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High-density lipoprotein regulates angiogenesis by affecting autophagy via miRNA-181a-5p

Science China(Life Sciences) 2024年第2期67卷 286-300页

作者： Bi-Ang Kang Hua-Ming Li ya-Ting Chen Meng-Jie Deng yan Li Yue-Ming Peng jian-jun gao Zhi-Wei Mo jia.guo Zhou Zhi-jun Ou jing-Song Ou Division of Cardiac Surgery Cardiovascular Diseases InstituteThe First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China National-guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases Guangzhou 510080China NHC key Laboratory of Assisted Circulation(Sun yat-sen University) Guangzhou 510080China guangdong Provincial Engineering and Technology Center for Diagnosis and Treatment of Vascular Diseases Guangzhou 510080China Division of Vascular Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China Department of Pharmacology Cardiac and Cerebral Vascular Research CenterZhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China Division of Hypertension and Vascular Diseases Department of CardiologyCardiovascular Diseases InstituteThe First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China guangdong Provincial Key Laboratory of Brain Function and Disease Zhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China

We previously demonstrated that normal high-density lipoprotein(nHDL)can promote angiogenesis,whereas HDL from patients with coronary artery disease(d HDL)is dysfunctional and impairs *** plays a critical role in angiogenesis,and HDL regulates ***,it is unclear whether n HDL and d HDL regulate angiogenesis by affecting *** cells(ECs)were treated with n HDL and d HDL with or without an autophagy ***,endothelial nitric oxide synthase(e NOS)expression,miRNA expression,nitric oxide(NO)production,superoxide anion(O2^(·-))generation,EC migration,and tube formation were evaluated.n HDL suppressed the expression of miR-181a-5p,which promotes autophagy and the expression of e NOS,resulting in NO production and the inhibition of O2^(·-)generation,and ultimately increasing in EC migration and tube formation.d HDL showed opposite effects compared to n HDL and ultimately inhibited EC migration and tube *** found that autophagy-related protein 5(ATg5)was a direct target of ***5 silencing or miR-181a-5p mimic inhibited n HDL-induced autophagy,e NOS expression,NO production,EC migration,tube formation,and enhanced O2^(·-)generation,whereas overexpression of ATg5 or miR-181a-5p inhibitor reversed the above effects of d ***5 expression and angiogenesis were decreased in the ischemic lower limbs of hypercholesterolemic low-density lipoprotein receptor null(LDLr^(-/-))mice when compared to C57BL/6 ***5 overexpression improved angiogenesis in ischemic hypercholesterolemic LDLr^(-/-)*** together,nHDL was able to stimulate autophagy by suppressing miR-181a-5p,subsequently increasing e NOS expression,which generated NO and promoted *** contrast,d HDL inhibited angiogenesis,at least partially,by increasing miR-181a-5p expression,which decreased autophagy and e NOS expression,resulting in a decrease in NO production and an increase in O2^(·-)*** findings reveal a nov

关键词： high-density lipoprotein angiogenesis autophagy ATg5 miRNA endothelial nitric oxide synthase

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The energy response of LaBr_(3)(Ce),LaBr_(3)(Ce,Sr),and NaI(Tl)crystals for gECAM

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Nuclear Science and Techniques 2024年第2期35卷 110-122页

作者： Pei-Yi Feng Xi-Lei Sun Zheng-Hua An Yong Deng Cheng-Er Wang Huang jia.g jun-Jie Li Da-Li Zhang Xin-Qiao Li Shao-Lin Xiong Chao Zheng Ke gong Sheng yang Xiao-jing Liu Min gao Xiang-yang Wen ya-Qing liu yan-Bing Xu Xiao-Yun Zhao jia-Cong Liu Fan Zhang Hong Lu Particle and Astrophysics Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China Experimental Physics Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China School of Nuclear Science and Technology University of South ChinaHengyang 421001China National Engineering Research Center for Rare Earth Grirem Advanced Materials Co.Ltd.and General Research Institute for Nonferrous MetalsBeijing 100088China

