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Chemotherapy induces breast cancer stem cell enrichment through repression of glutathione S-transferase Mu

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Genes & Diseases 2024年第2期11卷 528-531页

作者： jing he Yiran Yu Yilin he Jie he Guangyu Ji Haiquan Lu The Second Hospital and Advanced Medical Research Institute Cheeloo College of MedicineShandong UniversityJinanShandong 250012China Department of Nursing The First Affiliated Hospital of Shandong First Medical UniversityJinanShandong 250014China School of Medicine Xinjiang Medical UniversityUrumqiXinjiang 830054China School of Medicine Binzhou Medical UniversityYantaiShandong 264003China Oncology Department Jinan Zhangqiu District People's HospitalJinanShandong 250200China Key Laboratory for Experimental Teratology of the Ministry of Education Cheeloo College of MedicineShandong UniversityJinanShandong 250012China Center for Reproductive Medicine Shandong UniversityJinanShandong 250012China

Triple-negative breast cancer(TNBC)has aggressive characteristics as exemplified by the high risk of recurrence,metastasis,and patient mortality.1 Cytotoxic chemotherapy may reduce tumor burden initially,but leave behind chemo-resistant breast cancer stem cells(BCSCs)that lead to tumor recurrence and metastasis.2 Chemotherapy induces BCsC enrichment through the activation of glutathione biosynthesis pathways,which increases intracellular glutathione levels and specifies the BCSC phenotype through complicated downstream signaling pathways.3 Glutathione S-transferases(GSTs),a superfamily(which contains seven cytosolic classes:Alpha,Kappa,Mu,Omega,Pi,Theta,and Zeta,and one microsomal class MGSTs)of phase Il enzymes that catalyze the conjugation of glutathione with electrophilic compounds,play a critical role in detoxification and chemotherapy resistance of cancer cells.However,the role of GSTs in the regulation of BCSCs is largely elusive.

关键词： chemotherapy breast metastasis

Supramolecular phenolic network-engineered C-CeO_(2) nanofibers for simultaneous determination of isoniazid and hydrazine in biological fluids

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Chinese Chemical Letters 2024年第6期35卷 496-501页

作者： Gang lang jing Feng Bo Feng Junlan Hu Zhiling Ran Zhiting Zhou Zhenju Jiang Yunxiang he Junling Guo School of Science Xihua UniversityChengdu 610039China BMI Center for Biomass Materials and Nanointerfaces College of Biomass Science and EngineeringSichuan UniversityChengdu 610065China Southwest Computer Co. Ltd.Chongqing 400060China Bioproducts Institute Department of Chemical and Biological EngineeringThe University of British ColumbiaVancouver V6T 1Z4Canada State Key Laboratory of Polymer Materials Engineering Sichuan UniversityChengdu 610065China National Engineering Laboratory for Clean Technology of Leather Manufacture Sichuan University Chengdu 610065China

Electrochemical sensing provides a powerful technological means for the therapeutic drug monitoring of drug-resistant tuberculosis but requires a functionalized electrode to capture the analytes and catalyze their redox reactions.herein,we construct a nickel-tannic acid supramolecular network(Ni-TA)on the surface of electrospun-derived C-CeO_(2) nanofiber for the sensitive and simultaneous detection of isoniazid(INZ)and hydrazine(HYD).Mechanistic investigations demonstrate that Ni-TA is electronegative and hydrophilic,thus facilitating an efficient mass and electron transfer.Ni-TA/C-CeO_(2) has higher adsorption rate constants(0.091 g mg^(-1)h^(-1)for INZ,and 0.062 g mg^(-1)h^(-1)for HYD)than native C-CeO_(2)(0.075 g mg^(-1)h^(-1)for INZ,and 0.047 g mg^(-1)h^(-1)for HYD).Moreover,Ni-TA/C-CeO_(2)(56Ω)has lower charge transfer resistances than C-CeO_(2)(417Ω).Ni-TA/C-CeO_(2) performs low detection limits and wide linearity ranges for INZ(0.012μmol/L and 0.1-400μmol/L,respectively)and HYD(0.008μmol/L and 0.015-1420μmol/L,respectively),coupled with high selectivity,cycle stability and reproducibility.This research demonstrated the promising applications of Ni-TA/C-CeO_(2) by analyzing human-collected plasma and urine samples.

