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Promising way to address massive intragastric clotting in patients with acute upper gastrointestinal bleeding:A case report

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World Journal of Clinical Cases 2023年第15期11卷 3578-3582页

作者： Su-Xian Liu Bei Shi Ya-Feng Liu jing-yi shan Bo Sun Department of Gastroenterology Longhua Affiliated Hospital of Shanghai Traditional Chinese MedicineShanghai 210000China

BACKGROUND Massive intragastric clotting(MIC) makes endoscopic therapy difficult in patients with acute upper gastrointestinal bleeding. Literature data on how to address this problem are limited. Here, we report on a case of massive stomach bleeding with MIC that was successfully treated endoscopically using an overtube of singleballoon *** SUMMARY A 62-year-old gentleman with metastatic lung cancer was admitted to the intensive care unit due to tarry stools and hematemesis of 1500 mL of blood during hospitalization. Emergent esophagogastroduodenoscopy revealed massive blood clots and fresh blood in the stomach with evidence of active *** sites could not be observed even by changing the patient’s position and aggressive endoscope suction. The MIC was successfully removed using an overtube connected with a suction pipe, which was inserted into the stomach with an overtube of a single-balloon enteroscope. An ultrathin gastroscope was also introduced through the nose into the stomach to guide the suction. A massive blood clot was successfully removed, and an ulcer with oozing bleeding at the inferior lesser curvature of the upper gastric body was revealed, facilitating endoscopic hemostatic *** This technique appears to be a previously unreported method to suction MIC out of the stomach in patients with acute upper gastrointestinal bleeding. This technique could be considered when other methods are not available or if they fail to remove massive blood clots in the stomach.

关键词： Upper gastrointestinal bleeding Massive intragastric clotting Overtube for single-balloon enteroscope Ultrathin gastroscope Case report

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A CT Image Segmentation Algorithm Based on Level Set Method

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Chinese Journal of Biomedical Engineering(English Edition) 2006年第2期15卷 47-52页

作者： QU jing-yi SHI Hao-shan School of Electronic and Information Northwestern Polytechnical UniversityXi''an710072China School of Electronic and InformationNorthwestern Polytechnical UniversityXi''an710072China

Level Set methods are robust and efficient numerical tools for resolving curve evolution in image segmentation. This paper proposes a new image segmentation algorithm based on Mumford-Shah module. The method is used t... 详细信息

关键词： Medical image segmentation,Level set,Mumford-Shah model,Curve evolution

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Limiting current oxygen sensor based on Y,In co-doped SrTiO_(3)as a dense diffusion barrier layer

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Nano Research 2022年第6期15卷 4880-4885页

作者： Ke shan Zhongzhou yi jing Wang College of Science Honghe UniversityMengzi 661199China

A novel dense diffusion barrier material(Y_(x)Sr_(1−x)Ti_(0.9)In_(0.1)O_(3−δ)(x=0.03,0.05,0.07))was prepared by using a sol-gel *** crystal structure,microstructures,electrical conductivity and ionic conductivity of barrier material were *** results show that the samples exhibit the formation of cubic perovskite structure *** increase of Y-doping amount on A-site improved electrical conductivity and sinterability of materials.A limiting current oxygen sensor based on Y_(0.07)Sr_(0.97)Ti_(0.9)In_(0.1)O_(3–δ)as a dense diffusion barrier shows excellent sensing *** linear relationship between limiting current logIL and 1000/T can described logIL=4.603,8−3.847,5·1,000/*** 750°C,0.25%≤x(O_(2))≤5.0%,the linear relationship between limiting current(IL)and oxygen amount(x(O_(2)))can described as I_(L)=7.047,6+3.875,1·x(O_(2)).

关键词： limiting current oxygen sensor dense diffusion barrier strontium titanate mixed conductivity

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Sodium cellulose sulfate: A promising biomaterial used for microcarriers' designing

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Frontiers of Chemical Science and Engineering 2019年第1期13卷 46-58页

作者： Qing-Xi Wu yi-Xin Guan shan-jing Yao Key Laboratory of Biomass Chemical Engineering of Ministry of Education College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310027China School of Life Sciences Anhui UniversityAnhui Key Laboratory of Modem BiomanufacturingKey Laboratory of Eco-engineering and Biotechnology of Anhui ProvinceHefei 230601China

Due to a worldwide focus on sustainable materials for human health and economy services, more and more natural renewable biomass are regarded as promising materials that could replace synthetic polymers and reduce global dependence on petroleum resources. Cellulose is known as the most abundant renewable polymer in nature, varieties of cellulose-based products have been developed and have gained growing interest in recent years. In this review, a kind of water-soluble cellulose derivative, i.e., sodium cellulose sulfate (NaCS) is introduced. Details about NaCS's physicochemical properties like solubility, biocompatibility, biodegradability, degree of substitution, etc. are systematically elaborated. And promising applications of NaCS used as biomaterials for microcarriers' designing, such as microcell- carriers, micro-drug-carriers, etc., are presented.

