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Application of 3D bioprinting in the prevention and the therapy for human diseases

Signal Transduction and Targeted Therapy 2021年第6期6卷 1681-1697页

作者： Hee-Gyeong Yi Hyeonji Kim Junyoung Kwon Yeong-Jin Choi jinah jang Dong-Woo Cho Department of Rural and Biosystems Engineering College of Agriculture and Life SciencesChonnam National University77 Yongbong-RoGwangju 61186Korea Department of Mechanical Engineering Pohang University of Science and Technology(POSTECH)77 Cheongam-RoPohangKyungbuk 37673Korea Department of Advanced Biomaterials Research Korea Institute of Materials Science(KIMS)797 ChangwondaeroChangwonKyungnam 51508Korea Department of Convergence IT Engineering POSTECH77 Cheongam-RoPohangKyungbuk 37673Korea Institute of Convergence Science Yonsei University50 Yonsei-RoSeoul 03722Korea

Rapid development of vaccines and therapeutics is necessary to tackle the emergence of new pathogens and infectious *** speed up the drug discovery process,the conventional development pipeline can be retooled by introducing advanced in vitro models as alternatives to conventional infectious disease models and by employing advanced technology for the production of medicine and cell/drug delivery *** this regard,layer-by-layer construction with a 3D bioprinting system or other technologies provides a beneficial method for developing highly biomimetic and reliable in vitro models for infectious disease *** addition,the high flexibility and versatility of 3D bioprinting offer advantages in the effective production of vaccines,therapeutics,and relevant delivery ***,we discuss the potential of 3D bioprinting technologies for the control of infectious *** also suggest that 3D bioprinting in infectious disease research and drug development could be a significant platform technology for the rapid and automated production of tissue/organ models and medicines in the near future.

关键词： printing prevention introducing

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3D cell-printing of gradient multi-tissue interfaces for rotator cuff regeneration

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Bioactive Materials 2023年第1期19卷 611-625页

作者： Suhun Chae Uijung Yong Wonbin Park Yoo-mi Choi In-Ho Jeon Homan Kang jinah jang Hak Soo Choi Dong-Woo Cho Department of Mechanical Engineering Pohang University of Science and Technology77 Cheongam-roNam-guGyeongsangbuk-doPohang37673South Korea EDmicBio Inc. 111 Hoegi-roDongdaemun-guSeoul 02445South Korea Institute for Convergence Research and Education in Advanced Technology Yonsei University50 Yonsei-roSeodaemun-guSeoul03722South Korea Gordon Center for Medical Imaging Department of RadiologyMassachusetts General Hospital&Harvard Medical School14913th StreetBostonMA02114USA Department of Convergence IT Engineering Pohang University of Science and Technology77 Cheongam-roNam-guGyeongsangbuk-doPohang37673South Korea School of Interdisciplinary Bioscience and Bioengineering Pohang University of Science and Technology77 Cheongam-roNam-guGyeongsangbuk-doPohang37673South Korea Department of Orthopaedic Surgery Asan Medical CenterCollege of MedicineUniversity of Ulsan86 Asanbyeongwon-gilSongpa-guSeoul05505South Korea

Owing to the prevalence of rotator cuff(RC)injuries and suboptimal healing outcome,rapid and functional regeneration of the tendon-bone interface(TBI)after RC repair continues to be a major clinical *** the essential role of the RC in shoulder movement,the engineering of biomimetic multi-tissue constructs presents an opportunity for complex TBI reconstruction after RC ***,we propose a gradient cell-laden multi-tissue construct combined with compositional gradient TBI-specific bioinks via 3D cell-printing *** vitro studies demonstrated the capability of a gradient scaffold system in zone-specific inducibility and multi-tissue formation mimicking *** regenerative performance of the gradient scaffold on RC regeneration was determined using a rat RC repair *** particular,we adopted nondestructive,consecutive,and tissue-targeted near-infrared fluorescence imaging to visualize the direct anatomical change and the intricate RC regeneration progression in real time in ***,the 3D cell-printed implant promotes effective restoration of shoulder locomotion function and accelerates TBI healing in *** summary,this study identifies the therapeutic contribution of cell-printed constructs towards functional RC regeneration,demonstrating the translational potential of biomimetic gradient constructs for the clinical repair of multi-tissue interfaces.

