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户籍制度改革中进城农户城市融入感及影响机理——基于定居重庆市主城区472位“新市民”的调查

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人文地理 2017年第2期32卷 46-52页

作者：蔡进廖和平邱道持禹洋春骆东奇西南大学地理科学学院重庆400715 西南大学国土资源研究所重庆400715 重庆市国土资源和房屋管理局重庆400015 重庆工商大学商务策划学院重庆400067

本文基于重庆市户籍制度改革以来转户进入主城区农户的调查数据,运用probit回归分析模型,对定居主城区的农户城市融入感及影响机理进行分析。研究结果表明,转户定居重庆主城区的农户生活水平有了巨大提高,但城市融入感普遍较弱,大部分... 详细信息

本文基于重庆市户籍制度改革以来转户进入主城区农户的调查数据,运用probit回归分析模型,对定居主城区的农户城市融入感及影响机理进行分析。研究结果表明,转户定居重庆主城区的农户生活水平有了巨大提高,但城市融入感普遍较弱,大部分仍处于半市民化状态。农户要完全融入城市需要一个过程,就时间上来看,18.6%的样本农户只需要1年时间,高达69%的样本农户需要3至5年;影响新市民城市融入感的因素非常多,其中,农户的文化程度、农户的转户进城时间、家庭收入水平、工作情况、居住条件等因素对转户进城农户的城市融入感有正向显著作用,农户的年龄、家庭人口数量、家庭老人小孩数量、是否感觉被歧视等因素对农户的城市融入感有负向显著作用。

关键词：重庆市户籍制度改革城市融入感影响机理新市民

PROTAC分子的药代动力学特征及其在疾病治疗中的研究进展

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药学学报 2024年第9期59卷 2484-2490页

作者：吴瑾瑾扈金萍中国医学科学院、北京协和医学院药物研究所创新药物非临床药物代谢及PK/PD研究北京市重点实验室北京100050

蛋白靶向裂解嵌合体(proteolysis-targeting chimera, PROTAC)作为一种新兴的治疗方式,经过二十年的研究和发展,目前俨然成为新药研发领域最火热的技术之一。PROTAC分子利用细胞中天然存在的泛素-蛋白酶体系诱导靶向蛋白降解,尤其是一... 详细信息

蛋白靶向裂解嵌合体(proteolysis-targeting chimera, PROTAC)作为一种新兴的治疗方式,经过二十年的研究和发展,目前俨然成为新药研发领域最火热的技术之一。PROTAC分子利用细胞中天然存在的泛素-蛋白酶体系诱导靶向蛋白降解,尤其是一些传统小分子难以靶向的目标蛋白,并且其有望解决使用小分子药物常出现的耐药性问题。然而, PROTAC分子由于分子量较大、溶解度及膜渗透性差,口服吸收低,使其成药性研究面临诸多挑战。目前,应以药代动力学特征为着力点,不断优化设计,以期加快PROTAC药物从实验室到临床应用的转化步伐。本综述介绍了PROTAC分子的基本结构及作用机制,分析了其药代动力学特性及如何设计高效稳定的PROTAC分子,并总结了其目前在各类疾病治疗中的研究进展,评估了PROTAC药物的发展前景及面临的局限性,为PROTAC药物的进一步研究应用提供参考。

关键词：蛋白靶向裂解嵌合体药代动力学疾病靶向治疗

Associations between the use of red yeast rice preparations and adverse health outcomes:An umbrella review of meta-analyses of randomized controlled trials

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Journal of Integrative Medicine 2024年第2期22卷 126-136页

作者： Zhen-yu Ma Shu-ping Yang Ying Li Tian-tian Xu Ya-lin Yang Hui-yong Yang heng-bing Li Le-jin Zhou Yong Diao Su-yun Li School of Medicine Huaqiao UniversityQuanzhou 362021Fujian ProvinceChina College of Traditional Chinese Medicine Shandong University of Traditional Chinese MedicineJinan 250355Shandong ProvinceChina Second Clinical Medical College Nanjing Medical UniversityNanjing 211166Jiangsu ProvinceChina

