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Review of a new bone tumor therapy strategy based on bifunctional biomaterials

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Bone Research 2021年第2期9卷 153-165页

作者： jinfeng liao Ruxia Han Yongzhi Wu Zhiyong Qian State Key Laboratory of Oral Diseases National Clinical Research Centre for Oral DiseasesState Key Laboratory of Biotherapy and Cancer CenterWest China HospitalWest China Medical SchoolSichuan UniversityChengduSichuanP.R.China

Bone tumors,especially those in osteosarcoma,usually occur in *** standard clinical treatment includes chemotherapy,surgical therapy,and radiation ***,surgical resection often fails to completely remove the tumor,which is the main cause of postoperative recurrence and metastasis,resulting in a high mortality ***,bone tumors often invade large areas of bone,which cannot repair itself,and causes a serious effect on the quality of life of ***,bone tumor therapy and bone regeneration are challenging in the ***,this review presents the recent developments in bifunctional biomaterials to achieve a new strategy for bone tumor *** selected bifunctional materials include 3D-printed scaffolds,nano/microparticle-containing scaffolds,hydrogels,and bone-targeting *** related studies on bifunctional biomaterials combining tumor photothermal therapy with enhanced bone regeneration were ***,a perspective on the future development of biomaterials for tumor therapy and bone tissue engineering is *** review will provide a useful reference for bone tumor-related disease and the field of complex diseases to combine tumor therapy and tissue engineering.

关键词： biomaterials chemotherapy mortality

Global constraints from RHIC and LHC on transport properties of QCD fluids in CUJET/CIBJET framework

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Chinese Physics C 2019年第4期43卷 69-88页

作者： Shuzhe Shi jinfeng liao Miklos Gyulassy Physics Department and Center for Exploration of Energy and Matter Indiana University Nuclear Science Division Lawrence Berkeley National Laboratory Pupin Lab MS-5202 Department of Physics Columbia University Institute of Particle Physics and Key Laboratory of Quark &Lepton Physics (MOE) Central China Normal University

We report results of a comprehensive global х~2 analysis of nuclear collision data from RHIC(0.2 ATeV),LHC1(2.76 ATeV), and recent LHC2(5.02 ATeV) energies using the updated CUJET framework. The framework consistently combines viscous hydrodynamic fields predicted by VISHNU2+1(validated with soft p_T﹤2 GeV bulk observables) and the DGLV theory of jet elastic and inelastic energy loss generalized to QGP fluids with an sQGMP color structure, including effective semi-QGP color electric quark and gluon as well as emergent color magnetic monopole degrees of freedom constrained by lattice QCD data. We vary the two control parameters of the model(the maximum value of the running QCD coupling, c, and the ratio cm of color magnetic to electric screening scales) and calculate the global х~2(α_c,c_m) compared with available jet fragment observables( R_(AA),v_2). A global х~2 minimum is found with α_c≈0.9±0.1 and c_m≈0.25±0.03. Using CIBJET, the event-by-event(ebe) generalization of the CUJET framework, we show that ebe fluctuations in the initial conditions do not significantly alter our conclusions(except for v_3). An important theoretical advantage of the CUJET and CIBJET frameworks is not only its global х~2 consistency with jet fragment observables at RHIC and LHC and with non-perturbative lattice QCD data, but also its internal consistency of the constrained jet transport coefficient, ■(E,T)/T^3, with the near-perfect fluid viscosity to entropy ratio(η/s～T^3/■～0.1-0.2) property of QCD fluids near Tc needed to account for the low p_T﹤2 GeV flow observables. Predictions for future tests at LHC with 5.44 ATeV Xe + Xe and 5.02 ATeV Pb + Pb are also presented.

关键词： jet quenching quark-gluon plasma relativistic heavy-ion collisions heavy flavor physics

A potential flower-like coating consisting of calcium-phosphate nanosheets on titanium surface

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Chinese Chemical Letters 2017年第9期28卷 1893-1896页

作者： Quanquan Ma jinfeng liao Taoran Tian Qi Zhang Xiaoxiao Cai State Key Laboratory of Oral Diseases National Clinical Research Center for Oral Diseases West China Hospital of Stomatology Sichuan University Chengdu 610041 China

Titanium and its alloys have been widely used as implant materials in ***,surface modification has been utilized to improve the chemical and morphological properties of *** specifically,biocoating,especially the calcium-phosphate nano-coating,has been widely used in the research *** this study,a novel calcium-phosphate nanoflower coating was performed on the titanium surface by a simple *** study indicated that the novel calcium-phosphate flower-like coating consisting of calcium-phosphate nanosheets had high surface area,low cytotoxicity as well as promising cell *** it could be a potential alternative modification method for titanium.