关键词： Electrochemical detection Therapeutic drug monitoring Isoniazid Hydrazine Tuberculosis

pH Induced Self-assembly of AIE Fluorescent Probe for Tumor Imaging

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Chinese Journal of Polymer Science 2024年第1期42卷 7-13,I0005页

作者： jing-Yuan Xiang Wen-Long Zhang he-Ting Li Ya-Ning he Department of Chemical Engineering Key Laboratory of Advanced Materials(MOE)Tsinghua UniversityBejing 100084China

This work reported an AIE fluorescent probe for tumor imaging based on the p H induced self-assembly strategy. The fluorescent probe was composed of an acid-responsive soluble copolymer PEG-b-PAMA-DMMA with a maleic acid amide group and an anionic soluble aggregation-induced emission fluorogen(AIEgen) TPE-2SO_(3)^(-). The polymer could be transformed into a protonated amine-containing polymer after the hydrolysis of maleic acid amide in acidic tumor microenvironment, which would be further self-assembled with TPE-2SO_(3)^(-)to form aggregated nanoparticles. The transition of TPE-2SO_(3)^(-)from dispersed state to aggregated state led to an obvious increase in fluorescence intensity due to its AIE characteristics.

关键词： p H-responsive Self-assembly Fluorescent probe AIE Tumor imaging

Promising use of metformin in treating neurological disorders:biomarker-guided therapies

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Neural Regeneration Research 2024年第5期19卷 1045-1055页

作者： Allison Loan Charvi Syal Margarita Lui Ling he jing Wang Regenerative Medicine Program Ottawa Hospital Research InstituteOttawaONCanada Department of Biology Faculty of ScienceUniversity of OttawaOttawaONCanada Department of Pediatrics and Medicine Johns Hopkins Medical SchoolBaltimoreMDUSA Department of Cellular and Molecular Medicine Faculty of MedicineUniversity of OttawaOttawaONCanada University of Ottawa Brain and Mind Research Institute OttawaONCanada

Neurological disorders are a diverse group of conditions that affect the nervous system and include neurodegenerative diseases(Alzheimer’s disease,multiple sclerosis,Parkinson’s disease,Huntington’s disease),cerebrovascular conditions(stroke),and neurodevelopmental disorders(autism spectrum disorder).Although they affect millions of individuals around the world,only a limited number of effective treatment options are available today.Since most neurological disorders express mitochondria-related metabolic perturbations,metformin,a biguanide type II antidiabetic drug,has attracted a lot of attention to be repurposed to treat neurological disorders by correcting their perturbed energy metabolism.However,controversial research emerges regarding the beneficial/detrimental effects of metformin on these neurological disorders.Given that most neurological disorders have complex etiology in their pathophysiology and are influenced by various risk factors such as aging,lifestyle,genetics,and environment,it is important to identify perturbed molecular functions that can be targeted by metformin in these neurological disorders.These molecules can then be used as biomarkers to stratify subpopulations of patients who show distinct molecular/pathological properties and can respond to metformin treatment,ultimately developing targeted therapy.In this review,we will discuss mitochondria-related metabolic perturbations and impaired molecular pathways in these neurological disorders and how these can be used as biomarkers to guide metformin-responsive treatment for the targeted therapy to treat neurological disorders.

关键词： Alzheimer’s disease Huntington’s disease metformin mitochondrial perturbation multiple sclerosis neural degenerative diseases Parkinson’s disease stroke targeted therapy

PDOL-Based Solid Electrolyte Toward Practical Application:Opportunities and Challenges

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Nano-Micro Letters 2024年第7期16卷 109-141页

作者： Hua Yang Maoxiang jing Li Wang Hong Xu Xiaohong Yan Xiangming he Institute for Advanced Materials School of Materials Science and EngineeringJiangsu UniversityZhenjiang 212013People’s Republic of China Institute of Nuclear and New Energy Technology Tsinghua UniversityBeijing 100084People’s Republic of China

Polymer solid-state lithium batteries(SSLB)are regarded as a promising energy storage technology to meet growing demand due to their high energy density and safety.Ion conductivity,interface stability and battery assembly process are still the main challenges to hurdle the commercialization of SSLB.As the main component of SSLB,poly(1,3-dioxolane)(PDOL)-based solid polymer electrolytes polymerized in-situ are becoming a promising candidate solid elec-trolyte,for their high ion conductivity at room temperature,good battery elec-trochemical performances,and simple assembly process.This review analyzes opportunities and challenges of PDOL electrolytes toward practical application for polymer SSLB.The focuses include exploring the polymerization mechanism of DOL,the performance of PDOL composite electrolytes,and the application of PDOL.Furthermore,we provide a perspective on future research directions that need to be emphasized for commercialization of PDOL-based electrolytes in SSLB.The exploration of these schemes facilitates a comprehensive and profound understanding of PDOL-based polymer electrolyte and provides new research ideas to boost them toward practical application in solid-state batteries.