The gECAM series of satellites utilizes LaBr_(3)(Ce),LaBr_(3)(Ce,Sr),and NaI(Tl)crystals as sensitive materials for gamma-ray detectors(gRDs).To investigate the nonlinearity in the detection of low-energy gamma rays and address the errors in the calibration of the E-C relationship,comprehensive tests and comparative studies of the three aforementioned crystals were conducted using Compton electrons,radioactive sources,and mono-energetic *** nonlinearity test results of the Compton electrons and X-rays demonstrated substantial differences,with all three crystals presenting a higher nonlinearity for X/-rays than for Compton *** the LaBr_(3)(Ce)and LaBr_(3)(Ce,Sr)crystals having higher absolute light yields,they exhibited a noticeable nonlinear decrease in the light yield,especially at energies below 400 *** NaI(Tl)crystal demonstrated an"excess"light output in the 6-200 keV range,reaching a maximum"excess"of 9.2%at 30 keV in the X-ray testing and up to 15.5%at 14 keV during Compton electron testing,indicating a significant advantage in the detection of low-energy gamma ***,we explored the underlying causes of the observed nonlinearity in these *** study not only elucidates the detector responses of gECAM,but also initiates a comprehensive investigation of the nonlinearity of domestically produced lanthanum bromide and sodium iodide crystals.

关键词： LaBr_(3)(Ce)detector LaBr_(3)(Ce,Sr)detector NaI(Tl)detector gECAM Energy response Light yield nonlinearity

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基于BayesianOpt-XgBoost的煤电机组碳排放因子预测

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中国环境科学 2024年第1期44卷 417-426页

作者：赵敬皓王娜娜蒋嘉铭田亚峻中国科学院青岛生物能源与过程研究所泛能源大数据与战略研究中心山东青岛266101 山东能源研究院山东青岛266101 青岛新能源山东省实验室山东青岛266101 青岛科技大学信息科学技术学院山东青岛266061

以贝叶斯参数优化的XgBoost算法为基础,基于机组特征和煤炭特性建立BayesianOpt-XgBoost预测模型,其发电、供热碳排放因子预测的相关系数R^(2)分别为0.91和0.87,绝对误差百分比为2.51%和2.91%.进一步,通过特征标准化方法减少对煤炭特性... 详细信息

以贝叶斯参数优化的XgBoost算法为基础,基于机组特征和煤炭特性建立BayesianOpt-XgBoost预测模型,其发电、供热碳排放因子预测的相关系数R^(2)分别为0.91和0.87,绝对误差百分比为2.51%和2.91%.进一步,通过特征标准化方法减少对煤炭特性的依赖,模型预测R2分别为0.79和0.77,绝对误差百分比为3.94%和2.75%,精度仍可得到保障.基于该模型分析全国各省区煤电机组碳排放因子并与公布数据进行比较,证明了该模型的有效性.对机组预测结果的分析表明对现存的低容量机组进行改造、对新建造电机组采用大容量高参数可以减少碳排放强度.

关键词：碳核算煤电碳排放因子预测贝叶斯参数优化 XgBoost 特征标准化

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Senktide blocks aberrant RTN3 interactome to retard memory decline and tau pathology in social isolated Alzheimer’s disease mice

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Protein & Cell 2024年第4期15卷 261-284页

作者： He-Zhou Huang Wen-Qing Ai Na Wei Ling-Shuang Zhu Zhi-Qiang Liu Chao-Wen Zhou Man-Fei Deng Wen-Tao Zhang jia-Chen Zhang Chun-Qing yang ya-Zhuo Hu Zhi-Tao Han Hong-Hong Zhang jian-jun jia jing Wang Fang-Fang Liu Ke Li Qi Xu Mei Yuan Hengye Man Ziyuan guo Youming Lu Kai Shu Ling-Qiang Zhu Dan Liu Department of Pathophysiology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Medical genetics School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Pathology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450002China Department of Pathology School of Basic MedicineZhengzhou UniversityZhengzhou 450002China The Second Affiliated Hospital Department of NeurologyHengyang Medical SchoolUniversity of South ChinaHengyang 421001China Beijing Key Laboratory of Aging and geriatrics National Clinical Research Center for Geriatric DiseaseInstitute of GeriatricsChinese PLA General Hospital and Chinese PLA Medical AcademyBeijing 100853China Department of Neurosurgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Neurology Union HospitalHuazhong University of Science and TechnologyWuhan 430022China Department of Biology Boston UniversityBostonMA 02215USA Center for Stem Cell and Organoid Medicine(CuSTOM) Division of Developmental BiologyCincinnati Children’s Hospital Medical CenterCincinnatiOH 45229USA

