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Long non-coding RNA plasmacytoma variant translocation 1 linked to hypoxia-induced cardiomyocyte injury of H9c2 cells by targeting miR-135a-5p/forkhead box O1 axis

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Chinese Medical Journal 2020年第24期133卷 2953-2962页

作者： jin-juan xu Wei-Hong Zheng Jun Wang Yuan-Yuan Chen Department of General Practice Medicine The Fifth People’s Hospital of Yuhang DistrictHangzhouZhejiang 311100China School of Life Sciences Huzhou UniversityHuzhouZhejiang 313000China Binjiang Clinic Zhejiang Chinese Medical UniversityHangzhouZhejiang 310053China Department of Geriatrics Hangzhou Hospital of Traditional Chinese MedicineHangzhouZhejiang 310007China

Background:Myocardial infarction occurs due to insufficient(ischemia)blood supply to heart for long time;plasmacytoma variant translocation 1(PVT1)is a long non-coding RNAs(lncRNAs)involved in the pathogenesis of various diseases,including heart disease;However,few studies have explored its *** present study evaluated the effects of lncRNA PVT1 on hypoxic rat H9c2 ***:Hypoxic injury was examined by measuring cell viability and apoptosis by using cell counting kit-8 activity and flow cytometry *** expressions after hypoxia were estimated by quantitative real time polymerase chain reaction and the signaling pathway were explored by Western blot *** immunoprecipitation and luciferase reporter assays were applied to examine the interactions among *** were analyzed using t-test with one-way or two-way analysis of ***:The lncRNA PVT1 is up-regulated in hypoxia-stressed H9c2 cells and knockdown of PVT1 mitigates hypoxia-induced injury in H9c2 ***1 acts as a sponge for miR-135a-5p and knockdown of PVT1 attenuated the increased hypoxia-induced injury by up-regulating *** box O1(FOXO1)was identified as a target of miR-135a-5p,and the expression was negatively regulated by *** exploration of the underlying mechanism demonstrated that knockdown of FOXO1 reversed PVT1/miR-135a-5p mediated hypoxia-induced injury in H9c2 ***:PVT1 plays a crucial role in hypoxia-injured H9c2 cells through sponging miR-135a-5p and then positively regulating FOXO1.

关键词： Acute myocardial infarction PVT1 miR-135a-5p FOXO1

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A surface engineering strategy for the stabilization of zinc metal anodes with montmorillonite layers toward long-life rechargeable aqueous zinc ion batteries

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Journal of Energy Chemistry 2025年第1期100卷 94-105页

作者： Wenbo Wang Ruifeng xu xu Zhang Peiyu Wang Bao Yang Bingjun Yang juan Yang Kailimai Su Pengjun Ma Yanan Deng Xianfeng Fan Wanjun Chen Key Laboratory for Electronic Materials College of Electrical Engineering Northwest Minzu University Resource Chemistry and Energy Materials Research Center State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical Physics Chinese Academy of Sciences University of Chinese Academy of Sciences Institute for Materials and Processes School of Engineering University of Edinburgh

Rechargeable aqueous zinc-ion batteries （AZIBs） exhibit appreciable potential in the domain of electrochemical energy ***,there are serious challenges for AZIBs,for instance zinc dendrite growth,hydrogen evolution reaction （HER）,and corrosion side ***,we propose a surface engineering modification strategy for coating the montmorillonite （MMT） layer onto the surface of the Zn anode to tackle these issues,thereby achieving high cycling stability for rechargeable *** results reveal that the MMT layer on the surface of the Zn anode is able to provide ordered zincophilic channels for zinc ions migration,facilitating the reaction kinetics of zinc *** functional theory（DFT） calculations and water contact angle （CA） tests prove that MMT@Zn anode exhibits superior adsorption capacity for Zn2+and better hydrophobicity than the bare Zn anode,thereby achieving excellent cycling ***,the MMT@Zn||MMT@Zn symmetric cell holds the stable cycling over 5600 h at 0.5 mA cm-2and 0.125 m A h cm-2,even exceeding 1800 h long cycling under harsh conditions of 5 m A cm-2and 1.25 m A h *** MMT@Zn||V2O5full cell reaches over 3000 cycles at 2 A g-1with excellent rate ***,this surface engineering modification strategy for enhancing the electrochemical performance of AZIBs represents a promising application.

