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Nitrogen–sulfur co-doped porous carbon derived from asphalt as efficient catalyst for oxygen reduction

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Rare Metals 2024年第1期43卷 380-388页

作者： jing-sheng Ma Ming-Zai Wu Ling Chen Li-Xing Zhang Ying Xiong Key Laboratory of Structure and Functional Regulation of Hybrid Materials Ministry of EducationInstitute of EnergyHefei Comprehensive National Science CenterAnhui UniversityHefei 230601China

As an environment-friendly and low-cost petrochemical by-product, asphalt has great potential in the preparation of metal-free oxygen reduction electrocatalysts with excellent performance and outstanding stability. In this paper, we converted asphalt into porous carbon nanosheets by a simple activation method, using potassium citrate as the swelling agent.

关键词： stability porous catalyst

Unique polysulfide reaction on VO_(2) for restraining shuttle effect in soft-packaged Li-S pouch cells

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Rare Metals 2024年第6期43卷 2842-2850页

作者： Ruo-Xuan Yang Qing-Chun Zhang jing-sheng Cai Xuan Cao Qin Yang Ying-Ze Song Wei Zhang State Key Laboratory of Environment-Friendly Energy Materials Tianfu Institute of Research and InnovationSchool of Materials and ChemistrySouthwest University of Science and TechnologyMianyang 621010China School of Materials Engineering Changshu Institute of TechnologyChangshu 215500China Chongqing Institute of Green and Intelligent Technology Chinese Academy of SciencesChongqing 400714China

The shuttle phenomenon and retarded conversion kinetics of lithium poly sulfides(LiPSs)are relatively severe in lithium-sulfur(Li-S)pouch *** to their redox potential in the sulfur working window,VO_(2)nanobelts show ... 详细信息

关键词： mechanism sulfide lithium

Application of nanoscale metal–organic frameworks in tumor immunotherapy

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Rare Metals 2024年第10期43卷 4867-4883页

作者： Xiao-Xuan Zeng jing-sheng Lu Dong-Wei Ma Yu-Ting Huang Ling Chen Gang Wang Qing Chen Ning Lin College of Pharmacy Guangxi Scientific Research Center of Traditional Chinese MedicineGuangxi University of Chinese Medicine Guangxi Zhuang Yao Medicine Center of Engineering and Technology

Immunotherapy has attracted wide attention because it can not only kill tumor cells but also effectively prevent tumor recurrence. However, due to the poor efficacy of the monotherapy in tumor immunotherapy, combination therapies are needed to enhance their efficacy,such as chemodynamic therapy/immunotherapy, photodynamic therapy/immunotherapy, sonodynamic therapy/immunotherapy and so on. Nanoscale metal–organic frameworks(nMOFs) are widely used for drug delivery because of their rich and variable composition, high drug loading capacity and good biodegradability. Compared with other conventional drug delivery systems(DDSs),nMOFs play more advantageous role in inducing immune cell death of tumor cells and combination therapies. This article focuses on the application of n MOFs in tumor immunotherapy in terms of their use as gatekeepers, supplementary agents and drug carriers, respectively, with the aim of providing some ideas and references for the design of smart nanoscale DDS for tumor immunotherapy.

关键词： Drug delivery system Immunotherapy Metal–organic frameworks Tumor

Enhancement of polymyxin B1 production by an artificial microbial consortium of Paenibacillus polymyxa and recombinant Corynebacterium glutamicum producing precursor amino acids

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Synthetic and Systems Biotechnology 2024年第1期9卷 176-185页

作者： Hui-Zhong Sun Si-Yu Wei Qiu-Man Xu Wei Shang Qing Li jing-sheng Cheng Ying-Jin Yuan Frontiers Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering(Ministry of Education) School of Chemical Engineering and TechnologyTianjin UniversityYaguan Road 135Jinnan DistrictTianjin300350PR China Tianjin Key Laboratory of Animal and Plant Resistance College of Life ScienceTianjin Normal UniversityBinshuixi Road 393Xiqing DistrictTianjin300387PR China Department of Pharmaceutical School of Chemical Engineering and TechnologyTianjin UniversityYaguan Road 135Jinnan DistrictTianjin300350PR China

Polymyxin B,produced by Paenibacillus polymyxa,is used as the last line of defense *** this study,exogenous mixture of precursor amino acids increased the level and proportion of polymyxin B1 in the total of polymyxin B analogs of *** CJX518-AC(PPAC)from 0.15 g/L and 61.8%to 0.33 g/L and 79.9%,*** co-culture of strain PPAC and recombinant Corynebacterium glutamicum-leu01,which produces high levels of threonine,leucine,and isoleucine,increased polymyxin B1 production to 0.64 g/*** strains PPAC and ***-leu01 simultaneously inoculated into an optimized medium with 20 g/L peptone,polymyxin B1 production was increased to 0.97 g/***,the polymyxin B1 production in the co-culture of strains PPAC and ***-leu01 increased to 2.21 g/L after optimized inoculation ratios and fermentation medium with 60 g/L *** study provides a new strategy to improve polymyxin B1 production.

