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Effect of lymph node micrometastases on prognosis of gastric carcinoma

World Journal of Gastroenterology 2007年第30期13卷 4122-4125页

作者： Ze-Yu Wu jing-hua li Wen-hua Zhan Yu-Long He Jin Wan Department of General Surgery Guangdong Provincial People's Hospital Guangzhou 510080 Guangdong Province China Zhongshan Medical College Sun Yat-Sen University Guangzhou 510089 Guangdong Province China Department of Gastrointestinal and Pancreatic Surgery the First Affiliated Hospital Sun Yat-Sen University Guangzhou 510080 Guangdong Province China

AIM： To evaluate the relationship between lymph node micrometastases and prognosis of patients with gastric carcinoma and to evaluate the significance of the new assessment of nodal status in determining the pN categories in the 5th edition of the UICC TNM classification.METHODS： A total of 850 lymph nodes from 30 patients with gastric carcinoma who underwent gastrectomy with lymphadenectomy were assessed by reverse transcription polymerase chain reaction assay in addition to histologic examination. Cytokeratin-20 gene marker was used in this assay.RESULTS： Routine examination by HE staining confirmed metastasis in 233 lymph nodes from 20 patients. All these 233 lymph nodes were oltokeratin-20 positive. Moreover, lymph node micrometastases were detected in an additional 67 lymph nodes in 12 of these 20 patients. Lymph node micrometastases were also detected in t0 lymph nodes from 2 of 10 patients who had no obvious metastases identified by HE staining. Totally, lymph node micrometastases were identified by the reverse transcription polymerase chain reaction assay in 77 （12.5%） lymph nodes from 14 （46.7%） patients with gastric carcinoma. Of 27 patients who underwent curative resection, 7 （25.9%） were up-staged （from Ⅰ B stage to Ⅱ stage in 1 patient, from IB stage to ⅢA stage in 1 patient, from Ⅱ stage to ⅢA stage in 1 patient, from ⅢA stage to ⅢB stage in 1 patient, from ⅢA stage to Ⅳ stage in 1 patient, from ⅢB stage to Ⅳ stage in 2 patients）. In a median follow-up of 32 （range 8-36） too, Kaplan-Meier survival analysis showed significant improvements in median survival （22.86 ± 3.17 mo, 95% CI： 16.64-29.08 mo vs 18.00 ± 7.4 mo, 95% CI： 3.33-32.67 mo） of patients with negative lymph node micrometastases over patients with positive lymph node micrometastases （log-rank, P 〈 0.05）.CONCLUSION： Lymph node micrometastases have a significant impact on the current staging system of gastric carcinoma, and are significant risk factors for prognosis of patients with gast

关键词： Gastric carcinoma Lymph node micrometastases Prognosis Stage

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Lymph node micrometastasis and its correlation with MMP-2 expression in gastric carcinoma

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World Journal of Gastroenterology 2006年第18期12卷 2941-2944页

作者： Ze-Yu Wu jing-hua li Wen-hua Zhan Yu-Long He Department of Gastrointestinal and Pancreatic Surgery the First Affiliated Hospital Sun Yat-sen University Guangzhou 510080 Guangdong Province China Zhong Shan Medical College Sun Yat-sen University Guangzhou 510089 Guangdong Province China Department of General Surgery Guangdong Provincial People's Hospital Guangzhou 510080 Guangdong Province China

AIM： To examine matrix metalloproteinase-2 （MMP-2） expression in gastric cancer tissues and to evaluate its relationship with lymph node micrometastasis. MATERIALS： The authors studied 850 lymph nodes resected from 30 patients with gastric carcinoma who underwent gastrectomy with lymphadenetomy using reverse transcription polymerase chain reaction （RT-PCR） assay in addition to H-E staining. MMP-2 expression of the tumor tissues was detected by immunohistochemical technique （EliVision^TM plus）. RESULTS： MMP-2 expression was positive in 21 （70%） cases and negative in g （30%） cases. No significant correlations were found between MMP-2 expression and other variables such as age, gender, tumor location, tumor diameter, Lauren classification and lymphatic invasion. In contrast, MMP-2 expression correlated significantly with depth of tumor infiltration （P = 0.022）, lymph node metastasis （P = 0.030） and tumor differentiation （P = 0.043）. Lymph node micrometastases were detected in 77 （12.5%） lymph nodes of 14 （46.7%） gastric carcinoma patients. MMP-2 expression was positive in 12 （85.7%） of the 14 patients with lymph node micrometastasis, and in g （56.3%） of the 16 patients without lymph node micrometastasis （P = 0.118）. CONCLUSIONS： Our results demonstrate that MMP-2 expression has significant correlation with tumor invasion, tumor differentiation and lymph node metastases. MMP-2 expression may be an important biological characteristics and significant prognostic parameter of gastric carcinoma. We also conclude that MMP-2 may participate in the development of lymph node micrometastasis of gastric carcinoma. Further investigations are needed to draw a conclusion.