关键词： Titanium Surface treatment Calcium-phosphate ceramic Nanoflowers Biocoating

The design,mechanism and biomedical application of self-healing hydrogels

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Chinese Chemical Letters 2017年第9期28卷 1857-1874页

作者： Qiwen Li Chenlu Liu Junru Wen Yongzhi Wu Yue Shan jinfeng liao State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesWest China Hospital of StomatologySichuan University Laboratory of Molecular and Translational Medicine Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education at Sichuan UniversityWest China Second University HospitalSichuan University

Hydrogels are promising materials with outstanding characteristics such as tunable and reversible physical/chemical properties,stimuli-responsiveness,biomimetic,and ***,the structural and functional integrity of the hydrogels can be compromised by external mechanical forces or chemical erosion when used,especially in sophisticated in vivo *** address this problem,self-healing hydrogels which possess the intrinsic ability of self-repair have been developed to adapt to destructive *** this review,we focused on the current advances made in self-healing ***,the testing methods for self-healing hydrogels were ***,we looked into the designing strategies of self-healing hydrogels and illustrated the self-healing ***＇s more,the biomedical application of self-healing hydrogels in vivo was discussed.

关键词： Self-healing Hydrogels Chemical mechanism Biomaterials In vivo

Nanomaterials and bone regeneration

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Bone Research 2015年第3期3卷 123-129页

作者： Tao Gong Jing Xie jinfeng liao Tao Zhang Shiyu Lin Yunfeng Lin State Key Laboratory of Oral Diseases West China Hospital of Stomatology Sichuan University

The worldwide incidence of bone disorders and conditions has been increasing. Bone is a nanomaterials composed of organic （mainly collagen） and inorganic （mainly nano-hydroxyapatite） components, with a hierarchical structure ranging from nanoscale to macroscale. In consideration of the serious limitation in traditional therapies, nanomaterials provide some new strategy in bone regeneration. Nanostructured scaffolds provide a closer structural support approximation to native bone architecture for the cells and regulate cell proliferation, differentiation, and migration, which results in the formation of functional tissues. In this article, we focused on reviewing the classification and design of nanostructured materials and nanocarrier materials for bone regeneration, their cell interaction properties, and their application in bone tissue engineering and regeneration. Furthermore, some new challenges about the future research on the application of nanomaterials for bone regeneration are described in the conclusion and perspectives part.

关键词： bone ECM

Gold nanorods and nanohydroxyapatite hybrid hydrogel for preventing bone tumor recurrence via postoperative photothermal therapy and bone regeneration promotion

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Bioactive Materials 2021年第8期6卷 2221-2230页

作者： jinfeng liao Kun Shi Yanpeng Jia Yanting Wu Zhiyong Qian State Key Laboratory of Oral Diseases National Clinical Research Centre for Oral DiseasesWest China Hospital of StomatologySichuan UniversityChengdu610041P.R.China State Key Laboratory of Biotherapy State Key Laboratory and Collaborative Innovation Center of BiotherapyWest China HospitalSichuan UniversityChengdu610041SichuanP.R.China

Osteosarcoma is a malignant bone tumor,which often occurs in ***,surgical resection usually fails to completely remove the tumor clinically,which has been the main cause of postoperative recurrence and metastasis,resulting in the high death rate of *** the same time,osteosarcoma invades a large area of the bone defect,which cannot be self-repaired and seriously affects the life quality of the ***,a bifunctional methacrylated gelatin/methacrylated chondroitin sulfate hydrogel hybrid gold nanorods(GNRs)and nanohydroxyapatite(nHA),which possessed excellent photothermal effect,was constructed to eradicate residual tumor after surgery and bone *** vitro,K7M2wt cells(a mouse bone tumor cell line)can be efficiently eradicated by photothermal therapy of the hybrid ***,the hydrogel mimics the extracellular matrix to promote proliferation and osteogenic differentiation of mesenchymal stem *** GNRs/nHA hybrid hydrogel was capable of photothermal treatment of postoperative tumors and bone defect repair in a mice model of tibia ***,the hybrid hydrogel possesses dual functions of tumor therapy and bone regeneration,which shows great potential in curing bone tumors and provides a new hope for tumor-related bone complex disease.

