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Model-based risk assessment on dynamic control of twin-column continuous capture under feedstock variations

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Chinese Journal of Chemical Engineering 2024年第10期74卷 22-30页

作者： Yu fan Liang-Zhi Qiao Shan-jing yao Dong-Qiang Lin Key Laboratory of Biomass Chemical Engineering of Ministry of Education Zhejiang Key Laboratory of Smart BiomaterialsCollege of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310058China

Dynamic control is essential to guarantee the stable performance of continuous *** dynamic control strategy has been developed to ensure a consistent protein load in twincolumn CaptureSMB continuous capture by integrating the UV signal of *** this study,the process risk of CaptureSMB continuous capture under AutoMAb control towards the feedstock variations was assessed by a mechanistic model developed by *** effects of target protein and impurities under the variation range of±10 mAU·min^(-1) on load amount,protein loss,process productivity,and resin capacity utilization were *** results showed that the CaptureSMB process could be successfully controlled by AutoMAb towards increased or slightly decreased concentration of ***,the load process would be out of control with drastically decreased target protein or impurities,and the decreased impurities would lead to protein *** was found that AutoMAb control would cause 44.7%non-operational areas and 18.3%protein loss areas in the variation range of±10 mAU·min^(-1).To improve the stability of the CaptureSMB process,a modified AutoMAb control that would stop the load procedure when the absolute value of the integral area reached the preset value,was proposed to reduce the risk of protein loss and the non-operational area.

关键词： Continuous chromatography Process control Feedstock variations Mechanistic modeling Purification

Microglia lactylation in relation to central nervous system diseases

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Neural Regeneration Research 2025年第1期20卷 29-40页

作者： Hui Yang Nan Mo Le Tong Jianhong Dong Ziwei fan Mengxian Jia Juanqing Yue Ying Wang School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Clinical Laboratory The Fourth Clinical Medical College of Zhejiang University of Traditional Chinese Medicine(Hangzhou First People’s Hospital)HangzhouZhejiang ProvinceChina College of Medical Veterinary and Life SciencesUniversity of GlasgowGlasgowUK Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina

The development of neurodegenerative diseases is closely related to the disruption of central nervous system ***,as innate immune cells,play important roles in the maintenance of central nervous system homeostasis,injury response,and neurodegenerative *** has been considered a metabolic waste product,but recent studies are revealing ever more of the physiological functions of *** is an important pathway in lactate function and is involved in glycolysis-related functions,macrophage polarization,neuromodulation,and angiogenesis and has also been implicated in the development of various *** review provides an overview of the lactate metabolic and homeostatic regulatory processes involved in microglia lactylation,histone versus non-histone lactylation,and therapeutic approaches targeting ***,we summarize the current research on microglia lactylation in central nervous system diseases.A deeper understanding of the metabolic regulatory mechanisms of microglia lactylation will provide more options for the treatment of central nervous system diseases.

关键词： brain central nervous system glycolysis immune response inflammation lactate metabolism lactate lactylation microglia neurodegenerative diseases

Flexible Strain Sensors with Ultra‑High Sensitivity and Wide Range Enabled by Crack‑Modulated Electrical Pathways

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Nano-Micro Letters 2025年第3期17卷 246-264页

作者： Yunzhao Bai Yunlei Zhou Xuanyu Wu Mengfei Yin Liting Yin Shiyuan Qu fan Zhang Kan Li YongAn Huang State Key Laboratory of Intelligent Manufacturing Equipment and Technology Huazhong University of Science and TechnologyWuhan 430074People’s Republic of China Flexible Electronics Research Center Huazhong University of Science and TechnologyWuhan 430074People’s Republic of China Hangzhou Institute of Technology Xidian UniversityHangzhou 311200People’s Republic of China School of Mechano‑Electronic Engineering Xidian UniversityXi’an 710071People’s Republic of China Department of Aerospace and Mechanical Engineering University of Southern CaliforniaLos AngelesCA 90089USA

