检索结果-南通市图书馆

PHASE Ⅱ STUDY OF GEMCITABINE COMBINED WITH PLATINUM CheMOTheRAPY FOR RECURRENT EPITheLIAL OVARIAN CANCER

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Sciences Journal 2007年第3期22卷 177-182页

作者： Peng Peng Keng Shen Jia-xin Yang Ming Wu Hui-fang Huang Ling-ya Pan jing-he lang Department of Obstetrics ＆ Gynecology Peking Union Medical College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730

Objective To evaluate the anti-tumor effect and toxicity of gemcitabine combined with platinum chemotherapy on recurrent epithelial ovarian cancer. Methods Phase Ⅱ study of gemcitabine combined with platinum chemotherapy was carried out in 22 patients with recurrent epithelial ovarian cancer. Median age of patients was 50. 5 years old. Seven patients were platinum-sensitive and 15 patients were platinum-resistant or -refractory. All patients received gemcitabine combined with carboplatin or oxa/iplatin chemotherapy. Patients＇ response rate （RR） and toxicity of gemcitabine combined with platinum chemotherapy were evaluated. Results A total of 98 gemcitabine-based chemotherapy cycles were performed. Total RR was 36. 4%, RR of platinum-sensitive patients was 4/7 and platinum-resistant and -refractory patients was 4/15. The estimated median survival time was 10.0 months （95% CI. 7.0-13.0） after initiation of gemcitabine combined with platinum chemotherapy. There was no significant difference in survival time between platinum-resistant/refractory group and platinum-sensitive group （P = 0. 061 ）. Side effects of gemcitabine combined with platinum chemotherapy were observed in 81.8% of patients. Grade Ⅱ/Ⅲ anemia （54. 5% ） and grade Ⅲ/Ⅳ neutropenia （54. 5% ） were most common toxicities. Ten （45.5%） patients had to delay their chemotherapy cycles or reduce the dose of chemotherapeutic drugs because of the severe side effects. Fourteen （63.6%） patients received granulocyte colony-stimulating factor to relieve neutropenia, and 8 （ 36. 4% ） patients received component blood transfusion to treat anemia or thrombocytopenia. There was no treatment-associated death. Conclusion Gemcitabine combined with platinum chemotherapy appears to be an effective and well-tolerant treatment for recurrent epithelial ovarian cancer, including platinum-resistant or -refractory diseases.

关键词： second-line chemotherapy gemcitabine ovarian cancer phase Ⅱ

Prevalence and Factors Associated with Female Sexual Dysfunction in Beijing, China

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2017年第12期130卷 1389-1394页

作者： Wen-Jia Lou Bo Chen Lan Zhu Shao-Mei Han Tao Xu jing-he lang Lei Zhang Department of Obstetrics and Gynecology Peking Union Medical College Hospital Chinese Academy of Medical Sciences Beijing 100730 China Department of Clinical Medicine Peking Union Medical College Chinese Academy of Medical Sciences Beijing 100005 China Department of Epidemiology and Statistics Institute of Basic Medical Sciences Peking Union Medical College Chinese Academy of Medical Sciences and School of Basic Medicine Beijing 100005 China

