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Neural Regeneration Research 2016年第5期11卷 816-822页

作者： jin-lan jiang Xu-dong Guo Shu-quan Zhang Xin-gang Wang Shi-feng Wu Scientific Research Center China-Japan Union Hospital Jilin University Department of Orthopedics China-Japan Union Hospital Jilin University Department of Cardiovascular Medicine China-Japan Union Hospital Jilin University Department of Orthopedics Tianjin Nankai Hospital Department of Burns and Plastic Surgery China-Japan Union Hospital Jilin University

Repetitive magnetic stimulation has been shown to alter local blood flow of the brain, excite the corticospinal tract and muscle, and induce motor function recovery. We established a rat model of acute spinal cord injury using the modified Allen＇s method. After 4 hours of injury, rat models received repetitive magnetic stimulation, with a stimulus intensity of 35% maximum output intensity, 5-Hz frequency, 5 seconds for each sequence, and an interval of 2 minutes. This was repeated for a total of 10 sequences, once a day, 5 days in a week, for 2 consecutive weeks. After repetitive magnetic stimulation, the number of apoptotic cells decreased, matrix metalloproteinase 9/2 gene and protein expression decreased, nestin expression increased, somatosensory and motor-evoked potentials recovered, and motor function recovered in the injured spinal cord. These findings confirm that repetitive magnetic stimulation of the spinal cord improved the microenvironment of neural regeneration, reduced neuronal apoptosis, and induced neuroprotective and repair effects on the injured spinal cord.

关键词： nerve regeneration spinal cord injury repetitive magnetic stimulation motor function rats rehabilitation plasticity regenerative microenvironment neural regeneration

Current status and future prospects of stem cell therapy in Alzheimer’s disease

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Neural Regeneration Research 2020年第2期15卷 242-250页

作者： Fu-Qiang Zhang jin-lan jiang jing-Tian Zhang Han Niu Xue-Qi Fu Lin-Lin Zeng Scientific Research Centre of China-Japan Union Hospital Jilin UniversityChangchunJilin ProvinceChina School of Life Sciences Jilin UniversityChangchunJilin ProvinceChina

Alzheimer’s disease is a common progressive neurodegenerative disorder, pathologically characterized by the presence of β-amyloid plaques and neurofibrillary tangles. Current treatment approaches using drugs only alleviate the symptoms without curing the disease, which is a serious issue and influences the quality of life of the patients and their caregivers. In recent years, stem cell technology has provided new insights into the treatment of neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis. Currently, the main sources of stem cells include neural stem cells, embryonic stem cells, mesenchymal stem cells, and induced pluripotent stem cells. In this review, we discuss the pathophysiology and general treatment of Alzheimer’s disease, and the current state of stem cell transplantation in the treatment of Alzheimer’s disease. We also assess future challenges in the clinical application and drug development of stem cell transplantation as a treatment for Alzheimer’s disease.

关键词： Alzheimer's disease β-amyloid drug development embryonic stem cells induced pluripotent stem cells mesenchymal stem cells nerve regeneration neural regeneration neural stem cells neurodegenerative disorders stem cell therapy

Identification of a nine-gene prognostic signature for gastric carcinoma using integrated bioinformatics analyses

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World Journal of Gastrointestinal Oncology 2020年第9期12卷 975-991页

作者： Kun-Zhe Wu Xiao-Hua Xu Cui-Ping Zhan jing Li jin-lan jiang Scientific Research Center China-Japan Union Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina Department of Nephrology China-Japan Union Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina Department of Ultrasound China-Japan Union Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina

BACKGROUND Gastric carcinoma(GC)is one of the most aggressive primary digestive *** has unsatisfactory therapeutic outcomes and is difficult to diagnose *** To identify prognostic biomarkers for GC patients using comprehensive bioinformatics *** Differentially expressed genes(DEGs)were screened using gene expression data from The Cancer Genome Atlas and Gene Expression Omnibus databases for *** DEGs were analyzed using univariate and multivariate Cox regression analyses.A risk score model was then constructed and its prognostic value was validated utilizing an independent Gene Expression Omnibus dataset(GSE15459).Multiple databases were used to analyze each gene in the risk score ***-risk score-associated pathways and therapeutic small molecule drugs were analyzed and predicted,*** A total of 95 overlapping DEGs were found and a nine-gene signature(COL8A1,CTHRC1,COL5A2,AADAC,MAMDC2,SERPINE1,MAOA,COL1A2,and FNDC1)was constructed for the GC prognosis *** operating characteristic curve performance in the training dataset(The Cancer Genome Atlas-stomach adenocarcinoma)and validation dataset(GSE15459)demonstrated a robust prognostic value of the risk score *** database analyses for each gene provided evidence to further understand the nine-gene *** set enrichment analysis showed that the high-risk group was enriched in multiple cancer-related ***,several new small molecule drugs for potential treatment of GC were *** The nine-gene signature-derived risk score allows to predict GC prognosis and might prove useful for guiding therapeutic strategies for GC patients.

关键词： Gastric carcinoma Bioinformatic analysis Prognosis Overall survival Differentially expressed genes

Diffusion tensor imaging of spinal microstructure in healthy adults： improved resolution with the readout segmentation of long variable echo-trains

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Neural Regeneration Research 2017年第12期12卷 2067-2070页

作者： Bu-tian Zhang Meng Li Li-li Yu Yi-meng Dai Shao-nan Yu jin-lan jiang China-Japan Union Hospital of Jilin University Changchun Jilin Province China

Diffusion tensor imaging plays an important role in the accurate diagnosis and prognosis of spinal cord diseases. However, because of technical limitations, the imaging sequences used in this technique cannot reveal the fine structure of the spinal cord with precision. We used the readout segmentation of long variable echo-trains（RESOLVE） sequence in this cross-sectional study of 45 healthy volunteers aged 20 to 63 years. We found that the RESOLVE sequence significantly increased the resolution of the diffusion images and improved the median signal-to-noise ratio of the middle（C4–6） and lower（C7–T1） cervical segments to the level of the upper cervical segment. In addition, the values of fractional anisotropy and radial diffusivity were significantly higher in white matter than in gray matter. Our study verified that the RESOLVE sequence could improve resolution of diffusion tensor imaging in clinical applications and provide accurate baseline data for the diagnosis and treatment of cervical spinal cord diseases.

关键词： nerve regeneration diffusion tensor imaging cervical spinal cord microstructure gray matter white matter readout segmentationof long variable echo-train sequence signal-to-noise ratio fractional anisotropy neural regeneration

Senegenin inhibits neuronal apoptosis after spinal cord contusion injury

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Neural Regeneration Research 2016年第4期11卷 657-663页

作者： Shu-quan Zhang Min-fei Wu Rui Gu Jia-bei Liu Ye Li Qing-san Zhu jin-lan jiang Department of Orthopedics Nankai Hospital Department of Orthopedics the Second Hospital of Jilin University Department of Orthopedics China-Japan Union HospitalJilin University Scientific Research Center China-Japan Union HospitalJilin University

Senegenin has been shown to inhibit neuronal apoptosis,thereby exerting a neuroprotective *** the present study,we established a rat model of spinal cord contusion injury using the modified Allen＇s *** hours after injury,senegenin（30 mg/g） was injected into the tail vein for 3 consecutive *** reduced the size of syringomyelic cavities,and it substantially reduced the number of apoptotic cells in the spinal *** the site of injury,Bax and Caspase-3 m RNA and protein levels were decreased by senegenin,while Bcl-2 m RNA and protein levels were *** fiber density was increased in the spinal cord proximal to the brain,and hindlimb motor function and electrophysiological properties of rat hindlimb were *** together,our results suggest that senegenin exerts a neuroprotective effect by suppressing neuronal apoptosis at the site of spinal cord injury.