Sporadic or late-onset Alzheimer’s disease(LOAD)accounts for more than 95%of Alzheimer’s disease(AD)cases without any family *** genome-wide association studies have identified associated risk genes and loci for LOAD,numerous studies suggest that many adverse environmental factors,such as social isolation,are associated with an increased risk of ***,the underlying mechanisms of social isolation in AD progression remain *** the current study,we found that 7 days of social isolation could trigger pattern separation impairments and presynaptic abnormalities of the mossy fibre-CA3 circuit in AD *** also revealed that social isolation disrupted histone acetylation and resulted in the downregulation of 2 dentate gyrus(Dg)-enriched miRNAs,which simultaneously target reticulon 3(RTN3),an endoplasmic reticulum protein that aggregates in presynaptic regions to disturb the formation of functional mossy fibre boutons(MFBs)by recruiting multiple mitochondrial and vesicle-related ***,the aggregation of RTN3 also recruits the PP2A B subunits to suppress PP2A activity and induce tau hyperphosphorylation,which,in turn,further elevates RTN3 and forms a vicious ***,using an artificial intelligence-assisted molecular docking approach,we determined that senktide,a selective agonist of neurokinin3 receptors(NK3R),could reduce the binding of RTN3 with its ***,application of senktide in vivo effectively restored Dg circuit disorders in socially isolated AD *** together,our findings not only demonstrate the epigenetic regulatory mechanism underlying mossy fibre synaptic disorders orchestrated by social isolation and tau pathology but also reveal a novel potential therapeutic strategy for AD.

关键词： Alzheimer’s disease memory impairment synaptic disorder tau pathology

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定坤丹通过microRNA-30d-5p靶向调控卵巢组织Smad 2治疗多囊卵巢综合征模型大鼠的机制研究

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中国实用妇科与产科杂志 2024年第8期40卷 849-854页

作者：陈兰杨波罗立波颜晓静王地均蔡佳丽尹春燕常州市中医医院江苏常州213003 广誉远中药股份有限公司山西太原030000

目的通过观察定坤丹对多囊卵巢综合征(polycystic ovary syndrome,PCOS)模型大鼠卵巢组织形态学、血清性激素水平、转化生长因子β1(transforming growth factor-β1,TgF-β1)、Smad 2、Smad 3和microRNA-30d-5p表达的影响,进而探讨其通过microRNA-30d-5p靶向调控卵巢组织中Smad2治疗PCOS模型大鼠的作用机制。方法应用高、中、低剂量定坤丹[4.5、2.25、1.125 g/(kg·d)]干预脱氢表雄酮(dehydroepiandrosterone,DHEA)诱导的PCOS大鼠模型,采用酶联免疫吸附试验(enzyme linked immunosorbent assay,ELISA)、苏木精-伊红(hematoxylineosin,HE)染色、免疫组化、实时聚合酶链式反应(real time polymerase chain reaction,RT-PCR)及Western blot等方法检测各组大鼠卵巢组织形态学、血清性激素水平、microRNA-30d-5p的表达及TgF-β1、Smad 2、Smad 3 m RNA及蛋白的表达。结果与模型大鼠组相比较,定坤丹高、中、低剂量组卵巢分布有各级卵泡,可见较多黄体;雌二醇(estradiol,E_(2))、黄体生成素(luteinizing hormone,LH)及睾酮(testosterone,T)均下降,卵泡刺激素(follicle stimulating hormone,FSH)则升高,且差异均具有统计学意义;microRNA-30d-5p的表达升高,且差异均具有统计学意义;TgF-β1、Smad 2及Smad 3的mRNA及蛋白表达均下降,且差异均具有统计学意义。结论DHEA诱导的PCOS大鼠模型是研究PCOS排卵障碍较为理想的动物模型。定坤丹对PCOS大鼠有一定治疗作用,其机制可能是通过microRNA-30d-5p靶向调控卵巢组织中Smad 2的表达水平来实现。

关键词：多囊卵巢综合征定坤丹转化生长因子β1 Smad 2 Smad 3 microRNA-30d-5p

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Effects of different proportions of two Bacillus sp. on the growth performance, small intestinal morphology, caecal microbiota and plasma biochemical profile of Chinese Huainan Partridge Shank chickens

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Journal of Integrative Agriculture 2017年第6期16卷 1383-1392页

作者： yaNg jia-jun QIAN Kun WU Dong ZHANg Wei WU Yi-jing XU ya-yuan Institute of Animal Husbandry and Veterinary Medicine Anhui Academy of Agricultural Sciences Hefei 230031 P.R. China