关键词： Gastric carcinoma Lymph node micrometastasis MMP-2 RT-PCR Immunohistochemistry

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The influence of ionospheric thin shell height on TEC retrieval from GPS observation

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Research in Astronomy and Astrophysics 2016年第7期16卷 143-152页

作者： Xiao-Lan Wang Qing-Tao Wan Guan-Yi Ma jing-hua li Jiang-Tao Fan National Astronomical Observatories Chinese Academy of SciencesBeijing 100012China University of Chinese Academy of Sciences Beijing 100049China

We investigate the influence of assumed height for the thin shell ionosphere model on the Total Electron Content（TEC） derived from a small scale Global Positioning System（GPS） network. TEC and instrumental bias are determined by applying a grid-based algorithm to the data on several geomagnetically quiet days covering a 10 month period in 2006. Comparisons of TEC and instrumental bias are made among assumed heights from 250 km to 700 km with an interval of 10 km. While the TEC variations with time follow the same trend, TEC tends to increase with the height of the thin shell. The difference in TEC between heights 250 km and 700 km can be as large as～8 TECU in both daytime and nighttime. The times at which the TEC reaches its peak or valley do not vary much with the assumed heights. The instrumental biases, especially bias from the satellite, can vary irregularly with assumed height. Several satellites show a large deviation of～3 ns for heights larger than 550 km. The goodness of fit for different assumed heights is also examined. The data can be generally well-fitted for heights from 350 km to 700 km. A large deviation happens at heights lower than 350 km. Using the grid-based algorithm, there is no consensus on assumed height as related to data fitting. A thin shell height in the range 350-500 km can be a reasonable compromise between data fitting and peak height of the ionosphere.

关键词： Radiowave propagation Ionospheric TEC Ionospheric height GPS observation Instrumental bias

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EXPERIMENTAL STUDY OF DAM-BREAK FLOW IN CASCADE RESERVOIRS WITH STEEP BOTTOM SLOPE

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Journal of Hydrodynamics 2011年第4期23卷 491-497页

作者： XUE Yang XU Wei-lin LUO Shu-jing CHEN hua-yong li Nai-wen XU ling-jun State Key Laboratory of Hydraulics and Mountain River Engineering Sichuan University Chengdu 610065 China College of Water Conservancy and Hydropower Engineering Xi＇an University of Technology Xi＇an 710048China

Dam break can cause a significant disaster in the downstream, especially, in a valley with cascade reservoirs, which would aggravate the disaster extent. The experimental studies of the dam-break flow of cascade reservoirs are few and far between at the present, Most of related studies concern the failure of a single dam.. This article presents an experimental study of the characteristics of an instantly filled dam-break flow of cascade reservoirs in a rectangular glass flume with a steep bottom slope. A new method was used to simulate the sudden collapse of the dam. A series of sensors for automatic water-levels were deployed to record the rapid water depth fluctuation. The experimental results show that, the ratio of the initial water depth of the downstream reservoir to that of the upstream reservoir would greatly affect the flood peak water depth in the downstream reservoir area and in the stream channel behind the downstream dam, while the influence of the dam spacing is insignificant. In addition, the comparison between the single reservoir and the cascade reservoirs shows some difference in the dam-break flow pattern and the stage hydrograph at the corresponding gauging points.

