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An RNA-seq-based Gene Expression Profiling of Radiation-induced Tumorigenic Mammary Epithelial Cells

Genomics, Proteomics & Bioinformatics 2012年第6期10卷 326-335页

作者： Lina Ma Linghu Nie jing Liu Bing zha.g Shuhui Song Min Sun Jin Yang Yadong Yang Xiangdong Fang Songnian Hu Yongliang zha. Jun yu CAS Key Laboratory of Genome Sciences and Information Beijing Institute of Genomics Chinese Academy of Sciences Laboratory of Disease Genomics and Individualized Medicine Beijing Institute of Genomics Chinese Academy of Sciences Center for Radiological Research Columbia University

Immortality and tumorigenicity are two distinct characteristics of cancers. Immortalization has been suggested to precede tumorigenesis. To understand the molecular mechanisms of tumorigenicity and cancer progression in mammary epithelium, we established a tumori- genic cell model by means of heavy-ion radiation of an immortal cell model, which was created by overexpressing the human telomerase reverse transcriptase （hTERT） in normal human mammary epithelial cells. We examined the expression profile of this tumorigenic cell line （T hMEC） using the hTERT-overexpressing immortal cell line （IhMEC） as a control. In-depth RNA-seq data was generated by using the next-generation sequencing （NGS） platform （Life Technologies SOLID3）. We found that house-keeping （HK） and tissue-spe- cific （TS） genes were differentially regulated during the tumorigenic process. HK genes tended to be activated while TS genes tended to be repressed. In addition, the HK genes and TS genes tended to contribute differentially to the variation of gene expression at different RPKM （gene expression in reads per exon kilobase per million mapped sequence reads） levels. Based on transcriptome analysis of the two cell lines, we defined 7053 differentially-expressed genes （DEGs） between immortality and tumorigenicity. Differential expression of 20 manually-selected genes was further validated using qRT-PCR. Our observations may help to further our understanding of cellular mechanism（s） in the transition from immortalization to tumorigenesis.

关键词： NGS RNA-seq Tumorigenicity Immortality Radiation Breast cancer

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Analysis of tail bits generation of multilevel storage in resistive switching memory

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Chinese Physics B 2018年第11期27卷 626-629页

作者： jing Liu Xiaoxin Xu Chuanbing Chen Tiancheng Gong zha.an yu Qing Luo Peng yuan Danian Dong Qi Liu Shibing Long Hangbing Lv Ming Liu School of Microelectronics University of Chinese Academy of Sciences Beijing 100049 China Laboratory of Nano-Fabrication and Novel Devices Integrated Technology Institute of Microelectronics Chinese Academy of Sciences Beijing 100029 China

The tail bits of intermediate resistance states（IRSs） achieved in the SET process（IRSS） and the RESET process（IRSR） of conductive-bridge random-access memory were investigated. Two types of tail bits were observed, depending on the filament morphology after the SET/RESET operation.（i） Tail bits resulting from lateral diffusion of Cu ions introduced an abrupt increase of device resistance from IRS to ultrahigh-resistance state, which mainly happened in IRSS.（ii） Tail bits induced by the vertical diffusion of Cu ions showed a gradual shift of resistance toward lower value. Statistical results show that more than 95% of tail bits are generated in IRSS. To achieve a reliable IRS for multilevel cell（MLC） operation, it is desirable to program the IRS in RESET operation. The mechanism of tail bit generation that is disclosed here provides a clear guideline for the data retention optimization of MLC resistive random-access memory cells.

关键词： resistive random-access memory (RRAM) multilevel cell tail bits

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A high fidelity general purpose 3-D Monte Carlo particle transport program JMCT3.0

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Nuclear Science and Techniques 2022年第8期33卷 175-192页

作者： Li Deng Gang Li Bao-Yin zha.g Rui Li Ling-yu zha.g Xin Wang yuan-Gang Fu Dun-Fu Shi Peng Liu Yan Ma Dan-Hu Shangguan Ze-Hua Hu Sheng-Cheng Zhou jing-Wen Shen Institute of Applied Physics and Computational Mathematics(IAPCM) Beijing 100094China CAEP Software Centre for High Performance Numerical Simulation(CAEP-SCNS) Beijing 100088China