A total of 900 one-d-old Chinese Huainan Partridge Shank chickens were randomly allocated into nine groups with five replicates of 20 *** were fed with basal diet,basal diet supplemented with 150 mg kg^（–1） aureomycin,basal diet supplemented with different proportions of Bacillus licheniformis and Bacillus subtilis,which was 0：1.0×10~6,2.5×10~5：7.5×10~5,3.3×10~5：6.6×10~5,5.0×10~5：5.0×10~5,6.6×10~5：3.3×10~5,7.5×10~5：2.5×10~5 and 1.0×10~6：0,*** duration of the experiment was 56 *** results indicated that dietary supplementation of 6.6×10~5：3.3×10~5 of ***：*** improved final body weight,increased the average daily gain,and reduced feed/gain ratio（P〈0.05）.The numbers of total Lactobacillus and Bifidobacterium *** the caecum significantly increased,and the numbers of Escherichia coli and Salmonella *** declined compared to that of the control（P〈0.05）.Intestinal villous height and villous height to crypt depth ratio of the duodenum,jejunum,and ileum were significantly higher than that of the control,and intestinal crypt depth of the duodenum and ileum was significantly lower（P〈0.05）.The total antioxidant capacity,total superoxide dismutase,and glutathione peroxidase ability in plasma significantly improved,while the malondialdehyde concentration in plasma decreased（P〈0.05）.Compared to the control,plasma concentrations of ammonia,uric acid and urea nitrogen and the activity of xanthine oxidase were reduced（P〈0.05）.In conclusion,an inclusion of 6.6×10~5：3.3×10~5 of ***：*** to the diet improved the growth performance,caecal microbiota,plasma biochemical profile,and significantly improved the small intestine morphology,while reducing the mortality rate.

关键词： two-strain Bacillus proportion growth performance small intestinal morphology biochemical profile

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Enantiomeric pairs of meroterpenoids from Rhododendron fastigiatum

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Chinese Journal of Natural Medicines 2019年第12期17卷 963-969页

作者： HUANg guang-Hui LEI Chun ZHU Ke-Xin LI jing-ya LI jia HOU Ai-jun School of Pharmacy State Key Laboratory of Medical NeurobiologyFudan UniversityShanghai 201203China National Center for Drug Screening State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China

Five pairs of optically pure meroterpenoid enantiomers(1 a/1 b-5 a/5 b)and two known compounds(6 and 7)were isolated from Rhododendron *** 1 a/1 b-5 a/5 b were resolved from naturally scalemic mixtures by chiral *** structures were elucidated by spectroscopic methods,X-ray crystallographic experiments,and ECD *** 1 a/1 b,2 a/2 b,3 b,4 a/4 b,and 5 a/5 b were new meroterpenoids with different polycyclic *** enantiomeric pairs(2 a/2 b and 3 a/3 b),6,and 7 exhibited inhibitory effects on protein tyrosine phosphatase 1 B(PTP1 B)in vitro.

关键词： Rhododendron fastigiatum Meroterpenoid enantiomers Protein tyrosine phosphatase 1B

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高脂高热量饮食对中国健康受试者口服甲硝唑片药代动力学的影响

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中国临床药理学杂志 2024年第1期40卷 102-106页

作者：赵娜郭彩会刘亚丽宋浩静史犇胡义亭贾彩云董占军河北省人民医院Ⅰ期临床研究室河北石家庄050051 石家庄四药有限公司河北石家庄050051 苏州国辰生物科技股份有限公司江苏苏州215104

目的评价在空腹和高脂高热量饮食情况下甲硝唑片在中国健康受试者中的药代动力学特征。方法本方案按单中心、随机、开放、单剂量的试验设计。空腹和高脂高热量饮食条件下共入组47例中国健康受试者,单次口服甲硝唑片200 mg,给药前后按规... 详细信息

目的评价在空腹和高脂高热量饮食情况下甲硝唑片在中国健康受试者中的药代动力学特征。方法本方案按单中心、随机、开放、单剂量的试验设计。空腹和高脂高热量饮食条件下共入组47例中国健康受试者,单次口服甲硝唑片200 mg,给药前后按规定时间点采集静脉血样。用高效液相色谱串联质谱法测定血浆中甲硝唑的浓度并计算药代动力学参数。结果甲硝唑片空腹和高脂高热量饮食后的主要药代动力学参数如下:C_(max)分别为(4799.13±1195.32)和(4044.17±773.98)ng·mL^(-1),t_(max)分别为1.00和2.25 h,t1/2分别为(9.11±1.73)和(9.37±1.79)h,AUC_(0-t)分别为(5.59±1.19)×10^(4)和(5.51±1.18)×10^(4) ng·mL^(-1)·h,AUC_(0-∞)分别为(5.79±1.33)×10^(4)和(5.74±1.32)×10^(4) ng·mL^(-1)·h;高脂饮食后服药较空腹条件下服药,t_(max)延迟1.25 h(P0.05)。结论高脂餐饮食对甲硝唑的药代动力学参数影响较小,虽然不会显著改变药物的吸收程度,但是会使达峰时间明显延迟。