Background： Female sexual dysfunction （FSD） is a highly prevalent and often underestimated problem. However, large-scale, population-based epidemiological surveys of FSD are scarce in China. The present study was conducted to evaluate the prevalence and the potential risk factors of FSD across a selection of social groups in Beijing, China, based on the Female Sexual Function Index （FSFI）. Methods： A cross-sectional study based on the multiple-stage cluster sampling was performed with adult women throughout the Dongcbeng and Shunyi districts of Beijing. The Chinese version of FSFI was used, as well as questions on demographic characteristics, the disease-related context, and social relationships. Results： A total of 6000 consecutive women entered this study, with an actual response from 5024 women, corresponding to a response rate of 83.7%. A total of 4697 （78.3%） questionnaires were effective. The prevalence of adult FSD in Beijing was 2973 （63.3%） using a score of 26.55 as the boundary value, whereas the total mean FSFI score was 23.92 ~ 6.37. However, 1423 （30.3%） women did not seek help. By multivariate logistic regression analysis, the possible potential risk factors included age （odds ratio [OR] = 1.051 ）, dissatisfaction with the spouse＇s sexual ability （OR = 3.520）, poor marital affection （OR = 2.087）, spouse sexual difficulties （OR = 1.720）, dissatisfaction with married life （OR = 1.476）, living in a rural area （OR = 1.292）, chronic pelvic pain （OR = 1.261）, chronic disease （OR = 1.534）, previous pelvic surgery （OR = 1.605）, vaginal delivery （OR = 2.285）, lower education （OR = 3.449） and postmenopausal （OR = 3.183）. Conclusions： As suggested by the FSFI scores, female sexual problems are highly prevalent in Beijing. Dissatisfaction with the spouse＇s sexual ability, poor marital affection, sexual difficulties of the spouse, dissatisfaction with the marriage, rural life, CPP, and postmenopausal were conceivable risk factors for FSD in Beijing women.

关键词： Beijing, Female Sexual Dysfunction Female Sexual Function Index Potential Risk Factors Prevalence

Menorrhagia and Uterine Volume Associated with Lower Urinary Tract Symptoms in Patients with Adenomyosis

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2017年第13期130卷 1552-1556页

作者： Ting Li Xiao-Xuan Xu Yi Dai Jun-Ji Zhang jing-he lang Jin-Hua Leng Department of Obstetrics and Gynecology Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College Beijing 100730 China

Background： Adenomyosis is a gynecological disorder with symptoms most presenting as dysmenorrhea and heavy menstrual bleeding. However, the presence of lower urinary tract symptoms （LUTS） among women with adenomyosis remains unclear. This study was designed to determine the prevalence of LUTS and factors related to the severity of these symptoms in this population. Methods： From July 2016 to November 2016, a total of 298 untreated symptomatic adenomyosis patients and 280 age-matched controls were enrolled. Demographics, LUTS, pain symptoms, ultrasouographic uterine size, and serum CA125 level were recorded. LUTS were evaluated using the International Prostate Symptom Score （IPSS） questionnaire. Factors related to the severity of LUTS were detected using the logistic regression analysis presented as odds ratio （OR） and 95% confidence interval （CI）. Results： Compared with the control group, patients with adenomyosis had a greater IPSS total （4 [2-8] vs. 2 [0-3], Z = -8.159, P 〈 0.001 ）, IPSS storage （2 [1-4] vs. [[0 2], Z = -7.361 [P 〈 0.001）, and I PSS voiding （2 [0-4] vs. 0 [0-1], Z = -7.[94, P 〈 0.001）. Of the patients with adenomyosis, 30.2% had moderate-to-severe lower urinary tract symptoms （IPSS 〉8）. The most prevalent LUTS were daytime frequency （40.9%）, lbllowed by nocturia （24.8%）, weak stream （24.2%）, and incomplete emptying （23.5%）. In study group, patients with an IPSS total score ≥8 had higher proportion of menorrhagia （51.1% vs. 30.8%, χ2 = 11. 162 P = 0.025） and larger uterine volumes （183.3 [109.8-273.8] cm3 vs. 148.5 [96.4-262.7] cm3, Z=- 1.441, P = 0.150） compared to patients with an IPSS total score 〈8. On multivariate logistic regression analysis, patients with menorrhagia were associated with an increased risk of an IPSS total score 〉8 （OR： 2.309, 95% CI： 1.310-4.070, P= 0.004）, an IPSS storage subscore 〉4 （OR： 2.422, 95% CI： 1.395-4.206, P= 0.002）, and an IPSS voiding subscore 〉5 （OR： 1.971, 95% （CI： 1.176-3.302, p= 0.010）. However, patients wi

关键词： Adenomyosis International Prostate Symptom Score Lower Urinary Tract Symptoms

dentification of Circular RNAs as a Novel Biomarker for Ovarian Endometriosis

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2018年第5期131卷 559-566页

作者： Xiao-Xuan Xu Shuang-Zheng Jia Yi Dai Jun-Ji Zhang Xiao-Yan Li jing-Hua Shi Jin-Hua Leng jing-he lang Department of Obstetrics and Gynecology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China

