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Asymmetric carbonyl addition with the homochiral ketimine derived from (+) or (-)-pinanone and benzylamine

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Chinese Journal of Chemistry 1990年第6期8卷 561-567页

作者： mi Ai-Qiao CHEN Yuan-Wei WANG jing YANG Gui-Shu JIANG Yao-Zhong Chengdu Institute of Organic Chemistry Academia SinicaChengdu 610015

The carbonyl addition of the pinanone ketimine derived from (+) or (-)-2-hydroxy-pinan- 3-one and benzylamine has been studied and the optically active α,β-substituted-β-aminoethanol deriva- tives were obtained in ... 详细信息

关键词： OC pinanone and benzylamine

DYNAmiC VALUATION OF OPTIONS ON NON-TRADED ASSETS AND TRADING STRATEGIES

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Journal of Systems Science & Complexity 2013年第6期26卷 991-1001页

作者： mi Hui ZHANG Shuguang School of Mathematical Sciences Nanjing Normal University Department of Statistics and Finance University of Science and Technology of China

This paper investigates the pricing of options written on non-traded assets and trading strategies for the stock and option in an exponential utility maximization *** the assumption that the option can be continuously traded without friction just as the stock,a dynamic relationship between their optimal positions is derived by using the stochastic dynamic programming *** dynamic option pricing equations are also *** particular,the properties of the associated solutions are discussed and their explicit representations are demonstrated via the Feynman-Kac *** paper further compares the dynamic option price to the existing price notions,such as the marginal price and indifference price.

关键词： Non-traded asset option pricing portfolio selection stochastic control.

Acupuncture Regulates the Balance of CD4^+ T Cell Subtypes in Experimental Asthma mice

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Chinese Journal of Integrative Medicine 2019年第8期25卷 617-624页

作者： DONG ming WANG Wen-qian CHEN Juan LI mi-hui XU Fei CUI Jie DONG jing-cheng WEI Ying Gumei Community Health Center of min hang District Shanghai (201102)China Department of Integrative Medicine Huashan Hospital Fudan University Shanghai (200040)China Institutes of Integrative Medicine of Fudan University Shanghai (200040)China Department of Pediatric Neurological Rehabilitation Maternal and Child Health Hospital of Dengfeng Dengfeng (452470) Henan ProvinceChina

Objective: To evaluate the involvement of different CD4+ T cell subtypes in the anti-asthmatic effects of acupuncture in asthmatic mice. Methods: BALB/c mice were challenged by ovalbumin (OVA) for the establishment of experimental asthma model. mice were divided into 4 groups by a random number table including the normal control, asthma model, acupuncture and sham acupuncture groups (14 per group). Acupoints Dazhui (GV 14), bilateral Fengmen (BL 12) and Feishu (BL 13) were selected for manual acupuncture treatment every other day for 4 weeks and Huantiao (GB 30) was selected for sham acupuncture. Airway hyperresponsiveness was examined by Buxco Pulmonary System. Pulmonary histopathology analysis was performed for inflammatory cell infiltration and mucus hypersecretion by haematoxylin eosin staining and periodic acid-Schiff staining. Inflammatory mediators assays of serum were investigated by enzyme-linked immunosorbent assay and Bio-Plex. CD4+ T cell subpopulations including the expression levels of important factors in T lymphocyte polarization in lung tissue were examined by flow cytometric and Western blot analyses. Related pathways were detected by Western blot assay. Results: Compared with the OVA-induced asthma model group, acupuncture could attenuate airway hyperresponsiveness, inhibit inflammatory cell infiltration and mucus hypersecretion (P<0.05 or P<0.01). Furthermore, acupuncture increased the expressions of T-bet and Foxp3+, the cell numbers of CD4+ interferon gamma (IFN-γ)+ and CD4+ Foxp3+ in lung tissue and the level of Treg type cytokine interleukin (IL)-10 in serum (P<0.05 or P<0.01). Meanwhile, acupuncture reduced the RAR-related orphan receptor gamma t (RORγ t) level, the cell numbers of CD4+ IL-17A+ as well as the levels of IL-5, IL-13 and IL-17A in serum (P<0.05 or P<0.01). In addition, both acupuncture and sham acupuncture could inhibit the phosphorylation of p38 and p44/42 (P<0.01). Conclusion: Acupuncture could alleviate allergic airway infla