Background:Red yeast rice(RYR),a natural lipid-lowering agent,is widely used in clinical ***,the existing meta-analyses concerning the safety of RYR preparations have yielded inconsistent results,and the credibility of the evidence has not been ***:This study was designed to evaluate the existing evidence and offer a comprehensive understanding of the associations between the use of RYR preparations and various adverse health *** strategy:Seven literature databases were searched from inception to May 5,2023,using medical subject headings and free-text terms(e.g.,“red yeast rice,”“Xuezhikang,”and“Zhibitai”).Inclusion criteria:Meta-analyses that investigated and quantitatively estimated associations between the use of RYR preparations and adverse health outcomes were included in this *** extraction and analysis:Two researchers independently extracted data using a standardized data collection table;any disagreements were resolved by consulting a third *** on the participant,intervention,comparator and outcome(PICO)framework in each eligible meta-analysis,a series of unique associations between the use of RYR preparations and adverse health outcomes were *** associations’effect estimates were re-evaluated using random-effect ***:Fifteen meta-analyses,comprising 186(164 unique)randomized controlled trials,were *** on A Mea Surement Tool to Assess Systematic Reviews version 2,3(20%)and 12(80%)of these meta-analyses had low and critically low confidence,respectively.A total of 61 unique associations between the use of RYR preparations and adverse health outcomes were extracted from eligible *** on the random-effect models,10(16.4%)associations indicated a significant protective effect of RYR preparations against adverse health outcomes,while 5(8.2%)indicated an increased risk of adverse health outcomes related to uric acid,alanine transaminase and aspartate trans

关键词： Red yeast rice Safety Adverse health outcomes Umbrella review Meta-analysis Systematic review

Probing the Gamma-Ray Emission Region of Five TeV Flat Spectrum Radio Quasars

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Research in Astronomy and Astrophysics 2024年第6期24卷 156-169页

作者： Hu-Bing Xiao Hai-Tao Cao Rui Xue jin-Ting Cai Ge-Ge Wang Marina Manganaro Shao-Hua Zhang Zhi-Hao Ouyang Li-ping Fu Jun-Hui Fan Shanghai Key Lab for Astrophysics Shanghai Normal UniversityShanghai 200234China School of Information Engineering Guangzhou Panyu PolytechnicGuangzhou 511483China Department of Physics Zhejiang Normal UniversityJinhua 321004China College of Mathematics and Physics Guangxi Minzu UniversityNanning 530006China Key Laboratory of Cosmology and Astrophysics(Liaoning) College of SciencesNortheastern UniversityShenyang 110819China Department of Physics University of RijekaRijeka 51000Croatia Center for Astrophysics Guangzhou UniversityGuangzhou 510006China Key Laboratory for Astronomical Observation and Technology of Guangzhou Guangzhou 510006China Astronomy Science and Technology Research Laboratory of Department of Education of Guangdong Province Guangzhou 510006China

The location ofγ-ray emission of blazars remains a contested topic,inspiring the development of numerous investigative techniques to address this *** this work,we analyzed Fermiγ-ray light curves in the GeV and MeV bands,employing the discrete cross-correlation function method to discern time lags between the two *** 4C+21.35,Ton 599,B21420+32,and PKS 1510-089,we identified a time lag spanning several days,while for PKS 1441+25,the time lag was not statistically *** results imply that the soft photons necessary for inverse Compton scattering predominantly originate from the dusty torus in the first four sources,whereas for PKS1441+25,they seem to be sourced mainly from the broad-line *** analysis of the opacity(τγγ)and the GeV spectra study supports the conclusion that the location of the dissipation region must be beyond the BLR to avoid significant ***,for PKS 1441+25,the emission region is also posited to lie outside yet proximate to the *** parameters of describing the emission region were obtained by fitting broadband spectral energy distribution with contemporaneous observation *** findings suggest that for the five TeV FSRQs,during Te V flaring events,the jet appears to maintain an equilibrium between the energy density of the magnetic field and that of the particles for all investigated sources,with the exceptions of 4C+21.35 and PKS1441+*** terms of the overall jet power,particle energy is the dominant contributor,and the observed blazar radiation cannot be solely attributed to the magnetic field,except in the case of 4C+***,magnetic reconnection is unlikely to be the primary mechanism behind particle acceleration in these systems.

