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Interaction models of CYP1A1, GSTMl polymorphisms and tobacco smoking in intestinal gastric cancer

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World Journal of Gastroenterology 2005年第38期11卷 6056-6060页

作者： jing Shen run-Tian wang Yao-Chu Xu Li-Wei wang Xin-ru wang Department of Epidemiology and Biostatistics School of Public Health Nanjing Medical University Nanjing 210029 Jiangsu Province China Department of Environmental Health Sciences Mailman School of Public Health Columbia University New York NY 10032USA Department of Epidemiology and Biostatistics School of Public Health Peking University Beijing 100083China Yang Zhong Cancer Research Institute Yang Zhong City Municipal Hospital Yang Zhong 212200 China

AIM： To explore the interaction models of the cytochrome P-450 （CYP） 1A1 Valvariant and glutathione S-transferase （GST） M1 null polymorphisms with tobacco smoking in the occurrence of intestinal gastric cancer. METHODS： A community-based case-control study was conducted in Yangzhong. Subjects included 114 intestinal types of gastric cancer with endoscopic and pathological diagnosis during January 1997 and December 1998, and 693 controls selected from their spouse, siblings or siblingsin-law who had no history of digestive system cancer. Logistic regression was used to estimate the interaction models. RESULTS： The frequency of the CYPIA1 Valvariant allele in cases did not differ from that in controls. The OR of GSTM1 null genotype was 2.0 （95% confidence interval [95%CI]： 1.2-3.1, P〈0.01）. It showed a significant type 2 form of interaction model when both CYPIA1 Valvariant allele and former tobacco smoking existed （i.e., among the multiplicative effects, the disease risk is increased by the tobacco exposure alone but not by the CYPIA1 variant alone）. The interaction index y was 2.8, and OReg （95%CI） was 5.0 （1.9-13.4）. GSTM1 null genctype and former tobacco smoking were significant in a type 4 interaction model （i.e., the disease risk is increased by GSTM1 null genotype or tobacco exposure alone among the multiplicative effects）. The interaction index y and OReg （95%CI） were 3.4 and 8.4 （3.4-20.9）, respectively.CONCLUSION： Different interaction models of CYPIA1 Valvariant allele and GSTM1 null genotype with tobacco smoking will contribute to understanding carcinogenic mechanism, but there is a need to further investigate in larger scale studies.

关键词： Interaction models CYP1A1 GSTM1 Tobacco smoking Intestinal gastric cancer

Red light at intensities above 10lx alters sleep–wake behavior in mice

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Light(Science & Applications) 2016年第1期5卷 150-159页

作者： Ze Zhang Hui-jing wang Dian-ru wang Wei-Min Qu Zhi-Li Huang Institutes of Brain Science and Collaborative Innovation Center for Brain Science Department of PharmacologySchool of Basic Medical SciencesState Key Laboratory of Medical Neurobiology and Shanghai Key Laboratory of Clinical Geriatric MedicineShanghai Medical CollegeFudan UniversityShanghai 200032China

Sleep is regulated by two mechanisms:the homeostatic process and the circadian *** affects sleep and alertness by entraining the circadian clock,and acutely inducing sleep/alertness,in a manner mediated by intrinsically photosensitive retinal ganglion *** intrinsically photosensitive retinal ganglion cells are believed to be minimally sensitive to red light,which is widely used for illumination to reduce the photic disturbance to nocturnal animals during the dark ***,the appropriate intensity of the red light is *** the present study,we recorded electroencephalograms and electromyograms of freely moving mice to investigate the effects of red light emitted by light-emitting diodes at different intensities and for different durations on the sleep–wake behavior of *** light was used as a ***,red light exerted potent sleep-inducing effects and changed the sleep architecture in terms of the duration and number of sleep episodes,the stage transition,and the EEG power density when the intensity was 420 ***,we lowered the light intensity and demonstrated that red light at or below 10 lx did not affect sleep–wake *** light markedly induced sleep and disrupted sleep architecture even at an intensity as low as 10 *** findings highlight the importance of limiting the intensity of red light(⩽10 lx)to avoid optical influence in nocturnal behavioral experiments,particularly in the field of sleep and circadian research.