关键词： sodium cellulose sulfate biomaterial physicochemical properties microcarriers

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Influences of Iridium and Palladium on Oxidation Resistance of PtAl Coating

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Acta Metallurgica Sinica(English Letters) 2021年第8期34卷 1120-1130页

作者： Ling-yi Qian jing Wang Yun-shan Guo He Liu Ze-Bin Bao AECC Commercial Aircraft Engine Co. LtdShanghai 201108China Shi-Changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China

The overarching goal of present study is to investigate the effects of Ir and Pd additions on the oxidation behaviour of PtAl coatings. Prior to depositing standard PtAl coating, Ir layer was electroplated by IrBr 3 aqueous solution while Pd layer was prepared using electroless deposition. Comparing with normal PtAl coating, cyclic oxidation tests were carried out on both the Ir-and Pd-modified aluminide coatings. The results showed that Ir-modified PtAl coating exhibited better oxidation resistance than both Pd-modified and normal PtAl coatings because Ir partly served as diffusion barrier to reserve Al while Pd did not.

关键词： Thermal barrier coating PtAl coating Oxidation resistance Iridium Palladium

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A microarray analysis of early activated pathways in concanavalin A-induced hepatitis

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第5期11卷 366-377页

作者： Qing-yi CAO Feng CHEN Jie LI shan-shan WU jing WANG Zhi CHEN State Key Laboratory for Diagnosis and Treatment of Infectious Diseases the First Affiliated Hospital School ofl Medicine Zhejiang University Hangzhou 310003 China

Objective:To explore the mechanisms of fulminant hepatitis(FH) in the early stages,and to determine the critical pathways in its initiation and ***:Twelve BALB/c mice were divided into four groups:one group left as negative control and sacrificed immediately after injection of phosphate-buffered saline(PBS),and another three groups with concanavalin A(Con A) administration sacrificed at 1,3,and 6 h after *** GeneChip Mouse 430 2.0 Array was employed to evaluate the expression profile of each of the 12 *** analysis was done on the microarray data to extract the genes that were differentially *** analysis was carried out to determine relevant pathways within which regulated genes were significantly ***:A total of 393,8354 and 11 344 differentially expressed genes were found,respectively,at three time *** 0-1 h and 1-3 h,most of the pathways enriched with regulated genes were related to immune response and inflammation,among which Toll-like receptor(TLR) signaling and mitogen-activated protein kinase(MAPK) signaling appeared during both phases,while cytokine-cytokine receptor interaction,apoptosis,T cell receptor signaling,and natural killer(NK) cell-mediated cytotoxicity pathways emerged during the second *** found to be significant during 3-6 h were mostly related to metabolic ***:The TLR signaling pathway dominates the early responses of Con A-induced FH in *** stimulates the production of type I cytokines,therefore recruiting and activating T/NK *** T/NK cells exert their cytotoxicity on hepatocytes through inducing death receptorintermediated apoptosis,resulting in liver injury.

关键词： Concanavalin A Fulminant hepatitis Microarray Expression profile Pathway analysis

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Proteomics Study of Benzene Metabolite Hydroquinone Induced Hematotoxicity in K562 Cells

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Biomedical and Environmental Sciences 2024年第4期37卷 341-353页

作者： JIN yi shan yi Zong Chun ZHANG Yu jing RONG Long YU Chun Hong School of Biological Science and Medical Engineering Beihang UniversityBeijing 100191China School of Engineering Medicine Beihang UniversityBeijing 100191China

Objective Hydroquinone(HQ),one of the phenolic metabolites of benzene,is widely recognized as an important participant in benzene-induced ***,there are few relevant proteomics in HQ-induced hematotoxicity and the mechanism hasn’t been fully understood *** In this study,we treated K562 cells with 40μmol/L HQ for 72 h,examined and validated protein expression changes by Label-free proteomic analysis and Parallel reaction monitoring(PRM),and performed bioinformatics analysis to identify interaction *** One hundred and eighty-seven upregulated differentially expressed proteins(DEPs)and 279 downregulated DEPs were identified in HQ-exposed K562 cells,which were involved in neutrophilmediated immunity,blood microparticle,and other GO terms,as well as the lysosome,metabolic,cell cycle,and cellular senescence-related *** on the 23 DEGs and 5 DEPs in erythroid differentiation-related pathways,we constructed the network of protein interactions and determined 6 DEPs(STAT1,STAT3,CASP3,KIT,STAT5B,and VEGFA)as main hub proteins with the most interactions,among which STATs made a central impact and may be potential biomarkers of HQ-induced *** Our work reinforced the use of proteomics and bioinformatic approaches to advance knowledge on molecular mechanisms of HQ-induced hematotoxicity at the protein level and provide a valuable basis for further clarification.