关键词： Hydrogen evolution reaction

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Investigation on optical sinc-shaped Nyquist pulse generation based on external modulation

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Optoelectronics Letters 2025年

作者： YUAN jin xu Xiuxiu State Key Laboratory of Media Convergence and Communication， Communication University of China

In this paper， a scheme for generating sinc-shaped optical Nyquist pulses based on external modulation is proposed. First， five flat optical frequency comb (OFC) lines are generated by a dual-parallel Mach-Zehnder modulator (DP-MZM) for optical carrier phase cancellation interference. Then， the phase-locked OFC is split into two paths， one of which is transmitted to a single-drive Mach-Zehnder modulator (SD-MZM) for the modulation of the even-order side-band suppression， and the other is used to remodulate the signal in order to obtain equally spaced comb lines. Eventually， equal frequency spaced phase-locked 15-line OFCs are generated and extremely narrow over-zero width Nyquist pulses are realized at 2.5GHz， 5GHz， 10GHz and 20GHz. The root-mean-square error (RMSE) is calculated for the generated Nyquist pulses which enables the verification of the signal quality.

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Recent progress on photoactive nonprecious transition-metal complexes

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Science China Chemistry 2025年第1期68卷 46-95页

作者： Zhong-Liang Gong Hong-Jie Zhang Yan Cheng Jianxun Liu Yuhan Ai Yaqin Li Zhihui Feng Qiong Zhang Shaolong Gong Yong Chen Chang-Jiang Yao Yuan-Yuan Zhu Liang-jin xu Yu-Wu Zhong CAS Key Laboratory of Photochemistry Institute of Chemistry Chinese Academy of Sciences State Key Laboratory of Structural Cemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences School of Chemistry and Chemical Engineering Anhui Key Laboratory of Advanced Catalytic Materials and Reaction EngineeringHefei University of Technology State Key Laboratory of Explosion Science and Safety Protection School of Mechatronical Engineering Beijing Institute of Technology College of Chemistry and Molecular Sciences Hubei Key Lab on Organic and Polymeric Optoelectronic Materials Wuhan University School of Chemistry and Chemical Engineering Anhui University Key Laboratory of Photochemical Conversion and Optoelectronic Materials & CAS-HKU Joint Laboratory on New Materials Technical Institute of Physics and Chemistry Chinese Academy of Sciences

Photoactive complexes of nonprecious transition metals, mainly including those in the first-row and partially the second-row of the Periodic table of elements, have received increasing attention in view of their low cost and long-term sustainability. They are recognized as promising alternatives to noble transition metal complex congeners that have been extensively studied in optoelectronic devices, artificial photosynthesis, photocatalysis, biodiagnostics, and therapeutics, etc. This review is devoted to a comprehensive summary on the classical and recent advances on photoactive nonprecious transition metal complexes, including photoactive Zr, V, Cr, Mo, and W complexes, Mn complexes and hybrids, Fe, Co, Ni, and Cu complexes, and Zn and Cd complexes and hybrids. A particular focus is given on the molecular design, modulation of photophysical and photochemical properties, and applications of the representative and lately-developed nonprecious metal complexes. In addition, a perspective on the future development in this field is provided at the end of this review.

