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Association between heat shock factor protein 4 methylation and colorectal cancer risk and potential molecular mechanisms:A bioinformatics study

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World Journal of Gastrointestinal Oncology 2023年第12期15卷 2150-2168页

作者： Wen-jing Zhang Ke-Lin Yue jing-zhai Wang Yu Zhang Department of Medical Oncology The First People’s Hospital of Yunnan ProvinceAffiliated Hospital of Kunming University of Science and TechnologyKunming 650032Yunnan ProvinceChina Department of Gastroenterology The First People’s Hospital of Yunnan ProvinceAffiliated Hospital of Kunming University of Science and TechnologyKunming 650032Yunnan ProvinceChina

BACKGROUND We previously demonstrated that heat shock factor protein 4(HSF4)facilitates colorectal cancer(CRC)*** methylation,a major modifier of gene expression and stability,is involved in CRC development and *** To investigate the correlation between HSF4 methylation and CRC risk,and to uncover the underlying molecular *** Differences in β values of HSF4 methylation loci in multiple malignancies and their correlation with HSF4 mRNA expression were analyzed based on Shiny Methylation Analysis Resource ***4 methylation-related genes were identified by LinkedOmics in CRC,and Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were ***-protein interaction network of HSF4 methylation-related genes was constructed by String database and MCODE *** A total of 19 CpG methylation loci were identified in HSF4,and their β values were significantly increased in CRC tissues and exhibited a positive correlation with HSF4 mRNA ***,the prognostic and diagnostic performance of these CpG loci in CRC patients was *** CRC,there were 1694 HSF4 methylation-related genes;1468 of which displayed positive and 226 negative associations,and they were involved in regulating phenotypes such as immune,inflammatory,and metabolic ***,RELA,STAT3,FCGR3A,POLR2K,and AXIN1 are hub genes among the HSF4 methylation-related *** HSF4 is highly methylated in CRC,but there is no significant correlation between it and the prognosis and diagnosis of ***4 methylation may serve as one of the ways in which HSF4 mediates the CRC process.

关键词： Colorectal cancer DNA methylation Prognosis Diagnosis Bioinformatics Heat shock factor protein 4

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Metal-free regioselective construction of 2-aryl-2H-tetrazol-5-yl difluoromethylene phosphonates

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Chinese Chemical Letters 2022年第2期33卷 863-866页

作者： Shi-jing zhai Dominique Cahard Fa-Guang Zhang Jun-An Ma Department of Chemistry Tianjin Key Laboratory of Molecular Optoelectronic SciencesFrontiers Science Center for Synthetic Biology(Ministry of Education)and Tianjin Collaborative Innovation Centre of Chemical Science&EngineeringTianjin UniversityTianjin 300072China Joint School of National University of Singapore and Tianjin University International Campus of Tianjin UniversityFuzhou 350207China CNRS UMR 6014 COBRA Normandie UniversitéMont Saint Aignan 76821France

Three bench-stable difluoromethylene phosphonate hydrazones were prepared from simple diethyl(difluoromethyl)phosphonate within two steps in good yields. The [3 + 2] cycloaddition reaction of these diazo precursors with aryl diazonium salts has been accomplished under metal-free conditions with exclusive regioselectivity. This transformation provides practical access to a broad panel of 2-aryl-2 H-tetrazol-5-yl difluoromethylene phosphonates, including the corresponding derivatives of amino acid(phenylalanine) and drug cores(Pomalidomide and Lapatinib fragment).

关键词： Tetrazole Cycloaddition Difluoromethylene phosphonate Regioselectivity Diazonium salt

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Preparation of transparent BaSO_(4) nanodispersions by high-gravity reactive precipitation combined with surface modification for transparent X-ray shielding nanocomposite films

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Frontiers of Chemical Science and Engineering 2021年第4期15卷 902-912页

作者： Le Fang Qian Sun Yong-Hong Duan jing zhai Dan Wang Jie-Xin Wang Beijing Advanced Innovation Center for Soft Matter Science and Engineering State Key Laboratory of Organic-Inorganic CompositesBeijing University of Chemical TechnologyBeijing 100029China Research Center of the Ministry of Education for High Gravity Engineering and Technology Beijing University of Chemical TechnologyBeijing 100029China Mine Oil Products Branch Coal Science and Technology Research Institute CompanyBeijing 100013China

