueKowloonHong KongChina Department of Materials Science and Engineering City University of Hong Kong83 Tat Chee AvenueKowloonHong KongChina Kunming Institute of Precious Metals Sino-platinum Metals Co.Ltd.KunmingYunan ProvinceChina Centre for Advanced Structural Materials City University of Hong Kong Shenzhen Research Institute8 Yuexing 1st RoadShenzhen Hi-Tech Industrial ParkNanshan DistrictShenzhenChina Shenzhen Key Laboratory on Power Battery Safety Research and Shenzhen Geim Graphene Center Tsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhen518055China Institute of High Energy Physics Beijing100049China

Surface-enhanced Raman Spectroscopy(SERS)is a nondestructive technique for rapid detection of analytes even at the single-molecule ***,highly sensitive and reliable SERS substrates are mostly fabricated with complex nanofabrication techniques,greatly restricting their practical applications.A convenient electrochemical method for transforming the surface of commercial gold wires/foils into silver-alloyed nanostructures is demonstrated in this *** substrates are treated with repetitive anodic and cathodic bias in an electrolyte of thiourea,in a one-pot one-step manner.X-rays absorption fine structure(XAFS)spectroscopy confirms that the AuAg alloy is induced at the *** unique AuAg alloyed surface nanostructures are particularly advantageous when served as SERS substrates,enabling a remarkably sensitive detection of Rhodamine B(a detection limit of 10^(-14)M,and uniform strong response throughout the substrates at 10^(-12)M).

关键词： Electrodeposition Dealloying Surface-alloyed Noble metals Surface enhanced Raman spectroscopy substrates

Anti-atherosclerotic effects and molecular targets of ginkgolide B from Ginkgo biloba

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Acta Pharmaceutica Sinica B 2024年第1期14卷 1-19页

作者： Weile Ye Jiaojiao Wang Peter JLittle Jiami Zou Zhihua Zheng jing Lu Yanjun Yin Hao Liu Dongmei Zhang Peiqing Liu Suowen Xu Wencai Ye Zhiping Liu International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education(MOE)of China Jinan UniversityGuangzhou 510632China Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research College of PharmacyJinan UniversityGuangzhou 510632China State Key Laboratory of Bioactive Molecules and Druggability Assessment Jinan UniversityGuangzhou 510632China Pharmacy Australia Centre of Excellence School of PharmacyUniversity of QueenslandWoolloongabba QLD 4102Australia Sunshine Coast Health Institute and School of Health and Behavioural Sciences University of the Sunshine CoastBirtinya QLD 4575Australia national-Local Joint Engineering Lab of Druggability and New Drugs Evaluation Guangdong Provincial Key Laboratory of New Drug Design and EvaluationSun Yat-sen UniversityGuangzhou 510006China School of Pharmacy Bengbu Medical CollegeBengbu 233030China Institute of Endocrine and Metabolic Diseases the First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230026China

Bioactive compounds derived from herbal medicinal plants modulate various therapeutic targets and signaling pathways associated with cardiovascular diseases(CVDs),the world’s primary cause of *** biloba,a well-known traditional Chinese medicine with notable cardiovascular actions,has been used as a cardio-and cerebrovascular therapeutic drug and nutraceutical in Asian countries for *** studies have shown that ginkgolide B,a bioactive component in Ginkgo biloba,can ameliorate atherosclerosis in cultured vascular cells and disease *** clinical relevance,several clinical trials are ongoing or being completed to examine the efficacy and safety of ginkgolide B-related drug preparations in the prevention of cerebrovascular diseases,such as ischemia ***,we present a comprehensive review of the pharmacological activities,pharmacokinetic characteristics,and mechanisms of action of ginkgolide B in atherosclerosis prevention and *** highlight new molecular targets of ginkgolide B,including nicotinamide adenine dinucleotide phosphate oxidases(naDPH oxidase),lectin-like oxidized LDL receptor-1(LOX-1),sirtuin 1(SIRT1),platelet-activating factor(PAF),proprotein convertase subtilisin/kexin type 9(PCSK9)and ***,we provide an overview and discussion of the therapeutic potential of ginkgolide B and highlight the future perspective of developing ginkgolide B as an effective therapeutic agent for treating atherosclerosis.