关键词： Polymyxin Co-culture Paenibacillus polymyxa Corynebacterium glutamicum Medium optimization Metabolic precursors

Zinc-based metal-organic frameworks as efficient carriers for anticancer drug to reduce toxicity and increase efficacy

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Rare Metals 2024年第10期43卷 5152-5163页

作者： Dong-Wei Ma jing-sheng Lu Xiang-Xin Cao Yan-Wei Cheng Gang Wang Zi-Qian Zhang Bo-Cheng Chen Ning Lin Qing Chen College of Pharmacy Guangxi Scientific Research Center of Traditional Chinese MedicineGuangxi University of Chinese Medicine Guangxi Zhuang Yao Medicine Center of Engineering and Technology

The rational design of a specific co-drug delivery platform that can address the unavoidable resistance, toxic side effects and low targeting efficiency of traditional cancer treatments is of great ***, Zn-based MOF-zeolitic imidazole framework-90(ZIF-90) was selected as the drug delivery carrier, with the cancer therapeutic drug mercaptopurine(6-MP) and glucose oxidase(GOD) as the drug models, hyaluronic acid(HA) was used for protection and targeted delivery, which designed and fabricated an intelligent drug delivery platform(6-MP@ZIF-90@GOD@HA). This platform aims to reduce the toxic side effects of 6-MP and enhance its efficacy while improving the targeting ability of GOD,thereby further enhancing the treatment outcome. Notably,results from both in vitro and in vivo experiments demonstrate that the targeted synergistic chemo/reactive oxygen species(ROS)-mediated/starvation therapy inhibited the cancer cell growth while reducing the chemotherapy toxicity, which provides new possibilities for the development of more precise and effective treatment strategies.

关键词： Cancer treatment Combination therapy Drug delivery Metal-organic framework Reduced toxicity

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20世纪中国女性雕塑家的觉醒与表达

美术 2024年第4期 97-105页

作者：盛静北京工业大学艺术设计学院

中国女性雕塑家的产生和现代意义上雕塑学科的建立几乎是同步的。本文以生于20世纪初的中国女性雕塑家为研究对象,以其艺术作品为线索探寻影响现代中国第一代女性雕塑家群体创作观念的因素。这些女性雕塑家艺术创作的变化和中国社会主... 详细信息

中国女性雕塑家的产生和现代意义上雕塑学科的建立几乎是同步的。本文以生于20世纪初的中国女性雕塑家为研究对象,以其艺术作品为线索探寻影响现代中国第一代女性雕塑家群体创作观念的因素。这些女性雕塑家艺术创作的变化和中国社会主流意识的关系紧密,受西方女性主义和消费主义的影响较小,她们的创作旺盛期贯穿新民主主义革命到改革开放等多个历史阶段,其作品反映了中国社会变迁对艺术创作产生的主导性作用。

关键词：中国现代雕塑女性雕塑家女性主义个体意识

Plasma metabolites and risk of myocardial infarction:a bidirectional Mendelian randomization study

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Journal of Geriatric Cardiology 2024年第2期21卷 219-231页

作者： Dong-Hua LI Qiang WU jing-sheng LAN Shuo CHEN You-Yi HUANG Lan-Jin WU Zhi-Qing QIN Ying HUANG Wan-Zhong HUANG Ting ZENG Xin HAO Hua-Bin SU Qiang SU Department of Cardiovascular Medicine Minzu Hospital of Guangxi Zhuang Autonomous RegionGuangxiChina Senior Department of Cardiology the Sixth Medical CenterChinese PLA General HospitalBeijingChina Library of Graduate School Chinese PLA General HospitalBeijingChina Department of Cardiology Jiangbin Hospital of Guangxi Zhuang Autonomous RegionGuangxiChina Health Management Institute the Second Medical CenterChinese PLA General HospitalBeijingChina