BaSO_(4) nanoparticles as important functional materials have attracted considerable research interests,due to their X-rays barrier and absorption ***,most of BaSO_(4) nanoparticles prepared by traditional technology are nanopowders with broad size distribution and poor dispersibility,which may greatly limit their *** the best of our knowledge,the synthesis of transparent BaSO_(4) nanodispersions was rarely ***,we firstly present a novel and efficient method to prepare transparent and stable BaSO_(4) nanodispersions with a relatively small particle size around 10 to 17 nm using a precipitation method in a rotating packed bed(RPB),followed by a modification treatment using stearic *** with the BaSO_(4) prepared in a traditional stirred tank,the product prepared using an RPB has much smaller particle size and narrower size *** importantly,by using RPB,the reaction time can be significantly decreased from 20 min to 18 ***,the transparent BaSO_(4)-polyvinyl butyral nanocomposite films with good X-ray shielding performance can be easily *** believe that the stable BaSO_(4) nanodispersions may have a wide range of applications for transparent composite materials and coatings with X-ray shielding performance for future research.

关键词： BaSO_(4)nanoparticles rotating packed bed transparent nanodispersions BaSO_(4)-PVB films X-ray

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人工智能时代传统文化数字化保护与传承路径探讨

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大学图书情报学刊 2025年第1期43卷 111-114,121页

作者：翟婧媛申彦舒徐益湖南人文科技学院娄底417000

以人工智能为代表的新技术主导着传统文化资源的再生产、分发和传播,创设了万物为媒的服务情境,为传统文化保护与传承创新提供了新的视角。文章分析了当前传统文化保护与传承存在的主要问题,人工智能给传统文化保护与传承带来的机遇和挑... 详细信息

以人工智能为代表的新技术主导着传统文化资源的再生产、分发和传播,创设了万物为媒的服务情境,为传统文化保护与传承创新提供了新的视角。文章分析了当前传统文化保护与传承存在的主要问题,人工智能给传统文化保护与传承带来的机遇和挑战,从资源融合、技术融合、媒介融合、跨界融合、制度融合等5个方面提出了新的保护与传承路径。

关键词：人工智能传统文化数字化保护文化传承

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Crystal structure and some dynamic performances of Ti_(0.25)V_(0.34)Dy_(0.01)Cr_(0.1)Ni_(0.3) hydrogen storage electrode

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Chinese Chemical Letters 2011年第1期22卷 93-96页

作者： Yu Qing Qiao Min Shou Zhao Qiu Ming Zhang jing zhai College of Environmental and Chemical Engineering Yanshan University Qinhuangdao 066004 China

Crystal structure and some dynamic performances of Zi0.25V0.34Dy0.01Cr0.1Ni0.3 hydrogen storage electrode alloy have been investigated by XRD, FESEM-EDS, TEM and EIS measurements. The result shows that the alloy is mainly composed of V-based solid solution phase with body-centered-cubic structure and mono-crystal Ni3Ti phase with hexagonal structure （Space grope： P63/ mmc）, and it was first observed as TiNi-based secondary phase. The higher charge transfer resistance, higher apparent activation energy and lower hydrogen diffusion coefficient are reasons for the poor electrochemical activity of the dehydriding kinetics of Ti- V-Cr-Ni hydride alloy.

关键词： Hydrogen storage electrode alloy Ni-MH battery V-Based solid solution

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Experimental Investigation on Microstructure and Segregation of Ultrahigh Strength Al-Zn-Mg-Cu-Zr-Sc-Ni Alloy during Homogenization

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稀有金属材料与工程 2009年第A03期38卷 83-87页

作者： Li Zhenliang Xie Jianxin Chen Wei zhai jing Ren Huiping Wang Yufeng University of Science and Technology Beijing Beijing 100083 China Ningbo Branch of China Academy of Ordnance Science Ningbo 315103 China Inner Mongolia University of Science and Technology Baotou 014010 China

Ultrahigh strength Al-12Zn-2.4Mg-1.1Cu-0.20Zr-0.30Sc-0.30Ni alloy billets were fabricated by spray deposition method(the Osprey process). The effect of homogenization treatment on the microstructures and tensile properties were investigated by OM, SEM and EDS. The results show that adding small amount of Sc and Zr can greatly refine the grain size of the billet, with the average grain size of 10 μm. Grain-boundary becomes coarser firstly and then thinner under different homogenizing condition and grain coarsening were observed. The solute elements content of Zn inside grains has a peak at 490 ℃ /2 h, and Cu element, which was solved into matrix, can enhance the matrix hardness obviously during homogenization. The suitable homogenizing treatment is 460～490 °C/2 h for the hot extrusion of the studied alloy; after the optimized solid solution and T6 aging, the highest ultimate tensile strength (UTS) is 858 MPa with a ductility of 4.8%.