关键词： Hydroquinone Proteomics Hematotoxicity K562 cells

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Fatigue in patients with inflammatory bowel disease in Eastern China

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World Journal of Gastroenterology 2021年第11期27卷 1076-1089页

作者： shan-shan Gong yi-Hong Fan Bin Lv Mie-Qing Zhang yi Xu jing Zhao Department of Gastroenterology The Third Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310000Zhejiang ProvinceChina Department of Gastroenterology The First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310006Zhejiang ProvinceChina

BACKGROUND Fatigue is a very common but relatively neglected problem in patients with inflammatory bowel disease(IBD).The prevalence rate of IBD in China is the highest in Asia,but there is little research on fatigue in patients with *** the relationship between fatigue and quality of life(QoL)nor the relationship between fatigue and work productivity(WP)in Chinese IBD patients has been *** To investigate the prevalence of fatigue related to IBD in Eastern China,to identify the risk factors associated with fatigue,to assess the impact of fatigue on QoL,and to evaluate the relationship between fatigue and *** A cross-sectional study was conducted in a Regional Tertiary IBD Diagnostic and Treatment Center in Eastern *** data of patients were collected,and disease activity was *** samples were analyzed to assess anemia,albumin,and *** was assessed using the multidimensional fatigue *** and WP were measured using the short inflammatory bowel disease questionnaire and the work productivity and activity impairment general health questionnaire,*** patients also completed assessments of depression(Patient Health Questionnaire-9)and anxiety(Generalized Anxiety Disorder 7-item Scale).RESULTS A total of 311 IBD patients,comprising 168 Crohn's disease patients and 143 ulcerative colitis patients,were *** prevalence of fatigue in patients with IBD was 60.77%.In a univariate logistic regression analysis,factors such as disease activity,depression,anxiety,anemia,and IBD-related surgery were individually related to a significantly increased risk of fatigue in IBD *** logistic regression analysis indicated that depression[odds ratio(OR)=8.078,95%confidence interval(CI):4.113-15.865],anxiety(OR=2.373,95%CI:1.100-5.119),anemia(OR=2.498,95%CI:1.290-4.834),and IBD-related surgery(OR=2.035,95%CI:1.084-3.819)were related to fatigue in IBD *** was a negative correlat

关键词： Inflammatory bowel disease Fatigue Quality of life Work productivity Risk factors Eastern China

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Rapid preparation of size-tunable nano-TATB by microfluidics

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Defence Technology（防务技术） 2022年第7期18卷 1139-1147页

作者： Song Zhang Le-wu Zhan Guang-kai Zhu yi-yi Teng Yu shan jing Hou Li Bin-dong School of Chemical Engineering Nanjing University of Science and TechnologyNanjing 210094China

Nano-TATB was developed in microchannels by physical method and chemical method,*** effects of total flow rate,number of microreactor plates,solvent/non-solvent ratio and temperature on the particle size of TATB in the physical method were *** TATB were characterized by Nano Sizer,Scanning Electron Microscopy,Specific surface aperture analyzer,X-ray diffraction,Fourier transform infrared spectroscopy and Differential Scanning *** results show that the TATB obtained by physical method and chemical method are spherical,with average particle size of 130.66 nm and 108.51 nm,*** surface areas of TATB obtained by physical and chemical methods are 21.37 m^(2)/g and 21.91 m^(2)/g,*** with the specific surface area of micro-TATB(0.0808 m^(2)/g),the specific surface area of nano-TATB is significantly *** test results show that the smaller the particle size of TATB,the lower the thermal decomposition *** addition,by simulating the mixing state of fluid in microchannels and combining with the classical nucleation theory,the mechanism of preparing nano-TATB by microchannels was proposed.

关键词： Nano-TATB Microfluidics Energetic materials Solvent/non-solvent method Amination Simulation

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Clinical characteristics of adult-type annular pancreas:A case report

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World Journal of Clinical Cases 2020年第22期8卷 5722-5728页

作者： Dan yi Xiao-Bo Ding shan-shan Dong Chen Shao Li-jing Zhao Department of Hepatobiliary and Pancreatic Surgery First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina Department of Radiology First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina Department of Pathology Beijing You’an HospitalBeijing 100069China Department of Rehabilitation School of NursingJilin UniversityChangchun 130021Jilin ProvinceChina

BACKGROUND Annular pancreas(AP)is a rare congenital abnormal rotation of the *** rarely occurs in *** tumors and ampullary tumors are related to AP,so the discovery and treatment of AP are *** SUMMARY This study investigated the clinical manifestations,imaging features,complications,and treatment of six patients diagnosed with AP at the Department of Hepatobiliary and Pancreatic Surgery,First Hospital of Jilin University from January 2010 to June *** were four males and two females,with an average age of 56.00±9.86 years *** this study,abdominal pain and jaundice were the main clinical *** can show the“crocodile jaw sign”or“double bubble sign”.CONCLUSION For patients with duodenal or biliary obstruction,physicians should give priority to AP when imaging examinations suggest that the duodenum is wrapped with tissue similar to the density of the *** patients should actively undergo surgical treatment.

关键词： Annular pancreas Pancreas/abnormalities Congenital abnormalities Biliary obstruction Duodenal obstruction Case report

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