关键词： Cardiovascular disease Atherosclerosis Ginkgo biloba Ginkgolide B Endothelial dysfunction LOX-1 PCSK9 PAF-R antagonist

3D bioprinting of collagen-based materials for oral medicine

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Collagen and Leather 2024年第1期5卷 28-46页

作者： Bosen Yang Hai Liu Linli Jiang Yiwei Zeng Yiyuan Han Chuanlu Sha Xin Xie Hui Li Jiajing zhou Wei Lin College of Biomass Science and Engineering Key Laboratory of Leather Chemistry and Engineering of Ministry of EducationNational Engineering Laboratory for Clean Technology of Leather ManufactureSichuan UniversityChengdu 610065China State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesDepartment of Oral and Maxillofacial SurgeryWest China Hospital of StomatologySichuan UniversityChengdu 610065China Laboratory for Biomaterials and Drug Delivery Department of AnesthesiologyDivision of Critical Care MedicineBoston Children's HospitalHarvard Medical SchoolBostonMA 02115USA

Oral diseases have emerged as one of the leading public health challenges *** the existing clinical modalities for restoration of dental tissue loss and craniomaxillofacial injuries can achieve satisfactory therapeutic results,they cannot fully restore the original complex anatomical structure and physiological function of the tissue.3D printing of biological tissues has gained growing interest in the field of oral medicine with the ability to control the bioink component and printing structure for spatially heterogeneous repairing constructs,holding enormous promise for the precise treatment of oral ***,collagen-based materials have been recognized as promising biogenic bioinks for the regeneration of several tissues with high cell-activating and biocompatible *** this review,we summarize 3D printing methods for collagen-based biomaterials and their ***,we highlight the animal sources of collagen and their characteristics,as well as the methods of collagen ***,this review provides an overview of the 3D bioprinting technology for the regeneration of the pulpal nerve and blood vessels,cartilage,and periodontal *** envision that this technique opens up immense opportunities over the conventional ones,with high replicability and customized function,which can ultimately promote effective oral tissue regeneration.

关键词： 3D bioprinting Oral medicine Tissue engineering Collagen Scaffold materials Bioink Hydrogel

Electroacupuncture at Sensitized Acupoints Relieves Somatic Referred Pain in Colitis Rats by Inhibiting Sympathetic-Sensory Coupling to Interferewith 5-HT Signaling Pathway

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Chinese Journal of Integrative Medicine 2024年第2期30卷 152-162页

作者： YANG Ying QU Jin-yu GUO Hua zhou Hai-ying RUAN Xia PENG Ying-chun SHEN Xue-fang XIONG Jin WANG Yi-li School of Clinical Medicine Chengdu Medical CollegeChengdu(610500)China Department of Rehabilitation Medicine the First Affliated Hospital of Chengdu Medical CollegeChengdu(610500)China Department of Rehabilitation Medicine West China HospitalSichuan University/West China School of NursingSichuan UniversityChengdu(610041)China Department of Neurology the First Affiliated Hospital of Chengdu Medical CollegeChengdu(610500)China

