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Efficacy of Pudilan Xiaoyan Oral Liquid in the treatment of pneumonia induced by drug-resistant Pseudomonas aeruginosa

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Infectious Diseases Research 2024年第3期5卷 22-29页

作者： jing Ma Yan-Yan bao Xiao-Rui Wang Kuok Kuantai Leong-Man Chon Xiao-Lan Cui Ju-Ying Zhong Yu-jing Shi Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China Conde S.Januário Hospital(CHCSJ) pharmacy departmentMacao 999078China Lin Fong Charities Traditional Chinese Medicine Treatment Centre Macao 999078China Experimental Research Center China Academy of Chinese Medical SciencesBeijing 100700China

Background:Pudilan Xiaoyan Oral Liquid(PDL)is a Chinese patent medicine with notable pharmacological properties,including anti-inflammatory and antibacterial ***-resistant Pseudomonas aeruginosa infection is a common and refractory bacterial infection in clinical *** to its high drug resistance,it brings great challenges to *** study aimed to assess the therapeutic efficacy of PDL in a murine model of pneumonia induced by drug-resistant Pseudomonas ***:Three different doses of PDL(11 mL/kg/d,5.5 mL/kg/d,2.75 mL/kg/d)were used to observe lung tissue pathology and inflammatory cytokine levels in pneumonia mouse models induced by multidrug-resistant Pseudomonas aeruginosa(MDR-PA).Additionally,the protective efficacy of PDL against mortality in infected mice was evaluated using a death model caused by *** sub-MIC concentration of levofloxacin was used to induce drug-resistant mice pneumonia model to evaluate the role of PDL in reversing drug *** data are expressed as mean±standard *** significance was determined by one-way analysis of variance followed by Tukey’s multiple-comparisons ***:Treatment effect of PDL on MDR-PA pneumonia:the medium and small doses of PDL can significantly reduce the lung index of multi-drug resistant bacteria infected pneumonia model mice(P<0.05),the lung index inhibition rates for these groups were 55.09%and 58.43%,and improve the degree of lung tissue lesions of mice;The expression of serum cytokines keratinocyte chemoattractant,tumor necrosis factor-αand monocyte chemoattractant protein-1 could be decreased in the three dosage groups of PDL(P<0.01).PDL treatment not only lowered the mortality but also extended the survival duration in mice infected with *** was found after sub-MIC concentration of levofloxacin induced resistance of Pseudomonas aeruginosa to pneumonia in *** with the model group,the lung index of mice in high

关键词： pudilan Pseudomonas aeruginosa drug resistance mice model

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开源软件缺陷的跨项目相关问题推荐方法

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软件学报 2024年第5期35卷 2340-2358页

作者：刘宝川张莉刘桢炜蒋竞软件开发环境国家重点实验室(北京航空航天大学) 北京100191

GitHub是著名的开源软件开发社区,支持开发人员在开源项目中使用问题追踪系统来处理问题.在软件缺陷问题的讨论过程中,开发人员可能指出与该缺陷问题相关的其他项目问题(称为跨项目相关问题),为缺陷问题的修复提供参考信息.然而,GitHub... 详细信息

GitHub是著名的开源软件开发社区,支持开发人员在开源项目中使用问题追踪系统来处理问题.在软件缺陷问题的讨论过程中,开发人员可能指出与该缺陷问题相关的其他项目问题(称为跨项目相关问题),为缺陷问题的修复提供参考信息.然而,GitHub平台中托管了超过2亿的开源项目和12亿个问题,导致人工识别和获取跨项目相关问题的工作极其耗时.提出为缺陷问题自动化推荐跨项目相关问题的方法CPIRecom.为了构建预选集,采用项目之间历史相关问题对的数量和问题发布时间间隔筛选问题.其次,为了精准推荐,采用BERT预训练模型提取文本特征,分析项目特征.然后使用随机森林算法计算预选问题与缺陷问题的相关概率,最终根据相关概率排名得到推荐列表.模拟CPIRecom方法在GitHub平台的使用情况.CPIRecom方法的平均倒数排名达到0.603,前5项查全率达到0.715.