关键词： dam-break flow cascade reservoirs instantly full dam break steep bottom slope

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Analysis on the Effect of Asymmetric Information on Product Supply Chain and Pricing

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International Journal of Technology Management 2013年第5期 71-73页

作者： jing Na li hua Lanzhou Jiaotong University Lanzhou 730070 China

Along with the vigorous development of the markel economy, the transactions in the market are also increasingly frequent. In all kinds of market transactions, there are more or less inIbrmation asynunetry phenomena. Asynmaetric information makes supply chain unable to give a real reaction to the relationship between market supply and demand, and the personnel in the channels of supply chain are unable to make the optimal pricing, so that the overall profits are affected. Therefore, asymmetric information should be controlled within the normal range, for the purpose of ensuring the normal operation and healthy development of the market transactions.

关键词： Asymmetric Information Supply Chain Product Pricing

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Prognostic value of lateral lymph node metastasis for advanced low rectal cancer

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World Journal of Gastroenterology 2007年第45期13卷 6048-6052页

作者： Ze-Yu Wu Jin Wan jing-hua li Gang Zhao Yuan Yao Jia-lin Du Quan-Fang liu lin Peng Zhi-Du Wang Zhi-Ming huang hua-huan lin Department of General Surgery Guangdong Provincial People's Hospital Guangzhou 510080 Guangdong Province China Department of Clinical Laboratory The First Affiliated Hospital Huangpu Division Sun Yat-Sen University Guangzhou 510089 Guangdong Province China Department of Pathology Guangdong Provincial People's Hospital Guangzhou 510080 Guangdong Province China

AIM： To evaluate the risk factors for lateral lymph node metastasis in patients with advanced low rectal cancer, in order to make the effective selection of patients who could benefit from lateral lymph node dissection, as well as the relationship of lateral lymph node metastasis with local recurrence and survival of patients with advanced low rectal cancer. METHODS： A total of 96 consecutive patients who underwent curative surgery with lateral pelvic lymphadenectomy for advanced lower rectal cancer were retrospectively analyzed. The relation of lateral lymph node metastasis with clinicopathologic characteristics, local recurrence and survival of patients was identified. RESULTS： Lateral lymph node metastasis was observed in 14.6% （14/96） of patients with advanced low rectal cancer. Lateral lymph node metastasis was detected in 10 （25.0%） of 40 patients with tumor diameter ≥ 5 cm and in 4 （7.1%） of 56 patients with tumor diameter 〈 5 cm. The difference between the significant （X^2 = 5.973, P = two groups was statistically 0.015）. Lateral lymph node metastasis was more frequent in patients with 4/4 diameter of tumor infiltration （7 of 10 cases, 70.0%）, compared with patients with 3/4, 2/4 and 1/4 diameter of tumor infiltration （3 of 25 cases, 12.0%; 3 of 45 cases, 6.7%; 1 of 16 cases, 6.3%）（X^2 = 27.944, P = 0.0001）. The lateral lymph node metastasis rate was 30.0% （9 of 30 cases）, 9.1% （4 of 44 cases） and 4.5% （1 of 22cases） for poorly, moderately and well-differentiated carcinoma, respectively. The difference between the three groups was statistically significant （X^2 = 8.569, P = 0.014）. Local recurrence was 18.8% （18 of 96 cases）, 64.3% （9 of 14 cases）, and 11.0% （9 of 82 cases） in patients with advanced low rectal cancer, in those with and without lateral lymph node metastasis, respectively. The difference between the two groups was statistically significant （X^2 = 22.308, P = 0.0001）. Kaplan-Meier survival analysis showed significant improvements in median sur

关键词： Low rectal cancer Lateral lymph nodemetastasis Local recurrence Prognosis

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Study of circumferential resection margin in patients with middle and lower rectal carcinoma

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World Journal of Gastroenterology 2007年第24期13卷 3380-3383页

作者： Ze-Yu Wu Jin Wan jing-hua li Gang Zhao lin Peng Yuan Yao Jia-lin Du Quan-Fang liu Zhi-Du Wang Zhi-Ming huang hua-huan lin Department of General Surgery Guangdong Provincial People's Hospital Guangzhou 510080 Guangdong Province China Zhong Shan Medical-College Sun Yat-sen University Guangzhou 510089 Guangdong Province China Department of Pathology Guangdong Provincial People's Hospital Guangzhou 510080 Guangdong Province China