关键词： circadian light light-emitting diode masking

C^1 natural element method for strain gradient linear elasticity and its application to microstructures

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Acta Mechanica Sinica 2012年第1期28卷 91-103页

作者： Zhi-Feng Nie Shen-Jie Zhou ru-Jun Han Lin-jing Xiao Kai wang College of Mechanical and Electronic Engineering Shandong University of Science and Technology266510 QingdaoChina School of Mechanical Engineering Shandong University250061 JinanChina Department of Scientific Research Shandong University of Science and Technology266510 QingdaoChina Jinan Vocational and Technical College in Engineering 250200 JinanChina

C^1 natural element method （C^1 NEM） is applied to strain gradient linear elasticity, and size effects on mi crostructures are analyzed. The shape functions in C^1 NEM are built upon the natural neighbor interpolation （NNI）, with interpolation realized to nodal function and nodal gradient values, so that the essential boundary conditions （EBCs） can be imposed directly in a Galerkin scheme for partial differential equations （PDEs）. In the present paper, C^1 NEM for strain gradient linear elasticity is constructed, and sev- eral typical examples which have analytical solutions are presented to illustrate the effectiveness of the constructed method. In its application to microstructures, the size effects of bending stiffness and stress concentration factor （SCF） are studied for microspeciem and microgripper, respectively. It is observed that the size effects become rather strong when the width of spring for microgripper, the radius of circular perforation and the long axis of elliptical perforation for microspeciem come close to the material characteristic length scales. For the U-shaped notch, the size effects decline obviously with increasing notch radius, and decline mildly with increasing length of notch.

关键词： Strain gradient linear elasticity C^1 natural element method Sibson interpolation Microstructures Size effects

QoS-aware replica placement for data intensive applications

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The Journal of China Universities of Posts and Telecommunications 2013年第3期20卷 43-47页

作者： FU Xiong ZHU Xin-xin HAN jing-yu wang ru-chuan School of of Computer Nanjing University of Posts and Telecommunications

In recent years, with the rapid development of data intensive applications, data replication has become an enabling technology for the data grid to improve data availability, and reduce file transfer time and bandwidth consumption. The placement of replicas has been proven to be the most difficult problem that must be solved to realize the process of data replication. This paper addresses the quality of service （QoS） aware replica placement problem in data grid, and proposes a dynamic programming based replica placement algorithm that not only has a QoS requirement guarantee, but also can minimize the overall replication cost, including storage cost and communication cost. By simulation, experiments show that the replica placement algorithm outperforms an existing popular replica placement technique in data grid.

关键词： data grids data replication replica placement dynamic programming

Agricultural Ontology Based Feature Optimization for Agricultural Text Clustering

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Journal of Integrative Agriculture 2012年第5期11卷 752-759页

作者： SU Ya-ru wang ru-jing CHEN Peng WEI Yuan-yuan LI Chuan-xi HU Yi-min Institute of Intelligent Machines Chinese Academy of Sciences Hefei 230031 P.R.China School of Information Science and Technology University of Science and Technology of China Hefei 230026 P.R.China

Feature optimization is important to agricultural text mining. Usually, the vector space model is used to represent text documents. However, this basic approach still suffers from two drawbacks： thecurse of dimension and the lack of semantic information. In this paper, a novel ontology-based feature optimization method for agricultural text was proposed. First, terms of vector space model were mapped into concepts of agricultural ontology, which concept frequency weights are computed statistically by term frequency weights; second, weights of concept similarity were assigned to the concept features according to the structure of the agricultural ontology. By combining feature frequency weights and feature similarity weights based on the agricultural ontology, the dimensionality of feature space can be reduced drastically. Moreover, the semantic information can be incorporated into this method. The results showed that this method yields a significant improvement on agricultural text clustering by the feature optimization.

关键词： agricultural ontology feature optimization agricultural text clustering

Friction and wear properties of PM cam materials with different boron contents

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Rare Metals 2023年第12期42卷 4255-4263页

作者： rui wang Lin-Shan wang Xue-Bing Liang wang Zhang Yan-ru Mu jing-Jie Xu Li-Min wang Shao-Ming Zhang General Research Institute for Nonferrous Metals Beijing 100088China GRIPM Advanced Materials Co.Ltd Beijing 101407China Beijing Hengyuantianqiao Powder Metallurgy Co.Ltd Beijing 101407China Beijing Engineering Research Center for Metal Powder Beijing 101407China

In this study,effects of B addition on the sintering densification,microstructure,hardness,friction and wear properties of sintered Fe-2.4C-4Cr-1Mo-0.5P-0.7Si-2.5Cu(in wt%)were *** spite of the decreased sintered density,the addition of B changes the phase composition of the materials and their ***,hardness of either the matrix or the liquid solidification structure dramatically *** changes in micro structure result in higher friction coefficient and lower wear *** is observed that the addition of0.1 wt%B offers the optimum friction and wear properties with a running-in period of only 30 s and wear volume loss of 0.006 mm^(3) under the testing *** friction and wear properties are superior to those of the other two widely used cam materials,cast iron and 45 steel.

