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Insect Science 2008年第3期15卷 209-216页

作者： Chuan-Wang Cao jing zhang xi-Wu Gao Pei Liang Hui-Lin Guo Department of Entomology China Agricultural University Beijing China

Extensive use of insecticides on cotton has prompted resistance development in the cotton aphid, Aphis gossypii （Glover） in China, A deltamethrin-selected population of cotton aphids from xinjiang Uygur Autonomous Region, China with 228,59-fold higher resistance to deltamethrin was used to examine how carboxylesterase conferred resistance to this pyrethroid insecticide. The carboxylesterase activity in the deltamethrin-resistant strain was 3.67-, 2,02- and 1.16-fold of the susceptible strain when using α-naphthyl acetate （α-NA）, β-naphthyl acetate （β-NA） and α-naphthyl butyrate （α-NB） as substrates, respectively, Carboxylesterase cDNA was cloned and sequenced from both deltamethrinresistant and susceptible strains. The cDNA contained 1581 bp open reading frames （ORFs） coding a 526 amino acid protein. Only one amino acid substitution （Val^87-Ala） was observed between deltamethrin-resistant and susceptible strains but it is not genetically linked to resistance by the catalytic triad and signature motif analysis. The real-time polymerase chain reaction analysis indicated that the resistant strain had a 6.61-fold higher level of carboxylesterase mRNA than the susceptible strain. The results revealed that up-regulation of the carboxylesterase gene, not modified gene structure, may be responsible for the development of resistance in cotton aphids to deltamethrin.

关键词： Aphis gossypii (Glover) carboxylesterase deltamethrin resistance genesequence mRNA expression

First total synthesis of 10α-hydroxy-4-muurolen-3-one and its C_(10)-isomer

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Chinese Chemical Letters 2008年第11期19卷 1265-1267页

作者： Fu Qiang Bi Li jing Fang Chen xi zhang Yu Lin Li State Key Laboratory of Applied Organic Chemistry and Institute of Organic Chemistry Lanzhou University Lanzhou 730000 China

An efficient synthetic route to muurolane type sesquiterpenes starting from （R）-carvone, employing allylic diazene rearrangement and the ring closing methesis （RCM） reaction as key steps, is described. The first asymmetric total synthesis of （-）-10α- hydroxy-4-muurolen-3-one 11 and （-）-10β-hydroxy-4-muurolen-3-one C was accomplished. Through the total synthesis, the absolute configurations of the natural products A, B and C were established.

关键词： 10α-Hydroxy-4-muurolen-3-one 10β-Hydroxy-4-muurolen-3-one Allylic diazene rearrangement RCM reaction Total synthesis

Belching,regurgitation,chest tightness and dyspnea:Not gastroesophageal reflux disease but asthma

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World Journal of Gastroenterology 2015年第5期21卷 1680-1683页

作者： jing-xi zhang xian-Bao Zhan Chong Bai Qiang Li Department of Respiratory diseases Changhai Hospitalthe Second Military Medical University Department of Gastroenterology Changhai Hospitalthe Second Military Medical University

Belching is a common symptom of gastroesophageal reflux *** the symptoms are not relieved after anti-reflux treatment,another etiology should be ***,we report a case of a 43-yearold man who presented with belching,regurgitation,chest tightness and dyspnea for 18 mo,which became gradually more *** examination suggested superficial ***-four-houresophageal pH monitoring showed that the Demeester score was 11.4,in the normal ***-resolution manometry showed that integrated relaxation pressure and intrabolus pressure were higher than normal(20 mm Hg and 22.4 mm Hg,respectively),indicating gastroesophageal junction outflow tract *** function test showed severe obstructive ventilation dysfunction [forced expiratory volume in 1 second(FEV1)/forced vital capacity 32%,FEV1 was 1.21 L,occupying 35% predicted value after salbuterol inhalation],and positive bronchial dilation test(△FEV1 260 m L,△FEV1% 27%).Skin prick test showed Dermatophagoides farinae(++),house dust mite(++++),and shrimp protein(++).Fractional exhaled nitric oxide measurement was 76 *** the symptoms were alleviated completely and pulmonary function increased after combination therapy with corticosteroids and long-acting β*** asthma was eventually diagnosed by laboratory tests and the effect of anti-asthmatic treatment,therefore,physicians,especially the Gastrointestinal physicians,should pay attention to the belching symptoms of asthma.

关键词： Asthma Gastroesophageal reflux disease

Evidences for vagus nerve in-maintenance of immune balance and transmission of immune information from gut to brain in STM-infected rats

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World Journal of Gastroenterology 2002年第3期8卷 540-545页

作者： xi Wang Bai-Ren Wang Zhen Xu Yu-Qiang Ding Gong Ju,Institute of Neuroscience,Fourth Military Medical University,xi’an 710032,Shaanxi Province,China xi-jing zhang,Department of Anesthesiology,xi jing Hospital,Fourth Military Medical University,xi’an 710032,Shaanxi Province,China Institute of Neurosciences The Fourth Military Medical University Xi'an Shaanxi Province China.