AIM: To clarify the relationship between circumferential resection margin status and local and distant recurrence as well as survival of patients with middle and lower rectal carcinoma. The relationship between circumferential resection margin status and clinicopathologic characteristics of middle and lower rectal carcinoma was also evaluated. METHODS: Cancer specimens from 56 patients with middle and lower rectal carcinoma who received total mesorectal excision at the Department of General Surgery of Guangdong Provincial People's Hospital were studied. A large slice technique was used to detect mesorectal metastasis and evaluate circumferential resection margin status. RESULTS: Local recurrence occurred in 12.5% (7 of 56 cases) of patients with middle and lower rectal carcinoma. Distant recurrence occurred in 25% (14 of 56 cases) of patients with middle and lower rectal carcinoma. Twelve patients (21.4%) had positive circumferential resection margin. Local recurrence rate of patients with positive circumferential resection margin was 33.3% (4/12), whereas it was 6.8% (3/44) in those with negative circumferential resection margin (P = 0.014). Distant recurrence was observed in 50% (6/12) of patients with positive circumferential resection margin; conversely, it was 18.2% (8/44) in those with negative circumferential resection margin (P = 0.024). Kaplan-Meier survival analysis showed significant improvements in median survival (32.2 ± 4.1 mo, 95% CI: 24.1-40.4mo vs 23.0 ± 3.5 mo, 95% CI: 16.2-29.8 mo) for circumferential resection margin-negative patients over circumferential resection margin-positive patients (log-rank, P < 0.05). 37% T3 tumors examined were positive for circumferential resection margin, while only 0% T1 tumors and 8.7% T2 tumors were examined as circumferential resection margin. The difference between these three groups was statistically significant (P = 0.021). In 18 cancer specimens with tumor diameter ≥ 5 cm 7 (38.9%) were detected as positive c

关键词： Middle and lower rectal carcinoma Circumferential resection margin Prognosis

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Establish a normal fetal lung gestational age grading model and explore the potential value of deep learning algorithms in fetal lung maturity evaluation

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Chinese Medical Journal 2021年第15期134卷 1828-1837页

作者： Tai-Hui Xia Man Tan jing-hua li jing-jing Wang Qing-Qing Wu De-Xing Kong Department of Ultrasound Beijing Obstetrics and Gynecology HospitalCapital Medical UniversityBeijing 100026China The School of Mathematical Sciences Zhejiang UniversityHangzhouZhejiang 310058China

Background:Prenatal evaluation of fetal lung maturity(FLM)is a challenge,and an effective non-invasive method for prenatal assessment of FLM is *** study aimed to establish a normal fetal lung gestational age(GA)grading model based on deep learning(DL)algorithms,validate the effectiveness of the model,and explore the potential value of DL algorithms in assessing ***:A total of 7013 ultrasound images obtained from 1023 normal pregnancies between 20 and 41+6 weeks were analyzed in this *** were no pregnancy-related complications that affected fetal lung development,and all infants were born without neonatal respiratory *** images were divided into three classes based on the gestational week:class I:20 to 29+6 weeks,class II:30 to 36+6 weeks,and class III:37 to 41+6 *** were 3323,2142,and 1548 images in each class,***,we performed a pre-processing algorithm to remove irrelevant information from each ***,a convolutional neural network was designed to identify different categories of fetal lung ultrasound ***,we used ten-fold cross-validation to validate the performance of our *** new machine learning algorithm automatically extracted and classified lung ultrasound image information related to *** was used to establish a grading *** performance of the grading model was assessed using accuracy,sensitivity,specificity,and receiver operating characteristic ***:A normal fetal lung GA grading model was established and *** sensitivity of each class in the independent test set was 91.7%,69.8%,and 86.4%,*** specificity of each class in the independent test set was 76.8%,90.0%,and 83.1%,*** total accuracy was 83.8%.The area under the curve(AUC)of each class was 0.982,0.907,and 0.960,*** micro-average AUC was 0.957,and the macro-average AUC was ***:The normal fetal lung GA grading model could accurately identify ultraso

关键词： Convolutional neural network Deep learning algorithms Grading model Normal fetal lung Fetal lung maturity Gestational age Artificial intelligence

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Impact of personality and coping mechanisms on health-related quality of life in liver transplantation recipients

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Hepatobiliary & Pancreatic Diseases International 2005年第3期4卷 356-359页

作者： Sai-Jun Zhang, li-hua huang, Yan-ling Wen, Zhen-hua Hu, jing Jin, li-hua Shen and li-Xia Cai liver Transplantation Center, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China liver Transplantation Center First Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310003 China.

