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Constrained clustering with weak label prior

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Frontiers of Computer Science 2024年第3期18卷 117-132页

作者： jing ZHANG Ruidong FAN Hong TAO Jiacheng JIANG Chenping hou College of Sciences National University of Defense TechnologyChangsha 410073China

Clustering is widely exploited in data *** has been proved that embedding weak label prior into clustering is effective to promote its *** researches mainly focus on only one type of ***,in many real scenarios,two kinds of weak label prior information,e.g.,pairwise constraints and cluster ratio,are easily obtained or already *** to incorporate them to improve clustering performance is important but rarely *** propose a novel constrained Clustering with Weak Label Prior method(CWLP),which is an integrated *** the unified spectral clustering model,the pairwise constraints are employed as a regularizer in spectral embedding and label proportion is added as a constraint in spectral *** approximate a variant of the embedding matrix more precisely,we replace a cluster indicator matrix with its scaled *** of fixing an initial similarity matrix,we propose a new similarity matrix that is more suitable for deriving clustering *** for the theoretical convergence and computational complexity analyses,we validate the effectiveness of CWLP through several benchmark datasets,together with its ability to discriminate suspected breast cancer patients from healthy *** experimental evaluation illustrates the superiority of our proposed approach.

关键词： clustering weak label prior cluster ratio pairwise constraints

Biochanin A attenuates spinal cord injury in rats during early stages by inhibiting oxidative stress and inflammasome activation

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Neural Regeneration Research 2024年第9期19卷 2050-2056页

作者： Xigong Li jing Fu Ming Guan Haifei Shi Wenming Pan Xianfeng lou Department of Orthopedics The First Affiliated Hospital of Zhejiang UniversityHangzhouZhejiang ProvinceChina Department of Stomatology Xixi HospitalHangzhouZhejiang ProvinceChina Department of Orthopedics and Spine Surgerythe Affiliated Hospital of Xuzhou Medical Schoolthe Second People’s Hospital of ChangshuChangshuJiangsu ProvinceChina

Previous studies have shown that Biochanin A,a flavonoid compound with estrogenic effects,can serve as a neuroprotective agent in the context of cerebral ischemia/reperfusion injury;howeve r,its effect on spinal cord injury is still unclea r. In this study,a rat model of spinal cord injury was established using the heavy o bject impact method,and the rats were then treated with Biochanin A(40 mg/kg) via intrape ritoneal injection for 14 consecutive *** res ults showed that Biochanin A effectively alleviated spinal cord neuronal injury and spinal co rd tissue injury,reduced inflammation and oxidative stress in spinal cord neuro ns,and reduced apoptosis and *** addition,Biochanin A inhibited the expression of inflammasome-related proteins(ASC,NLRP3,and GSDMD)and the Toll-like receptor 4/nuclear factor-κB pathway,activated the Nrf2/heme oxygenase 1 signaling pathway,and increased the expression of the autophagy markers LC3 Ⅱ,Beclin-1,and *** r,the therapeutic effects of Biochanin A on early post-s pinal cord injury were similar to those of *** findings suggest that Biochanin A protected neurons in the injured spinal cord through the Toll-like receptor 4/nuclear factor κB and Nrf2/heme oxygenase 1 signaling *** findings suggest that Biochanin A can alleviate post-spinal cord injury at an early stage.

关键词： apoptosis autophagy Biochanin A heme oxygenase 1 inflammation Nrf2 protein nuclear factor kappa-B oxidative stress spinal cord injury Toll-like receptor 4

Quick Hosting Capacity Evaluation Based on Distributed Dispatching for Smart Distribution Network Planning with Distributed Generation

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Journal of Modern Power Systems and Clean Energy 2024年第1期12卷 128-140页

作者： Bing Sun Ruipeng jing Leijiao Ge Yuan Zeng Shimeng Dong Luyang hou the School of Electrical and Information Engineering Tianjin UniversityTianjin 300072China State Grid Corporation of China BeijingChina the School of Computer Science(National Pilot Software Engineering School) Beijing University of Posts and TelecommunicationsBeijingChina