关键词： acupuncture asthma Th2 Th17 Treg

Antibacterial property,corrosion and discoloration resistance of pure copper containing Zn or Ni

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Rare Metals 2022年第12期41卷 4041-4046页

作者： Yun Jiang Wen-jing Zhang Xu-Jun mi Guo-Jie Huang Hao-Feng Xie Xue Feng Li-Jun Peng Zhen Yang State Key Laboratory of Nonferrous Metals and Processes GRINM Group Co.LtdBeijing 100088China GRIMAT Engineering Institute Co. LtdBeijing 101407China General Research Institute for Nonferrous Metals Beijing 100088China

This study focused on the effects of Zn and Ni addition on the antibacterial properties and corrosion resistance of copper *** antimicrobial properties of copper and copper alloys were evaluated using Escherichia coli... 详细信息

关键词： corrosion resistance alloys

microstructure and electrical conductivity of 10% Yb-doped SrCeO3 ceramics

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Progress in Natural Science:Materials International 2021年第5期31卷 672-678页

作者： Qinghe Yu Yumei Ren jing mi Lei Hao Hao Liu Shanshan Li Shijie Li Shuai Li miao Du min Liu GRINM Group Co. Ltd. National Engineering Research Center of Nonferrous Metals Materials and Products for New Energy GRIMAT Engineering Institute Co. Ltd. College of Material Science and Technology Liaoning Technical University

As a candidate material for hydrogen separation, Yb-doped SrCeO3has attracted increasing attention in recent decades. In the present study, Yb-doped SrCe0.9Yb0.1O3-αceramics were prepared by the dry pressing and sintering approach, with the microstructure evolution and the micro morphology investigated. It was indicated that the ceramics sintered in air were of a pure perovskite structure, and that the sintering temperature had a significant effect on the growth of ceramic grains. The average grain size increased from 1 μm to 10 μm with an increase in sintering temperature from 1300 to 1500°C. Further investigation of the thermodynamics and kinetics of grain growth revealed that the grain boundary diffusion was the main driving force of grain growth during solid phase sintering, with a grain growth index of 4 and an activation energy of approximately 61.23 kJ mol-1. These results illustrate an obvious tendency of grain size growth. By electrochemical workstation with different atmospheres the effects of sintering temperature on the conductivity were characterized in the temperature range of 700–900°C. The electrical conductivities σ of SrCe0.9Yb0.1O3-αceramics in different atmospheres were as follows:σ（wet hydrogen） > σ（dry hydrogen） > σ（dry air） > σ（wet air）. In the test atmosphere containing water and hydrogen the conductivity of protons increased with increasing temperature because of the protons jump between lattices in the form of interstitial hydrogen ions or bare protons.

关键词： SrCe 0.9 Yb 0.1 O 3-α ceramics Sintering Grain growth Kinetics Electrical conductivity Proton conductor

The molecular and cellular choreography of early mammalian lung development

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Medical Review 2024年第3期4卷 192-206页

作者： Xianfa Yang Yingying Chen Yun Yang Shiting Li Panpan mi Naihe jing Guangzhou National Laboratory No.9 XingDaoHuanBei RoadGuangzhou International Bio IslandGuangzhou 510005Guangdong ProvinceChina Guangzhou National Laboratory GuangzhouGuangdong ProvinceChina Guangzhou Medical University GuangzhouGuangdong ProvinceChina Institute of Biomedical Research Yunnan UniversityKunmingYunnan ProvinceChina Department of Histology and Embryology Zhongshan School of MedicineSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Mammalian lung development starts from a specific cluster of endodermal cells situated within the ventral foregut *** the orchestrating of delicate choreography of transcription factors,signaling pathways,and cell–cell communications,the endodermal diverticulum extends into the surrounding mesenchyme,and builds the cellular and structural basis of the complex respiratory *** review provides a comprehensive overview of the current molecular insights of mammalian lung development,with a particular focus on the early stage of lung cell fate differentiation and spatial ***,we explore the implications of several congenital respiratory diseases and the relevance to early ***,we summarize the unprecedented knowledge concerning lung cell compositions,regulatory networks as well as the promising prospect for gaining an unbiased understanding of lung development and lung malformations through stateof-the-art single-cell omics.