关键词： nerve regeneration spinal cord contusion senegenin thinleaf milkwort root motor function apoptosis electrophysiology neural regeneration

The gut-eye axis:from brain neurodegenerative diseases to age-related macular degeneration

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Neural Regeneration Research 2025年第10期20卷 2741-2757页

作者： Qianzi jin Suyu Wang Yujia Yao Qin jiang Keran Li Department of Ophthalmology The Affiliated Eye Hospital of Nanjing Medical UniversityNanjingJiangsu ProvinceChina The Fourth School of Clinical Medicine Nanjing Medical UniversityNanjingJiangsu ProvinceChina

Age-related macular degeneration is a serious neurodegenerative disease of the retina that significantly impacts ***,the specific pathogenesis remains unclear,and effective early treatment options are consequently *** microbiome is defined as a large ecosystem of microorganisms living within and coexisting with a *** intestinal microbiome undergoes dynamic changes owing to age,diet,genetics,and other *** dysregulation of the intestinal flora can disrupt the microecological balance,resulting in immunological and metabolic dysfunction in the host,and affecting the development of many *** recent decades,significant evidence has indicated that the intestinal flora also influences systems outside of the digestive tract,including the ***,several studies have demonstrated the critical role of the gut-brain axis in the development of brain neurodegenerative diseases,including Alzheimer’s disease and Parkinson’s ***,the role of the“gut-eye axis”has been confirmed to play a role in the pathogenesis of many ocular ***,age-related macular degeneration and many brain neurodegenerative diseases have been shown to share several risk factors and to exhibit comparable *** such,the intestinal flora may play an important role in age-related macular *** the above context,the present review aims to clarify the gut-brain and gut-eye connections,assess the effect of intestinal flora and metabolites on age-related macular degeneration,and identify potential diagnostic markers and therapeutic ***,direct research on the role of intestinal flora in age-related macular degeneration is still relatively limited,while studies focusing solely on intestinal flora are insufficient to fully elucidate its functional role in age-related macular ***-on-a-chip technology has shown promise in clarifying the gut-eye interactions,while integrating analysis of the inte

关键词： age-related macular degeneration biological agents blinding eye disease dietary nutrition fecal microbial transplantation gut-eye axis intestinal flora metabolite microecology neurodegenerative disease

CaH2-promoted activity of Ni-carbonate interface for CO2 methanation

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Journal of Energy Chemistry 2025年第1期100卷 522-532页

作者： jin-Peng Wang Guo-Cui Mao Hui-Lin jiang Bao-Xia Dong Yun-Lei Teng School of Chemistry and Chemical Engineering Yangzhou University

Transition metal-carbonate interfaces often act as active sites in heterogeneous catalytic *** interface between transition metal and metal carbonate exhibits a dynamic equilibrium during the CO2hydrogenation reaction,involving surface carbonate hydrogenation and ***,there have been few reports on engineering the activity of the interface between transition metal and alkaline earth metal carbonate for catalytic *** work demonstrated that the incorporation of CaH2in Ni/CaCO3enhances the CO2methanation activity of the *** CO2conversion for Ni/CaH2-CaCO3reached 68.5%at 400°C,which was much higher than that of the Ni/CaCO3（31.6%） and Ni/CaH2-CaO （42.4%） ***,the Ni/CaH2-CaCO3catalysts remained stable during the stability test for 24 h at 400°C and 8 *** research revealed that CaH2played a crucial role in promoting the activity of the Ni-carbonate interface for ***2could modify the electronic structure of Ni and tune the structural properties of CaCO3to generate medium basic sites （OH groups）,which are favorable for the activation of H2and ***-situ Fourier transform infrared spectroscopy （FTIR） analysis combined with density functional theory calculations demonstrated that CO2activation occurs at the hydroxyl group （OH） on the CaH2-modified Ni-carbonate surface,leading to the formation of CO3H****,our study has confirmed that CO2methanation over the Ni/CaH2-CaCO3catalysts proceeds via the formate pathway.

关键词： CO 2 methanation Metal hydride Ni catalysts Carbonate Metal-carbonate interface

Separation of the ionospheric and thermospheric contributions in the data from the Triple Ionosophere Photo Meter onboard the Feng-Yun 3E satellite

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Science China Earth Sciences 2025年第1期68卷 172-184页

作者： Fang jiang Tian MAO jin-Song WANG Xiu-Qing HU Xiao-Xin ZHANG Liping FU Nan JIA Tianfang WANG National Space Science Center Chinese Academy of Sciences Beijing Key Laboratory of Space Environment Exploration Key Laboratory of Environmental Space Situation Awareness Technology National Satellite Meteorological Center China Meteorological Administration