Objective:To investigate whether electroacupuncture(EA) at sensitized acupoints could reduce sympathetic-sensory coupling(SSC) and neurogenic inflammatory response by interfering with 5-hydroxytryptamine(5-HT)ergic neural pathways to relieve colitis and somatic referred pain,and explore the underlying ***:Rats were treated with 5% dextran sodium sulfate(DSS) solution for 7 days to establish a colitis *** rats were randomly divided into the control and model groups according to a random number table(n=6).According to the Research on Rat Acupoint Atlas",sensitized acupoints and non-sensitized acupoints were *** were randomly divided into the control,model,Zusanli-EA(ST 36),Dachangshu-EA(BL 25),and Xinshu(BL 15) groups(n=6),as well as the control,model,EA,and EA+GR113808(a 5-HT inhibitor)groups(n=6).The rats in the control group received no *** was administered on 2 days after modeling using the stimulation pavameters:1 mA,2 Hz,for 30 min,with sparse and dense waves,for 14 consecutive ***113808 was injected into the tail vein at 5 mg/kg before EA for 10 min for 7 consecutive *** sensitivity was assessed with von Frey *** weight and disease activity index(DAI) scores of rats were *** and eosin staining was performed to observe colon *** was analyzed by immunofluorescence *** staining was performed to detect 5-HT and substance P(SP) *** calcitonin gene-related peptide(CGRP) in skin tissue and tyrosine hydroxylase(TH) protein levels in DRG were detected by Western *** levels of hyaluronic acid(HA),bradykinin(BK),prostaglandin I2(PGI2) in skin tissue,5-HT,tryptophan hydroxylase 1(TPH1),serotonin transporters(SERT),5-HT 3 receptor(5-HT3R),and 5-HT 4 receptor(5-HT4R) in colon tissue were measured by enzyme-linked immunosorbent assay(ELISA).Results:BL 25 and ST 36 acupoints were determined as sensitized acupoints,and BL 1

关键词： electroacupuncture sensitized acupoints sympathetic-sensory coupling 5-hydroxytryptamine neurogenic inflammation somaticreferredpain

干湿循环作用下岩桥破裂演化及前兆异常定量识别研究

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工程地质学报 2024年第1期32卷 64-73页

作者：张科李娜昆明理工大学电力工程学院昆明650500 昆明理工大学建筑工程学院昆明650500

为探究干湿循环作用下锁固段型岩质边坡内部岩桥的破裂演化及前兆异常,对岩桥试件开展不同干湿循环次数下的单轴压缩试验。基于数字图像相关(DIC)技术,实现加载过程中试件全场变形的实时测量,通过求解位移矢量识别裂纹扩展类型。引入协... 详细信息

为探究干湿循环作用下锁固段型岩质边坡内部岩桥的破裂演化及前兆异常,对岩桥试件开展不同干湿循环次数下的单轴压缩试验。基于数字图像相关(DIC)技术,实现加载过程中试件全场变形的实时测量,通过求解位移矢量识别裂纹扩展类型。引入协方差矩阵,定量描述应变场多元分量的离散程度,提出一种识别岩桥应变场前兆异常的方法,并分析干湿循环作用的影响规律。研究结果表明:随着干湿循环次数的增加,岩桥的起裂应力和抗压强度均逐渐劣化。岩桥中裂纹发展时,周围岩石的位移矢量会发生明显的差异,共识别出两种基本裂纹,即张拉裂纹和剪切裂纹。裂纹起裂和贯通所需的轴向应力随着干湿循环次数的增加而逐渐减小。应变场有效方差的演化过程可划分为初始分异、稳定分异和加速分异3个阶段;当剪切裂纹起裂时,干燥状态下的试件有效方差突增,而干湿循环作用后的试件有效方差出现加速增长的态势,均可识别为前兆点。经过干湿循环作用的试件前兆应力水平和时间水平均小于干燥状态下的试件,这是因为干湿循环作用对岩样产生了软化作用。

关键词：干湿循环作用岩桥数字图像相关位移矢量协方差矩阵前兆

Incorporating physiological knowledge into correlative species distribution models minimizes bias introduced by the choice of calibration area

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Marine Life Science & Technology 2024年第2期6卷 349-362页