关键词：喷射沉积方法晶粒合金热挤压

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Comparison of two statistical methods for handling missing values of quantitative data in Bayesian N-of-1 trials: a simulation study

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Medical Data Mining 2024年第1期7卷 10-15页

作者： jing-Bo zhai Tian-Ci Guo Wei-Jie Yu School of Public Health Tianjin University of Traditional Chinese MedicineTianjin 301617China.

Background:Missing data are frequently occurred in clinical *** to the development of precision medicine,there is an increased interest in N-of-1 *** models are one of main statistical methods for analyzing the data of N-of-1 *** simulation study aimed to compare two statistical methods for handling missing values of quantitative data in Bayesian N-of-1 ***:The simulated data of N-of-1 trials with different coefficients of autocorrelation,effect sizes and missing ratios are obtained by SAS 9.1 *** missing values are filled with mean filling and regression filling respectively in the condition of different coefficients of autocorrelation,effect sizes and missing ratios by SPSS 25.0 *** models are built to estimate the posterior means by Winbugs 14 ***:When the missing ratio is relatively small,e.g.5%,missing values have relatively little effect on the *** effects may be underestimated when the coefficient of autocorrelation increases and no filling is ***,it may be overestimated when mean or regression filling is used,and the results after mean filling are closer to the actual effect than regression *** the case of moderate missing ratio,the estimated effect after mean filling is closer to the actual effect compared to regression *** a large missing ratio(20%)occurs,data missing can lead to significantly underestimate the *** this case,the estimated effect after regression filling is closer to the actual effect compared to mean ***:Data missing can affect the estimated therapeutic effects using Bayesian models in N-of-1 *** present study suggests that mean filling can be used under situation of missing ratio≤10%.Otherwise,regression filling may be preferable.

关键词： N-of-1 trial Bayesian missing data simulation study

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XingNaojing injections protect against cerebral ischemia/reperfusion injury and alleviate blood-brain barrier disruption in rats, through an underlying mechanism of NLRP3 inflammasomes suppression

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Chinese Journal of Natural Medicines 2019年第7期17卷 498-505页

作者： QU Xiao-Yu ZHANG Yue-Ming TAO Li-Na GAO Huan zhai jing-Hui SUN jing-Meng SONG Yan-Qing ZHANG Si-Xi Department of Pharmacy the First Hospital of Jilin University

The aim of this study was to explore the neuroprotective effect and mechanism of XingNaojing injections(XNJ) on cerebral ischemia injury and blood-brain barrier(BBB) disruption. Middle cerebral artery occlusion(MCAO) method was applicated to establish the model of cerebral ischemia/reperfusion(I/R) injury in rats. BBB permeability after I/R injury was assessed with the leaking amount of Evans Blue and the expression of occludin and ZO-1. The expression of NOD-like receptor family, pyrin domain containing(NLRP3) was checked to explore the inhibition of inflammation by XNJ. The results showed that XNJ could significantly increase the survival percent, decrease the infarct area and ameliorate neurological deficits and brain damage after I/R injury. Leaking amount of Evans Blue was reduced by XNJ, and the expression of tight junction protein, occludin and ZO-1 was also up-regulated by XNJ, which showed a role of protection on BBB disruption. The expression of NLRP3 was inhibited after exposure of XNJ, which was associated with inhibition of the inflammatory response. In summary, XNJ could suppress NLRP3 inflammasomes and improve BBB disruption and brain damage in rats after cerebral I/R injury, which provided a beneficial insight to further explore XNJ.