The smart distribution network(SDN)is integrat ing increasing distributed generation(DG)and energy storage(ES).Hosting capacity evaluation is important for SDN plan ning with *** and ES are usually invested by users or a third party,and they may form friendly microgrids(MGs)and operate *** centralized dispatching meth od no longer suits for hosting capacity evaluation of SDN.A quick hosting capacity evaluation method based on distributed optimal dispatching is ***,a multi-objective DG hosting capacity evaluation model is established,and the host ing capacity for DG is determined by the optimal DG planning *** steady-state security region method is applied to speed up the solving process of the DG hosting capacity evalua tion ***,the optimal dispatching models are estab lished for MG and SDN respectively to realize the operating *** the distributed dispatching strategy,the dual-side optimal operation of SDN-MGs can be realized by several iterations of power exchange ***,an SDN with four MGs is conducted considering multiple flexible *** shows that the DG hosting capacity of SDN oversteps the sum of the maximum active power demand and the rated branch ***,the annual DG electricity oversteps the maximum active power demand value.

关键词： Smart distribution network(SDN) microgrid hosting capacity multi-objective optimization distributed opti mal dispatching flexible resource

Alterations of sleep deprivation on brain function:A coordinatebased resting-state functional magnetic resonance imaging metaanalysis

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World Journal of Psychiatry 2024年第2期14卷 315-329页

作者： Qin Zhang Yong-Zhe hou Hui Ding Yan-Ping Shu jing Li Xi-Zhao Chen Jia-Lin Li Qin lou Dai-Xing Wang Department of Radiology The Second People’s Hospital of Guizhou ProvinceGuiyang 550000Guizhou ProvinceChina Department of Radiology Guizhou Provincial People’s HospitalGuiyang 550000Guizhou ProvinceChina Department of Psychiatry of Women and Children The Second People’s Hospital of Guizhou ProvinceGuiyang 550000Guizhou ProvinceChina Medical Humanities College Guizhou Medical UniversityGuiyang 550000Guizhou ProvinceChina

BACKGROUND Sleep deprivation is a prevalent issue that impacts cognitive *** numerous neuroimaging studies have explored the neural correlates of sleep loss,inconsistencies persist in the reported results,necessitating an investigation into the consistent brain functional changes resulting from sleep *** To establish the consistency of brain functional alterations associated with sleep deprivation through systematic searches of neuroimaging *** metaanalytic methods,signed differential mapping(SDM)and activation likelihood estimation(ALE),were employed to analyze functional magnetic resonance imaging(fMRI)*** A systematic search performed according to PRISMA guidelines was conducted across multiple databases through July 29,*** that met specific inclusion criteria,focused on healthy subjects with acute sleep deprivation and reported whole-brain functional data in English were considered.A total of 21 studies were selected for SDM and ALE *** Twenty-one studies,including 23 experiments and 498 subjects,were *** to pre-sleep deprivation,post-sleep deprivation brain function was associated with increased gray matter in the right corpus callosum and decreased activity in the left medial frontal gyrus and left inferior parietal *** revealed increased brain functional activity in the left striatum and right central posterior gyrus and decreased activity in the right cerebellar gyrus,left middle frontal gyrus,corpus callosum,and right *** This meta-analysis consistently identified brain regions affected by sleep deprivation,notably the left medial frontal gyrus and corpus callosum,shedding light on the neuropathology of sleep deprivation and offering insights into its neurological impact.

关键词： Sleep deprivation Resting-state-functional magnetic resonance imaging Activation likelihood estimation-meta Signed differential mapping-meta

White Matter Lesions in Young-Middle Aged Migraineurs with Patent Foreman Ovale: A Case-Control Study

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Congenital Heart Disease 2024年第3期19卷 279-291页

作者： Yang Hua Jinyu Sun Yuxuan lou Hao Zhang jing Shi Wei Sun Department of Cardiology The First Affiliated Hospital of Nanjing Medical UniversityNanjing210000China

