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AAV mediated carboxyl terminus of Hsp70 interacting protein overexpression mitigates the cognitive and pathological phenotypes of APP/PS1 mice

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Neural Regeneration Research 2025年第1期20卷 253-264页

作者： Zhengwei Hu jing yang Shuo Zhang Mengjie Li Chunyan Zuo Chengyuan Mao Zhongxian Zhang Mibo Tang Changhe Shi Yuming Xu Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Academy of Medical Sciences of Zhengzhou University ZhengzhouHenan ProvinceChina NHC Key Laboratory of Prevention and treatment of Cerebrovascular Diseases The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Henan Key Laboratory of Cerebrovascular Diseases The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Institute of Neuroscience Zhengzhou UniversityZhengzhouHenan ProvinceChina Sino-British Research Centre for Molecular Oncology National Centre for International Research in Cell and Gene TherapySchool of Basic Medical SciencesAcademy of Medical SciencesZhengzhou UniversityZhengzhouHenan ProvinceChina Department of Gerontology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina

The E3 ubiquitin ligase,carboxyl terminus of heat shock protein 70(Hsp70)interacting protein(CHIP),also functions as a co-chaperone and plays a crucial role in the protein quality control *** this study,we aimed to investigate the neuroprotective effect of overexpressed CHIP on Alzheimer’s *** used an adeno-associated virus vector that can cross the blood-brain barrier to mediate CHIP overexpression in APP/PS1 mouse *** overexpression significantly ameliorated the performance of APP/PS1 mice in the Morris water maze and nest building tests,reduced amyloid-βplaques,and decreased the expression of both amyloid-βand phosphorylated *** also alleviated the concentration of microglia and astrocytes around *** APP/PS1 mice of a younger age,CHIP overexpression promoted an increase in ADAM10 expression and inhibitedβ-site APP cleaving enzyme 1,insulin degrading enzyme,and neprilysin *** of HSP70 and HSP40,which have functional relevance to CHIP,were also *** nuclei transcriptome sequencing in the hippocampus of CHIP overexpressed mice showed that the lysosomal pathway and oligodendrocyte-related biological processes were up-regulated,which may also reflect a potential mechanism for the neuroprotective effect of *** research shows that CHIP effectively reduces the behavior and pathological manifestations of APP/PS1 ***,overexpression of CHIP could be a beneficial approach for the treatment of Alzheimer’s disease.

关键词： adeno-associated virus Alzheimer’s disease APP/PS1 mice carboxyl terminus of Hsp70 interacting protein gene therapy

Extramedullary plasmacytoma with the uvula as first affected site:A case report

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World Journal of Clinical Oncology 2025年第1期16卷 53-58页

作者： jing yang Hui Peng Sheng-Ke Tu Min Li Kui Song Department of Hematology The First Affiliated Hospital of Jishou UniversityJishou 416000Hunan ProvinceChina Department of Pharmacy The First Affiliated Hospital of Jishou UniversityJishou 416000Hunan ProvinceChina

BACKGROUND Extramedullary plasmacytoma(EMP)represents one of the rarer forms of plasma cell malignancies,capable of impacting a variety of tissues and organs throughout the *** majority of EMP cases are predominantly found in the head and neck region,especially within the laryngopharynx,as well as in the gastrointestinal *** there have been documented instances of oropharyngeal involvement in EMP cases in the academic literature,it is important to note that EMP specifically affecting the uvula is exceedingly ***,it is noteworthy that over 60% of epithelial carcinomas in the upper respiratory tract and oropharynx tend to metastasize to the cervical lymph nodes,indicating a propensity for regional spread in these types of *** this context,we present a rare case of extramedullary plasmacytoma where the uvula served as the initially affected *** case emphasizes the need for heightened awareness among clinicians regarding such unusual comorbidities,as early recognition and diagnosis can significantly influence patient management and treatment *** addition,a review of the relevant literature is included to further educate and inform healthcare professionals about this rare presentation,ultimately aiming to enhance clinical understanding and improve patient care in similar *** SUMMARY A 51-year-old man was admitted to our hospital because of a slowly enlarging neck mass.A physical examination revealed a palpable left lymph node,and magnetic resonance imaging(MRI)of the oropharynx and the neck showed a soft tissue mass in the oropharynx and enlargement of multiple lymph nodes in the *** soft tissue mass was diagnosed as plasmacytoma by immunohistochemical *** immunoglobulins and bone marrow biopsy showed normal ***,we diagnosed that as EMP of the *** four cycles of adjuvant chemotherapy dominated by bortezomib,MRI reexamination showed a significant reduction of the mass

关键词： Extramedullary plasmacytoma Plasmacytoma Uvula Multiple myeloma Case report

Highly conductive and stable iodine doped argyrodite electrolyte for all-solid-state lithium batteries

