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Establishment of endometriotic models: the past and future

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Chinese Medical Journal 2020年第14期133卷 1703-1710页

作者： Zhi-Yue Gu Shuang-Zheng Jia jin-hua leng Department of Obstetrics and Gynecology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China

Endometriosis is a prevalent chronic disease that affects approximately 6%to 10%of reproductive-aged *** numerous researchers have endeavored to explore the etiology of endometriosis over a century,its etiology still remains an *** exploration of pathophysiologic mechanism and novel therapy for endometriosis depends on ideal endometriotic *** the previous decade,various endometriotic models have been established;therefore,we made a conclusion for available information on these *** review summarized the common experimental models used in endometriotic studies,including their origins,characteristics,applications,and *** models played an important role in studying etiologies and novel treatments of endometriosis during the last *** them,animal models and endometriotic cell lines were viewed as most common studying tools to explore the intrinsic entities of *** addition,endometrial organoid also emerged and was regarded as an ideal studying tool for endometriosis *** research models collectively complement each other to advance the endometriosis *** successful establishment of endometrial organoids means that organoids are expected to become an ideal model for studying endometriosis in the future.

关键词： Endometriosis Endometriotic studying models Endometriotic cell lines Animal models Endometrial organoids

Obstetric Outcomes in Chinese Women with Endometriosis： A Retrospective Cohort Study

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Chinese Medical Journal 2015年第4期128卷 455-458页

作者： Hong Lin jin-hua leng Jun-Tao Liu jing-He Lang Department of Obstetrics and Gynecology Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College Beijing 100730 China

Background：The effect of endometriosis on obstetric outcomes is still *** aim of our study was to determine the association between endometriosis and adverse obstetric outcomes in a cohort of Chinese ***：A retrospective cohort study was undertaken to compare obstetric outcomes between 249 women with endometriosis and 249 women without *** women were nulliparous and achieved singleton pregnancies *** with endometriosis were diagnosed during surgery and confirmed *** ratios （ORs） and 95％ confidence intervals （CIs） of measures of obstetric outcomes were ***：Women with endometriosis showed significantly increased risks of preterm labor （adjusted OR,2.42; 95％ CI,1.05-5.57）,placenta previa （adjusted OR,4.51; 95％ CI,1.23-16.50）,and cesarean section （adjusted OR,1.93; 95％ CI,1.31-2.84）.No significant differences were observed in the incidence of pregnancy-induced hypertension,fetal growth restriction,small for gestational age,placental abruption,or luteal support in the first trimester between the two ***：Women with endometriosis are at a higher risk of preterm labor,placenta previa,and cesarean section during pregnancy and need additional care.

关键词： Endometriosis Pregnancy Outcome Premature Birth

COMBINED EFFECT OF MODIFIED ZEOLITE 13X AND β-NUCLEATING AGENT ON IMPROVING β-CRYSTAL CONTENT AND TOUGHENING POLYPROPYLENE RANDOM COPOLYMER

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Chinese Journal of Polymer Science 2013年第11期31卷 1563-1578页

作者： jin-hua leng Heng Liu 何波兵 Bin Yang Xian Chen Qing-quan Qin Polymer Physics and Chemistry College of ChemistrySichuan University Chengdu Product Quality Supervision and Inspection Institute Kaixian Chenjia Middle School

Although addition of β-nucleating agent directly into homo-polypropylene （PPH） is a useful method to improve ,β-crystal content and toughen PPH, polypropylene random copolymer （PPR） makes this method powerless due to its random structure and low crystallinity. In this study, the β-nucleated PPR with high β-crystal content was prepared by a novel high effective β-nucleating system which consists of β-nucleation agent （TMB-5） and modified zeolite 13X （M13X）. It was found that M13X and TMB-5 had a synergistic influence on improving β-crystal content and toughening PPR. The content of β-crystal in PPR/M13X/TMB-5 was significantly larger than the sum of that in PPR/M13X and PPR/TMB-5. Besides, fracture behavior, phase morphology and relaxation of matrix chain segments were also investigated. The results showed that M13X and TMB-5 improved the mobility of amorphous chain segments at low temperature and contributed to much energy dissipation. This work provides a powerful method to modify PPR.