关键词：开源项目缺陷修复跨项目相关问题问题推荐

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Influence of biological treatments on intestinal microbiota of psoriasis patients

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中华医学杂志(英文版) 2024年第16期137卷 2024 Jul 9页

作者： Wen Zhuyuan Lu Xiaoling nie Hao Xu jing Zou Yang Huang Kun Chen Aijun Zhang Yichi Cao Min Yin Qi Wang Ping Department of Dermatology The First Affiliated Hospital of Chongqing Medical University Chongqing China School of Pediatrics Chongqing Medical University Pediatric College Chongqing China School of Public Health Chongqing Medical University Chongqing China Department of Urology Third People’s Hospital of Chengdu Chengdu Sichuan China

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Association between triglyceride-glucose index and colorectal polyps:A retrospective cross-sectional study

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World Journal of Gastrointestinal Endoscopy 2024年第2期16卷 55-63页

作者： Ya-Jie Teng Ying-Xue Yang jing-jing Yang Qiu-Yan Lu Jia-Yi Shi Jian-Hao Xu Jie bao Qing-Hua Wang Department of Gastroenterology The First People's Hospital of KunshanSuzhou 215300Jiangsu ProvinceChina Department of Pathology The First People's Hospital of KunshanSuzhou 215300Jiangsu ProvinceChina

BACKGROUND Colorectal polyps(CPs)are frequently occurring abnormal growths in the colorectum,and are a primary precursor of colorectal cancer(CRC).The triglyceride-glucose(TyG)index is a novel marker that assesses metabolic health and insulin resistance,and has been linked to gastrointestinal *** To investigate the potential association between the TyG index and CPs,as the relation between them has not been *** A total of 2537 persons undergoing a routine health physical examination and colonoscopy at The First People's Hospital of Kunshan,Jiangsu Province,China,between January 2020 and December 2022 were included in this retrospective cross-sectional *** excluding individuals who did not meet the eligibility criteria,descriptive statistics were used to compare characteristics between patients with and without *** regression analyses were conducted to determine the associations between the TyG index and the prevalence of *** TyG index was calculated using the following formula:Ln[triglyceride(mg/dL)×glucose(mg/dL)/2].The presence and types of CPs was determined based on data from colonoscopy reports and pathology *** A nonlinear relation between the TyG index and the prevalence of CPs was identified,and exhibited a curvilinear pattern with a cut-off point of 2.31.A significant association was observed before the turning point,with an odds ratio(95% confidence interval)of 1.70(1.40,2.06),P<***,the association between the TyG index and CPs was not significant after the cut-off point,with an odds ratio(95% confidence interval)of 0.57(0.27,1.23),P=*** Our study revealed a curvilinear association between the TyG index and CPs in Chinese individuals,suggesting its potential utility in developing colonoscopy screening strategies for preventing CRC.

关键词： Triglyceride-glucose index Colorectal polyps Colorectal cancer Insulin resistance Cross-sectional study

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精准设计的纳米机器药物及其抗肿瘤应用

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中国科学：化学 2024年第5期54卷 734-752页

作者：王婧聂广军赵宇亮国家纳米科学中心中国科学院纳米生物效应与安全性重点实验室中国科学院纳米科学卓越创新中心北京100190 中国科学院大学材料与光电研究中心北京100049

纳米医药是当今生物和医学研究最具创新活力的领域之一,尤其是在恶性肿瘤等复杂难治疾病的治疗中展现出广阔的应用前景.随着纳米生物技术近年来的快速发展,能够在活体环境执行精密、复杂操作的纳米生物机器受到高度关注.本文总结了我们... 详细信息

纳米医药是当今生物和医学研究最具创新活力的领域之一,尤其是在恶性肿瘤等复杂难治疾病的治疗中展现出广阔的应用前景.随着纳米生物技术近年来的快速发展,能够在活体环境执行精密、复杂操作的纳米生物机器受到高度关注.本文总结了我们团队在抗肿瘤纳米机器药物方面的科研工作,从精准设计、体内操控和创新性治疗等方面,系统性介绍了基于核酸、多肽、膜结构等生物模块的纳米机器药物设计策略,讨论了不同类型纳米机器药物在肿瘤治疗中的优势,并结合当前肿瘤临床治疗的重点发展方向,讨论了纳米机器药物对治疗范式创新的潜在推动作用.