AIM：To determine whether salmonella Typhimurium(STM) in gastrointestinal tract can induce the functional activation of brain,whether the vagus nerve involves in signaling immune infomation from gastrointestinal tract to brain and how it influences the immune function under natural infection ***:Animal model of gastrointestinal tract infection in the rat was established by an intuation of Salmonella Typhimurium(STM) into stomach to minic the condition of natural bacteria infection,Subdiagphragmatic vagotomy was performed in some of the animals 28 days before infection The changes of Fos expression visualized with immunohistochemistry technique in hypothalamic paraventricular nucleus(pVN) and superaoptic nuclesu (SON)were ***,the percentage and the Mean Intensities of Flurescent (MIFs)of CD4+ and CD8+ T cells in peripheral blood were measured by using flow cytometry(FCM),and the pathological changes in ileum and mesenteric lymph node were observed in HE stained ***:In bacteria-stimulated groups,inflammatory pathological changes were seen in ileum and mesenteric lymph node,The percentages of CD4+ T cells in peripheral blood were decreased from 43%±4.5%to 34%±4.9%(P<0.5)and MIFs of CD8+ T cells were also decreased from 2.9±0.39to 2.1±0.36(P<0.05)with STM *** of them proved that our STM-infection model was reliable Fos immunoreactive(Fos-ir) cells in PVN and SON incerased significantly with STM stimulation,from 189±41 to467±62(P<0.05)and from 64±21 to 282±47(P<0.05)individually,which suggested that STM in gastointestinal tract induced the functional activation of brain Subdiagphragmatic vagotomy attenuated FOs expression in PVN and SON induced by STM,from 467±62to 226±45(P<0.05)and from 282±47to 71±19(P<0.05)individually,and restored the decreased percentages of CD4+ T cells induced by STM from 34%±4.9% to original level 44%±6.0%(P<0.05).In addition,subdiagphragmatic vagotomy itself also decreased the percentages of CD

关键词：鼠伤寒沙门菌感染免疫信息传递免疫平衡迷走神经

Study of implementing the FEC on SoC FPGA for digital quench detector

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Radiation Detection Technology and Methods 2018年第1期2卷 161-168页

作者： jing-xi zhang Fu-San Chen Jian Cheng xiao-Juan Bian Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China University of Chinese Academy of Science Beijing 100049China

Purpose Generally,the front-end computer(FEC)in a digital quench detector always acts as a communication platform between front-end data acquisition system and upper monitoring *** FPGA is the optimal option for building system on *** at developing a digital quench detector with higher integration degree,lower cost and stronger portability that meets the needs of different kinds of superconducting magnets,it is essential to develop a universal FEC based on SoC *** The development platform is Cyclone V SX SoC FPGA development board which has a FPGA integrated with an ARM *** hardware architecture of the FEC is built by using IP cores and developing custom function *** the other hand,the software design mainly consists of transplanting the embedded Linux and developing essential application program for communicating *** The main function of FEC is reading quench detection data and transferring it to upper monitor computer through Ethernet;the test results indicate that the system design is reasonable and the function is *** The implementing of FEC on SoC FPGA has set a proper platform for upgrading to support more function for digital quench detection,and it is feasible to integrate more discrete devices onto one piece of SoC FPGA.

关键词： SoC FPGA FEC ARM Embedded Linux Digital quench detector

Study on Numerical Simulation of Initial Residual Stress and Its Release of Typical Welded Joints in Large Underwater Ships

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Study on Numerical Simulation of Initial Residual Stress and...

Chinese expert consensus on the diagnosis and treatment of severely and critically ill patients with coronavirus disease 2019

中国造船工程学会船舶力学学术委员会测试技术学组2021年学术会议

作者： jing-xi zhang Jiangsu University of science and technology

Submergence and buoyancy may cause fatigue damage to cone-cylinder pressure structure(CCPS) in large underwater ships. Large underwater ships is usually constructed with high-strength steel, which is prone to generate large welding residual stress. The residual stress of CCPS in large underwater ships may be released differently under external load, which would have an impact on the fatigue strength and safety assessment of CCPS. Therefore, it is necessary to study the effects of residual stress and its release on fatigue strength of CCPS typical welded joints of in large underwater ships. In this paper, the CCPS typical welded joints in large underwater ships were taken as the research object. The welding residual stress was studied by means of numerical simulation based on the thermal elastic-plastic theory. The results show that the residual stress near the welding seam would be released greatly under external load. Moreover, the closer it is to the weld seam, the more residual tensile stress is released.