关键词： Polypropylene random copolymer Zeolite fl-nucleating agent Crystallization Toughness.

Menorrhagia and Uterine Volume Associated with Lower Urinary Tract Symptoms in Patients with Adenomyosis

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Chinese Medical Journal 2017年第13期130卷 1552-1556页

作者： Ting Li Xiao-Xuan Xu Yi Dai Jun-Ji Zhang jing-He Lang jin-hua leng Department of Obstetrics and Gynecology Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College Beijing 100730 China

Background： Adenomyosis is a gynecological disorder with symptoms most presenting as dysmenorrhea and heavy menstrual bleeding. However, the presence of lower urinary tract symptoms （LUTS） among women with adenomyosis remains unclear. This study was designed to determine the prevalence of LUTS and factors related to the severity of these symptoms in this population. Methods： From July 2016 to November 2016, a total of 298 untreated symptomatic adenomyosis patients and 280 age-matched controls were enrolled. Demographics, LUTS, pain symptoms, ultrasouographic uterine size, and serum CA125 level were recorded. LUTS were evaluated using the International Prostate Symptom Score （IPSS） questionnaire. Factors related to the severity of LUTS were detected using the logistic regression analysis presented as odds ratio （OR） and 95% confidence interval （CI）. Results： Compared with the control group, patients with adenomyosis had a greater IPSS total （4 [2-8] vs. 2 [0-3], Z = -8.159, P 〈 0.001 ）, IPSS storage （2 [1-4] vs. [[0 2], Z = -7.361 [P 〈 0.001）, and I PSS voiding （2 [0-4] vs. 0 [0-1], Z = -7.[94, P 〈 0.001）. Of the patients with adenomyosis, 30.2% had moderate-to-severe lower urinary tract symptoms （IPSS 〉8）. The most prevalent LUTS were daytime frequency （40.9%）, lbllowed by nocturia （24.8%）, weak stream （24.2%）, and incomplete emptying （23.5%）. In study group, patients with an IPSS total score ≥8 had higher proportion of menorrhagia （51.1% vs. 30.8%, χ2 = 11. 162 P = 0.025） and larger uterine volumes （183.3 [109.8-273.8] cm3 vs. 148.5 [96.4-262.7] cm3, Z=- 1.441, P = 0.150） compared to patients with an IPSS total score 〈8. On multivariate logistic regression analysis, patients with menorrhagia were associated with an increased risk of an IPSS total score 〉8 （OR： 2.309, 95% CI： 1.310-4.070, P= 0.004）, an IPSS storage subscore 〉4 （OR： 2.422, 95% CI： 1.395-4.206, P= 0.002）, and an IPSS voiding subscore 〉5 （OR： 1.971, 95% （CI： 1.176-3.302, p= 0.010）. However, patients wi

关键词： Adenomyosis International Prostate Symptom Score Lower Urinary Tract Symptoms

URETERAL INJURY DURING GYNECOLOGICAL LAPAROSCOPIC SURGERIES: REPORT OF TWELVE CASES

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Chinese Medical Sciences Journal 2007年第1期22卷 13-16页

作者： jin-song Gao jin-hua leng Zhu-feng Liu Keng Shen jing-he Lang Department of Obstetrics and Gynecology Peking Union Medical College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730

Objective To investigate ureteral injury during gynecological laparoscopic *** From January 1990 to December 2005, 12868 gynecological laparoscopic surgeries were conducted in Peking Union Medical College Hospital with 12 ureteral injuries reported. The present study investigated several aspects, including surgical indications, uterine size, pelvic adhesion, operative procedures, symptoms, diagnostic time and methods, injury site and type, subsequent treatment, and prognosis. Results The incidence of ureteral injury was 0.093% (12/12868) in all cases, 0.42% (11/2586) in laparoscopic hysterectomy [laparoscopically assisted vaginal hysterectomy (LAVH) or total laparoscopic hysterectomy (TLH)], and 0.01% (1/10282) in non-LAVH surgeries. Enlarged uterus, pelvic adhesion, and endometrosis were risk factors associated with ureteral injury. Only one injury was found intraoperatively while others were found postoperatively. The injury sites were at the pelvic brim (2 cases) or the lower part of ureter (10 cases). Patients were treated with ureteral stenting (effective in 2 cases) or laparotomy and open repair. Prognoses were favorable in most cases. Conclusions Most laparoscopic ureteral injuries occur during laparoscopic hysterectomy. Further evaluation is required when ureteral injury is suspected, and surgical repair is the major treatment for ureteral injury.