JMCT is a large-scale,high-fidelity,three-dimensional general neutron–photon–electron–proton transport Monte Carlo software *** was developed based on the combinatorial geometry parallel infrastructure JCOGIN and the adaptive structured mesh infrastructure *** is equipped with CAD modeling and visualizes the image *** supports the geometry of the body and the structured/unstructured *** has most functions,variance reduction techniques,and tallies of the traditional Monte Carlo particle transport *** energy models,multi-group and continuous,are *** recent years,some new functions and algorithms have been developed,such as Doppler broadening on-thefly(OTF),uniform tally density(UTD),consistent adjoint driven importance sampling(CADIS),fast criticality search of boron concentration(FCSBC)domain decomposition(DD),adaptive control rod moving(ACRM),and random geometry(RG)*** JMCT is also coupled with the discrete ordinate SNcode JSNT to generate source-biasing factors and weight-window *** present,the number of geometric bodies,materials,tallies,depletion zones,and parallel processors are sufficiently large to simulate extremely complicated device *** can be used to simulate reactor physics,criticality safety analysis,radiation shielding,detector response,nuclear well logging,and dosimetry calculations *** particular,JMCT can be coupled with depletion and thermal-hydraulics for the simulation of reactor nuclear-hot feedback *** paper describes the progress in advanced modeling,high-performance numerical simulation of particle transport,multiphysics coupled calculations,and large-scale parallel computing.

关键词： Advanced modeling High-performance numerical simulation Multi-physics coupled calculation Large-scale parallel computing JMCT

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Exploring the effect and mechanisms of Epimedium on diabetic testicular injury using network pharmacology,molecular docking,and cell experiments

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TMR Modern Herbal Medicine 2024年第2期7卷 19-27页

作者： Jun-Jun Wei Qiong-Yao Xu zha.-Wen Pan Yi-Wei Tu Wei yu Lan Huang Wen-Liang zha College of Pharmacy Hubei University of Science and TechnologyXianning 437100China Xianning Medical College Hubei University of Science and TechnologyXianning 437100China School of Stomatology and Ophthalmology Xianning Medical CollegeHubei University of Science and TechnologyXianning 437100China

Background:Studying the potential targets and mechanisms of Epimedium for anti-diabetic testicular injury using network pharmacology,molecular docking,and cell ***:Acquisition of major components and targets of Epimedium was based on TCMSP,TCMID,and Symmap databases and retrieval of diabetic testicular injury targets by OMIM,GeneCards,Pharmgkb,and Drugbank *** targets were obtained from the Venny 2.1.0 database and input SRTING data to construct a protein-protein interaction(PPI)network,and key targets were screened in Cytoscape 3.8.0 *** the Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analyses of intersecting targets were conducted through the DAVID ***,AutoDock software was used to verify docking between the main components and the core target *** addition,a Cell Counting Kit-8(CCK-8)assay was used to determine the survival effect of quercetin,the main component of Epimedium,on TM4 sertoli-like cells exposed to palmitic acid(PA).Results:Quercetin,kaempferol and luteolin in epimedium were identified as the main components in the treatment of diabetic testicular *** has core target proteins including MMP9,AKT1,and *** biological process mainly involves the regulation of the apoptotic signaling *** key pathways of KEGG are the AGE-RAGE signaling pathway in diabetic complications,PI3K-Akt and MAPK signaling *** docking results showed that quercetin had the strongest binding ability to ***,PA-challenged cells had a lower survival rate,which was alleviated by the administration of ***:Our findings suggest that Epimedium attenuates diabetes mellitus(DM)-induced testicular injury through AGE-RAGE,PI3K-Akt and MAPK signaling *** insights offer a potential therapeutic strategy for managing DM-induced testicular injury,will be the basis for future clinical research.

关键词： Epimedium diabetic testicular injury network pharmacology molecular docking

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Nonalcoholic fatty liver disease and microvascular complications in type 2 diabetes

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World Journal of Gastroenterology 2013年第20期19卷 3134-3142页

作者： Wen-Shan Lv Rui-Xia Sun Yan-Yan Gao Jun-Ping Wen Rong-Fang Pan Li Li jing Wang yu-Xin Xian Cai-Xia Cao Ming Zheng the Department of Internal Medicine the Affiliated Hospital of Medical CollegeQingdao University Fujian Provincial Hospital Fujian Provincial Geriatric Hospital Fujian Medical University

