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余热锅炉高压蒸发器下联箱端盖爆破原因分析

热加工工艺 2008年第22期37卷 109-110页

作者：耿进锋冯文吉河南电力试验研究院河南郑州450052

对余热锅炉高压蒸发器下联箱端盖的爆破原因进行分析,结果表明,由于工艺控制不当,出现过热和过烧组织,造成材料强度、塑性和韧性急剧下降,脆性显著增大,导致锅炉高压蒸发器下联箱手孔球形端盖脆性爆破。

关键词：余热锅炉过热脆性爆破

An engineered DNA aptamer-based PROTAC for precise therapy of p53-R175H hotspot mutant-driven cancer

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Science Bulletin 2024年第13期69卷 2122-2135页

作者： Lingping Kong Fanlu Meng Ping Zhou Ruixin Ge Xiaoshan geng Zhihao Yang Guo Li Linlin Zhang Jing Wang jinfeng Ma Cheng Dong Jun Zhou Sijin Wu Diansheng Zhong Songbo Xie Department of Medical Oncology Tianjin Medical University General HospitalTianjin 300052China Center for Cell Structure and Function Collaborative Innovation Center of Cell Biology in Universities of ShandongCollege of Life SciencesShandong Normal UniversityJinan 250014China The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics Key Laboratory of Immune Microenvironment and Disease(Ministry of Education)School of Basic Medical SciencesTianjin Medical UniversityTianjin 300070China Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment Lung Cancer InstituteTianjin Medical University General HospitalTianjin 300052China Haihe Laboratory of Cell Ecosystem State Key Laboratory of Medicinal Chemical BiologyCollege of Life SciencesNankai UniversityTianjin 300071China Wisdom Lake Academy of Pharmacy Xi’an Jiaotong-Liverpool UniversitySuzhou 215028China Department of Ophthalmology Tianjin Medical University General HospitalLaboratory of Molecular OphthalmologyTianjin Key Laboratory of Ocular TraumaTianjin Medical UniversityTianjin 300052China

Targeting oncogenic mutant p53 represents an attractive strategy for cancer treatment due to the high frequency of gain-of-function mutations and ectopic expression in various cancer *** extensive efforts,the absence of a druggable active site for small molecules has rendered these mutants therapeutically *** we develop a selective and effective proteolysis-targeting chimera(PROTAC)for p53-R175H,a common hotspot mutant with dominant-negative and oncogenic *** a novel iterative molecular docking-guided post-SELEX(systematic evolution of ligands by exponential enrichment)approach,we rationally engineer a high-performance DNA aptamer with improved affinity and specificity for *** this resulting aptamer as a binder for PROTACs,we successfully developed a selective p53-R175H degrader,named ***53m induces the ubiquitin–protea some-dependent degradation of p53-R175H while sparing wildtype ***,dp53m demonstrates significant antitumor efficacy in p53-R175H-driven cancer cells both in vitro and in vivo,without ***,dp53m significantly and synergistically improves the sensitivity of these cells to cisplatin,a commonly used chemotherapy *** findings provide evidence of the potential therapeutic value of dp53m in p53-R175H-driven cancers.

关键词： P53 Aptamer PROTAC Cancer Drug resistance

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果蔬采后内部损伤无损检测研究进展

食品科学 2017年第15期38卷 277-287页

作者：高迎旺耿金凤饶秀勤浙江大学生物系统工程与食品科学学院浙江杭州310058

果蔬产品含人体所必需的一些维生素、无机盐及植物纤维等营养元素,是人们日常膳食的重要组成部分。果蔬在采后处理过程中容易遭受机械损伤,不仅会降低果蔬自身外观品质,而且使果蔬容易受到真菌或细菌侵染,造成腐烂(如晚疫病、干腐病、... 详细信息

果蔬产品含人体所必需的一些维生素、无机盐及植物纤维等营养元素,是人们日常膳食的重要组成部分。果蔬在采后处理过程中容易遭受机械损伤,不仅会降低果蔬自身外观品质,而且使果蔬容易受到真菌或细菌侵染,造成腐烂(如晚疫病、干腐病、软腐病等),影响其食用安全性。受侵染果蔬在运输、贮存等过程中会感染正常果蔬,进一步扩大经济损失。由碰压引起的内部损伤因损伤果蔬和正常果蔬外部特征差别不明显,容易相互混杂,对果蔬外观及食用品质造成潜在危害。因此,识别并剔除有内部损伤的果蔬日益引起国内外学者的注意。本文从果蔬损伤后发生的生理和物理变化角度入手,阐述了无损检测技术应用于内部损伤检测的机理,并综述了利用光、热、声和电磁学特性检测果蔬采后内部损伤的研究进展,最后指出了研究难点和今后研究方向。