关键词：抗肿瘤纳米药物纳米机器智能纳米材料可控自组装肿瘤微环境免疫治疗

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A pathological joint-liver axis mediated by matrikine-activated CD4^(+)T cells

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2679-2693页

作者： Junzhi Yi Hui Zhang Fangyuan bao Zhichu Chen Yuliang Zhong Tianning Ye Xuri Chen jingyi Qian Mengya Tian Min Zhu Zhi Peng Zongyou Pan Jianyou Li Zihao Hu Weiliang Shen Jiaqi Xu Xianzhu Zhang Youzhi Cai Mengjie Wu Hua Liu jing Zhou Hongwei Ouyang Department of Sports Medicine of the Second Affiliated Hospital and Liangzhu LaboratoryZhejiang University School of MedicineHangzhouChina Dr.Li Dak Sum&Yip Yio Chin Center for Stem Cells and Regenerative Medicine Zhejiang University School of MedicineHangzhouChina Stomatology Hospital School of StomatologyZhejiang University School of MedicineZhejiang Provincial Clinical Research Center for Oral DiseasesHangzhouChina The MOE Key Laboratory of Biosystems Homeostasis&Protection The Key Laboratory of Cancer Molecular Cell Biology of Zhejiang ProvinceLife Sciences InstituteZhejiang UniversityHangzhouChina Department of Orthopedics Huzhou Central HospitalAffiliated Huzhou HospitalZhejiang University School of MedicineHuzhouChina China Orthopedic Regenerative Medicine Group(CORMed) HangzhouChina Department of Orthopedics The First Affiliated HospitalZhejiang University School of MedicineHangzhouChina

The knee joint has long been considered a closed *** pathological effects of joint diseases on distant organs have not been ***,our clinical data showed that post-traumatic joint damage,combined with joint bleeding(hemarthrosis),exhibits a worse liver function compared with healthy *** mouse model,hemarthrosis induces both cartilage degeneration and remote liver ***,we found that hemarthrosis induces the upregulation in ratio and differentiation towards Th17 cells of CD4^(+)T cells in peripheral blood and *** of CD4^(+)T cells reverses hemarthrosis-induced liver *** of cartilage matrix induced by hemarthrosis upregulates serological type Ⅱ collagen(COL Ⅱ),which activates CD4^(+)T *** application of a COL Ⅱ antibody blocks the ***,bulk RNAseq and single-cell qPCR analysis revealed that the cartilage Akt pathway is inhibited by blood ***-articular application of Akt activator blocks the cartilage degeneration and thus protects against the liver impairment in mouse and pig *** together,our study revealed a pathological joint-liver axis mediated by matrikine-activated CD4^(+)T cells,which refreshes the organ-crosstalk axis and provides a new treatment target for hemarthrosis-related disease.

关键词： degeneration damage inhibited

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Licorice-saponin A3 is a broad-spectrum inhibitor for COVID-19 by targeting viral spike and anti-inflammation

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Journal of Pharmaceutical Analysis 2024年第1期14卷 115-127页

作者： Yang Yi Wenzhe Li Kefang Liu Heng Xue Rong Yu Meng Zhang Yang-Oujie bao Xinyuan Lai jingjing Fan Yuxi Huang jing Wang Xiaomeng Shi Junhua Li Hongping Wei Kuanhui Xiang Linjie Li Rong Zhang Xin Zhao Xue Qiao Hang Yang Min Ye State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing100191China Yunnan Baiyao International Medical Research Center Peking UniversityBeijing100191China CAS Key Laboratory of Pathogen Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing100101China CAS Key Laboratory of Special Pathogens and Biosafety Center for Biosafety Mega-ScienceWuhan Institute of VirologyChinese Academy of SciencesWuhan430071China University of Chinese Academy of Sciences Beijing100049China Department of Microbiology and Infectious Disease Center School of Basic Medical SciencesPeking University Health Science CenterPeking UniversityBeijing100191China Hubei Jiangxia Laboratory Wuhan430000China Shenzhen Children's Hospital ShenzhenGuangdong518036China

