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Predictive value of intracranial high-density areas in neurological function

World Journal of Psychiatry 2024年第7期14卷 1080-1086页

作者： Zhi-Juan Lu Jin-Xing Lai jing-Ru Huang Shu-Hua Xie Zhao-hui Lai Department of Neurology Ganzhou People’s HospitalGanzhou 341000Jiangxi ProvinceChina

BACKGROUND Intracranial high-density areas(HDAs)have attracted considerable attention for predicting clinical outcomes;however,whether HDAs predict worse neurological function and mental health remains controversial and unclear,which requires further *** this prospective study,96 patients with acute ischemic stroke(AIS)who accepted endovascular mechanical thrombectomy(EMT)were *** enrolled patients underwent cranial computed tomography(CT)examination within 24 hours after *** data in terms of National Institutes of health Stroke Scale(NIHSS),the 3-month modified Rankin Scale(mRS),self-rating depression scale(SDS),and self-rating anxiety scale(SAS)scores were collected and compared between patients with HDAs and non-HDAs and between patients with good and poor clinical *** to patients without HDAs,patients with HDAs presented severe neurological deficits(admission NIHSS score:18±3 vs 19±4),were more likely to have post-stroke disabilities(mRS<3:35%vs 62%),and suffered more severe depression(SDS score:58±16 vs 64±13)and anxiety disorder(SAS score:52±8 vs 59±10).Compared to patients with a good prognosis,patients with a poor prognosis presented severe neurological deficits(admission NIHSS score:17±4 vs 20±3),were more likely to have HDAs on CT images(64%vs 33%),and suffered more severe depression(SDS score:55±19 vs 65±11)and anxiety(SAS score:50±8 vs 58±12).Multivariate analysis revealed that HDAs were independent nega-tive prognostic *** In conclusion,HDAs on CT images predicted poor prognosis and severe depressive and anxiety symptoms in patients with AIS who underwent EMT.

关键词： Acute ischemic stroke Endovascular mechanical thrombectomy High-density areas Depressive disorder Anxiety disorder

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CRL2^(APPBP2)-mediated TSPYL2 degradation counteracts human mesenchymal stem cell senescence

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Science China(Life Sciences) 2024年第3期67卷 460-474页

作者： Daoyuan Huang Qian Zhao Kuan Yang jinghui Lei Ying jing Hongyu Li Chen Zhang Shuai Ma Shuhui Sun Yusheng Cai Guibin Wang jing Qu Weiqi Zhang Si Wang Guang-hui Liu Advanced Innovation Centerfor Human Brain Protection National Clinical Research Centerfor Geriatric DisordersXuanwu Hospital Capital Medical UniversityBeijing 100053China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Aging Translational MedicineCenter International Centerfor Aging and CancerBejing Municipal GeriatricMedical Research CenterXuanwu HospitalCapital Medical UniversityBeijing 100053China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Beijing Institute for Stem Cell and Regenerative Medicine Beijing100101China CAS Key Laboratory of Genomic and Precision Medicine Bejing Institute of Genomics and China National Center for BioinformationChinese Academy of SciencesBeijing 100101China Institute for Stem Cell and Regeneration CASBeijing 100101China The Fifth People's Hospital of Chongqing Chongqing 400062China Sino-Danish Cllege University of Chinese Academy of SciencesBeijing101408China National Laboratory of Biomacromolecules CAS Center for Excelence in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing100101China State Key Laboratory of Proteomics Beijing Proteome Research CenterNational Center for Protein Sciences(Beijing)Beijing Institute of LifeomicsBeijing 102206China

Cullin-RING E3 ubiquitin ligases(CRLs),the largest family of multi-subunit E3 ubiquitin ligases in eukaryotic cells,represent core cellular machinery for executing protein degradation and maintaining ***,we asked what roles Cullin proteins play in human mesenchymal stem cell(hMSC)homeostasis and *** this end,we conducted a comparative aging phenotype analysis by individually knocking down Cullin members in three senescence models:replicative senescent hMSCs,Hutchinson-Gilford Progeria Syndrome hMSCs,and Werner syndrome *** all family members,we found that CUL2 deficiency rendered hMSCs the most susceptible to *** investigate CUL2-specific underlying mechanisms,we then applied CRISPR/Cas9-mediated gene editing technology to generate CUL2-deficient human embryonic stem cells(heSCs).When we differentiated these into h MSCs,we found that CUL2 deletion markedly accelerates hMSC ***,we identified that CUL2 targets and promotes ubiquitin proteasome-mediated degradation of TSPYL2(a known negative regulator of proliferation)through the substrate receptor protein APPBP2,which in turn downregulates one of the canonical aging marker-P21^(waf1/cip1),and thereby delays *** work provides important insights into how CRL2^(APPBP2)-mediated TSPYL2 degradation counteracts hMSC senescence,providing a molecular basis for directing intervention strategies against aging and aging-related diseases.