关键词： 3D cell-printing Tissue-specific bioink Gradient tissue scaffolds Near-infrared fluorophores Rotator cuff repair

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Dragging 3D printing technique controls pore sizes of tissue engineered blood vessels to induce spontaneous cellular assembly

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Bioactive Materials 2024年第1期31卷 590-602页

作者： Hun-Jin Jeong Hyoryung Nam Jae-Seok Kim Sungkeon Cho Hyun-Ha Park Young-Sam Cho Hyungkook Jeon jinah jang Seung-Jae Lee Department of Mechanical Engineering Wonkwang University54538IksanRepublic of Korea Department of Convergence IT Engineering Pohang University of Science and Technology37673PohangGyeongbukRepublic of Korea Department of Mechanical and Design Engineering Wonkwang University54538IksanRepublic of Korea Department of Mechanical Engineering Pohang University of Science and Technology37673PohangGyeongbukRepublic of Korea School of Interdisciplinary Bioscience and Bioengineering Pohang University of Science and Technology37673PohangGyeongbukRepublic of Korea Institute of Convergence Science Yonsei University03722SeoulRepublic of Korea Regenerative Engineering Laboratory Columbia University630W 168th STNew York10032USA Department of Manufacturing Systems and Design Engineering Seoul National University of Science and Technology01811SeoulRepublic of Korea

To date,several off-the-shelf products such as artificial blood vessel grafts have been reported and clinically tested for small diameter vessel(SDV)***,conventional artificial blood vessel grafts lack endothelium and,thus,are not ideal for SDV transplantation as they can cause *** addition,a suc-cessful artificial blood vessel graft for SDV must have sufficient mechanical properties to withstand various external ***,we developed a spontaneous cellular assembly SDV(S-SDV)that develops without additional *** improving the dragging 3D printing technique,SDV constructs with free-form,multilayers and controllable pore size can be fabricated at ***,The S-SDV filled in the natural poly-mer bioink containing human umbilical vein endothelial cells(HUVECs)and human aorta smooth muscle cells(HAoSMCs).The endothelium can be induced by migration and self-assembly of endothelial cells through pores of the SDV *** antiplatelet adhesion of the formed endothelium on the luminal surface was also *** addition,this S-SDV had sufficient mechanical properties(burst pressure,suture retention,leakage test)for *** believe that the S-SDV could address the challenges of conventional SDVs:notably,endothelial formation and mechanical *** particular,the S-SDV can be designed simply as a free-form structure with a desired pore *** endothelial formation through the pore is easy even in free-form con-structs,it is expected to be useful for endothelial formation in vascular structures with branch or curve shapes,and in other tubular tissues such as the esophagus.

关键词： Small diameter vessel Dragging 3D printing Pore control Spontaneous cellular assembly

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Customized 3D-printed occluders enabling the reproduction of consistent and stable heart failure in swine models

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Bio-Design and Manufacturing 2021年第4期4卷 833-841页

作者： Han B.Kim Seungman Jung Hyukjin Park Doo S.Sim Munki Kim Sanskrita Das Youngkeun Ahn Myung H.Jeong jinah jang Young J.Hong Division of Cardiology Chonnam National University Medical SchoolGwangjuRepublic of Korea School of Interdisciplinary Bioscience and Bioengineering Pohang University of Science and TechnologyPohangRepublic of Korea Department of Creative IT Engineering Pohang University of Science and TechnologyPohangRepublic of Korea Department of Mechanical Engineering Pohang University of Science and TechnologyPohangRepublic of Korea

Reproducibility of clinical output is important when investigating therapeutic efficacy in pre-clinical animal *** to its physiological relevance,a swine myocardial infarction(MI)model has been widely used to evaluate the effectiveness of stem cells or tissue-engineered constructs for ischemic heart *** methods are used to induce MI in the swine ***,it is difficult,using these approaches,to obtain a similar level of functional outcomes from a group of animals due to interpersonal variation,leading to increased experimental ***,in order to minimize human intervention,we developed an approach to use a customized occluder that has dimensional similarities with that of the coronary artery of animals in the case of the swine *** carried out angiography to measure the diameter of the middle left anterior descending artery of each individual animal to fabricate the customized occluder using a 3D-printing *** fabricated occluder contained a central hole smaller than that of the targeted middle left anterior descending artery to mimic an atherosclerotic coronary artery that has an approximately 20%blocked ***,the 3D-printed occluder can provide continuous blood flow through the central pore,indicating a high survival rate(88%)of up to 28 days *** method showed the possibility of creating consistent myocardial infarction induction as compared to the conventional representative closed-chest method(50%survival rate),thus highlighting how our method can have a profound effect on accelerating reliable experiments for developing new therapeutic approaches to ischemic heart diseases.

关键词： 3D bioprinting Myocardial infarction Ischemic heart failure Swine model Left anterior descending artery

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