Currently,human health due to corona virus disease 2019(COVID-19)pandemic has been seriously *** coronavirus severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)spike(S)protein plays a crucial role in virus transmission and several S-based therapeutic approaches have been approved for the treatment of ***,the efficacy is compromised by the SARS-CoV-2 evolvement and *** we report the SARS-CoV-2 S protein receptor-binding domain(RBD)inhibitor licorice-saponin A3(A3)could widely inhibit RBD of SARS-CoV-2 variants,including Beta,Delta,and Omicron BA.1,XBB and ***,A3 could potently inhibit SARS-CoV-2 Omicron virus in Vero E6 cells,with EC50 of 1.016μ*** mechanism was related to binding with Y453 of RBD determined by hydrogen-deuterium exchange mass spectrometry(HDX-MS)analysis combined with quantum mechanics/molecular mechanics(QM/MM)***,phosphoproteomics analysis and multi fluorescent immunohistochemistry(mIHC)respectively indicated that A3 also inhibits host inflammation by directly modulating the JNK and p38 mitogen-activated protein kinase(MAPK)pathways and rebalancing the corresponding immune *** work supports A3 as a promising broad-spectrum small molecule drug candidate for COVID-19.

关键词： COVID-19 Inflammation Licorice-saponin A3 Receptor-binding domain(RBD) SARS-CoV-2

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Study of tree shrew biology and models: A booming and prosperous field for biomedical research

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Zoological Research 2024年第4期45卷 877-909页

作者： Yong-Gang Yao Li Lu Rong-Jun Ni Rui Bi Ceshi Chen Jia-Qi Chen Eberhard Fuchs Marina Gorbatyuk Hao Lei Hongli Li Chunyu Liu Long-bao Lv Kyoko Tsukiyama-Kohara Michinori Kohara Claudia Perez-Cruz Gregor Rainer bao-Ci Shan Fang Shen An-Zhou Tang jing Wang Wei Xia Xueshan Xia Ling Xu Dandan Yu Feng Zhang Ping Zheng Yong-Tang Zheng Jumin Zhou Jiang-Ning Zhou Key Laboratory of Genetic Evolution and Animal Models Yunnan Key Laboratory of Animal Models and Human Disease MechanismsKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650204China National Research Facility for Phenotypic&Genetic Analysis of Model Animals(Primate Facility) and National Resource Center for Non-Human PrimatesKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650107China KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650204China Kunming College of Life Science University of Chinese Academy of SciencesKunmingYunnan 650204China Mental Health Center and Psychiatric Laboratory West China HospitalSichuan UniversityChengduSichuan 610041China Sichuan Clinical Medical Research Center for Mental Disorders ChengduSichuan 610044China German Primate Center Leibniz Institute of Primate ResearchGöttingen 37077Germany Department of Optometry and Vision Science School of OptometryUniversity of Alabama at BirminghamBirminghamAL 35294USA State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Innovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhanHubei 430071China Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhanHubei 430074China Soong Ching Ling Institute of Maternity and Child Health International Peace Maternity and Child Health HospitalShanghai Jiao Tong University School of MedicineShanghai 200030China Transboundary Animal Diseases Center Joint Faculty of Veterinary MedicineKagoshima UniversityKagoshima-cityKagoshima 890-8580Japan Department of Microbiology and Cell Biology Tokyo Metropolitan Institute of Medical ScienceTokyo 156-8506Japan Pharmacology Department CinvestavMexico City 07360Mexico Department of Medicine University of FribourgFribourg CH-1700Switzerland Beijing Engineering Research Center of Radiog