关键词：甲硝唑片高脂饮食药代动力学食物效应

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Association between brain N-acetylaspartate levels and sensory and motor dysfunction in patients who have spinal cord injury with spasticity:an observational case-control study

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Neural Regeneration Research 2023年第3期18卷 582-586页

作者： jia-Yi Liu ya-jing Li Xin-Ying Cong Zuliyaer Talifu Xin Zhang Feng gao jian-jun Li School of Rehabilitation Capital Medical UniversityBeijingChina Department of Spinal and Neural Function Reconstruction China Rehabilitation Research CenterBeijingChina China Rehabilitation Science Institute BeijingChina Beijing Key Laboratory of Neural Injury and Rehabilitation BeijingChina Center of Neural Injury and Repair Beijing Institute for Brain DisordersBeijingChina Rehabilitation Department Shanghai Huashan HospitalShanghaiChina Department of Medical Imaging China Rehabilitation Research CenterBeijingChina

Spinal cord injury is a severe and devastating disease,and spasticity is a common and severe complication that is notoriously refractory to ***,the pathophysiological mechanisms underlying spasticity and its development remain largely *** goal of the present study was to find differences,if any,in metabolites of the left precentral gyrus and basal ganglia of patients who have spinal cord injury with or without spasticity,and to explore the relationship between the brain metabolite concentrations and clinical ***-six participants were recruited for magnetic resonance spectroscopic examination:23 with spinal cord injury(12 with spasticity and 11 without spasticity)and 13 healthy *** acquired localized proton spectra from the precentral gyrus and basal ganglia via 10 mm^(3) ***,univariate linear regression analysis demonstrated that the lower that the N-acetylaspartate concentration(a marker for neuronal loss)was in the precentral gyrus of the patients,the lower their ASIA(American Spinal Injury Association)light-touch scores,pinprick scores,and motor ***,longer durations of injury were associated with higher N-acetylaspartate levels in the precentral *** with the healthy participants and patients without spasticity,N-acetylaspartate levels in the patients with spasticity were significantly lower in both the precentral gyrus and basal *** N-acetylaspartate levels also correlated with greater sensory and motor dysfunction in the patients who had spinal cord injury with spasticity.

关键词： ASIA motor score ASIA sensory score basal ganglia central nervous system duration of injury magnetic resonance spectroscopy N-acetylaspartate precentral gyrus spasticity spinal cord injury

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基于生物信息技术探究桂枝加芍药汤治疗炎症性肠病的作用机制

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五邑大学学报（自然科学版） 2024年第2期38卷 1-8页

作者：黄泽彬林烁佳金富军鲍雅丹卢宇靖广东工业大学生物医药学院广东广州510006 佛山市汇腾生物技术有限公司广东佛山528225

桂枝加芍药汤为《伤寒论》中的经典中医方剂,在治疗胃肠道疾病方面具有悠久的历史,但其药效作用机制却鲜有报道.本研究通过生物信息学手段来探究桂枝加芍药汤治疗炎症性肠病的潜在机制.在TCMSP和geneCards平台分别筛选桂枝加芍药汤中的... 详细信息

桂枝加芍药汤为《伤寒论》中的经典中医方剂,在治疗胃肠道疾病方面具有悠久的历史,但其药效作用机制却鲜有报道.本研究通过生物信息学手段来探究桂枝加芍药汤治疗炎症性肠病的潜在机制.在TCMSP和geneCards平台分别筛选桂枝加芍药汤中的化合物和炎症性肠病的靶点,通过Cytoscape软件构建关于桂枝加芍药汤的“药材—化合物—靶点”拓扑网络,并确定核心化合物;分别采用STRINg和DAVID在线工具分析桂枝加芍药汤治疗炎症性肠病靶点之间的蛋白相互作用,确定核心靶点,并分析gO和KEgg通路;用Autodock软件将核心化合物与靶点一一进行分子对接.结果显示,收集到的桂枝加芍药汤的活性化合物有94个,对应靶点有263个,炎症性肠病靶点有7 851个.核心化合物包括槲皮素、β-谷甾醇和山奈酚,核心靶点包括IL6、AKT1、TP53、IL1B和TNF等.具有显著性差异的KEgg信号通路一共有173条,包括TNF、PI3K-AKT和IL-17通路等. 3个核心化合物与其中的4个核心靶点具有较高的结合能.桂枝加芍药汤可通过干预多个靶点和多种信号通路来发挥其治疗炎症性肠病的作用.

关键词：桂枝加芍药汤生物信息技术炎症性肠病作用机制

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