This study presents a breakthrough in flexible strain sensor technology with the development of an ultrahigh sensitivity and wide-range sensor,addressing the critical challenge of reconciling sensitivity with measurement *** by the structure of bamboo slips,we introduce a novel approach that utilises liquid metal to modulate the electrical pathways within a cracked platinum fabric *** resulting sensor demonstrates a gauge factor greater than 108 and a strain measurement capability exceeding 100%.The integration of patterned liquid metal enables customisable tuning of the sensor’s response,while the porous fabric structure ensures superior comfort and air permeability for the *** design not only optimises the sensor’s performance but also enhances the electrical stability that is essential for practical *** systematic investigation,we reveal the intrinsic mechanisms governing the sensor’s response,offering valuable insights for the design of wearable strain *** sensor’s exceptional performance across a spectrum of applications,from micro-strain to large-strain detection,highlights its potential for a wide range of real-world uses,demonstrating a significant advancement in the field of flexible electronics.

关键词： Flexible strain sensor Fabric Crack Response regulation Epidermal device

Single-cell technologies: current and near future

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Science China Life Sciences 2025年第01期 1-4页

作者： Chenfei Wang Qi Liu Xiaohui fan Tieliu Shi Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration Ministry of EducationOrthopedics DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Key Laboratory of Advanced Theory and Application in Statistics and Data Science (MOE) School of StatisticsEast China Normal University

Single-cell technologies enable the indepth exploration of multiple biological hierarchies at the scale of individual cells,which have deepened our knowledge of cellular diversity, tissue organization, and overall organism function(Sun et al.,2024). In 2009, single-cell RNA sequencing(sc RNA-seq) was first developed as a powerful tool to dissect gene expression and uncover transcriptional *** the rapid advancement of technology, single-cell approaches have expanded to encompass other omics, such as genomics, epigenomics, proteomics,and metabolomics.

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Stability and Stabilization of Sampled-Data Based LFC for Power Systems:A Data-Driven Method

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IEEE/CAA Journal of Automatica Sinica 2025年第1期 291-293页

作者： Yu-Long fan Chuan-Ke Zhang Yong He the School of Automation China University of Geosciences the Hubei Key Laboratory of Advanced Control and Intelligent Automation for Complex Systems the Engineering Research Center of Intelligent Technology for Geo-Exploration Ministry of Education IEEE

Dear Editor,This letter is concerned with stability analysis and stabilization design for sampled-data based load frequency control(LFC) systems via a data-driven method. By describing the dynamic behavior of LFC systems based on a data-based representation, a stability criterion is derived to obtain the admissible maximum sampling interval(MSI) for a given controller and a design condition of the PI-type controller is further developed to meet the required MSI. Finally, the effectiveness of the proposed methods is verified by a case study.

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多无人机协同规划研究综述

计算机工程与应用 2025年第1期61卷 42-58页

作者：宁聪范菁孙书魁云南民族大学电气信息工程学院昆明650500 云南民族大学云南省高校信息与通信安全灾备重点实验室昆明650500 云南民族大学云南省无人自主系统重点实验室昆明650500

无人机在各行各业中发挥重要作用,多无人机之间的合作已成为研究热点。针对任务分配与路径规划两个核心问题,整理和分析了多无人机协同规划两个关键问题之间的复杂性,以及子问题间的信息耦合因素,并重点探讨了解耦策略;从数学模型方面... 详细信息

无人机在各行各业中发挥重要作用,多无人机之间的合作已成为研究热点。针对任务分配与路径规划两个核心问题,整理和分析了多无人机协同规划两个关键问题之间的复杂性,以及子问题间的信息耦合因素,并重点探讨了解耦策略;从数学模型方面对多无人机协同规划问题的通用模型进行描述,整理归纳出常见环境建模方法和多目标优化求解的约束条件;综述了基于集中式控制和分布式控制的任务规划方法,以及启发式算法在多无人机协同规划中的应用和研究进展,并重点介绍了多无人机协同规划问题面临实时性要求下的协同规划方法;结合典型研究,讨论了多无人机协同规划问题的未来研究方法与挑战,展望多无人机协同规划的发展。