关键词： Cullins stem cell senescence aging proteostasis ubiquitination APPBP2 TSPYL2

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Single-nucleus transcriptomics uncovers a geroprotective role of YAP in primate gingival aging

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Protein & Cell 2024年第8期15卷 612-632页

作者： Qinchao Hu Bin Zhang Yaobin jing Shuai Ma Lei Hu jingyi Li Yandong Zheng Zijuan Xin Jianmin Peng Si Wang Bin Cheng jing Qu Weiqi zhang Guang-hui Liu Songlin Wang State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Hospital of Stomatology Guanghua School of StomatologyGuangdong Provincial Key Laboratory of StomatologySun Yat-sen UniversityGuangzhou 510060China Salivary Gland Disease Center and Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction Beijing Laboratory of Oral Health and Beijing Stomatological HospitalCapital Medical UniversityBeijing 100050China Department of Biochemistry and Molecular Biology School of Basic Medical SciencesCapital Medical UniversityBeijing 100069China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Key Laboratory of Organ Regeneration and Reconstruction Institute of ZoologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China Advanced Innovation Center for Human Brain Protection and National Clinical Research Center for Geriatric Disorders Xuanwu Hospital Capital Medical UniversityBeijing 100053China Aging Translational Medicine Center Intermational Center for Aging and CancerBeijing Municipal Geriatric Medical Research CenterXuan Wu HospitalCapital Medical UniversityBeijing 100053China Intemational Center for Aging and Cancer Hainan Medical UniversityHaikou 571199China Aging Biomarker Consortium Beijing 100101China

Aging has a profound impact on the gingiva and significantly increases its susceptibility to periodontitis,a worldwide prevalent inflammatory ***,a systematic characterization and comprehensive understanding of the regulatory mechanism underlying gingival aging is still ***,we systematically dissected the phenotypic characteristics of gingiva during aging in primates and constructed the first single-nucleus transcriptomic landscape of gingival aging,by which a panel of cell type-specific signatures were *** cells were identified as the most affected cell types by aging in the *** analyses pinpointed the crucial role of YAP in epithelial self-renew and homeostasis,which declined during aging in epithelial cells,especially in basal *** decline of YAP activity during aging was confrmed in the human gingival tissues,and downregulation of YAP in human primary gingival keratinocytes recapitulated the major phenotypic defects observed in the aged primate gingiva while overexpression of YAP showed rejuvenation *** work provides an in-depth understanding of gingival aging and serves as a rich resource for developing novel strategies to combat aging-associated gingival diseases,with the ultimate goal of advancing periodontal health and promoting healthy aging.

关键词： single-nucleus RNA-sequencing primate gingiva aging YAP

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A novel route to enhance high-temperature mechanical property and thermal shock resistance of low-carbon Mgo-C bricks by introducing ZrSiO_(4)

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Journal of Iron and Steel Research International 2024年第6期31卷 1436-1448页

作者： Chun-hui Sun Ling-ling Zhu Hao Yan Wei Zhao jing-xuan Liu Lin Ren Xian-tang Zhao Xiao-song Tong Shu-wen Yu Beijing Lirr High-Temperature Materials Co. Ltd.Beijing 102211China School of Materials Science and Engineering Henan Province Industrial Technology Research Institute of Resources and MaterialsZhengzhou UniversityZhengzhou 450001HenanChina School of Chemistry and Chemical Engineering Suzhou UniversitySuzhou 234000AnhuiChina