The tree shrew(Tupaia belangeri)has long been proposed as a suitable alternative to non-human primates(NHPs)in biomedical and laboratory research due to its close evolutionary relationship with *** recent years,significant advances have facilitated tree shrew studies,including the determination of the tree shrew genome,genetic manipulation using spermatogonial stem cells,viral vector-mediated gene delivery,and mapping of the tree shrew brain ***,the limited availability of tree shrews globally remains a substantial challenge in the ***,determining the key questions best answered using tree shrews constitutes another *** shrew models have historically been used to study hepatitis B virus(HBV)and hepatitis C virus(HCV)infection,myopia,and psychosocial stress-induced depression,with more recent studies focusing on developing animal models for infectious and neurodegenerative *** these efforts,the impact of tree shrew models has not yet matched that of rodent or NHP models in biomedical *** review summarizes the prominent advancements in tree shrew research and reflects on the key biological questions addressed using this *** emphasize that intensive dedication and robust international collaboration are essential for achieving breakthroughs in tree shrew *** use of tree shrews as a unique resource is expected to gain considerable attention with the application of advanced techniques and the development of viable animal models,meeting the increasing demands of life science and biomedical research.

关键词： Tree shrew Animal model Neurodegenerative diseases Infectious diseases Neuroscience Phenome

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以景观感知为中介的生态美学践行途径:目标体系与营造策略

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中国园林 2024年第4期40卷 77-81页

作者：费凡岳邦瑞聂静延安大学鲁迅艺术学院延安716000 西安建筑科技大学建筑学院西安710055 西安建筑科技大学艺术学院西安710055

生态美学是一门面向生态危机、致力审美体验与环境健康共赢的规范性学说,对生态文明建设具有重要现实意义。如何借由景观感知研究助推生态美学观的传播,引导公众审美意识转向自然关怀与伦理正义,是风景园林学科关注的重点问题。基于此,... 详细信息

生态美学是一门面向生态危机、致力审美体验与环境健康共赢的规范性学说,对生态文明建设具有重要现实意义。如何借由景观感知研究助推生态美学观的传播,引导公众审美意识转向自然关怀与伦理正义,是风景园林学科关注的重点问题。基于此,旨在借由理论综述与案例分析探讨以景观感知为中介的生态美学践行途径。具体包括:(1)在概念框架层面,讨论了景观感知、生态美学观及风景园林实践的关系;(2)在价值规范层面,构建了践行生态美学的目标体系,包含“安全氛围的暗示”“关怀意图的显露”“地方文脉的反映”“生态规律的阐释”及“生态伦理的激发”5个关键维度;(3)在实践应用层面,凝练了围绕目标体系的一系列风景园林营造策略。通过系统认识美学规范与景观实践间的作用关系,以期为基于人本感知的、面向当代美学诉求的风景园林研究提供有益参考。

关键词：风景园林生态美学景观感知目标策略

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基于量子反应均衡的政府与共享单车企业停车管理博弈分析

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控制与决策 2024年第2期39卷 641-648页

作者：张书婧贾顺平彭芃毛保华北京交通大学交通运输学院北京100044 北京交通大学综合交通运输大数据应用技术交通运输行业重点实验室北京100044 北京交通大学中国综合交通研究中心北京100044

共享单车停车问题是城市交通治理中最主要的问题之一,其表面为共享单车用户停车行为不规范、共享单车企业管理调度不及时所致,究其本质实为共享单车各利益主体缺乏有效协同治理机制、停车权责划分不清晰、成本分担失衡的结果.考虑政府... 详细信息

共享单车停车问题是城市交通治理中最主要的问题之一,其表面为共享单车用户停车行为不规范、共享单车企业管理调度不及时所致,究其本质实为共享单车各利益主体缺乏有效协同治理机制、停车权责划分不清晰、成本分担失衡的结果.考虑政府与共享单车企业的有限理性,建立扩展式博弈的量子反应均衡(QRE)模型分析双方停车管理博弈机理,并利用Gambit软件进行算例仿真分析.研究表明:双方博弈结果随理性程度增加逐渐趋向于基于完全理性的子博弈精炼纳什均衡,政府掌握更多企业运营信息有利于达到社会效用最大化的博弈结果;政府引入有效处罚措施或主导负责停车管理可以降低自身的财政支出和社会总成本,建立量化的处罚标准能够促进企业主动承担停车管理责任;有限理性程度、违停数量、激励机制和科技手段运行效率会影响企业的停车管理策略选择.

关键词：共享单车停车治理研究有限理性量子反应均衡扩展式博弈仿真

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