关键词：无人机解耦策略智能算法任务分配路径规划

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Skeletal muscle-specific Bambi deletion induces hypertrophy and oxidative switching coupling with adipocyte thermogenesis against metabolic disorders

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Science China Life Sciences 2025年

作者： Xiangping yao Xudong Mai Ye Tian Yifan Liu Guanghui Jin Ze Li Shujie Chen Xiaoshuang Dai Liujing Huang Zijing fan Guihua Pan Xiaohan Pan Xiangmin Li Michael C Yu Jia Sun jingxing Ou Hong Chen Liwei Xie College of Life and Health Sciences Guangdong Industry Polytechnic Department of Endocrinology and Metabolism Zhujiang Hospital Southern Medical University State Key Laboratory of Applied Microbiology Southern China Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application Guangdong Open Laboratory of Applied MicrobiologyInstitute of Microbiology Guangdong Academy of Sciences Institute of Aging Research Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics School of Medical Technology Guangdong Medical University Department of Hepatic Surgery and Liver transplantation Center of the Third Affiliated Hospital Organ Transplantation Institute Sun Yat-sen University Organ Transplantation Research Center of Guangdong ProvinceGuangdong province engineering laboratory for transplantation medicine Guangdong Provincial Key Laboratory of Liver Disease Research School of Public Health Xinxiang Medical University BGI Institute of Applied Agriculture BGI-Shenzhen Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic University Department of Biological Sciences State University of New York at Buffalo Department of Internal Medicine Shunde Women and Children's Hospital (Maternity and Child Healthcare Hospital of Shunde Foshan) Guangdong Medical University

Skeletal muscle plays a significant role in both local and systemic energy metabolism. The current investigation aims to explore the role of the Bambi gene in skeletal muscle, focusing on its implications for muscle hypertrophy and systemic metabolism. We hypothesize that skeletal muscle-specific deletion of Bambi induces muscle hypertrophy, improves metabolic performance, and activates thermogenic adipocytes via the reprogramming of progenitor of i WAT, offering potential therapeutic strategies for metabolic syndromes. Leveraging the Chromatin immunoprecipitation(ChIP)-seq and bioinformatics analysis, Bambi gene is shown to be a direct target of HIF2α, which is further confirmed by ChIP-qPCR and promoter luciferase assay. Skeletal muscle-specific Bambi deletion led to significant muscle hypertrophy and improved metabolic parameters, even under high-fat diet conditions. This deletion induced metabolic reprogramming of stromal vascular fractions(SVFs) into thermogenic adipocytes, contributing to systemic metabolic improvements, potentially through the secretory ***, mice with skeletal muscle-specific Bambi deletion demonstrate resistance to high-fat diet-induced metabolic disorders, highlighting a potential therapeutic pathway for metabolic syndrome management. Thus, skeletal muscle-specific deletion of Bambi triggers muscle growth, enhances metabolic performance, and activates thermogenic adipocytes. These findings suggest Bambi as a novel therapeutic target for metabolic syndromes, providing new insights into the interaction between muscle hypertrophy and systemic metabolic improvement. The study underscores the potential of manipulating muscle physiology to regulate whole-body metabolism, offering a novel perspective on treating metabolic disorders.

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卒中后失语语言和非语言认知功能相关的静息态功能磁共振成像研究

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中国卒中杂志 2021年第3期16卷 251-258页

作者：姚婧璠徐成陈红燕王铄张玉梅国家神经系统疾病临床医学研究中心首都医科大学附属北京天坛医院神经病学中心北京100070 首都医科大学附属北京天坛医院影像科首都医科大学附属北京天坛医院神经精神医学与临床心理科首都医科大学附属北京天坛医院康复医学科