With the great development of liver transplantation in China, long survival and quality of life after liver transplantation have been matters of growing interest. This study was designed to investigate the impact of personality and coping skills on the quality of life after liver transplantation. METHODS:Fifty-five outpatients who had been followed up after liver transplantation at our center were assessed by general quality of life inventory (GQOli-74 ), a medical coping modes questionnaire (MCMQ), an eysenck personality questionnaire (EPQ), and a general condition questionnaire (GCQ). RESULTS: The score for material well-being was the lowest (63.22±12.67) and for psychological well-being the highest (73.43±12.60) in 4 dimensions of the GQOli in post transplantation patients. Their main coping method was confrontation (21.40±3.70). The main characteristics of their personality were extraversation (E score 12.96±4.13) and neuroticism (N score 8.20±4.90) . The total score of the GQOli was positively correlated with confrontation and E score, and it was negatively correlated with acceptance and N score. The physical well-being positively associated with the E score. The psychological well-being was positively correlated with confrontation and L score, and was negatively correlated with acceptance, P and N score. Social well-being was positively correlated with confrontation and E score, and was negatively correlated with acceptance and N score. Material well-being was not correlated with coping methods and personality. CONCLUSION:The quality of life in post liver transplantation patients is associated with their psychological characteristics.

关键词： liver transplantation quality of life medical coping modes questionnaire eysenck personality questionnaire

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Matrix-assisted laser desorption/ionization time of flight mass spectrometry in the genetic basis of systemic lupus erythematosus and the complicating kidney injury

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Chinese Medical Journal 2013年第15期126卷 2821-2825页

作者： ZHOU Xiao-shuang li jing WANG li-hua WANG Chen WU Rui-ping li Rong-shan Shanxi Med Univ Hosp 2 Dept Nephrol Taiyuan 030001 Shanxi Peoples R China Shanxi Med Univ Hosp 2 Dept Pathol Taiyuan 030001 Shanxi Peoples R China Shanxi Med Univ Taiyuan 030001 Shanxi Peoples R China Shanxi Prov Peoples Hosp Dept Nephrol Taiyuan 030012 Shanxi Peoples R China

Background It is necessary to develop some innovative methods to reveal and discover the novel （SLE）-related protein molecules. In the present study, matrix-assisted laser desorption/ionization time of flight mass spectrometry （MALDI- TOF MS） was employed to detect the differential expression of serum polypeptides in the patients with systemic lupus erythematosus （SLE） presenting with a family history or complicating with kidney injury so as to identify the proteins associated with the genetic factors and kidney injury in SLE. Methods The subjects recruited were divided into four groups, that is, a group of SLE patients with both family history and kidney injury, a group of SLE patients with only kidney injury but no family history, a group of SLE patients with neither family history nor kidney injury, and a control group consisting of healthy volunteers. By adopting MALDI-TOF MS analysis, the serum samples obtained from the three groups of SLE patients were examined and compared with those from the control group; the categorized peptide fingerprint profile was established via the biological data collected from the samples. Results The expression of protein with a mlz of 4207 Da increased significantly in SLE patients; the protein with a ml z of 2658 Da was expressed in all SLE patients; three proteins （with mlz of 1465, 5332, and 5900 Da respectively） were expressed in the SLE patients complicated with kidney injury and the protein with a mlz of 1943 Da was expressed in SLE patients with family history. Conclusion A number of differential proteins were successfully detected and identified through MALDI-TOF MS detection and these proteins may be associated with the genetic basis of SLE and the complicating kidney injury.

关键词： systemic lupus erythematosus " genetic diseases " kidney injury " matrix-assisted laser desorption/ionization-mas sspectrometry

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