AIM:To evaluate the correlation between nonalcoholic fatty liver disease(NAFLD) and microvascular complications in type 2 diabetes mellitus(T2DM).METHODS:Data were obtained from 1217 inpatients with T2DM(757 females,460 males;aged 63.39 ± 12.28 years).NAFLD was diagnosed by hepatic *** nephropathy(DN),diabetic peripheral neuropathy(DPN),and diabetic retinopathy(DR) were diagnosed according to their respective *** prevalence of NAFLD and the independent correlations of clinical characteristics with NAFLD were determined by cross-tabulation and logistic regression,***:Approximately 61% of inpatients with T2DM in Qingdao,China had NAFLD,which decreased significantly with increase in age and prolonged course of *** prevalence of NAFLD in patients presenting with DN,DPN and DR was 49.4%,57.2% and 54.9%,*** rates were significantly lower than those of patients without DN,DPN and DR(65.9%,65.6% and 66.1%,respectively,P < 0.05).Participants with NAFLD had greater body weight,waist circumference(WC),body mass index(BMI),fasting blood glucose(FBG),hemoglobin A1c,alanine aminotransferase,aspartate aminotransferase,γ-glutamyltransferase,blood pressure,as well as triglyceride(TG) levels and lower high-density lipoprotein(HDL) concentration than those without NAFLD(P < 0.05).NAFLD was positively correlated with BMI,WC,TG,FBG,diastolic blood pressure,and systolic blood pressure but negatively correlated with the duration of diabetes,DR,DPN,DN,and ***:Despite the benign nature of NAFLD,efforts should be directed toward early diagnosis,intensive blood glucose and blood pressure control,and effective dyslipidemia correction.

关键词： Nonalcoholic fatty liver disease Type 2 diabetes mellitus Diabetic nephropathy Diabetic retinopathy Diabetic neuropathy

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人类学参与商业研究的价值及其反身性

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广西民族大学学报（哲学社会科学版） 2017年第4期39卷 11-17页

作者：朱宇晶华东师范大学社会发展学院人类学研究所

目前商业实践者对人类学的理解仍然受制于各种刻板印象,这使得人类学在商业研究中的价值实现非常有限;不过随着市场环境的转变(比如从复杂市场到庞杂市场),人类学对市场将有更深入的参与机会。另一方面,在商业领域做田野研究,人类学者... 详细信息

目前商业实践者对人类学的理解仍然受制于各种刻板印象,这使得人类学在商业研究中的价值实现非常有限;不过随着市场环境的转变(比如从复杂市场到庞杂市场),人类学对市场将有更深入的参与机会。另一方面,在商业领域做田野研究,人类学者既要学习新技能,也要面对"杂交"所带来的认知和实践的可能性。

关键词：蓝海战略复杂市场庞杂市场

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Influence of Wallach’s Rule on Chiral AIE Systems and Its Application in Cryptographic Information Storage

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CCS Chemistry 2022年第12期4卷 3686-3692页

作者： Qiu Chen Peng Xi Ming Luo yu jing Qin Ting Wang Bing Bai Xi Long Wei Kai Li Shuang Quan Zang Henan Key Laboratory of Crystalline Molecular Functional Materials Henan International Joint Laboratory of Tumor Theranostical Cluster MaterialsGreen Catalysis CenterCollege of ChemistryZhengzhou UniversityZhengzhou 450001

Aggregation-induced emission luminogens(AIEgens)exhibit excellent luminescence properties in the aggregated *** chiral AIEgens,a combination of right-and left-handed objects can be packed more tightly than homochiral objects due to Wallach’s ***,the manner in which Wallach’s rule can affect the luminescence properties of chiral AIEgens remains *** report that,in contrast to their homochiral counterparts,racemic AIEgens obtained using binaphthyl-2,2′-diamine salicylaldehyde Schiff-bases(BINAPAS)exhibit racemism-enhanced *** was found that the intramolecular motion of racemic BINAPAS is more restricted than that of chiral BINAPAS due to its denser packing mode,which significantly enhances the emission intensity of racemic *** on this finding,a novel single-molecule cryptographic information storage system was *** work offers a new perspective for understanding the influence of Wallach’s rule on the aggregationinduced emission properties of organic molecules,and more importantly,extends Wallach’s rule to the fundamental difference in chiral-photophysics.