Conventional MgO-C bricks(graphite content>14 wt.%)produce a great deal of greenhouse gas emission,while low-carbon MgO-C bricks have serious thermal shock resistance during high-temperature *** enhance the high-temperature mechanical property and thermal shock resistance of low-carbon MgO-C bricks,a novel route of introducing ZrSiO_(4) powder into low-carbon MgO-C bricks was reported in such refractories with 2 wt.% flaky *** results indicate that the low-carbon MgO-C brick with 0.5 wt.%ZrSiO_(4) addition has the maximum hot modulus of rupture at 1400℃ and the corresponding specimen fired in the carbon embedded atmosphere has the maximum residual strength ratio(98.6%)after three thermal shock *** is found that some needle-like AlON and plate-like Al_(2)O_(3)-ZrO_(2) composites were in situ formed in the matrices after the low-carbon MgO-C bricks were coked at 1400℃,which can enhance the high-temperature mechanical property and thermal shock resistance due to the effect of fiber toughening and particle ***,CO_(2) emission of the newly developed low-carbon MgO-C bricks is reduced by 58.3% per ton steel after using them as the working lining of a 90 t vacuum oxygen decarburization ladle.

关键词： Low-carbon MgO-C brick ZrsiO_(4) Synergistic toughening effect High-temperature mechanical property Thermal shock resistance Vacuum oxygen decarburization ladle

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Eco-friendly calcium alginate microspheres enable enhanced profile control and oil displacement

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Petroleum Science 2024年第3期21卷 1928-1943页

作者： Xiao-Han Zhang Chang-jing Zhou Yuan-Xiang Xiao Bo hui Yong-Gang Xie Yu-Bin Su Xin-Ru Li Jie Huang Mao-Chang Liu International Research Center for Renewable Energy State Key Laboratory of Multiphase Flow in Power EngineeringXi'an Jiaotong UniversityXi'an710049ShaanxiPR.China Shaanxi Key Laboratory of Advanced Stimulation Technology for Oil&Gas Reservoirs School of Petroleum EngineeringXi'an Shiyou UniversityXi'an 710065ShaanxiPR.China Oil&Gas Technology Research Institute Changqing Oilfield Branch CompanyPetroChinaXi'an710021ShaanxiPR China Suzhou Academy of Xi'an Jiaotong University Suzhou215123JiangsuPR China

Polymer microspheres(PMs),such as polyacrylamide,have been widely applied for enhanced oil recovery(EOR),yet with environmental ***,we report a microfluid displacement technology containing a bio-based eco-friendly material,i.e.,calcium alginate(CaAlg)microspheres for *** dominant mechanisms responsible for EOR over Ca Alg fluid have been verified,including the microscopic oil displacement efficacy augmented by regulating capillary force(determined by the joint action of interfacial tension and wettability between different phases)and macroscopic sweep volume increment through profile control and mobility ratio *** comprehensive effectiveness can be further impacted when the CaAlg microsphere is embellished ulteriorly by using appropriate amount of sodium dodecyl sulfonate(SDS).The core flooding and nuclear magnetic resonance(NMR)tests demonstrate that CaAlg-SDS microsphere can balance the interphase property regulation(wettability alteration and IFT reduction)and rheology properties,enabling simultaneous profile control and oil *** introduction of SDS will have a negative impact on rheological properties,which is not favored for *** results show that the involvement of 4-m M SDS will provide the best behavior,with an EOR rate of 34.38%.This cost-effective and environmentally-friendly bio-microspherebased microfluidic displacement technology is expected to achieve“green”oil recovery in future oilfield exploitation.

关键词： Calcium alginate microspheres Wettability Interfacial tension Rheology Viscoelasticity Enhanced oil recovery(EOR)

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Notably Accelerated Nano-Bainite Transformation via Increasing Undissolved Carbides Content on GCr15Si1Mo Bearing Steel

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Acta Metallurgica Sinica(English Letters) 2024年第4期37卷 703-712页

作者： Yan-hui Wang Hua-Qiang Sun Wen-jing Feng Lei-Jie Zhao Xiang Chen Qing-An Chen Hai-Tao Sun Jian-Jun Wang Zhi-Nan Yang Key Laboratory of Intelligent Industrial Equipment Technology of hebei Province School of Mechanical and Equipment EngineeringHebei University of EngineeringHandan056038China Collaborative Innovation Center for Modern Equipment Manufacturing of Jinan New Area Hebei University of EngineeringHandan056038China School of Materials Science and Engineering Tsinghua UniversityBeijing100084China Avic Shang da Superalloys Company Limited Xingtai054800China National Engineering Research Center for Equipment and Technology of Cold Strip Rolling Yanshan UniversityQinhuangdao066004China