关键词： photoactive metal complexes earth-abundant metals nonprecious metal complexes luminescence photochemistry

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Enhanced subacute ischemic stroke treatment via multistage drug delivery system design for combination therapy

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Science China Chemistry 2025年

作者： Xihan xu juan-juan Li Jiamin Li Hui-Yan Zhang Yilin Qi Bing-Sen Shi Tianqi Li Shan-Shan Su Weitao Zhao Chang Chen Zhongying Gong Huiyu Liu Ke-Rang Wang Dong-Sheng Guo xue xue State Key Laboratory of Medicinal Chemical Biology College of Pharmacy Nankai University College of Chemistry State Key Laboratory of Elemento-Organic Chemistry Key Laboratory of Functional Polymer Materials (Ministry of Education) Frontiers Science Center for New Organic Matter Collaborative Innovation Center of Chemical Science and EngineeringNankai University College of Chemistry and Materials Science State Key Laboratory of New Pharmaceutical Preparations and Excipients Key Laboratory of Medicinal Chemistry and Molecular Diagnosis (Ministry of Education) Key Laboratory of Chemical Biology of Hebei Province Hebei Research Center of the Basic Discipline of Synthetic Chemistry Hebei University Department of Neurology Tianjin First Central Hospital School of Medicine Nankai University Beijing Advanced Innovation Center for Soft Matter Science and Engineering State Key Laboratory of Organic-Inorganic Composites Beijing Laboratory of Biomedical Materials Bionanomaterials & Translational Engineering Laboratory Beijing Key Laboratory of BioprocessBeijing University of Chemical Technology

The management of acute ischemic stroke remains challenging due to its abrupt onset and the narrow treatment window,resulting in high rates of disability and *** therapy for neuroprotection and neurorepair strategies provided new hopes for subacute stroke *** we designed a multistage nanodelivery system that matches the unique microenvironment of the subacute phase of stroke,which utilizes calixarene as a building block to effectively load the neuroprotective drug *** calixarene is designed with glycosidic linkages targeting the glucose transporter 1 (GLUT1)on the blood-brain barrier (BBB) and azo bonds that are responsive to hypoxic ***,the decomposed calixarene molecules themselves possess intrinsic bio-activation to modulate inflammatory responses,achieving a multistage therapeutic approach that transitions from targeting to release and finally to *** approach combines anti-inflammation and neuroprotection,providing a multi-level treatment *** system was validated in a rat model of permanent middle cerebral artery occlusion (pMCAO),demonstrating that intravenous administration of the nanodelivery system repairs brain damage and improves motor function 24 h post-pMCAO *** work offers a precise and integrative strategy for stroke patients missing the acute therapy window to improve functional recovery and enhance the effect of comprehensive treatment.

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消费者估值不确定下众筹定价策略及退款机制研究

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管理工程学报 2025年第1期39卷 256-270页

作者：徐扬毕功兵宋文吴娟安徽财经大学金融学院安徽蚌埠233030 中国科学技术大学管理学院安徽合肥230026 南京审计大学金融学院江苏南京211815

众筹作为最受欢迎的互联网金融产品之一,受到工业界和学术界的广泛关注。基于现实背景,本文建立了两阶段众筹模型,研究了消费者估值不确定下消费者的策略性选择行为及其对众筹定价策略的影响。结论表明,若消费者参与众筹的额外效用较低... 详细信息

众筹作为最受欢迎的互联网金融产品之一,受到工业界和学术界的广泛关注。基于现实背景,本文建立了两阶段众筹模型,研究了消费者估值不确定下消费者的策略性选择行为及其对众筹定价策略的影响。结论表明,若消费者参与众筹的额外效用较低,消费者估值不确定会造成“搭便车”现象,导致最优众筹价格不是关于项目所需资金的单增函数。当项目所需资金较低或较高时,发起人应该设置较高的众筹价格,否则应该降低价格以激励更多的消费者参与众筹。通过对比传统销售模式,本文揭示了发起人可以利用消费者估值不确定性及众筹的预售机制增加销量或边际收益以提升利润。进一步,本文证明了退款机制可以有效增加消费者参与众筹的意愿,从而提高众筹的可行域。最后,本文将基本模型拓展到更加一般的情形,研究发现众筹市场大小、项目运作风险和生产能力均对最优定价决策有不可忽视的影响。

关键词：众筹定价决策估值不确定策略型消费者退款机制

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Boosting aqueous nickel-zinc battery stability with bimetallic ion-integrated 1D metal-organic nanowires