关键词： aggregation-induced emission Wallach’s rule chiral-photophysics

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明代蕲簟的来源及工艺的考古研究

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科学通报 2018年第13期63卷 1189-1198页

作者：查良平彭华胜于大庆黄璐琦安徽中医药大学药学院合肥230012 安徽省中医药科学院中药资源保护与开发研究所合肥230012 中国中医科学院中药资源中心道地药材国家重点实验室培育基地北京100700

蕲簟,是李时珍家乡蕲春的"蕲州四宝"之一,曾为贡品,被唐宋诗词竞相吟诵.目前,蕲簟已经消失,其制作工艺也已失传.利用扫描电子显微镜对湖北蕲春县蕲州镇王要村刘家咀明代墓葬中出土的蕲簟、湖北蕲春竹类样品制成的竹炭进行超微结构比较分... 详细信息

蕲簟,是李时珍家乡蕲春的"蕲州四宝"之一,曾为贡品,被唐宋诗词竞相吟诵.目前,蕲簟已经消失,其制作工艺也已失传.利用扫描电子显微镜对湖北蕲春县蕲州镇王要村刘家咀明代墓葬中出土的蕲簟、湖北蕲春竹类样品制成的竹炭进行超微结构比较分析,发现蕲簟和水竹的部分纹孔均呈1~2列纵向排列,推测明墓出土的蕲簟原植物(蕲竹)即为水竹Phyllostachys heteroclada Oliver及其近缘种.进一步对古代诗句中蕲簟特征进行研究,认为出土蕲簟与诗句中描述特征基本一致,并结合出土蕲簟断面超微结构分析,对蕲簟加工工艺进行了探讨,为复原蕲春历史名物"蕲簟"文化提供了依据.

关键词：刘家咀明墓蕲簟考古竹唐诗

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一类带有强Allee效应捕食-食饵系统的Hopf分支

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兰州大学学报（自然科学版） 2014年第4期50卷 564-568,576页

作者：高玉景兰州大学数学与统计学院兰州730000

研究了一类带有强Allee效应的HollingⅡ型功能反应函数的捕食-食饵动力系统.讨论了平衡点的存在性及稳定性,证明了在一定参数范围内存在Hopf分支,且由Hopf分支产生一个稳定的极限环,极限环随着同宿闭轨的产生而消失.还利用文献[13]的方... 详细信息

研究了一类带有强Allee效应的HollingⅡ型功能反应函数的捕食-食饵动力系统.讨论了平衡点的存在性及稳定性,证明了在一定参数范围内存在Hopf分支,且由Hopf分支产生一个稳定的极限环,极限环随着同宿闭轨的产生而消失.还利用文献[13]的方法在一定的参数条件下把系统转化为一个Liénard-type系统,利用焦点的重数也可得到系统(3)存在一个稳定的极限环,同时利用数值模拟也证实了系统存在一个稳定的极限环.

关键词：捕食-食饵系统 Allee效应 Hopf分支极限环 Liénard-type系统

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Genetic Effects on Sensorineural Hearing Loss and Evidence-based Treatment for Sensorineural Hearing Loss

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Chinese Medical Sciences Journal 2015年第3期30卷 179-188页

作者： Yong-qiang yu Huai-an Yang Ming Xiao jing-wei Wang Dong-yan Huang Yagesh Bhambhani Lyn Sonnenberg Brenda Clark yuan-zhe Jin Wei-neng Fu Jie zha.g Qian yu Xue-ting Liang Ming zha.g Department of Communication Sciences and Disorders Faculty of Rehabilitation MedicineFaculty of Medicine & DentistryUniversity of Alberta Department of Otolaryngology The First Affiliated HospitalChina Medical University Department of Surgery The People’s Hospital of Liaoning Province Department of Obstetrics and Gynecology Faculty of Medicine & DentistryUniversity of Alberta Department of Otolaryngology-Head & Neck Surgery PLA General Hospital Department of Developmental Pediatrics Glenrose Rehabilitation Hospital Department of Cardiology The Fourth Affiliated HospitalChina Medical University Department of Medical Genetics China Medical University Department of Biochemistry China Medical University School of Business University of AlbertaEdmonton Department of Medical Imageology China Medical University Department of Surgery-Otolaryngology Faculty of Medicine & DentistryUniversity of Alberta Department of Audiology Glenrose Rehabilitation Hospital

In this article,the mechanism of inheritance behind inherited hearing loss and genetic susceptibilityin noise-induced hearing loss are *** treatments for sensorineural hearing loss(SNHL),*** aid and cochlear implant,are effective for some cases,but not without *** example,they provide little benefit for patients of profound SNHL or neural hearing loss,especially when the hearing loss is in poor dynamic range and with low frequency *** emphasize the most recent evidence-based treatment in this field,which includes gene therapy and allotransplantation of stem *** promising results have shown that they might be options of treatment for profound SNHL and neural hearing *** some treatments are still at the experimental stage,it is helpful to be aware of the novel therapies and endeavour to explore the feasibility of their clinical application.

关键词： inherited hearing loss inheritance noise-induced hearing loss genetic susceptibility gene therapy stem cell

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