In this study, a high-carbon nano-bainitic GCr15Si1Mo bearing steel was investigated. Specifically, the effects of content and size of undissolved carbides on the microstructure and transformation kinetics of nano-bainite were analyzed. The results demonstrated that after prolonged austempering at low temperatures, the mixed microstructure composed of nano-bainite (NB), undissolved carbides (UC), and retained austenite (RA) was obtained in GCr15SiMo steel. When the experimental steel was austenitized at 900 ℃, the undissolved carbides gradually dissolved until reaching a stable state with increasing holding time. Furthermore, at the same austempering temperature, despite different volume fractions of undissolved carbides in the substrate, the volume fractions of nano-bainite in the final microstructures remained essentially the same. Moreover, the higher the content of undissolved carbides in steel, the faster the transformation rate of nano-bainite and the shorter the total transformation time.

关键词： Nano-bainite Undissolved carbides Bainitic transformation kinetics Carbon concentration

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Meta-analysis of factors influencing anterior knee pain after total knee arthroplasty

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World Journal of Orthopedics 2024年第2期15卷 180-191页

作者： hui Feng Ming-Li Feng jing-Bo Cheng Xiang Zhang Hai-Cheng Tao Department of Orthopaedic Surgery Xuanwu HospitalCapital Medical UniversityBeijing 100053China

BACKGROUND Total knee arthroplasty(TKA)is a mature procedure recommended for correcting knee osteoarthritis deformity,relieving pain,and restoring normal *** TKA is a successful and cost-effective procedure,patient dissatisfaction is as high as 50%.Knee pain after TKA is a significant cause of patient dissatisfaction;the most common location for residual pain is the anterior *** 4%and 40%of patients have anterior knee pain(AKP).AIM To investigate the effect of various TKA procedures on postoperative *** We searched PubMed,EMBASE,and Cochrane from January 2000 to September *** controlled trials with one intervention in the experimental group and no corresponding intervention(or other interventions)in the control group were *** researchers independently read the title and abstract of the studies,preliminarily screened the articles,and read the full text in detail according to the selection *** were resolved by consultation with a third *** relevant data from the included studies were extracted and analyzed using Review Manager 5.4 *** There were 25 randomized controlled trials;13 were comparative studies with or without patellar *** meta-analysis showed no significant difference between the experimental and control groups(P=0.61).Six studies were comparative studies of circumpatellar denervation vs non-denervation,divided into three subgroups for *** two-subgroup meta-analysis showed no significant difference between the experimental and the control groups(P=0.31,P=0.50).One subgroup meta-analysis showed a significant difference between the experimental and control groups(P=0.001).Two studies compared fixed-bearing TKA and mobile-bearing TKA;the results meta-analysis showed no significant difference between the experimental and control groups(P=0.630).Two studies compared lateral retinacular release vs non-release;the meta-analysis showed a signi

关键词： Total knee arthroplasty Anterior knee pain Knee osteoarthritis Interventions Meta-analysis

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Hierarchical Self-assembly of Atomically Precise Au Nanoclusters with Molecular Rotor-based Ligands

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Chemical Research in Chinese Universities 2024年第4期40卷 670-674页

作者： WANG Guanzhong LU hui LI Jiang WANG Lihua ZHU Ying SONG Shiping GE Zhilei LI Qian CheN jing FAN Chunhai Division of Physical Biology Shanghai Institute of Applied PhysicsChinese Academy of SciencesShanghai201800P.R.China University of Chinese Academy of Sciences Beijing100049P.R.China Zhangjiang Laboratory Shanghai201210P.R.China Institute of Materiobiology Department of ChemistryCollege of SciencesShanghai UniversityShanghai200444P.R.China School of Chemistry and Chemical Engineering New Cornerstone Science LaboratoryFrontiers Science Center for Transformative MoleculesZhangjiang Institute for Advanced Study and National Center for Translational MedicineShanghai Jiao Tong UniversityShanghai200240P.R.China