关键词： galaxies:active gamma-rays:galaxies galaxies:jets

空间信息技术在水电工程全生命周期中的应用综述

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水利水电科技进展 2010年第6期30卷 84-89页

作者：朱强樊启祥金和平李纪人中国长江三峡集团公司湖北宜昌443002 北京大学遥感与地理信息研究所北京100871 中国水利水电科学研究院北京100038

简要介绍以地理信息系统、遥感和全球卫星导航系统为代表的空间信息技术的基本情况,针对空间信息技术在水电工程规划、建设实施和运行全生命周期的应用分别进行详细阐述。最后指出空间信息技术在水电工程应用中存在的问题并给出建议。

关键词：空间信息技术 GIS RS GNSS 水电工程全生命周期综述

高烈度区连续刚构桥弹塑性地震反应及断层走向影响研究

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工程抗震与加固改造 2024年第5期46卷 151-158页

作者：何通涂金平邹雨鹤中交基础设施养护集团有限公司北京100011 河北工业大学土木与交通学院天津300401

我国西部高烈度区建设了较多的连续刚构桥,部分临近活动断层。建立2座连续刚构桥Midas Civil有限元模型,选取10组脉冲型近断层地震动记录进行弹塑性时程分析,分析了断层走向对刚构桥地震反应的影响。断层走向与桥轴线夹角为75°~125°时... 详细信息

我国西部高烈度区建设了较多的连续刚构桥,部分临近活动断层。建立2座连续刚构桥Midas Civil有限元模型,选取10组脉冲型近断层地震动记录进行弹塑性时程分析,分析了断层走向对刚构桥地震反应的影响。断层走向与桥轴线夹角为75°~125°时,在纵桥向上主墩及主梁地震的反应最大,若不考虑断层走向的影响,则可能会低估20%;而横桥向最大位移则发生在0°~30°或150°~180°夹角范围之间。上述规律几乎未受加速度峰值(PGA)和桥梁墩高、跨度不同的影响。研究还发现,若不考虑断层走向的影响,对近断层地震动下桥墩塑性铰区的发生及位置存在较大的误判可能。

关键词：连续刚构桥弹塑性地震反应近断层地震动断层走向

heterophase junction engineering-induced Co spin-state modulation of CoSe_(2) for large-current hydrogen evolution reaction

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Rare Metals 2024年第6期43卷 2660-2670页

作者： Bao-Chai Xu Ya-ping Miao Min-Qin Mao Dong-Lian Li Song Xie Wei-Hong jin Shu Xiao jing Wen Zaenab Abd-Allah Zhi-Tian Liu Xiang Peng Paul K.Chu Hubei Key Laboratory of Plasma Chemistry and Advanced Materials School of Materials Science and EngineeringWuhan Institute of TechnologyWuhan 430205China School of Textile Science and Engineering Xi'an Polytechnic UniversityXi'an 710048China Institute of Advanced Wear and Corrosion Resistant and Functional Materials Jinan UniversityGuangzhou 510632China Institute of Safety Science and Engineering South China University of TechnologyGuangzhou 510641China Department of Engineering Manchester Metropolitan UniversityManchester M156BHUK Department of Physics Department of Materials Science and Engineeringand Department of Biomedical EngineeringCity University of Hong KongHong Kong 999077China

Efficient electrocatalysts are vital to large-current hydrogen production in commercial water splitting for green energy ***,a novel heterophase engineering strategy is described to produce polymorphic CoSe_(2)*** composition of the electrocatalysts consisting of both cubic CoSe_(2)(c-CoSe_(2))and orthorhombic CoSe_(2)(o-CoSe_(2))phases can be controlled *** results demonstrate that junction-induced spin-state modulation of Co atoms enhances the adsorption of intermediates and accelerates charge transfer resulting in superior large-current hydrogen evolution reaction(heR)***,the CoSe_(2)based heterophase catalyst with the optimal c-CoSe_(2)content requires an overpotential of merely 240 mV to achieve 1,000 mA·cm^(-2)as well as a Tafel slope of 50.4 mV·dec^(-1).Furthermore,the electrocatalyst can maintain a large current density of 1,500 mA·cm^(-2)for over 320 h without *** results reveal the advantages and potential of heterophase junction engineering pertaining to design and fabrication of low-cost transition metal catalysts for large-current water splitting.