关键词： Bone tumor Gold nanorods Hybrid hydrogel Photothermal therapy Bone regeneration

The fabrication of biomimetic biphasic CAN-PAC hydrogel with a seamless interfacial layer applied in osteochondral defect repair

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Bone Research 2017年第2期5卷 137-151页

作者： jinfeng liao Taoran Tian Sirong Shi Xueping Xie Quanquan Ma Guo Li Yunfeng Lin State Key Laboratory of Oral Diseases National Clinical Research Center for Oral Diseases West China Hospital of Stomatology Sichuan University Chengdu China

Cartilage tissue engineering based on biomimetic scaffolds has become a rapidly developing strategy for repairing cartilage defects. In this study, a biphasic CAN-PAC hydrogel for osteochondral defect(OCD)regeneration was fabricated based on the density difference between the two layers via a thermally reactive,rapid cross-linking method. The upper hydrogel was cross-linked by CSMA and NIPAm, and the lower hydrogel was composed of PECDA, AAm and PEGDA. The interface between the two layers was first grafted by the physical cross-linking of calcium gluconate and alginate, followed by the chemical cross-linking of the carbon-carbon double bonds in the other components. The pore sizes of the upper and lower hydrogels were ~ 187.4 and ~ 112.6 μm, respectively. The moduli of the upper and lower hydrogels were ~ 0.065 and~ 0.261 MPa. This prepared bilayer hydrogel exhibited the characteristics of mimetic composition, mimetic structure and mimetic stiffness, which provided a microenvironment for sustaining cell attachment and viability. Meanwhile, the biodegradability and biocompatibility of the CAN-PAC hydrogel were examined in vivo. Furthermore, an osteochondral defect model was developed in rabbits, and the bilayer hydrogels were implanted into the defect. The regenerated tissues in the bilayer hydrogel group exhibited new translucent cartilage and repaired subchondral bone, indicating that the hydrogel can enhance the repair of osteochondral defects.

关键词： hydrogel biomimetic fabrication

Chiral magnetic effect in isobar collisions from stochastic hydrodynamics

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Chinese Physics C 2020年第9期44卷 103-111页

作者： Gui-Rong Liang jinfeng liao Shu Lin Li Yan Miao Li School of Physics and Astronomy Sun Yat-Sen UniversityZhuhai 519082China Physics Department and Center for Exploration of Energy and Matter Indiana University2401 N Milo B.Sampson LaneBloomingtonIndiana 47408USA Key laboratory of Nuclear Physics and Ion-beam Application(MOE)&Institute of Modern Physics Fudan UniversityShanghai 200433China Department of Physics Southern University of Science and TechnologyShenzhen 518055GuangdongChina

We studied the chiral magnetic effect in AuAu,RuRu,and ZrZr collisions at sNN−√=*** axial charge evolution was modeled with stochastic hydrodynamics,and geometrical quantities were calculated with the Monte Carlo Glauber *** adjusting the relaxation time of the magnetic field,we found our results are in good agreement with background subtracted data for AuAu collisions at the same *** also made predictions for RuRu and ZrZr *** found a weak centrality dependence on initial chiral imbalance,which implies that the centrality dependence of chiral magnetic effect signals results mainly from the effects of the magnetic field and volume ***,our results show an unexpected dependence on system *** the AuAu system has larger chiral imbalance and magnetic field,it was observed to have a smaller signal for the chiral magnetic effect due to the larger volume suppression factor.

关键词： chiral magnetic effect axial charge evolution stochastic hydrodynamics isobar collisions

Biomaterial-based strategies for maxillofacial tumour therapy and bone defect regeneration

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International Journal of Oral Science 2021年第1期13卷 17-32页

作者： Bowen Tan Quan Tang Yongjin Zhong Yali Wei Linfeng He Yanting Wu Jiabao Wu jinfeng liao State Key Laboratory of Oral Diseases&National Clinical Research Centre for Oral Diseases&West China Hospital of Stomatology Sichuan UniversityChengduChina

Issues caused by maxillofacial tumours involve not only dealing with tumours but also repairing jaw bone *** traditional tumour therapy,the systemic toxicity of chemotherapeutic drugs,invasive surgical resection,intractable tumour recurrence,and metastasis are major threats to the patients’lives in the ***,biomaterial-based intervention can improve the efficiency of tumour treatment and decrease the possibility of recurrence and metastasis,suggesting new promising antitumour *** addition,maxillofacial bone tissue defects caused by tumours and their treatment can negatively affect the physiological and psychological health of patients,and investment in treatment can result in a multitude of burdens to *** are promising options because they have good biocompatibility and bioactive properties for stimulation of bone *** interestingly,an integrated material regimen that combines tumour therapy with bone repair is a promising treatment ***,we summarized traditional and biomaterial-mediated maxillofacial tumour treatments and analysed biomaterials for bone defect ***,we proposed a promising and superior design of dual-functional biomaterials for simultaneous tumour therapy and bone regeneration to provide a new strategy for managing maxillofacial tumours and improve the quality of life of patients in the future.

关键词： tumour maxillofacial defect