BACKGROUND Myocardial infarction(MI)is a critical cardiovascular event with multifaceted etiology,involving several genetic and environmental *** is essential to understand the function of plasma metabolites in the development of MI and unravel its complex *** This study employed a bidirectional Mendelian randomization(MR)approach to investigate the causal relationships between plasma metabolites and MI *** used genetic instruments as proxies for plasma metabolites and MI and conducted MR analyses in both directions to assess the impact of metabolites on MI risk and vice *** addition,the large-scale genome-wide association studies datasets was used to identify genetic variants associated with plasma metabolite(1400 metabolites)and MI(20,917 individuals with MI and 440,906 individuals without MI)*** variance weighted was the primary method for estimating causal *** estimates are expressed as beta coefficients or odds ratio(OR)with 95%*** We identified 14 plasma metabolites associated with the occurrence of MI(P<0.05),among which 8 plasma metabolites[propionylglycine levels(OR=0.922,95%CI:0.881–0.965,P<0.001),gamma-glutamylglycine levels(OR=0.903,95%CI:0.861–0.948,P<0.001),hexadecanedioate(C16-DC)levels(OR=0.941,95%CI:0.911–0.973,P<0.001),pentose acid levels(OR=0.923,95%CI:0.877–0.972,P=0.002),X-24546 levels(OR=0.936,95%CI:0.902–0.971,P<0.001),glycine levels(OR=0.936,95%CI:0.909–0.964,P<0.001),glycine to serine ratio(OR=0.930,95%CI:0.888–0.974,P=0.002),and mannose to trans-4-hydroxyproline ratio(OR=0.912,95%CI:0.869–0.958,P<0.001)]were correlated with a decreased risk of MI,whereas the remaining 6 plasma metabolites[1-palmitoyl-2-arachidonoyl-GPE(16:0/20:4)levels(OR=1.051,95%CI:1.018–1.084,P=0.002),behenoyl dihydrosphingomyelin(d18:0/22:0)levels(OR=1.076,95%CI:1.027–1.128,P=0.002),1-stearoyl-2-docosahexaenoyl-GPE(18:0/22:6)levels(OR=1.067,95%CI:1.027–1.109,P=0.001),alpha-ketobutyrate levels(OR=1.108,95%

关键词： infarction alterations diagnosis

配合间隙对直线共轭内啮合齿轮泵流场特性的影响

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农业机械学报 2024年第2期55卷 442-449页

作者：陈鼎张杨叶绍干盛精厦门理工学院机械与汽车工程学院厦门361024 厦门大学萨本栋微米纳米科学技术研究院厦门361021

直线共轭内啮合齿轮泵是液压系统中的关键组件,因其高效的压力输送特性而广泛应用于工程领域。本文采用计算流体动力学模拟方法对直线共轭内啮合齿轮泵进行研究,分析轴向间隙和径向间隙对齿轮泵泄漏和流场的影响。研究结果表明:配合间... 详细信息

直线共轭内啮合齿轮泵是液压系统中的关键组件,因其高效的压力输送特性而广泛应用于工程领域。本文采用计算流体动力学模拟方法对直线共轭内啮合齿轮泵进行研究,分析轴向间隙和径向间隙对齿轮泵泄漏和流场的影响。研究结果表明:配合间隙的变化对齿轮泵的流场特性产生广泛影响,轴向间隙是引发泄漏的主要因素,约占总泄漏量的80%;当轴向间隙由0.03 mm增加到0.07 mm后,输出流量减少20.81%,平均压力下降33.15%,空化产生的气体体积分数增加0.021;而设置相同径向间隙后,输出流量仅下降0.69%,平均压力下降2.76%,空化产生的气体体积分数增加0.005。此外,导致泵内流速变化的主要配合间隙是轴向间隙,适当减小轴向间隙可提升泵内的流体速度,从而提升泵的整体效率。

关键词：直线共轭内啮合齿轮泵泄漏流场特性配合间隙

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波前编码红外成像系统的温度梯度适应能力探究

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天津大学学报（自然科学与工程技术版） 2024年第5期57卷 521-529页

作者：盛婧蔡怀宇汪毅陈晓冬天津大学精密仪器与光电子工程学院天津300072

利用波前编码技术为红外光学系统进行无热化设计可提高其在不同均匀工作温度下的适应能力,但针对温度突变、成像系统内温度分布不均情况,波前编码技术是否能正常进行成像及其适用的温度范围还有待进一步研究.为简化分析流程,采用温度梯... 详细信息

利用波前编码技术为红外光学系统进行无热化设计可提高其在不同均匀工作温度下的适应能力,但针对温度突变、成像系统内温度分布不均情况,波前编码技术是否能正常进行成像及其适用的温度范围还有待进一步研究.为简化分析流程,采用温度梯度模型来仿真非稳态下的温度变化.利用温度梯度模型来定性分析光学系统在轴向、径向温度梯度为系统引入的附加像差.计算两个方向下的光程差变化来比较两种温度梯度环境下系统的成像性能差异.在此基础上,为非稳态温度环境下红外光学系统的设计建立了结合光/机/热分析的无热化设计流程,通过ZEMAX设计了一套最大轴向尺寸为85 mm、最大径向尺寸为25 mm的红外光学系统,通过SolidWorks加载轴向和径向的热形变,探究所设计的系统能够适用的温度梯度范围.结果表明,结合光/机/热分析的无热化设计流程可以有效表明系统在非稳态温度下的成像情况.对上述采用三次相位板进行无热化设计的红外光学系统,在非稳态温度下可以适应±10℃的轴向温差范围,但是仅可以适应±1℃的径向温差范围.因此在进行红外波前编码光学系统的无热化设计时,需要对径向方向进行重点优化.

关键词：波前编码技术红外光学成像系统温度梯度三次相位板