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Science China Chemistry 2025年

作者： Yihao Chen jin Liang Yichun Su Guoyin Zhu Hengyue xu Hongye Ding Guangxun Zhang Dianheng Yu Zizhou Shen Yizhou Zhang Wei Huang Huan Pang School of Chemistry and Chemical Engineering Yangzhou University Key Laboratory of Flexible Electronics (KLoFE) & Institute of Advanced Materials (IAM) School of Flexible Electronics (Future Technologies) Nanjing Tech University (NanjingTech) Institute of Advanced Materials and Flexible Electronics (IAMFE) School of Chemistry and Materials Science Nanjing University of Information Science & Technology Department of Chemistry Tsinghua University State Key Laboratory of Coordination Chemistry Nanjing University

Limited by low conductivity,designing cathode materials with excellent electron transfer efficiency for high-performance nickel-zinc batteries （NZBs） remains *** this study,a series of bimetallic metal-organic nanowires were fabricated by doping M ions in NiNTA,resulting in NiMNTA (M=Mg2+,Mn2+,Co2+,Zn2+,Ag+),and NixCo6-xNTA （x=1,2,3,4,5）.The proportions and types of metal ions can be modified without altering the initial coordination structure.X-ray absorption fine structure spectroscopy （XAFS） revealed that only M–O bonds,not metal bonds,were present in the *** performance of Ni2Co4NTA as the cathode for aqueous NZBs was significantly improved,achieving the maximum energy density of 279.17Wh kg-1with the high cycle stability （retention rate of 72.0%after 1,000 cycles）.The flexible Ni2Co4NTA//Zn@carbon cloth battery employing gel electrolyte also exhibits the excellent Coulombic efficiency of 96%after 350 *** approach shows considerable potential for designing one-dimensional materials with bimetallic modifications,providing new strategies for developing cathode materials for NZBs with high specific capacity and cycle stability.

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Peri-centrosomal localization of small interfering RNAs in C. elegans

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Science China Life Sciences 2025年

作者： Qile jin xuezhu Feng Minjie Hong Ke Wang Xiangyang Chen Jiewei Cheng Yan Kuang Xiaoyue Si Mingjing xu Xinya Huang Shouhong Guang Chengming Zhu Department of Obstetrics and Gynecology The First Affiliated Hospital of USTC The USTC RNA Institute Hefei National Research Center for Physical Sciences at the Microscale School of Life Sciences Division of Life Sciences and Medicine Biomedical Sciences and Health Laboratory of Anhui Province University of Science and Technology of China School of Basic Medicine Anhui Medical University

The centrosome is the microtubule-organizing center and a crucial part of cell division. Centrosomal RNAs(cnRNAs) have been reported to enable precise spatiotemporal control of gene expression during cell division in many species. Whether and how cnRNAs exist in C. elegans are unclear. Here, using the nuclear RNAi Argonaute protein NRDE-3 as a reporter, we observed potential peri-centrosome localized small interfering(si)RNAs in C. elegans. NRDE-3 was previously shown to associate with pre-mRNAs and pre-rRNAs via a process involving the presence of complementary siRNAs. We generated a GFP-NRDE-3 knock-in transgene through CRISPR/Cas9 technology and observed that NRDE-3 formed peri-centrosomal foci neighboring the tubulin protein TBB-2, other centriole proteins and pericentriolar material(PCM)components in C. elegans embryos. The peri-centrosomal accumulation of NRDE-3 depends on RNA-dependent RNA polymerase(RdRP)-synthesized 22G siRNAs and the PAZ domain of NRDE-3, which is essential for siRNA binding. Mutation of eri-1, ergo-1, or drh-3 significantly increased the percentage of pericentrosome-enriched NRDE-3. At the metaphase of the cell cycle, NRDE-3 was enriched in both the peri-centrosomal region and the spindle. Moreover, the integrity of centriole proteins and pericentriolar material(PCM) components is also required for the peri-centrosomal accumulation of NRDE-3. Therefore, we concluded that siRNAs could accumulate in the pericentrosomal region in C. elegans and suggested that the peri-centrosomal region may also be a platform for RNAi-mediated gene regulation.

