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Internet access, usage and trust among medical professionals in China:A web-based survey

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International Journal of Nursing Sciences 2020年第S01期7卷 38-45页

作者： Hairuo Zhou jing Zhang jing su Health Communication in Peking University BeijingChina Health Communication Research Center of Tsinghua University BeijingChina Humanity School of Tsinghua University BeijingChina

Objectives:Social media has changed methods of communication in the medical *** part of a"doctor as communicator"strategy,Chinese medical professionals are actively embracing social media,which may have an impact on tense physician-patient relationships in *** paper aims to examine a pattern of Internet access,Internet usage,and trust among Chinese medical professionals and further explores the reasons for these relationships on an individual ***:A web-based questionnaire was designed,based on a media literacy model,and was divided into 3 dimensions:public information,general medical information,and specialty *** a two-round pilot study,1001 physicians were ***,4 interviewees were chosen to participate in in-depth interviews and content analysis was *** were analyzed using SPSS ***:Findings showed that new media has become a major approach for medical professionals in China to retrieve and get access to various ***,they still trust traditional media(n=1001,P<0.01)and professional journals more(n=1001,P<0.01).Internet access,usage,and trust were positively correlated(r-0.185-0.344,P<0.01).Regarding usage habits,47.66%of the participating physicians would practice science popularization through their new media accounts and 71.23%would forward approved health information within their professional realm.A validated instrument can be provided for further related ***:Science popularization is a specific usage of new media among Chinese medical professionals,through which they have achieved new authority and empowered communication because of *** some extent,physician-patient relationships in China can be improved because this online interaction is conducive to building harmonious and lasting offline physician-patient relationships.

关键词： China Internet access Physician-patient relations Social media Communication Physicians surveys and QuestionnairesTrust

Interaction of Chelerythrine Choloride in Acid Buffer with Calf-thymus DNA

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Chinese Chemical Letters 2006年第5期17卷 691-694页

作者： Yah jing su Xiong Hui WEI Department of Applied Chemistry College of Chemistry and Molecular Engineering Peking University Beijing 100871

The binding of chelerythrine （CHE） iminium to calf-thymus （CT） DNA is characterized by hypochromism and bathochromism in the absorption band, enhancement of fluorescence intensity, increase in fluorescence polarization, and the perturbation of the CD spectra of DNA. These changes are characteristic of intercalation. Scatchard plots constructed from fluorescence titration data gave a binding constant of 5.77×10^5 and a binding site size of 3,4 base pairs at 25 ℃. The intercalative interaction is exothermic with a Van＇t Hoff enthalpy of -33.7 kJ/mol. In addition, △G =-32.9 kJ/mol, and △S =-2.9 J/mol/K. The intercalation of CHE into the DNA helix is enthalpy-driven.

关键词： Chelerythrine CT-DNA intercalation thermodynamic.

Theoretical Study on Two C_(16)H_(12)O_4 Isomers of Derivatives of Pagodane

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Chinese Journal of Structural Chemistry 2006年第2期25卷 180-186页

作者： LIU Feng-Ling DU Ai-Ming WANG su-jing Department of Chemistry Shandong Normal University Jinan 250014 China

Two C16H12O4 isomers of derivatives of pagodane were firstly reported and studied by using DFT method. Geometries, energies, and vibrational frequencies have been calculated for the two C16H12O4 isomers with pagodane-like structures at the B3LYP/6-31G^＊＊ level of theory. Symmetries of isomer 1 and 2 are D2h and D2d, respectively. Heats of formation for the two C16H12O4 isomers have been estimated in this paper. According to the heats of formation, the two C16H12O4 isomers are more stable than pagodane. Heats of formation as well as the vibrational analysis indicate that the two C16H12O4 isomers enjoy sufficient stability to allow for the experimental preparation.

关键词： two C16H12O4 isomers of derivatives of pagodane B3LYP/6-31G^**,vibrational frequency heat of formation

Smoc2 potentiates proliferation of hepatocellular carcinoma cells via promotion of cell cycle progression

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World Journal of Gastroenterology 2016年第45期22卷 10053-10063页

作者： jing-Ran su jing-Hua Kuai Yan-Qing Li Department of Gastroenterology Laboratory of Translational Gastroenterology Shandong University Qilu Hospital Department of Gastroenterology Shandong University Qilu Hospital of Shandong University (Qingdao)