Background： Endometriosis is a challenging disease with symptoms such as dysmenorrhea and infertility. However, its etiology is still vague and there is still no effective markers or treatment. This study aimed to profile the circular RNAs （circRNAs） expressed in eutopic endometrium from patients with ovarian endometriosis and explore potential clues to the pathogenesis of endometriosis, providing an evidence for clinical diagnosis and treatment. Methods： A total of 63 clinical samples, including control endometrium 01 = 22） and eutopic endoxnetrium （n = 41）, were collected from Peking Union Medical College Hospital between May 1,2016, and December 31,2016. Of them, four samples in each group were used for circRNA microarray. Then, tbur upregulated circRNAs were screened out for quantitative real-time polymerase chain reaction （qRT-PCR） validation. After that, bioinformatics analysis was pertbrmed to predict miRNAs targeted by validated circRNAs and investigate the circRNA-miRNA-mRNA interactions. Results： Among 88 differentially expressed circRNAs, 11 were upregulated and 77 were downregulated in eutopic endometrium of patients with endometriosis, qRT-PCR validation results for two upregulated circRNAs （circ0004712 and circ_O002198） matched the microarray results. The area under the receiver operating characteristic curve of circ_0002198 for distinguishing ovarian endometriosis was 0.846 （95% confidence interval [C1]： 0.752-0.939; P 〈 0.001 ） while that ofcitv_O004712 was 0.704 （95% CI： 0.571-0.837; P = 0.008）. On the basis of target prediction, we depicted the molecular interactions between the identified circRNAs and their dominant target miRNAs, as well as constructed a circRNA-miRNA-mRNA network. Conclusions： This study provides evidence that circRNAs are differentially expressed between eutopic and normal endometrium, which suggests that circRNAs are candidate factors in the activation ofendometriosis, circ_0002198 and circ0004712 may be potential novel biomar

关键词： Circular RNA Endometriosis Microarray miRNA mRNA

Factors Associated with Effectiveness of Treatment and Reproductive Outcomes in Patients with Thin Endometrium Undergoing Estrogen Treatment

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2015年第23期128卷 3173-3177页

作者： Si-Miao Liu Yuan-Zheng Zhou Han-Bi Wang Zheng-Yi Sun jing-Ran Zhen Keng Shen Cheng-Yan Deng jing-he lang Department of Obstetrics and Gynecology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China

Background： Thin endometrium is associated with poor reproductive outcomes; estrogen treatment can increase endomctrial thickness （EMT）. The aim of this retrospective cohort study was to investigate the factors influencing the effectiveness of estrogen treatment and reproductive outcomes after the treatment in patients with thin endometrium. Methods： Relevant clinical data of 101 patients with thin endometrium who had undergone estrogen treatment were collected. Possible factors influencing the effectiveness of treatment were analyzed retrospectively by logistic regression analysis. Eighty-seven infertile women without thin endometrium who had undergone assisted reproduction served as controls. The cases and controls were matched for age, assisted reproduction method, and number of embryos transferred. Reproductive outcomes of study and control groups were compared using Student＇s t-test and the Chi-square test. Results： At the end of estrogen treatment, EMT was ≥8 mm in 93/101 patients （92.1%）. Effectiveness of treatment was significantly associated with maximal pretreatment EMT （P = 0.017） and treatment duration （P = 0.004）. The outcomes of assisted reproduction were similar in patients whose treatment was successful in increasing EMT to ≥8 mm and the control group. The rate of clinical pregnancy in patients was associated with the number of good-quality embryos transferred in both fresh （P = 0.005） and frozen-thawed （P = 0.000） embryo transfer cycles. Conclusions： Thinner EMT before estrogen treatment requires longer treatment duration and predicts poorer treatment outcomes. The effectiveness of treatment depends on the duration of estrogen administration. Assisted reproductive outcomes of patients whose treatment is successful （i.e., achieves an EMT ≥8 mm） are similar to those of controls. The quality of embryos transferred is an important predictor of assisted reproductive outcomes in patients treated successfully with exogenous estrogen.