目的本研究拟借助静息态功能磁共振成像(resting-state functional magnetic resonance imaging,rsfMRI),探讨卒中后失语(post-stroke aphasia,PSA)患者语言及非语言认知功能特征及其相关的脑功能变化情况。方法选择2019年3月-2020年1月连续就诊于首都医科大学附属北京天坛医院的PSA患者作为病例组,筛选年龄、性别、受教育程度相匹配的健康志愿者作为健康对照(healthy controls,HCs)组。应用西方失语成套测验(western aphasia battery,WAB)及洛文斯顿作业疗法认知评定(Loewenstein occupational therapy cognitive assessment,LOTCA)评估语言及非语言认知功能。应用rs-fMRI采集低频振幅(amplitude of low frequency fluctuation,ALFF)及功能连接密度(functional connectivity density,FCD)等参数。比较两组影像学参数,并将其与WAB及LOTCA评分进行Pearson相关分析。结果本研究纳入16例PSA患者及17例HCs。与HCs组比较,PSA组双侧海马、海马旁回、颞下回等区域ALFF值升高,左侧额下回岛盖部、岛叶等部位ALFF值降低;右侧海马、海马旁回的FCD值升高,左侧顶下回、枕上回、枕中回、楔前叶等脑区FCD值降低。ALFF值与WAB及LOTCA评分的相关性分析显示,左侧额下回岛盖部的ALFF值与WAB-失语商及流畅度得分呈正比(r=0.693,P=0.026;r=0.662,P=0.037);左侧额下回岛盖部的ALFF值与LOTCA定向得分呈正比(r=0.642,P=0.045),左侧海马的ALFF值与LOTCA注意力及专注力评分呈正比(r=0.706,P=0.022)。结论PSA患者合并部分脑区局部自发活动的强度变化及脑区间的连通性改变,这些改变与PSA患者语言障碍和非语言认知功能障碍密切相关,这些影像学改变可以作为PSA重要影像学标记。

关键词：卒中后失语语言障碍非语言认知功能障碍静息态功能磁共振成像

Patient-Specific Echo-Based Fluid-Structure Interaction Modeling Study of Blood Flow in the Left Ventricle with Infarction and Hypertension

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Computer Modeling in Engineering & Sciences 2018年第2期114卷 221-237页

作者： Longling fan jing yao Chun Yang Di Xu Dalin Tang Department of Mathematics Southeast UniversityNanjing210096China Department of Cardiology First Affiliated Hospital of Nanjing Medical UniversityNanjing210029China Network Technology Research Institute China United Network Communications Co.Ltd.Beijing100048China Mathematical Sciences Department Worcester Polytechnic Institute100 Institute RoadWorcesterMA 01609USA

Understanding cardiac blood flow behaviors is of importance for cardiovascular research and clinical assessment of ventricle ***-specific Echo-based left ventricle(LV)fluid-structure interaction(FSI)models were introduced to perform ventricle mechanical analysis,investigate flow behaviors,and evaluate the impact of myocardial infarction(MI)and hypertension on blood flow in the *** image data were acquired from 3 patients with consent obtained:one healthy volunteer(P1),one hypertension patient(P2),and one patient who had an inferior and posterior myocardial infarction(P3).The nonlinear Mooney-Rivlin model was used for ventricle tissue with material parameter values chosen to match echo-measure LV volume *** the healthy case as baseline,LV with MI had lower peak flow velocity(30%lower at beginejection)and hypertension LV had higher peak flow velocity(16%higher at begin-filling).The vortex area(defined as the area with vorticity>0)for P3 was 19%smaller than that of *** vortex area for P2 was 12%smaller than that of *** peak of filling,the maximum flow shear stress(FSS)for P2 and P3 were 390%higher and 63%lower than that of P1,***,LV stress and strain of P2 were 41%and 15%higher than those of P1,*** stress and strain of P3 were 36%and 42%lower than those of P1,*** conclusion,FSI models could provide both flow and structural stress/strain information which would serve as the base for further cardiovascular investigations related to disease initiation,progression,and treatment strategy ***-scale studies are needed to validate our findings.

关键词： Fluid-structure interaction model ventricle flow fluid dynamic ventricle material properties ventricle mechanics