关键词：水果蔬菜内部损伤物理特性无损检测

Mixed Dead-time Effect Suppression Strategy for Modular Multilevel Converters

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CSEE Journal of Power and Energy Systems 2024年第3期10卷 1075-1084页

作者： Zhi geng Minxiao Han School of Electrical and Electronic Engineering North China Electric Power UniversityBeijing 102206China IEEE

Dead time is necessary for the coupled power switches to prevent shoot-through,especially in the modular multilevel converters(MMCs)with a large number of power *** paper proposes a dead-time effect suppression strategy for MMCs with nearest level *** operational principles of MMCs are first *** to the operational features of MMCs,the method that removes a switching signal from the coupled switches and the reduced switching frequency voltage balancing algorithms(RSFVBAs)are mixed in the proposed *** the intervals that are furthest away from the zerocrossing points(ZCP)of arm currents,the single switching signal method can completely eliminate the dead-time effect(DTE).Alternatively,the DTE is suppressed by the RSFVBA in intervals that are close to the *** the combination of the two methods,the dependence of the DTE suppression method on currents is reduced and the influences of ZCP are also released without degrading the normal operation performance of ***,the output performance of MMCs is improved and the voltage stress on the arm inductor dramatically ***,the validation of the method is verified by the simulation results with the professional tool Matlab/Simulink.

关键词： Dead-time effect modular multilevel converters switching frequency voltage balancing algorithm

Investigation and measurement of old building response to the overlapped shield tunnel of multiple schemes in the sandy cobble stratum

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Underground Space 2024年第2期15卷 260-274页

作者： Xue Li Aopeng geng School of Geoscience and Technology Southwest Petroleum UniversityChengduSichuan 610500China China Railway Construction Bridge Engineering Bureau Group Co. Ltd.Tianjin 300300China

Ground movements due to tunneling are becoming increasingly critical as buildings are located around construction *** study proposes a new combined reinforcement method using a foundation grouting oblique pipe *** former improves the bearing capacity of the subsoil,and the latter blocks the transmission of soil deformation,which weakens the influence of construction during overlapped tunnel *** on this new method,a case study of the shield tunneling response to an old building in Line 6 of China’s Chengdu Metro is ***,three-dimensional numerical models without reinforcement,traditional foundation grouting reinforcement,and the new combined reinforcement schemes were *** numerical simulation performance was verified using a set of field instrumentation data,which demonstrated that the old building response to the overlapped tunnels was under control,and the maximum deformation,angular distortion,and principal tensile strain of the building were 5.25 mm,5.1010–6 rad/m,and 0.0081%,*** with the traditional reinforcement scheme,the deformation,angular distortion,and principal tensile strain in the combined reinforcement scheme were reduced by 54.78%,71.02%,and 70.22%,*** results have important implications for the design and construction of shield tunnels and their response to old buildings.

关键词： Overlapped tunnels Reinforcement schemes Under-crossing Old building Numerical simulation

Boosting electrocatalytic nitrate reduction to ammonia via Cu_(2)O/Cu(OH)_(2)heterostructures promoting electron transfer

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Nano Research 2024年第6期17卷 4898-4907页

作者： Jing geng Sihan Ji Anhui Province International Research Center on Advanced Building Materials School of Materials Science and Chemical EngineeringAnhui Jianzhu UniversityHefei 230601China Anhui Province Key Laboratory of Advanced Building Materials Anhui Jianzhu UniversityHefei 230601China School of Energy Materials and Chemical Engineering Hefei UniversityHefei 230601China

Electrocatalytic nitrate(NO_(3)^(−))reduction to ammonia(NH_(3))offers a viable approach for sustainable NH_(3)production and environmental ***(Cu)possesses a distinctive electronic structure,which can augment the reaction kinetics of NO_(3)^(−)and impede hydrogen evolution reaction(HER),rendering it a promising contender for the electrosynthesis of NH_(3)from NO_(3)^(−).Nevertheless,the role of Cu_(2)O in copper-based catalysts still requires further investigation for a more comprehensive ***,the Cu_(2)O/Cu(OH)_(2)heterostructures are successfully fabricated through liquid laser irradiation using CuO nanoparticles as a *** and theoretical researches reveal that Cu_(2)O/Cu(OH)_(2)heterostructure exhibits enhanced electrocatalytic performance for NO_(3)^(−)to NH_(3)because Cu(OH)_(2)promotes electron transfer and reduces the valence state of Cu active site in Cu_(2)***−0.6 V(*** hydrogen electrode(RHE)),the NH_(3)yield reaches its maximum at 1630.66±29.72μg·h^(−1)·mgcat^(−1),while the maximum of Faraday efficiency(FE)is 76.95%±5.51%.This study expands the technical scope of copper-based catalyst preparation and enhances the understanding of the electrocatalytic mechanism of NO_(3)^(−)to NH_(3).