关键词： Assisted Reproduction Endometrial Thickness Estrogen Thin Endometrium

Risk Factors for Recurrence of Ovarian Endometriosis in Chinese Patients Aged 45 and Over

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2018年第11期131卷 1308-1313页

作者： Zheng-Xing he Ting-Ting Sun Shu Wang Hong-Hui Shi Qing-Bo Fan Lan Zhu Jin-Hua Leng Da-Wei Sun Jian Sun jing-he lang Department of Gynecology and Obstetrics Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China Department of Pathology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China

Background： When considering the issue of recurrence, perimenopausal women may have more dilemma during management comparing with young women, for example, whether to retain the uterus and ovary during surgery, whether it is necessary to add adjuvant medicine treatment after operation, and there is no evidence for reference about using ofgonadotropin-releasing hormone agonist. This study aimed to study the risk factors for the recurrence of ovarian endometriosis （EM） in patients aged 45 and over. Methods： This is a retrospective nested case-control study. We reviewed the medical records of patients aged over 45 years who underwent surgical treatments for ovarian EM from 1994 to 2014, in Peking Union Medical College Hospital of Chinese Academy of Medical Sciences. By following up to January 2016, 45 patients were found to have relapses and regarded as the recurrence group. The patients with no recurrence during the same follow-up period were randomly selected by the ratio of 1：4 as the nonrecurrence group （ 180 patients in total）. Stratified Cox regression was used to analyze the risk factors of the recurrence. Results： Univariate analysis showed that there was a significant difference in the postoperative treatment （the percentage of patients who received postoperative treatment in non-recurrence group and recurrence group, 23.9% vs. 40.0%, x2=4.729, P = 0.030） and ovarian preservation （the percentage of patients who received surgery of ovarian preservation in non-recurrence group and recurrence group. 25.0 % vs. 44.4%, x2 = 19.462, P 〈 0.001 ） between the nonrecurrence group and the recurrence group. There was no correlation between recurrence and the following factors including patient＇s age, menarche age, gravidity, parity, CA125 level, ovarian lesions, menopausal status, combined benign gynecological conditions （such as myoma and adenomyoma） and endometrial abnormalities, and surgical approach or surgical staging （all P 〉 0.05）. Multivariate analysis indicated t

关键词： Ovarian Endometriosis Recurrence Risk Factor

Pathogenetic gene changes of eutopic endometrium in patients with ovarian endometriosis

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2019年第9期132卷 1107-1109页

作者： Ling Li Qian Chen Qing-Bo Fan Shu Wang Hong-Hui Shi Lan Zhu Da-Wei Sun Jin-Hua Leng jing-he lang Department of Gynecology and Obstetrics Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China

To the Editor:Endometriosis refers to the endometrial tissue (interstitial substance and gland) with growth function occurring in the uterine lining of uterine cavity and the places outside *** often leads to pain,infertility,nodules or masses and other symptoms and signs,and thus,brings a heavy burden on individuals and *** blood reflux theory,immune theory,inflammatory theory,hormone theory,etc.,cannot fully elucidate the pathogenesis of endometriosis.

关键词： Editor gland substance

在线全文

学校读者我要写书评

暂无评论

剖宫产术后瘢痕妊娠的早期诊断与治疗

生殖与避孕 2005年第10期25卷 630-634页

作者：金力范光升郎景和中国医学科学院中国协和医科大学北京协和医院妇产科北京100730

目的:探讨剖宫产术后疤痕妊娠(CSP)的早期诊断和最佳治疗方法。方法:回顾性分析我院收治的15例CSP及1998年以来美国Medline收集的有关CSP的英文发表的病例报道29篇,共46例。结果:CSP的发生率1/1800-2216。有47．8％在妊娠早期表现为阴... 详细信息