Background:White matter lesion(WML)is common in aging brain and is associated with cognitive impairment and ***,recent studies reported an association between patent foramen ovale(PFO)and WML in migraineurs,especially in young,middle-aged *** retrospective,case-control study aims to describe the clinical characteristics of WML in this population and to explore potential risk ***:226 patients with migraine and PFO were consecutively initially *** factors were selected by the least absolute shrinkage and selection operator(LASSO)regression and multivariable logistic regression model.A Nomogram was employed to visualize the prediction model *** discrimination and calibration abilities were evaluated using the Receiver Operating Characteristic(ROC)curve,the Hosmer-Lemeshow test,and calibration ***:One hundred and nineteen participants were ultimately enrolled in our study,with a median age of 36.9±12.7 years and 80.7%of *** magnetic resonance imaging MRI showed 67(56.3%)patients had WML,whereas 52(43.7%)patients were categorized into the non-WML *** regression screened out potential variables and subsequent multivariate analysisﬁnally identiﬁed age,mean platelet volume,andﬁbri-nogen(FIB)as independent predictive factors of *** area under the ROC curve(AUC)was ***-mer-Lemeshow test and calibration curve veriﬁed a consistency between the predicted and actual ***:The predictive nomogram established and validated in our study may assist clinicians in screening WML among young middle-aged migraineurs with PFO and developing individualized preventive and treatment strategies.

关键词： White matter lesion migraine patent foreman ovale nomogram predictive model

Improved forecasting via physics-guided machine learning as exemplified using“21·7”extreme rainfall event in Henan

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Science China Earth Sciences 2024年第5期67卷 1652-1674页

作者： Qi ZHONG Zhicha ZHANG Xiuping YAO Shaoyu hou Shenming FU Yong CAO Linguo jing China Meteorological Administration Training Center Beijing 100081China State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesBeijing 100081China Zhejiang Meteorological Observatory Hangzhou 310017China Hebei Provincial Weather Modification Center Shijiazhuang 050020China Institute of Atmospheric Physics Chinese Academy of SciencesBeijing 100029China National Meteorological Center Beijing 100081China School of Computer Science Chengdu University of Information TechnologyChengdu 610225China

As a natural disaster,extreme precipitation is among the most destructive and influential,but predicting its occurrence and evolution accurately is very challenging because of its rarity and *** the example of the“21·7”extreme precipitation event(17–21 July 2021)in Henan Province,this study explores the potential of using physics-guided machine learning to improve the accuracy of forecasting the intensity and location of extreme *** physics-guided ways of embedding physical features,fusing physical model forecasts and revised loss function are used,i.e.,(1)analyzing the anomalous circulation and thermodynamical factors,(2)analyzing the multi-model forecast bias and the associated underlying reasons for it,and(3)using professional forecasting knowledge to design the loss function,and the corresponding results are used as input for machine learning to improve the forecasting *** results indicate that by learning the relationship between anomalous physical features and heavy precipitation,the forecasting of precipitation intensity is improved significantly,but the location is rarely adjusted and more false alarms *** reasons for this are as *** anomalous features used here mainly contain information about large-scale systems and factors which are consistent with the model precipitation deviation;moreover,the samples of extreme precipitation are sparse and so the algorithm used here is ***,by combining“good and different”multi models with machine learning,the advantages of each model are extracted and then the location of the precipitation center in the forecast is improved ***,by combining the appropriate anomalous features with multi-model fusion,an integrated improvement of the forecast of the rainfall intensity and location is ***,this study is a novel exploration to improve the refined forecasting of heavy precipitation with extreme intensity and high variability,

关键词： Extreme precipitation event Refined assessment Anomalous physical features Multi-model fusion Machine learning

Corrosion Behavior of Graphene Nanosheets Reinforced Magnesium Matrix Composites in Simulated Body Fluids

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Acta Metallurgica Sinica(English Letters) 2024年第3期37卷 525-536页

作者： Liwen Chen Jianhui jing Lulu Zhang jing Li Weipeng Chen Limin Li Yuan Zhao Hua hou Yuhong Zhao School of Materials Science and Engineering Collaborative Innovation Center of Ministry of Education and Shanxi Province for High-Performance Al/Mg Alloy MaterialsNorth University of ChinaTaiyuan 030051China Shanxi Key Laboratory of Advanced Manufacturing Technology School of Mechanical EngineeringNorth University of ChinaTaiyuan 030051China School of Materials Science and Engineering Taiyuan University of Science and TechnologyTaiyuan 030024China Beijing Advanced Innovation Center for Materials Genome Engineering University of Science and Technology BeijingBeijing 100083China Institute of Materials Intelligent Technology Liaoning Academy of MaterialsShenyang 110004China