The Triple Ionosphere Photo Meter （TRIPM） is a far ultraviolet nadir-view photometer that is onboard the secondgeneration,polar-orbiting Chinese meteorological satellite Feng-Yun 3E （FY-3E）,which was launched on July 5,*** has three channels,and each is used to measure different types of emissions:（1） 135.6 nm airglow produced by the recombination of the O+ions and electrons in the absence of sunlight （nighttime channel）;（2） 135.6 nm airglow from the OI when sunlight is present （daytime/dusk-dawn 135.6 nm channel）;and （3） Airglow in the N2LBH of the TRIPM （daytime/dusk-dawn N2LBH channel）.FY-3E is a satellite operating in the early morning ***,the data are mostly distributed on the dawndusk side or at times when the solar zenith angle is relatively *** this study,combined with simulation calculations,the data are *** further explore the application value of the data products,a model is used to separate the ionospheric radiative recombination contribution from the thermosphere photoelectron impact excitation contribution in the data from the daytime/dusk-dawn 135.6 nm *** approach not only improves the accuracy of O/N2derived from the 135.6 nm channel and N2LBH channel but also provides the ionospheric 135.6 nm radiance at the same time as the *** results show that the 135.6 nm radiance originating from the combination of O+and electrons extracted from the measurement data exhibits similar equatorial anomaly peak structure characteristics and seasonal variations as the corresponding GPS total electron content （TEC） *** the other hand,the separated 135.6 nm radiance generated from the thermosphere photoelectron collision excitation does not contain radiative recombination contributions;thus,the ionosphere influence is greatly avoided when the O/N2is obtained.

关键词： Far ultraviolet 135.6 nm emission intensity Photoelectron impact excitation Radiative recombination excitation

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明目益气方辅助常规对症干预治疗屈光不正性视疲劳临床研究

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中南药学 2016年第10期14卷 1125-1127页

作者：金兰朱江西安市中医医院眼科西安710021 西安市第四医院眼科西安710004

目的探讨明目益气方辅助常规对症干预治疗屈光不正性视疲劳临床疗效。方法研究对象选取本院2011年4月-2015年4月收治屈光不正性视疲劳患者共80例,以随机分组法分为对照组(40例)和治疗组(40例),分别采用常规对症干预和在此基础上加用明... 详细信息

目的探讨明目益气方辅助常规对症干预治疗屈光不正性视疲劳临床疗效。方法研究对象选取本院2011年4月-2015年4月收治屈光不正性视疲劳患者共80例,以随机分组法分为对照组(40例)和治疗组(40例),分别采用常规对症干预和在此基础上加用明目益气方辅助治疗;比较2组患者临床疗效,治疗前后视疲劳评分、裸眼视力及屈光度水平等。结果对照组和治疗组患者临床治疗总有效率分别为72.50%(29/40),95.00%(38/40);治疗组患者临床疗效显著优于对照组,差异有统计学意义(P<0.05);治疗组患者治疗后视疲劳评分显著低于对照组和治疗前,差异有统计学意义(P<0.05);同时治疗组患者治疗后裸眼视力和屈光度水平均显著优于对照组和治疗前,差异有统计学意义(P<0.05)。结论明目益气方辅助常规对症干预治疗屈光不正性视疲劳可有效缓解眼部症状体征,提高视力水平,并有助于纠正屈光不正。

关键词：中医药屈光不正性视疲劳疗效

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基于多类支持向量机的基本信度分配确定方法

通信学报 2010年第S1期31卷 100-104页

作者：金宏斌蓝江桥空军雷达学院预警监视情报系湖北武汉430019

在多传感器信息融合中,证据理论是一种重要方法,但其基本信度分配的确定已成为实际应用的瓶颈问题。针对此,提出了一种基于多类支持向量机的基本信度分配确定方法,以Platt后验概率为基础,将两类后验概率扩展到多类,并对后验概率形式的... 详细信息

在多传感器信息融合中,证据理论是一种重要方法,但其基本信度分配的确定已成为实际应用的瓶颈问题。针对此,提出了一种基于多类支持向量机的基本信度分配确定方法,以Platt后验概率为基础,将两类后验概率扩展到多类,并对后验概率形式的软判决进行了改进,从而构造了信度分配函数。通过仿真对比分析验证了该方法的合理性和有效性。

关键词：多类支持向量机基本信度分配证据理论 Platt后验概率