关键词： heterophase junction Spin-state Hydrogen evolution reaction Large current electrochemical hydrogen production Water splitting

Gene cloning,protein expression,and enzymatic characterization of a double-stranded RNA degrading enzyme in Apolygus lucorum

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Insect Science 2024年第1期31卷 119-133页

作者： Jie-Yu Zhang jing Zhao Keyan Zhu-Salzman Qin-Qin Ji Yi-ping Jiang Liu-Bin Xiao De-jin Xu Guang-Chun Xu Lin-Quan Ge Yong-An Tan College of Plant Protection Yangzhou UniversityYangzhouJiangsu ProvinceChina Institute of Plant Protection Jiangsu Academy of Agricultural SciencesNanjingJiangsu ProvinceChina Department of Entomology Texas A&M UniversityCollege StationTXUSA Taizhou Customs of the People's Republic of China TaizhouJiangsu ProvinceChina

RNA interference(RNAi)is a powerful tool that post-transcriptionally silences target genes in eukaryotic ***,silencing efficacy varies greatly among different insect ***,we met with little success when attempting to knock down genes in the mirid bug Apolygus lucorum via dsRNA *** disappearance of double-stranded RNA(dsRNA)could be a potential factor that restricts RNAi ***,we found that dsRNA can be degraded in midgut fluids,and a dsRNase of ***(AldsRNase)was identified and *** alignment indicated that its 6 key amino acid residues and the Mg2+-binding site were similar to those of other insects’*** signal peptide and endonuclease non-specific domain shared high sequence identity with the brown-winged green stinkbug Plautia stali *** showed high salivary gland and midgut expression and was continuously expressed through the whole life cycle,with peaks at the 4th instar ecdysis in the whole *** purified AldsRNase protein obtained by heterologously expressed can rapidly degrade *** comparing the substrate specificity of AldsRNase,3 specific substrates(dsRNA,small interfering RNA,and dsDNA)were all degraded,and the most efficient degradation is ***,immunofluorescence revealed that AldsRNase was expressed in the cytoplasm of midgut *** cloning and functional study of AldsRNase,the enzyme activity and substrate specificity of the recombinant protein,as well as the subcellular localization of nuclease,the reason for the disappearance of dsRNA was explained,which was useful in improving RNAi efficiency in *** and related species.

关键词： Apolygus lucorum cloning dsRNase enzymatic activity protein expression

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新生儿轮状病毒感染流行病学特征分析

中国病原生物学杂志 2017年第9期12卷 883-886页

作者：李锦汪萍何祥英毛淑琼四川省简阳市人民医院四川简阳641400

目的研究医院新生儿轮状病毒感染流行病学,为疾病治疗提供指导。方法收集781例2014-2016年新生儿腹泻患者病例标本,采用清洁灭菌的青霉素小瓶,收集各新生儿新鲜大便2~4g,-20℃保存待检。粪便样品HRV PAGE阳性者即为新生儿轮状病毒感染... 详细信息

目的研究医院新生儿轮状病毒感染流行病学,为疾病治疗提供指导。方法收集781例2014-2016年新生儿腹泻患者病例标本,采用清洁灭菌的青霉素小瓶,收集各新生儿新鲜大便2~4g,-20℃保存待检。粪便样品HRV PAGE阳性者即为新生儿轮状病毒感染。结果 781例新生儿患者中检出轮状病毒感染患儿246例,检出率31.50%,其中2014年检出率为23.35%(39/167),2015年33.46%(87/260),2016年33.90%(120/354)。2014-2016年的春、夏、秋、冬四季轮状病毒检出率分别为28.78%(59/205)、34.22%(64/187)、36.50%(73/200)和26.46%(50/189);2014年四季的轮状病毒检出率分别为17.39%、28.00%、27.78%和20.00%,2015年分别为32.84%、36.23%、35.29%和28.57%,2016年分别为31.52%、36.76%、40.63%和27.55%。2014-2016年男性患儿轮状病毒检出率为31.49%(142/451),女性为31.52%(104/330);2014年男、女性患儿的轮状病毒检出率分别为23.08%和23.68%,2015年分别为32.03%和35.51%,2016年分别为34.78%和32.65%。2014-2016年医院早期新生儿的轮状病毒检出率为35.93%(143/398),晚期新生儿的轮状病毒检出率为26.89%(103/383);2014年分别为26.39%和21.05%,2015年分别为35.61%和31.25%,2016年分别为39.69%和26.88%。结论 2014-2016年新生儿轮状病毒的感染率呈逐年上升趋势。秋季检出率最高,男性患儿与女性患儿感染率较接近,早期新生儿感染率较低。临床应高效预防感染发生并及时开发有效疫苗,为疾病治疗提供指导。

关键词：新生儿轮状病毒感染流行病学