Magnesium(Mg)alloy is considered as a promising biodegradable implant material but restricted to rapid ***,the new strategies based on thixomolding process had been explored to utilize the outstanding anti-permeability of graphene nanosheets(GNPs)while inhibit its galvanic corrosion with the matrix,so as to improve the corrosion resistance of *** agglomerate of GNPs with 0.9 wt%content is the main reason for the deterioration of corrosion performance due to the formation of micro-galvanic *** grain refinement of composites with 0.6 wt%content had positive effects on the better corrosion *** process adjusting,the unique distributions of GNPs along grain boundaries play a vital role in improving the corrosion *** can be ascribed to the following mechanisms:(I)The barriers can be established between the Mg matrix and corrosive medium,hence blocking the charge transfer at the interface;(II)The GNPs can effectively promote apatite deposition on the Mg matrix,leading to form dense apatite layers and prevent the further invasion of SBF;(III)The GNPs acting as reinforcements exists in the corrosion layer and apatite layer,impede the apatite layer falling off from the Mg *** findings broaden the horizon for biomedical applications in Mg matrix composites to realize desired performances.

关键词： Magnesium matrix composite Graphene nanosheets Corrosion resistance

Recent advances in photochemistry for positron emission tomography imaging

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Chinese Chemical Letters 2024年第8期35卷 149-162页

作者： jing-jing Zhang Lujun lou Rui Lv Jiahui Chen Yinlong Li Guangwei Wu Lingchao Cai Steven H.Liang Zhen Chen Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources Jiangsu Provincial Key Lab for the Chemistry and Utilization of Agro-Forest BiomassJiangsu Key Lab of Biomass-Based Green Fuels and ChemicalsInternational Innovation Center for Forest Chemicals and MaterialsCollege of Chemical EngineeringNanjing Forestry UniversityNanjing 210037China Department of Radiology and Imaging Sciences Emory UniversityAtlantaGA 30322United States

As a powerful noninvasive imaging technology,positron emission tomography(PET)has been playing an important role in disease theranostics and drug *** successful application of PET relies on not only the biological properties of PET tracers but also the availability of facile and efficient radiochemical reactions to enable practical production and widespread use of PET *** recently,photochemistry is emerging as a novel,mild and efficient approach to generating PET *** this review,we focus on the recent advances in newly developed photocatalytic radiochemical reactions,innovation on automated photochemical radiosynthesis modules,as well as implementation in late-stage radiolabeling and radio-pharmaceutical synthesis for PET *** believe that this review will inspire the development of more promising radiolabeling protocols for the preparation of clinically useful PET agents.

关键词： Positron emission tomography(PET) Fluorine-18 Carbon-11 Photocatalysis Automation Late-stage functionalization

Echinacoside attenuates glandular fibrosis in benign prostatic hyperplasia via inhibiting MKK6/MK2 signaling pathway

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Traditional Medicine Research 2024年第3期9卷 24-31页

作者： Si Qin jing-lou Chen Xiao-Feng Zhou Cong-Yue Xu jing Guo Department of Pharmacy Jianghan UniversityWuhan 430056China Department of Clinical Medicine Jianghan UniversityWuhan 430056China Institutes of Biomedical Sciences Jianghan UniversityWuhan 430056China Department of Basic Medicine School of MedicineJianghan UniversityWuhan 430056China

Background:Lower urinary tract symptoms commonly occur in the elderly population and seriously constrain the quality of *** fibrosis is an important pathobiological process in benign prostatic hyperplasia and is also a main inducing factor for benign prostatic hyperplasia-associated lower urinary tract *** species is an important herbal medicine resource and is traditionally used in ameliorating renal and prostatic ***:This study was to investigate the potential protective function of echinacoside(a bioactive compound from Cistanches)against prostatic fibrosis in mice and human benign prostatic hyperplasia epithelial-1 cell ***:It was found that echinacoside attenuated testosterone-induced prostatic hyperplasia and collagen deposition in mice,relieved prostate local inflammation and oxidative damage,and ameliorated prostatic epithelial-mesenchymal ***,echinacoside inhibited the activation of the MKK6/MK2 signaling pathway both in vivo and in ***:This study added new evidence for the anti-fibrotic function of echinacoside on the prostate and provided new insights for understanding its possible pharmacological mechanisms.

关键词： benign prostatic hyperplasia echinacoside epithelial-mesenchymal transition fibrosis