AIM To determine the influence of Smoc2 on hepatocellular carcinoma(HCC) cell proliferation and to find a possible new therapeutic target for preventing HCC *** We detected expression of Smoc2 in HCC tissues and corresponding non-tumor liver(CNL) tissues using PCR, western blot, and immunohistochemistry methods. subsequently, we down-regulated and upregulated Smoc2 expression using siR NA and lentivirus transfection assay, respectively. Then, we identified the effect of Smoc2 on cell proliferation and cell cycle using CCK-8 and flow cytometry, respectively. The common cell growth signaling influenced by Smoc2 was detected by western blot assay. REsuLTS The expression of Smoc2 was significantly higher in HCC tissues compared with CNL tissues. Overexpression of Smoc2 promoted HCC cell proliferation and cell cycle progression. Down-regulation of Smoc2 led to inhibition of cell proliferation and cell cycle progression. Smoc2 had positive effect on ERK and AKT *** Smoc2 promotes the proliferation of HCC cells through accelerating cell cycle progression and might act as an anti-cancer therapeutic target in the future.

关键词： Smoc2 Hepatocellular carcinoma Cell cycle Proliferation

Cutaneous leishmaniasis presenting with painless ulcer on the right forearm:A case report

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World Journal of Clinical Cases 2022年第7期10卷 2301-2306页

作者： Le Zhuang jing su Ping Tu Department of Dermatology Peking University The First HospitalBeijing 100034China Department of Dermatology Qilu Hospital of Shandong UniversityJinan 250012Shandong provinceChina Department of Pathology School of Basic Medical SciencesThe Third HospitalPeking University Health Science CenterBeijing 100034China

BACKGROUND Leishmaniasis includes a range of chronic infections in humans and animals and can be caused by more than 20 species of Leishmania *** manifestations of leishmaniasis are diverse and dependent on the immune response capacity of the host and the type of *** East Asia,leishmaniasis is relatively rare and prone to misdiagnosis and *** suMMARY We report a case of a 36-year-old male with cutaneous *** patient had been misdiagnosed with a bacterial skin infection and was given a dressing change and oral levofloxacin,which proved *** examination revealed amastigote(Leishman-Donovan body)in the histocytes,and nucleic acid sequencing proved that the pathogen was Leishmania *** patient was treated successfully by regional injection of sodium gluconate(600 mg)three *** ulcer healed and did not recur at 1.5-year *** Skin ulcers caused by leishmaniasis are easily misdiagnosed in non-epidemic countries,yet it should not be overlooked.

关键词： Leishmaniasis Leishmania major Skin ulcer Protozoan Skin infection Diagnostic errors Case report

Theoretical studies on the complexation of uranyl with typical carboxylate and amidoximate ligands

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Science China Chemistry 2013年第11期56卷 1525-1532页

作者： XU ChaoFei su jing XU Xiang LI Jun Department of Chemistry & Key Laboratory of Organic Optoelectronics and Molecular Engineering of the Ministry of Education Tsinghua University Division of Nuclear Materials Science and Engineering Shanghai Institute of Applied PhysicsChinese Academy of Sciences Key Laboratory of Nuclear Radiation and Nuclear Energy Technology Chinese Academy of Sciences College of Chemistry and Pharmaceutical Sciences Qingdao Agricultural University

Understanding of the bonding nature of uranyl and various ligands is the key for designing robust sequestering agents for uranium extraction from seawater. In this paper thermodynamic properties related to the complexation reaction of uranyl（VI） in aqueous solution （i.e. existing in the form of UO2（H20）52＋） by several typical ligands （L） including acetate （CH3CO2）, bicar- bonate （HOCO2-）, carbonate （CO32-）, CH3（NH2）CNO- （acetamidoximate, AO-） and glutarimidedioximate （denoted as GDO2-） have been investigated by using relativistic density functional theory （DFT）. The geometries, vibrational frequencies, natural net charges, and bond orders of the formed uranyl-L complexes in aqueous solution are studied. Based on the DFT analysis we show that the binding interaction between uranyl and amidoximate ligand is the strongest among the selected complexes. The thermodynamics of the complexation reaction are examined, and the calculated results show that complexation of uranyl with amidoximate ligands is most preferred thermodynamically. Besides, reaction paths of the substitution complexation of solvated uranyl by acetate and AO have been studied, respectively. We have obtained two minima along the reaction path of solvated uranyl with acetate, the monodentate-acetate complex and the bidentate-acetate one, while only one minimum involving monodentate-AO complex has been located for AO- ligand. Comparing the energy barriers of the two reaction paths, we find that complexation of uranyl with AO is more difficult in kinetics, though it is more preferable in thermodynamics. These results show that theoretical studies can help to select efficient ligands with fine-tuned thermodynamic and kinetic properties for binding uranyl in seawater.