关键词： Boron addition Friction and wear property Cam material Microstructure Wear mechanism

Biological sources, paleoenvironment, and organic matter enrichment in source rocks of the Ordovician Majiagou Formation, Ordos Basin, China:Evidence from biomarkers,microfossils, and inorganic geochemical analyses

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Journal of Palaeogeography 2024年第1期13卷 92-115页

作者： jing-jing Cao Wen-Zhe Gang Shang-ru Yang State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum(Bejing)Beijing 102249China College of Geosciences China University of Petroleum(Bejing)Beijing 102249China Oil and Gas Technology Research Institute PetroChina Changqing Oifield CompanyXi'an 710018Shaanxi ProvinceChina

Carbonate deposits in the Ordovivian Majiagou Formation are significant source rocks for natural gas generation in the Ordos Basin, northwestern China. Previous studies mainly focused on the organic matter enrichment mechanism of shales rather than carbonate rocks. The biological sources and paleoenvironment of carbonate source rocks, and the main controlling factors of organic matter enrichment in the carbonate source rocks were studied in this paper in combination with evidence from biomarkers, microfossils and inorganic geochemistry analysis. The results show that four types of microfacies were identified in the Majiagou Formation, respectively as: mud flat microfacies, mud-dolomite flat microfacies, dolomite flat microfacies, and open marine microfacies. The biological sources of organic matter are chiefly planktonic algae, followed by bacteria. The mud flat and mud-dolomite flat contain a high abundance of terrigenous detrital inputs, as indicated by the high content of Al_(2)O_(3), TiO_(2), Th, and Zr. The low Sr/Cu and high Rb/Sr values reveal warm and humid paleoclimate conditions in the mud flat and mud-dolomite flat, whereas the dolomite flat and open marine were likely formed in hot and arid paleoclimate conditions. The mud flat and mud-dolomite flat deposits were characterized by high paleoproductivity of the Majiagou Formation. Low Sr/Ba values were found in the mud flat samples, indicating fresh to brackish water condition, whereas samples of other facies have a relatively high degree of salinity. Based on U_(auth), Mo_(auth), Cr_(auth), Co_(auth), δCe, and δEu values, the mud flat microfacies was formed in a suboxic and anoxic environment, whereas the mud-dolomite flat, dolomite flat and open marine microfacies were within dysoxic to oxic conditions. A model of organic matter enrichment in the Majiagou Formation is thus established. The level of terrigenous detrital inputs is the principal factor of organic matter enrichment in the Majiagou Formation,

关键词： Biological source Microfacies Trace elements Organic matter Majiagou Formation Ordos Basin

Influence of cerium treatment on inclusion modification and as-cast microstructure of high-strength low-alloy steel

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Journal of Iron and Steel Research International 2022年第10期29卷 1659-1668页

作者： ru-ming Geng jing Li Cheng-bin Shi State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing100083China

The influence of cerium treatment on the inclusion evolution and as-cast microstructure of high-strength low-alloy steel was *** including the inclusions characteristics,element distribution,and the in situ solidification were analyzed by scanning electron microscopy,energy-dispersive spectroscopy,and high-temperature confocal laser scanning microscopy,*** results indicated that,after the addition of Ce,the Al_(2)O_(3) inclusions evolved to form Ce_(2)O_(2)S and CeAlO_(3) inclusions,which exhibited a decrease in size alongside corresponding increase in their number *** equiaxed grain ratio exhibited by the as-cast microstructure increased significantly upon the addition of Ce,while a reduction in the segregation and a corresponding increase in the homogeneity of the carbon distribution within the as-cast microstructure were also *** results of the in situ observation of the solidification suggested that the addition of Ce significantly reduced the solidification temperature range,thus reducing the carbon *** nucleation effect imparted by Al_(2)O_(3),Ce_(2)O_(2)S,and CeAlO_(3) on theδ-Fe formation was discussed in the context of the disregistry theory,which revealed that the formation of a large number of fine Ce_(2)O_(2)S inclusions promotedδ-Fe formation via heterogeneous nucleation.

关键词： Ce treatment Non-metallic inclusion As-cast microstructure In situ observation Disregistry theory

A Neurodynamical Model for Selective Visual Attention

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Chinese Physics Letters 2011年第10期28卷 24-27页

作者： QU jing-Yi wang ru-Bin ZHANG Yuan DU Ying Institute for Cognitive Neurodynamics School of Information Science and EngineeringSchool of ScienceEast China University of Science and TechnologyShanghai 200237 School of Electronics and Information Northwestern Polytechnical UniversityXi'an 710072

A neurodynamical model for selective visual attention considering orientation preference is *** orientation preference is one of the most important properties of neurons in the primary visual cortex,it should be fully considered besides external stimuli *** tuning the parameter of orientation preference,the regimes of synchronous dynamics associated with the development of the attention focus are *** attention focus is represented by those peripheral neurons that generate spikes synchronously with the central neuron while the activity of other peripheral neurons is *** dynamics correspond to the partial synchronization *** results show that the model can sequentially select objects with different orientation preferences and has a reliable shift of attention from one object to another,which are consistent with the experimental results that neurons with different orientation preferences are laid out in pinwheel patterns.

关键词： Visual visual dynamical