关键词： organogenesis embryonic pattern formation cell-to-cell interaction lung malformation single-cell analysis

Types of tolerance seen in autoreactive phosphocholine-specific B cells are dependent on the idiotype of the receptors expressed

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Cellular & Molecular Immunology 2013年第4期10卷 311-316页

作者： Qing-Sheng mi Henry Ford Immunology Program Henry Ford .Healt.h.System Detroit.MI.USA Department of Dermatology Henry Ford Health System Detroit M I USA Department of Internal Medicine Henry Ford Health System Detroit MI USA Laboratory of Immunology Gerontology Research Institute NIH Baltimore MD USA JJK was retired from Gerontology Research Institute NIH Baltimore

Phosphocholine （PC） is the immunodominant epitope found on the surface of a number of microorganisms, including Streptococcus pneumoniae （SPn）, and is thought to play a vital role in the pathogenesis of SPn. B cells expressing M 167Hκ24L immunoglobulin receptors specific for PC have been shown to be autoreactive in that they undergo clonal deletion in both X-linked immune-deficient and Rag-/- mice. We have now shown that B cells expressing M603HK8L PC-specific receptors also delete in Rag-/- mice, whereas those expressing T15HK22L transgenes do not delete. However, T15HK22L B cells are lost in normal heterozygous transgenic mice because they cannot compete with normal B cells. These data indicate that M167Hκ24L and M603H^8L PC-specific B cells are recognizing an autoantigen expressed on membranes which causes them to downregulate their receptors and clonally delete, while T15Hκ22L B cells are tolerized by a soluble form of PC-antigen which results in their being trapped in the spleen. Thus, the types of tolerance seen in autoreactive PC-specific B cells are dependent on the idiotype of the receptors expressed.

关键词： B cells idiotype phosphocholine Streptococcus pneumoniae tolerance

Synthesis, Crystal Structure and Fungicidal Activity of 2-Chloro-N-(o-tolylcarbamoyl)nicotinamide

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Chinese Journal of Structural Chemistry 2020年第3期39卷 452-458,377页

作者： mi Li-jing WANG Qiao TAN Cheng-Xia WENG Jian-Quan LIU Xing-Hai College of Life Science Huzhou UniversityHuzhouZhejiang 313000China College of Chemical Engineering Zhejiang University of TechnologyHangzhou 310014China

The title compound 2-chloro-N-(o-tolylcarbamoyl)nicotinamide(C(14)H(12)ClN3O2) was synthesized, and its structure was confirmed by ~1H NMR, H RMS and X-ray diffraction. It crystallizes in the monoclinic system, space group P21/n with a = 7.8356(7), b = 12.7949(8), c = 13.6326(10) ?, β = 91.929(7)°, V = 1365.97(18) ?~3, Z = 4, the final R = 0.0416 and wR = 0.0971 for 2467 observed reflections with I > 2σ(I). The preliminary biological test shows that the title compound has certain fungicidal activities.

关键词： synthesis crystal structure fungicidal activity

Concavity of minimal L^(2) integrals related to multiplier ideal sheaves on weakly pseudoconvex Kahler manifolds

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Science China Mathematics 2022年第5期65卷 887-932页

作者： Qi'an Guan Zhitong mi School of Mathematical Sciences Peking UniversityBeijing 100871China Institute of Mathematics Academy of Mathematics and Systems ScienceChinese Academy of SciencesBeijing 100190China

In this paper,we present the concavity of the minimal L^(2)integrals related to multiplier ideal sheaves on the weakly pseudoconvex Kahler manifolds,which implies the sharp effectiveness results of the strong openness conjecture and a conjecture posed by Demailly and Kollar(2001)on weakly pseudoconvex Kahler *** obtain the relation between the concavity and the L^(2)extension theorem.

关键词： multiplier ideal sheaf plurisubharmonic function weakly pseudoconvex Kahler manifold sublevel set