关键词： uranyl seawater carboxylate amidoximate complexation thermodynamics density functional theory

Crystal Structure of a New Cembranolide Diterpene

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Chemical Research in Chinese Universities 2002年第2期18卷 189-191页

作者： LIN Cui wu su jing yu ZENG Long mei School of Chemistry and Chemical Engineering Zhongshan UniversityGuangzhou 510275P.R.China Department of Chemistry Guangxi UniversityNanning 530004P.R.China

A new cembranoide deterpene was isolated from the soft coral Sinularia Tenella . The crystal and chemical structure of the title compound were determined by means of spectroscopic methods and X ray diffraction analysis as ( 1R *,4R *,5S *,12S *,12R * ) 9 acetoxy cembr 8\%E\%,15(17) dien 16,4 olide. It shows a moderate cytotoxicity against P 388 and L 1210 cell lines.

关键词： Crystal structure Cembranolide diterpene X ray diffraction Sinularia tenella

On the oxidation states of metal elements in MO-3(M=V,Nb,Ta,Db,Pr,Gd,Pa)anions

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Science China Chemistry 2016年第4期59卷 442-451页

作者： jing su Shuxian Hu Wei Huang Mingfei Zhou Jun Li Key Laboratory of Organic Optoelectronics and Molecular Engineering of Ministry of Education Department of ChemistryTsinghua UniversityBeijing 100084China Collaborative Innovation Center of Chemistry for Energy Materials Shanghai Key Laboratory of Molecular Catalysts and Innovative Materials Department of ChemistryFudan UniversityShanghai 200433China

Relativistic quantum chemistry investigations are carried out to tackle the puzzling oxidation state problem in a series of MO3 trioxide anions of all d- and f-block elements with five valence electrons. We have shown here that while the oxidation states of V, Nb, Ta, Db, Pa are, as usual, all ＋V with divalent oxygen O（-II） in MO3- anions, the lanthanide elements Pr and Gd cannot adopt such high ＋V oxidation state in similar trioxide anions. Instead, lanthanide element Gd retains its usual ＋III oxi- dation state, while Pr retains a ＋IV oxidation state, thus forcing oxygen into a non-innocent ligand with an uncommon mono- valent radical （O＇） of oxidation state -I. A unique Pr＂- ＂（0）3 biradical with highly delocalized unpairing electron density on Pr（IV） and three O atoms is found to be responsible for stabilizing the monovalent-oxygen species in PRO3- ion, while GdO3 ion is in fact an OGd＋（O22-） complex with Gd（III）. These results show that a naive assignment of oxidation state of a chemical element without electronic structure analysis can lead to erroneous conclusions.

关键词： oxidation state non-innocent ligand biradical lanthanide trioxide anion

Extreme weather as a window:Exploring the seek and supply of climate change information during meteorological disasters in China

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Advances in Climate Change Research 2023年第4期14卷 615-623页

作者： Wen SHI San-Mei WEN jing ZHANG Bowering DANNA Chen-Chen HOU jing YANG jing su School of Journalism and Communication Jinan UniversityGuangzhou 510632China School of Journalism and Communication Tsinghua UniversityBeijing 100084China Journalism School Fudan UniversityShanghai 200433China School of Humanities Tsinghua UniversityBeijing 100084China School of Culture and Media Xinjiang University of Finance&EconomicsUrumqi 830012China

Public engagement is essential for China to address climate change;however,few studies have explored how to encourage climate awareness among Chinese *** objective of this study is to explore the role of local extreme weather in advancing Chinese people's climate change *** local extreme weather functions as an opportunity to trigger the public's interest in climate change across China and whether the local online information environment resonances with extreme weather by providing climate change news feeds have been examined by a combination of city-level meteorological warnings and search engine *** results have verified that residents from 50 of the 360 cities show increasing concern for climate change when an extreme weather event occurs locally;however,only the online information environment of two cities echoes local extreme weather by providing more information about climate change or global *** between extreme weather events such as heavy rain,an extreme weather event that has occurred in China,and climate change are *** effect of extreme cold events and snowfall on climate change awareness should also be noted more in *** study suggests there is still a lot of room for improvement regarding both increasing and satisfying the public's pre-existing climate change-related concerns.A promising approach would be adopting climate change prevention and adaptation as a news report framework for extreme weather events.

关键词： Climate change Extreme weather Public engagement Search engine