作者： Zhixin Zhang Jinxin zhou Jorge García Molinos Stefano Mammola Ákos Bede‑Fazekas Xiao Feng Daisuke Kitazawa Jorge Assis Tianlong Qiu Qiang Lin CAS Key Laboratory of Tropical Marine Bio-resources and Ecology South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China Guangdong Provincial Key Laboratory of Applied Marine Biology South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China Marine Biodiversity and Ecological Evolution Research Center South China Sea Institute of OceanologyGuangzhou 510301China Global Ocean and Climate Research Center South China Sea Institute of OceanologyGuangzhou 510301China Institute of Industrial Science The University of Tokyo5-1-5 KashiwanohaKashiwaChiba 277-8574Japan Arctic Research Center Hokkaido UniversitySapporoHokkaido 001-0021Japan Finnish Museum of natural History University of HelsinkiHelsinkiFinland Molecular Ecology Group(MEG) Water Research Institute(IRSA)National Research Council of Italy(CNR)28922 Verbania PallanzaItaly national Biodiversity Future Center(NBFC) PalermoItaly Institute of Ecology and Botany HUN-REN Centre for Ecological ResearchVácrátótHungary Department of Environmental and Landscape Geography ELTE Eötvös Loránd UniversityBudapestHungary Department of Biology University of North CarolinaChapel HillNC 27599USA Centre of Marine Sciences University of AlgarveCampus de GambelasFaroPortugal CAS Key Laboratory of Experimental Marine Biology Institute of OceanologyChinese Academy of SciencesQingdao 266071China University of Chinese Academy of Sciences Beijing 100049China

Correlative species distribution models(SDMs)are important tools to estimate species’geographic distribution across space and time,but their reliability heavily relies on the availability and quality of occurrence *** can be biased when occurrences do not fully represent the environmental requirement of a *** tested to what extent species’physiological knowledge might influence SDM *** on the Japanese sea cucumber Apostichopus japonicus within the coastal ocean of East Asia,we compiled a comprehensive dataset of occurrence *** then explored the importance of incorporating physiological knowledge into SDMs by calibrating two types of correlative SDMs:a naïve model that solely depends on environmental correlates,and a physiologically informed model that further incorporates physiological information as *** further tested the models’sensitivity to calibration area choices by fitting them with different buffered areas around known *** with naïve models,the physiologically informed models successfully captured the negative influence of high temperature on *** and were less sensitive to the choice of calibration *** naïve models resulted in more optimistic prediction of the changes of potential distributions under climate change(i.e.,larger range expansion and less contraction)than the physiologically informed *** findings highlight benefits from incorporating physiological information into correlative SDMs,namely mitigating the uncertainties associated with the choice of calibration *** these promising features,we encourage future SDM studies to consider species physi-ological information where available.

关键词： Bayesian approach Climate change Habitat suitability Physiological knowledge Species distribution model

Modeling drug-induced mitochondrial toxicity with human primary cardiomyocytes

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Science China(Life Sciences) 2024年第2期67卷 301-319页

作者： Xiaoli Tang Hong Liu Rongjia Rao Yafei Huang Mengqi Dong Miaomiao Xu Shanshan Feng Xun Shi Li Wang Zengwu Wang Bingying zhou State Key Laboratory of Cardiovascular Disease Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100037China Department of Epidemiology Cardiovascular Institute and Fuwai HospitalChinese Academy of Medical Science&Peking Union Medical CollegeBeijing 100037China Shenzhen Key Laboratory of Cardiovascular Disease Fuwai Hospital Chinese Academy of Medical SciencesShenzhenShenzhen 518020China

Mitochondrial toxicity induced by therapeutic drugs is a major contributor for cardiotoxicity,posing a serious threat to pharmaceutical industries and patients’***,mitochondrial toxicity testing is not incorporated into routine cardiac safety screening *** accurately model native human cardiomyocytes,we comprehensively evaluated mitochondrial responses of adult human primary cardiomyocytes(h PCMs)to a nucleoside analog,remdesivir(RDV).Comparison of their response to human pluripotent stem cell-derived cardiomyocytes revealed that the latter utilized a mitophagy-based mitochondrial recovery response that was absent in h ***,action potential duration was elongated in h PCMs,reflecting clinical incidences of RDV-induced QT *** a screen for mitochondrial protectants,we identified mitochondrial ROS as a primary mediator of RDV-induced *** study demonstrates the utility of h PCMs in the detection of clinically relevant cardiac toxicities,and offers a framework for h PCM-based high-throughput screening of cardioprotective agents.