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Journal of Energy Chemistry 2025年第01期 50-58页

作者： Gaozhan Liu jing Zhang jing yang jinghui Chen Xingyue Xiao Xiayin Yao Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences

Lithium argyrodites with high ionic conductivity and low cost are considered as one of the most prospective solid electrolytes for all-solid-state lithium ***,the poor chemical stability and compatibility with lithium metal limit their ***,Li5.4PS4.4Cl1.4I0.2solid electrolyte with high ionic conductivity of 11.49 m S cm-1and improved chemical stability is synthesized by iodine *** ultra-thin Li5.4PS4.4Cl1.4I0.2membrane with thickness of 10μm can be obtained by wet coating process,exhibiting a high ionic conductivity of 2.09 mS cm-1and low areal resistance of 1.17Ω***,iodine doping could in-situ form LiI at the lithium/electrolyte interface and improve the critical current density of Li5.4PS4.4Cl1.6from 0.8 to 1.35 mA *** resultant LiCoO2/Li5.4PS4.4Cl1.4I0.2/Li battery shows excellent cycling stability at 1 C,with a reversible specific capacity of 110.1 mA h g-1and a retention of 80.5% after 1000 *** addition,the assembled LiCoO2/Li5.4PS4.4Cl1.4I0.2membrane/Li pouch cell delivers an initial discharge capacity of 110.4 mA h g-1and 80.5% capacity retention after 100 cycles.

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Excavator Energy-saving Efficiency Based on Diesel Engine Cylinder Deactivation Technology

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Chinese Journal of Mechanical Engineering 2012年第5期25卷 897-904页

作者： yang jing QUAN Long yang yang Key Laboratory of Advanced Transducers and Intelligent Control System of Ministry of Education Taiyuan University of Technology Taiyuan 030024 China The State Key Lab of Fluid Power Transmission and Control Zhejiang University Hangzhou 31002 7 China

The hydraulic excavator energy-saving research mainly embodies the following three measures： to improve the performance of diesel engine and hydraulic component, to improve the hydraulic system, and to improve the power matching of diesel-hydraulic system-actuator. Although the above measures have certain energy-saving effect, but because the hydraulic excavator load changes frequently and fluctuates dramatically, so the diesel engine often works in high-speed and light load condition, and the fuel consumption is higher. Therefore, in order to improve the economy of diesel engine in light load, and reduce the fuel consumption of hydraulic excavator, energy management concept is proposed based on diesel engine cylinder deactivation technology. By comparing the universal characteristic under diesel normal and deactivated cylinder condition, the mechanism that fuel consumption can be reduced significantly by adopting cylinder deactivation technology under part of loads condition can be clarified. The simulation models for hydraulic system and diesel engine are established by using AMESim software, and fuel combustion consumption by using cylinder-deactivation-technology is studied through digital simulation approach. In this way, the zone of cylinder deactivation is specified. The testing system for the excavator with this technology is set up based on simulated results, and the results show that the diesel engine can still work at high efficiency with part of loads after adopting this technology; fuel consumption is dropped down to 11% and 13% under economic and heavy-load mode respectively under the condition of driving requirements. The research provides references to the energy-saving study of the hydraulic excavators.

关键词： diesel engine cylinder deactivation hydraulic excavator energy-saving

An overview of cryptographic primitives for possible use in 5G and beyond

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Science China(Information Sciences) 2020年第12期63卷 5-26页

作者： jing yang Thomas JOHANSSON Department of Electrical and Information Technology Lund University

This survey overviews the potential use of cryptographic primitives in the fifth-generation mobile communications system(aka 5G) and beyond. It discusses the new security challenges that come with 5G and presents the upcoming security architecture. It shows the use of current cryptographic algorithms and discusses new algorithms or modifications of existing ones, that can be relevant. It also discusses the need for lightweight algorithms to meet the new use cases as well as the general demand for algorithms secure even when large quantum computers are available.

关键词： 5G cryptographic primitives lightweight cryptography post-quantum cryptography

The Center Problem and Time-Reversibility with Respect to a Quadratic Involution for a Class of Polynomial Differential Systems with Order 2 or 3

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Journal of Systems Science & Complexity 2022年第4期35卷 1608-1636页

作者： yang jing yang Ming LU Zhengyi Chengdu Institute of Computer Application Chinese Academy of SciencesChengdu610041China University of Chinese Academy of Sciences Beijing100049China School of Mathematical Sciences Sichuan Normal UniversityChengdu610068China

Most studies of the time-reversibility are limited to a linear or an affine *** this paper,the authors consider the case of a quadratic *** a polynomial differential system with a linear part in the standard form(-y,x)in R~2,by using the method of regular chains in a computer algebraic system,the computational procedure for finding the necessary and sufficient conditions of the system to be time-reversible with respect to a quadratic involution is *** the system is quadratic,the necessary and sufficient conditions can be completely obtained by this *** some cubic systems,the necessary and sufficient conditions for these systems to be time-reversible with respect to a quadratic involution are also *** conditions can guarantee the corresponding systems to have a ***,a property of a center-focus system is discovered that if the system is time-reversible with respect to a quadratic involution,then its phase diagram is symmetric about a parabola.