关键词： Poly(1,3-dioxolane) Solid electrolyte Polymerization mechanism Composite electrolyte Practical application

Variable projection algorithms with sparse constraint for separable nonlinear models

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Control Theory and Technology 2024年第1期22卷 135-146页

作者： Hui-lang Xu Guang-Yong Chen Si-Qing Cheng Min Gan jing Chen College of Computer and Data Science Fuzhou UniversityFuzhou350116FujianChina Fujian Key Laboratory of Network Computing and Intelligent Information Processing Fuzhou UniversityFuzhou350116FujianChina Key Laboratory of Intelligent Metro of Universities in Fujian Fuzhou UniversityFuzhou350116FujianChina Engineering Research Center of Big Data Intelligence Ministry of EducationFuzhou UniversityFuzhou350116FujianChina School of Science Jiangnan UniversityWuxi214122JiangsuChina

Separable nonlinear models are widely used in various fields such as time series analysis, system modeling, and machine learning, due to their flexible structures and ability to capture nonlinear behavior of data. However, identifying the parameters of these models is challenging, especially when sparse models with better interpretability are desired by practitioners. Previous theoretical and practical studies have shown that variable projection (VP) is an efficient method for identifying separable nonlinear models, but these are based on \(L_2\) penalty of model parameters, which cannot be directly extended to deal with sparse constraint. Based on the exploration of the structural characteristics of separable models, this paper proposes gradient-based and trust-region-based variable projection algorithms, which mainly solve two key problems: how to eliminate linear parameters under sparse constraint;and how to deal with the coupling relationship between linear and nonlinear parameters in the model. Finally, numerical experiments on synthetic data and real time series data are conducted to verify the effectiveness of the proposed algorithms.

关键词： Variable projection(VP) Non-smooth constraint Separable nonlinear models

Transfer of Highest Weight Modules and Small Unipotent Representations

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Acta Mathematica Sinica,English Series 2024年第3期40卷 772-791页

作者： Hai An he jing Song HUANG Kayue Daniel WONG Department of Mathematics College of SciencesShanghai UniversityShanghai 200444P.R.China Newtouch Center for Mathematics of Shanghai University Shanghai 200444P.R.China Mathematics Research Center School of Science and EngineeringThe Chinese University of Hong KongShenzhen 518172P.R.China

We study the transfer between small special unipotent representations for all equal rank real forms of type E_(6) and E_(7). As a consequence, one can verify these modules are unitarity using the results of Wallach an... 详细信息

关键词： Unipotent representations Wallach representations Transfer of unitary modules

Mushroom Poisoning Outbreaks—China,2023

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China CDC weekly 2024年第4期6卷 64-68,I0001-I0005页

作者： Haijiao Li Yizhe Zhang Hongshun Zhang jing Zhou Zuohong Chen Jiaqi Liang Yu Yin Qian he Shaofeng Jiang Yutao Zhang Yuan Yuan Nan lang Bowen Cheng Jiaju Zhong Zhongfeng Li Chengye Sun National Institute of Occupational health and Poison Control Chinese Center for Disease Control and PreventionBeijingChina College of Life Sciences Hunan Normal UniversityChangsha CityHunan ProvinceChina

What is already known about this topic?Mushroom poisoning poses a significant food safety concern in China,with a total of 196 species identified in poisoning incidents by the end of 2022.What is added by this report?In 2023,the China CDC conducted an investigation into 505 cases of mushroom poisoning spanning 24 provincial-level administrative divisions.This investigation resulted in 1,303 patients and 16 deaths,yielding a case fatality rate of 1.23%.A total of 97 mushrooms were identified as the cause of 6 distinct clinical disease types,with 12 species newly documented as poisonous mushrooms in China.What are the implications for public health practice?Close collaboration among CDC staff,physicians,and mycologists remains crucial for the control and prevention of mushroom poisoning in the future.

关键词： prevention yielding poisoning

Microstructure and mechanical properties of a cast TRIP-assisted multiphase stainless steel

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China Foundry 2024年第3期21卷 221-228页

作者： Meng-xin Wang Zi-xiang Wu jing-yu he Xiang Chen School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China Key Laboratory for Advanced Materials Processing Technology Ministry of EducationBeijing 100084China

Stainless steels are used in a wide range of complex environments due to their excellent corrosion resistance.Multiphase stainless steels can offer an excellent combination of strength,toughness and corrosion resistance due to the coexistence of different microstructures.The microstructure and mechanical properties of a novel cast multiphase stainless steel,composed of martensite,ferrite,and austenite,were investigated following appropriate heat treatment processes:solution treatment at 1,050℃ for 0.5 h followed by water quenching to room temperature,and aging treatment at 500℃ for 4 h followed by water quenching to room temperature.Results show reversed austenite is formed by diffusion of Ni element during aging process,and the enrichment of Ni atoms directly determines the mechanical stability of austenite.The austenite with a lower Ni content undergoes a martensitic transformation during plastic deformation.The tensile strength of the specimen exceeds 1,100 MPa and the elongation exceeds 24%after solid solution,and further increases to 1,247 MPa and 25%after aging treatment.This enhancement is due to the TRIP effect of austenite and the precipitation of the nanoscale G-phase pinning dislocations in ferrite and martensite.

关键词： multiphase stainless steel mechanical properties TRIP effect reversed austenite G-phase