关键词： residual stress elease one-cylinder pressure structure typical welded joint

来源： cnki会议评论

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Chinese Medical Journal 2020年第24期133卷 2963-2965页

作者： Tong-Wen Sun xi-jing zhang Zhui Yu You Shang General Intensive Care Unit The First Affiliated Hospital of Zhengzhou UniversityHenan Key Laboratory of Critical Care MedicineZhengzhou Key Laboratory of SepsisHenan Engineering Research Center for Critical Care MedicineZhengzhouHenan 450052China Intensive Care Unit The First Affiliated Hospital of Air Force Military Medical UniversityXi’anShaanxi 710032China Department of Critical Care Medicine Renmin Hospital of Wuhan UniversityWuhanHubei 430060China Department of Critical Care Medicine Union Hospital Affiliated to Huazhong University of Science and TechnologyWuhanHubei 430022China

The coronavirus disease 2019(COVID-19)threatens the health of humans worldwide,and at the time of this writing,there is no specifically targeted effective drug for *** major initial symptoms of patients with COVID-19 are fever,dry cough,and fatigue,although some patients mainly experience vomiting,diarrhea,and other gastrointestinal *** severe symptoms,namely chest tightness,dyspnea,and respiratory distress,usually appear one week later,with some patients rapidly developing acute respiratory distress syndrome(ARDS),septic shock,and possibly even death.A retrospective study of critically ill patients with COVID-19 has recently reported that 67.3%of patients presented with ARDS,28.9%with acute kidney injury,23.1%with heart injury,and 28.9%with abnormality in liver *** addition,the 28-day mortality rate was up to 61.5%.[1]

关键词： patients distress diagnosis

Structural Analysis and Physicochemical Properties of the Collagen Sponge

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Chinese Journal of Biomedical Engineering(English Edition) 2003年第3期12卷 126-132页

作者： WU Ji-min, GUAN jing, zhang xi-zheng, LI Rui-xin, GUO Yong

This paper summed up experimental data for the structural analyses and properties of collagen sponge to be used as wound dressing or scaffolds of cell growth in tissue engineering. The structural analyses included UV spectrum, amino acid and electrophoresis, while the physicochemical properties were bulk density, water-binding capacity, digestibility and residue on ignition. The structural analysis showed that the collagen sponge made from bovine tendon was purely composed of type Ⅰ collagen, and contained many aggregated compositions with high molecular mass owing to the storage under ambient condition. The bulk density of the collagen sponge was between 18 and 21 mg/cm 3, water-binding capacity from 44 to 53 mg/mg, digestive time about half an hour and residue on ignition between 0.42% and 0.45%.

关键词： TypeⅠcollagen Physicochemical properties Structural analysis

传统图书馆向数字图书馆转型过程中的版权问题

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上海交通大学学报 2003年第S1期37卷 255-257页

作者：张静张西亚西安交通大学图书馆西安710049

在传统图书馆向数字图书馆转型的过程中 ,数字图书馆的服务模式和功能发生了前所未有的变化 ,如何解决好版权问题是关系到数字图书馆可持续发展的重要问题 ,在转型阶段应当具体问题具体分析 ,综合运用合理使用、法定许可、授权许可等原... 详细信息

在传统图书馆向数字图书馆转型的过程中 ,数字图书馆的服务模式和功能发生了前所未有的变化 ,如何解决好版权问题是关系到数字图书馆可持续发展的重要问题 ,在转型阶段应当具体问题具体分析 ,综合运用合理使用、法定许可、授权许可等原则解决不同的版权问题 ,在版权人、数字图书馆、用户之间建立新的利益平衡关系 ,充分发挥数字图书馆作为超大规模信息资源中心的功能。

关键词：数字图书馆版权保护资源共享

Persistent papules with adult-onset Still's disease:a case report

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International Journal of Dermatology and Venereology 2019年第1期2卷 53-55页

作者： Na-Na Zheng xiao-xiao Yang jing-xi zhang Lian-Sheng Zhong Department of Dermatology Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu 221002China

Introduction Adult-onset Still's disease (AOSD) is a systemic infl ammatory disease with unknown *** is classically characterized by a high spiking fever,evanescent rash,liver dysfunction,leukocytosis with neutrophilia,generalized lymphadenopathy,and *** typical skin rash of AOSD is evanescent,appearing and disappearing along with the rise and fall of the ***,recent reports have highlighted atypical rashes associated with AOSD,such as persistent pruritic plaques and *** herein report a case of AOSD with persistent pruritic papules on the chest in a 47-year-old woman,who was suspected of septicemia and lymphoma for more than 3 weeks before diagnosis confirmed.

关键词： disappearing diagnosis neutrophilia