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Lipomatous ependymoma with ZFTA:RELA fusion-positive:A case report

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World Journal of Clinical Cases 2025年第1期13卷 48-55页

作者： Xiao-Yu Zhao juan-Han Yu Yi-Hua Wang Yi-Xin Liu Lu xu Lin Fu Ning Yi China Medical University The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Department of Pathology The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Anshan Cancer Hospital Anshan 114000Liaoning ProvinceChina

BACKGROUND Ependymoma with lipomatous differentiation is a rare type of *** ZFTA fusion-positive supratentorial ependymoma is a novel tumor type in the 2021 World Health Organization classification of central nervous system *** fusion-positive lipomatous ependymoma has not been reported to *** SUMMARY We reported a case of a 15-year-old Chinese male who had a sudden convulsion lasting approximately six *** resonance imaging showed a round cystic shadow of approximately 1.9 cm×1.5 cm×1.9 cm under the right parieto-occipital *** examination showed characteristic perivascular pseudorosettes and adipose differentiation in the ***-chemical staining showed that the tumor cells were negative for cytokeratin,NeuN,Syn and p53,but positive for GFAP,vimentin and S-100 ***-ficant punctate intracytoplasmic EMA immunoreactivity was *** level of Ki-67 was about 5%.Genetic analysis revealed ZFTA:RELA fusion.A cranio-tomy with total excision of the tumor was *** follow-up time was 36 months,no evidence of disease recurrence was found in magnetic resonance *** Based on these findings,the patient was diagnosed as a ependymoma with ZFTA fusion and lipomatous *** case report provides information on the microscopic morphological features of ependymoma with ZFTA fusion and lipomatous differentiation,which can help pathologists to make a definitive diagnosis of this tumor.

关键词： Ependymoma Lipomatous Molecular classification Supratentorial ZFTA:RELA fusion Case report

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循环加载与卸围压组合扰动下红砂岩损伤破裂与渗透特性

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岩土工程学报 2025年第1期47卷 48-56页

作者：姚玮俞缙周先齐常方强常旭厦门理工学院土木工程与建筑学院福建厦门361024 华侨大学福建省隧道与城市地下空间工程技术研究中心福建厦门361021

为探究深地工程开挖诱导岩体损伤破裂及渗透性演化规律,开展了同步测定波速与渗透率的循环加载与卸围压组合扰动三轴试验,研究了不同条件下红砂岩的损伤与渗透性演化规律。结果表明:①岩石在不同组合扰动阶段具有不同的应力应变曲线形态... 详细信息

为探究深地工程开挖诱导岩体损伤破裂及渗透性演化规律,开展了同步测定波速与渗透率的循环加载与卸围压组合扰动三轴试验,研究了不同条件下红砂岩的损伤与渗透性演化规律。结果表明:①岩石在不同组合扰动阶段具有不同的应力应变曲线形态,其末端形态取决于在何种扰动阶段破坏,初始应力比为决定组合扰动诱发岩石破坏难易的主要因素;②总峰值轴向应变随初始应力比增大而增大,其中组合扰动轴向应变占比始终较低,总峰值体积应变绝对值随初始应力比增大而先增大后减小,其中组合扰动体积应变占比较高;③在初始加载阶段,波速增大,渗透率降低,在组合扰动阶段,波速下降,渗透率增加,且损伤与体积应变近似呈线性关系,损伤与渗透率随扰动次数增加均呈先慢后快的增长趋势,且拐点分别近似在一条直线上;④岩石在组合扰动卸围压阶段破坏为单剪切破坏模式,在组合扰动循环加载阶段破坏为共轭剪切破坏模式;⑤双高(高初始应力比与高初始围压)条件将显著加剧岩体开挖失稳破坏风险。

关键词：深地工程组合扰动力学特性损伤渗透性

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