关键词： XingNaojing injections Cerebral ischemia/reperfusion injury Blood-brain barrier NLRP3 inflammasomes

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Impacts of Uncertainty in AVOC Emissions on the Summer RO_x Budget and Ozone Production Rate in the Three Most Rapidly-Developing Economic Growth Regions of China

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Advances in Atmospheric Sciences 2014年第6期31卷 1331-1342页

作者： WANG Feng AN Junling LI Ying TANG Yujia LIN Jian QU Yu CHEN Yong ZHANG Bing zhai jing State Key Laboratory of Atmospheric Boundary Layer Physics and Atmospheric Chemistry Institute of Atmospheric Physics Chinese Academy of Sciences University of Chinese Academy of Sciences Anhui Meteorological Bureau

High levels of uncertainty in non-methane volatile organic compound （NMVOC） emissions in China could lead to significant variation in the budget of the sum of hydroxyl （OH） and peroxy （HO2,RO2） radicals （ROx =OH ＋ HO2 ＋ RO2） and the ozone production rate [P（O3）],but few studies have investigated this possibility,particularly with three-dimensional air quality *** added diagnostic variables into the WRF-Chem model to assess the impact of the uncertainty in anthropogenic NMVOC （AVOC） emissions on the ROx budget and P（O3） in the Beijing-Tianjin-Hebei region,Yangtze River Delta,and Pearl River Delta of *** WRF-Chem simulations were compared with satellite and ground observations,and previous observation-based model *** indicated that 68％ increases （decreases） in AVOC emissions produced 4％-280％ increases （2％-80％ decreases） in the concentrations of OH,HO2,and RO2 in the three regions,and resulted in 35％-48％ enhancements （26％-39％ reductions） in the primary ROx production and ～ 65％ decreases （68％-73％ increases） of the P（O3） in Beijing,Shanghai,and *** the three cities,the two largest contributors to the ROx production rate were the reaction of O1D ＋ H2O and photolysis of HCHO,ALD2,and others; the reaction of OH ＋ NO2 （71％-85％） was the major ROx sink; and the major contributor to P（O3） was the reaction of HO2 ＋ NO （～ 65％）.Our results showed that AVOC emissions in 2006 from Zhang et al.（2009） have been underestimated by ～ 68％ in suburban areas and by ＞ 68％ in urban areas,implying that daily and hourly concentrations of secondary organic aerosols and inorganic aerosols could be substantially underestimated,and cloud condensation nuclei could be underestimated,whereas local and regional radiation was overestimated.

关键词： volatile organic compounds ROx ozone WRF-Chem model

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Effect of a novel tyrosine kinase inhibitor nintedanib on bFGF and VEGF concentrations in a rabbit retinal vein occlusion model

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International Journal of Ophthalmology(English edition) 2023年第9期16卷 1450-1455页

作者： Wei Fang jing zhai Zhen-Bin Qian Hai-Dong Li Meng-Di Wang Li-Jun Shen The Eye Hospital of Wenzhou Medical University School of Opthalmology&OptometryWMUZhejiang Eye HospitalHangzhou 310000Zhejiang ProvinceChina

AIM:To evaluate whether a novel tyrosine kinase inhibitor nintedanib could inhibit basic fibroblast growth factor(bFGF)and vascular endothelial growth factor(VEGF)simultaneously for retinal vascular disease in ***:After a laser induced rabbit retinal vein occlusion(RVO)model was made,0.5 mg of nintedanib was injected intravitreally in the left eye on the third day while the right eye was as a *** samples were taken on the day before laser treatment and days 1,3,7,14,21,and 28 after ***-linked immunosorbent assay(ELISA)was used to test the bFGF and VEGF-A concentrations in the aqueous ***:Both bFGF and VEGF-A rose significantly on the third day after laser treatment in both *** the control eye the bFGF concentration peaked on the 14th day while the VEGF-A concentration dropped rapidly soon after the third *** nintadanib injection in the study eye,both bFGF and VEGF-A showed a significant reduction on the 4th day(7th day after laser treatment)when compared to the control eye,and kept on low level in the following several ***:Intravitreal injection of nintedanib can inhibit the expression of bFGF and VEGF in the process of RVO model to a certain extent,which is expected to become a new method for the treatment of retinal vascular diseases or fibrotic diseases.

关键词： retinal vein occlusion nintedanib tyrosine kinase inhibitor basic fibroblast growth factor vascular endothelial growth factor rabbit model

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