关键词： Center polynomial differential systems quadratic involution regular chains time-reversibility

ManyInsights: A Visual Analytics Approach to Supporting Effective Insight Management

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Tsinghua Science and Technology 2013年第2期18卷 171-181页

作者： yang Chen jing yang the Department of Computer Science University of North Carolina at CharlotteCharlotte NC 28223 USA

Although significant progress has been made towards effective insight discovery in visual analytics systems, there are few effective approaches for managing the large number of insights generated in visual analytics processes. This paper presents Manylnsights, a multidimensional visual analytics prototype that integrates several novel insight management approaches proposed by the authors in their previous work. These approaches include insight annotation, browsing, retrieval, organization, and association. This paper also reports a long-term case study that evaluated Manylnsights with a domain expert, realistic analytic tasks, and real datasets.

关键词： visual analytics insight management multidimensional visualization

Tag clustering algorithm LMMSK: improved K-means algorithm based on latent semantic analysis

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Journal of Systems Engineering and Electronics 2017年第2期28卷 374-384页

作者： jing yang Jun Wang School of Economics and Management Beihang University Beijing 100191 China

With the wide application of Web-2.0 and social software, there are more and more tag-related studies and applications. Because of the randomness and the personalization in users' tagging, tag research continues to encounter data space and semantics obstacles. With the min-max similarity (MMS) to establish the initial centroids, the traditional K-means clustering algorithm is firstly improved to the MMSK-means clustering algorithm, the superiority of which has been tested; based on MMSK-means and combined with latent semantic analysis (LSA), here secondly emerges a new tag clustering algorithm, LMMSK. Finally, three algorithms for tag clustering, MMSK-means, tag clustering based on LSA (LSA-based algorithm) and LMMSK, have been run on Matlab, using a real tag-resource dataset obtained from the Delicious Social Bookmarking System from 2004 to 2009. LMMSK's clustering result turns out to be the most effective and the most accurate. Thus, a better tag-clustering algorithm is found for greater application of social tags in personalized search, topic identification or knowledge community discovery. In addition, for a better comparison of the clustering results, the clustering corresponding results matrix (CCR matrix) is proposed, which is promisingly expected to be an effective tool to capture the evolutions of the social tagging system. © 2017 Beijing Institute of Aerospace Information.

关键词： Application programs Data mining MATLAB Semantics Social networking (online) Websites

Alterations of RNA Editing for the Mitochondrial ATP9 Gene in a New orf220-type Cytoplasmic Male-sterile Line of Stem Mustard （Brassica juncea var. tumida）

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Journal of Integrative Plant Biology 2007年第5期49卷 672-677页

作者： jing-Hua yang Laboratory of Genetic Resources & Functional Improvement for Horticultural Plants Department of Horticulture Zhejiang University Hangzhou 310029 China Laboratory of Horticultural Plant Growth Development & Biotechnology Ministry of Agriculture Zhejiang University Hangzhou 310029 China

RNA editing for the mitochondrlal ATP9 gene of encoding regions has been observed in both cytoplasmic malesterile and maintainer lines of stem mustard, where its editing capacity varied spatially and temporally in the cytoplasmic male sterility （CMS） line. There were four RNA editing sites for the mitochondrial ATP9 gene according to Its normal editing sites in mustard, of which three sites occurred as C-to-U changes and one as a U-to-C change. As a result, the hydrophobicity of deduced ATP9 protein was reduced due to the conversions at its 17th, 45th and 64th positions. Meanwhile, the conservation of deduced ATP9 protein was enhanced by changes at the 56th position. Loss of a specific editing site for ATP9 was observed in juvenile roots, senile roots, senile leaves and floret buds of the CMS line. Comparatively, complete RNA editing for ATP9 gene was retained in juvenile roots, juvenile leaves and floret buds of its maintainer line; however, the loss of a specific editing site for ATP9 gene occurred at senile roots and senile leaves in its maintainer line. These observations allow us to produce a hypothesis that the dysfunction of a specific mitochondrial gene arising from RNA editing could probably be a factor triggering CMS and organ senescence through unknown cross-talk pathways during development.

关键词： ATP9 Brassica juncea cytoplasmic male sterility RNA editing.