The hierarchical assemblies of precise nanoparticles(NPs)have created materials with emergent properties and ***,the complex assemblies remain unclear at a precise ***,we show the hierarchical self-assembly of atomically precise gold nanoclusters(Au NCs)with molecular rotor-based ligands(MRL),featuring a double-layer *** to two other types of monolayer-protected(MLP)Au NCs,the significantly reduced surface density for MRL Au NCs profoundly influences their assembly behavior within the ***,the long length of rotor-based ligands and the rotational freedom of the phenyl-rings of rotor-based ligands also facilitate the assembly of *** works elucidate the hierarchical assembly on a precise scale,suggesting that the rotor-based ligand’s strategy offers promising potential for designing well-defined and more complex structures in supercrystals.

关键词： Gold nanocluster Molecular rotor Hierarchical assembly Double-layer surface

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近30年来洞里萨湖沿岸土地覆被变化及其对水位的响应

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Journal of Geographical Sciences 2024年第2期34卷 329-354页

作者：张静马凯樊辉何大明 Yunnan Key Laboratory of International Rivers and Transboundary Eco-Security Kunming 650091China Institute of International Rivers and Eco-Security Yunnan UniversityKunming 650091China

The transboundary influence of environmental change is a critical issue in the Lancang-Mekong *** the largest river-connected lake in the lower Mekong,the ecological change and influence of Tonle Sap Lake have received widespread attention and discussion,especially after 2008,when the hydrological regime of the Lancang-Mekong River mainstream underwent distinct ***,the linkage and coupling mechanism between the lake riparian environment and mainstream water level change are still *** this study,the interannual spatiotemporal changes in land cover in the Tonle Sap Lake riparian zone(TSLRZ)and their relationship with mainstream water levels were *** results showed that the expansion of farmland was the most notable change in 1988–*** 2008,the land cover changes intensified,manifested as accelerated farmland expansion,intensified woodland fragmentation and significant water body ***,the responses of the water body,degraded land,wasteland and grassland areas to the mainstream water levels weakened after ***,the land cover changes in the TSLRZ in the last 30 years were less related to the mainstream water level change than to local reclamation and *** results can offer a new scientific basis for the transboundary influence analysis of hydrological change.

关键词： riparian zone land cover change mainstream water level change and transboundary influence Tonle Sap Lake Lancang-Mekong River

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On the evolutionary trail of MagRs

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Zoological Research 2024年第4期45卷 821-830页

作者： jing Zhang Yafei Chang Peng Zhang Yanqi Zhang Mengke Wei Chenyang Han Shun Wang hui-Meng Lu Tiantian Cai Can Xie High Magnetic Field Laboratory Hefei Institutes of Physical ScienceChinese Academy of SciencesScience IslandHefeiAnhui 230031China Science Island Branch of Graduate School University of Science and Technology of ChinaHefeiAnhui 230036China Institutes of Physical Science and Information Technology Anhui UniversityHefeiAnhui 230039China School of Life Sciences Key Laboratory for Space Bioscience and BiotechnologyNorthwestern Polytechnical UniversityXi’anShaanxi 710072China Institute of Quantum Sensing Zhejiang UniversityHangzhouZhejiang 310027China

Magnetic sense,or termed magnetoreception,has evolved in a broad range of taxa within the animal kingdom to facilitate orientation and ***,highly conserved A-type iron-sulfur proteins,are widely distributed across all phyla and play essential roles in both magnetoreception and iron-sulfur cluster ***,the evolutionary origins and functional diversification of MagRs from their prokaryotic ancestor remain *** this study,MagR sequences from 131 species,ranging from bacteria to humans,were selected for analysis,with 23 representative sequences covering species from prokaryotes to Mollusca,Arthropoda,Osteichthyes,Reptilia,Aves,and mammals chosen for protein expression and *** studies revealed a gradual increase in total iron content in MagRs during *** types of MagRs were identified,each with distinct iron and/or iron-sulfur cluster binding capacity and protein stability,indicating continuous expansion of the functional roles of MagRs during speciation and *** evolutionary biochemical study provides valuable insights into how evolution shapes the physical and chemical properties of biological molecules such as MagRs and how these properties influence the evolutionary trajectories of MagRs.

关键词： Magnetoreception Magnetoreceptor(MagR) Iron-sulfur cluster Stability Evolutionary biochemistry

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