关键词： Cu_(2)O/Cu(OH)_(2)heterostructures electron transfer ammonia synthesis electrocatalysts nitrate

Structural engineered living materials

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Nano Research 2024年第2期17卷 715-733页

作者： Yang geng Zian Jia Ling Li 635 Prices Fork Road Department of Mechanical EngineeringVirginia Polytechnic Institute and State UniversityBlacksburg VA24061USA

Biological structural materials not only exhibit remarkable mechanical properties but also often embody dynamic characteristics such as environmental responsiveness,autonomy,and self-healing,which are difficult to achieve in conventional engineering *** merging materials science,synthetic biology,and other disciplines,engineered living materials(ELMs)provide a promising solution to combine living organisms with abiotic components,thus facilitating the construction of functional“living”*** natural materials,ELMs possess vitality and hold immense application potential in areas such as medicine,electronics,and construction,captivating increasing research attention *** an emerging branch of ELMs,structural ELMs aim to mimic living biological structural materials by achieving desired mechanical performance while maintaining important“living”*** we summarize the recent progress and provide our perspectives for this emerging research *** first summarize the superiority of structural ELMs by reviewing biological structural materials and biomimetic material design ***,we provide a systematic discussion on the definition and classifications of structural ELMs,their mechanical performance,and physiological ***,we summarize some critical challenges faced by structural ELMs and highlight directions of future *** hope this review article can provide a timely summary of the state of the art and relevant perspectives for future development of structural ELMs.

关键词： structural materials engineered living materials(ELMs) structural ELMs composites mechanical properties

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航空软件研制过程质量评价及信度效度分析

计算机集成制造系统 2016年第9期22卷 2175-2186页

作者：汪邦军耿金凤戴伟余元冠北京科技大学东凌经济管理学院北京100083 中国航空综合技术研究所北京100028 中国航空工业集团公司质量安全管理部北京100022 北京航空航天大学可靠性与系统工程学院北京100191

为了提高软件产品研制过程的质量,提出了一种将质量要求嵌入软件工程化管理流程的航空软件研制过程质量管理评价方法。该评价方法中,软件研制过程的关键实践和子实践对应一套量化评价指标和评价准则,评分结果对应质量管理成熟度等级,实... 详细信息

为了提高软件产品研制过程的质量,提出了一种将质量要求嵌入软件工程化管理流程的航空软件研制过程质量管理评价方法。该评价方法中,软件研制过程的关键实践和子实践对应一套量化评价指标和评价准则,评分结果对应质量管理成熟度等级,实现了用质量管理成熟度等级量化评价代替传统的质量管理体系符合性定性评价。为了验证该方法的科学性和实践性,运用经典测度理论和相关分析、因子分析等方法,分析了其内部一致性信度、结构效度和效标关联效度,确保其信度和效度满足要求;运用实证研究法,研究了某研究所软件研制过程质量管理评价案例,以验证该评价方法在企业层面的可行性。

关键词：软件质量管理信度效度

Optimizing urban block morphologies for net-zero energy cities:Exploring photovoltaic potential and urban design prototype

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Building Simulation 2024年第4期17卷 607-624页

作者： Xiaotian geng Dong Xie Zhonghua Gou School of Urban Design Wuhan UniversityWuhanChina

The morphology of urban areas plays a crucial role in determining solar potential,which directly affects photovoltaic capacity and the achievement of net-zero *** study focuses on the City of Melbourne to investigate the utilization of solar energy across different urban densities and proposes optimized *** analysis encompasses blocks with diverse population densities,examining medium and high-density *** utilizing a multi-objective genetic optimization approach,the urban morphology of these blocks is *** findings indicate that low-density blocks exhibit photovoltaic potential ranging from 1 to 6.6 times their total energy *** and high-density blocks achieve photovoltaic potential levels approximately equivalent to 40%-85%of their overall energy ***,significant variations in photovoltaic potential are observed among different urban forms within medium and high-density ***“elevated corners with central valley”prototype is proposed as an effective approach,enhancing the overall photovoltaic potential by approximately 14%.This study introduces novel analytical concepts,shedding light on the intricate relationship between urban morphologies and photovoltaic potential.

关键词： net-zero energy solar energy urban density urban morphology multi-objective optimization photovoltaic potential