目的:探讨剖宫产术后疤痕妊娠(CSP)的早期诊断和最佳治疗方法。方法:回顾性分析我院收治的15例CSP及1998年以来美国Medline收集的有关CSP的英文发表的病例报道29篇,共46例。结果:CSP的发生率1/1800-2216。有47．8％在妊娠早期表现为阴道少量出血及或下腹隐痛。28．3％在人工流产或刮宫术中或术后大出血或反复出血,重复超声检查方确诊。4．3％在妊娠3个月出现自发子宫破裂。1例为第1次诊为CSP,保守治疗成功,但于3个月后再次妊娠,于孕38周时,子宫破裂死亡。20例行单纯氨甲喋呤(methotrexate,MTX)治疗,总成功率为85％。21．7％行经腹子宫切开妊娠物取出术及疤痕修补术。34．8％行子宫动脉栓塞,栓塞后期待疗法或联合MTX或手术治疗均无1例大出血发生。结论:CSP发生率呈上升趋势。超声检查使其早期诊断成为可能。子宫动脉栓塞为首选,能迅速止血或预防出血。单纯MTX药物治疗可以有效终止妊娠,但潜在有子宫破裂的危险。手术切除妊娠组织及疤痕修补,有利于hCG恢复及再次妊娠。

关键词：剖宫产子宫疤痕异位妊娠氨甲喋呤子宫动脉栓塞

An epidemiology study of fecal incontinence in adult Chinese women living in urban areas

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2020年第3期133卷 262-268页

作者： Yuan Yuan Lin Qiu Zhi-Yi Li Lei Zhang Tao Xu jing-he lang Zhao-Ai Li Jian Gong Qing Liu Xiao-Chun Liu Jun-Tao Wang Zhi-Jun Xia Zhu Lan Department of Obstetrics and Gynecology Peking Union Medical College HospitalPeking Union Medical CollegeBeijing 100730China Department of Epidemiology and Statistics Institute of Basic Medical SciencesChinese Academy of Medical Sciences and School of Basic MedicinePeking Union Medical CollegeBeijing 100730China Department of Obstetrics and Gynecology Children’s Hospital of Shanxi Province TaiyuanShanxi 030013China Department of Obstetrics and Gynecology Maternal and Child health Hospital of Wuxi Jiangsu 214002China Department of Obstetrics and Gynecology Maternal and Child health Hospital of Gansu Province LanzhouGansu 730050China Department of Obstetrics and Gynecology Maternal and Child health Hospital of Foshan Guangdong 528000China Department of Obstetrics and Gynecology Maternal and Child health Hospital of Guiyang Guizhou 550001China Department of Obstetrics and Gynecology Shengjing Hospital of China Medical UniversityShenyangLiaoning 110004China.

Background:Fecal incontinence(FI)has been shown to be a common symptom in Western countries;however,there is few researches focusing on its epidemic condition in Chinese *** conducted this national population-based epidemiology study to estimate the prevalence and risk factors of FI among adult Chinese women living in urban ***:This is a subgroup analysis of a national population-based epidemiology study of *** 28,196 adult women from urban regions of six provinces and municipalities participated in this research from 2014 to *** finished the questionnaire under the direction of trained *** was defined as accidental leakage of flatus and/or liquid or solid stool at least once in the *** FI prevalence trend and risk factors were identified by the Cochran-Armitage test,Chi-square test,and multivariable logistic ***:The prevalence of FI in adult females in urban China was 0.43%(95%confidence interval:0.35%-0.51%).Among women with FI,42.96%,82.96%,and 42.22%reported having leakage of solid,liquid stool,and gas,*** overall FI prevalence and the incidence rate of solid stool/liquid stool/gas leakage increased with *** mean Wexner score was 4.0%and 12.0%FI patients reported Wexner score≥*** mass index≥24 kg/m2,pelvic organ prolapses,chronic constipation,chronic cough,alcohol consumption,physical diseases including chronic bronchitis and cancer,gynecological diseases like gynecological inflammation are risk factors for *** delivery was the risk factor for FI in females with labor ***:FI was not a common symptom in adult Chinese women living in urban areas and there were some potential modifiable risk factors.

关键词： Epidemiology Fecal incontinence Prevalence Risk factor Urban area