关键词： remdesivir mitochondrial toxicity cardiotoxicity human primary cardiomyocytes high-throughput screening

数字时代的认知域安全:理论解构、风险生成及治理路径

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国际安全研究 2024年第3期42卷 55-75,158,159页

作者：韩娜董小宇中国人民公安大学网络空间国际治理研究基地中国人民公安大学国家安全学院北京100038

“认知域”是大国博弈的关键领域,在数字时代认知域安全已成为影响全球安全的重要议题。认知域安全研究经历了科学化、军事化、战略化再到国家安全化的四重演进,其理念被逐渐重塑。国家安全视角下的认知域安全,是指国家内部和外部的意... 详细信息

“认知域”是大国博弈的关键领域,在数字时代认知域安全已成为影响全球安全的重要议题。认知域安全研究经历了科学化、军事化、战略化再到国家安全化的四重演进,其理念被逐渐重塑。国家安全视角下的认知域安全,是指国家内部和外部的意识形态、思想文化、战略决策、价值观念、思维方式等不被内外势力操纵和改造,从而使认知的过程及其结果保持稳定有序的状态,并持续保障这种安全状态的能力。在要素特征方面,数字时代认知域安全呈现出主体多元、对象精准、智能驱动、战略隐蔽和全局领域的特点;在风险生成方面,内外势力往往通过观察-导向-决策-行动(OODA)循环模型进行精准操控,涵盖观察阶段的精准识别、导向阶段的信息加工、决策阶段的信息集成、行动阶段的主体协同以及评估阶段的信息反馈,形成了一个完整的操控链条,对认知域安全构成了严重威胁。中国必须双管齐下,积极有效应对认知域的安全风险。在顶层战略层面,国家需要制定全面而前瞻的战略政策框架;在务实策略层面,需在风险识别、风险评估、风险防控、风险应对等方面开展协同创新治理,进一步有效降低认知域操纵带来的安全风险。

关键词：国家安全认知域安全认知域操纵国家安全治理

乙型病毒性肝炎肝硬化患者血清cTNT、LPS水平、FIB-4指数与幽门螺杆菌感染的关系

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中华医院感染学杂志 2024年第7期34卷 998-1001页

作者：陈媛徐晶谌翠容孙振江周婧玮杭州市西溪医院肝病科浙江杭州310023

目的探讨乙型病毒性肝炎肝硬化(HBV-LC)患者血清心肌肌钙蛋白T(cTNT)、脂多糖(LPS)水平、基因4因子的肝纤维化指数(FIB-4)及与幽门螺杆菌(Hp)感染的关系。方法选取2022年1月-2023年6月杭州市西溪医院收治的72例HBV-LC患者作为研究对象,... 详细信息

目的探讨乙型病毒性肝炎肝硬化(HBV-LC)患者血清心肌肌钙蛋白T(cTNT)、脂多糖(LPS)水平、基因4因子的肝纤维化指数(FIB-4)及与幽门螺杆菌(Hp)感染的关系。方法选取2022年1月-2023年6月杭州市西溪医院收治的72例HBV-LC患者作为研究对象,根据有无Hp感染情况分为感染组42例与未感染组30例,抽取患者空腹静脉血,检测血清cTNT、LPS水平及天门冬氨酸氨基转氨酶(AST)、血小板计数(PLT)、丙氨酸氨基转移酶(ALT)水平,计算FIB-4,并行Hp感染定量检测。比较两组血清学指标及FIB-4指数,Pearson相关性分析血清指标与Hp感染的关系,观察有无Hp感染HBV-LC患者并发症发生情况。结果HBV-LC患者Hp感染率为58.33%(42/72);感染组cTNT、LPS水平及FIB-4指数均高于未感染组(P<0.05);HBV-LC感染组14C呼气试验值与cTNT、LPS水平及FIB-4指数均呈正相关(P<0.05);感染组患者消化性溃疡和门脉高血压胃病发生率为71.43%、42.86%高于未感染组的40.00%和20.00%(P<0.05)。结论HBV-LC患者Hp发生率较高,且与血清cTNT、LPS水平、FIB-4指数变化有关;Hp感染可能会增加HBV-LC患者消化性溃疡和门脉高血压胃病的发生率,建议对HBV-LC患者定期进行Hp监测。

关键词：乙型病毒性肝炎肝硬化肝纤维化指数心肌肌钙蛋白T 脂多糖幽门螺杆菌感染