关键词： ureteral injury laparoscopy iatrogenic complication

dentification of Circular RNAs as a Novel Biomarker for Ovarian Endometriosis

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Chinese Medical Journal 2018年第5期131卷 559-566页

作者： Xiao-Xuan Xu Shuang-Zheng Jia Yi Dai Jun-Ji Zhang Xiao-Yan Li jing-hua Shi jin-hua leng jing-He Lang Department of Obstetrics and Gynecology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China

Background： Endometriosis is a challenging disease with symptoms such as dysmenorrhea and infertility. However, its etiology is still vague and there is still no effective markers or treatment. This study aimed to profile the circular RNAs （circRNAs） expressed in eutopic endometrium from patients with ovarian endometriosis and explore potential clues to the pathogenesis of endometriosis, providing an evidence for clinical diagnosis and treatment. Methods： A total of 63 clinical samples, including control endometrium 01 = 22） and eutopic endoxnetrium （n = 41）, were collected from Peking Union Medical College Hospital between May 1,2016, and December 31,2016. Of them, four samples in each group were used for circRNA microarray. Then, tbur upregulated circRNAs were screened out for quantitative real-time polymerase chain reaction （qRT-PCR） validation. After that, bioinformatics analysis was pertbrmed to predict miRNAs targeted by validated circRNAs and investigate the circRNA-miRNA-mRNA interactions. Results： Among 88 differentially expressed circRNAs, 11 were upregulated and 77 were downregulated in eutopic endometrium of patients with endometriosis, qRT-PCR validation results for two upregulated circRNAs （circ0004712 and circ_O002198） matched the microarray results. The area under the receiver operating characteristic curve of circ_0002198 for distinguishing ovarian endometriosis was 0.846 （95% confidence interval [C1]： 0.752-0.939; P 〈 0.001 ） while that ofcitv_O004712 was 0.704 （95% CI： 0.571-0.837; P = 0.008）. On the basis of target prediction, we depicted the molecular interactions between the identified circRNAs and their dominant target miRNAs, as well as constructed a circRNA-miRNA-mRNA network. Conclusions： This study provides evidence that circRNAs are differentially expressed between eutopic and normal endometrium, which suggests that circRNAs are candidate factors in the activation ofendometriosis, circ_0002198 and circ0004712 may be potential novel biomar

关键词： Circular RNA Endometriosis Microarray miRNA mRNA

Risk Factors for Recurrence of Ovarian Endometriosis in Chinese Patients Aged 45 and Over

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Chinese Medical Journal 2018年第11期131卷 1308-1313页

作者： Zheng-Xing He Ting-Ting Sun Shu Wang Hong-Hui Shi Qing-Bo Fan Lan Zhu jin-hua leng Da-Wei Sun Jian Sun jing-He Lang Department of Gynecology and Obstetrics Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China Department of Pathology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China

Background： When considering the issue of recurrence, perimenopausal women may have more dilemma during management comparing with young women, for example, whether to retain the uterus and ovary during surgery, whether it is necessary to add adjuvant medicine treatment after operation, and there is no evidence for reference about using ofgonadotropin-releasing hormone agonist. This study aimed to study the risk factors for the recurrence of ovarian endometriosis （EM） in patients aged 45 and over. Methods： This is a retrospective nested case-control study. We reviewed the medical records of patients aged over 45 years who underwent surgical treatments for ovarian EM from 1994 to 2014, in Peking Union Medical College Hospital of Chinese Academy of Medical Sciences. By following up to January 2016, 45 patients were found to have relapses and regarded as the recurrence group. The patients with no recurrence during the same follow-up period were randomly selected by the ratio of 1：4 as the nonrecurrence group （ 180 patients in total）. Stratified Cox regression was used to analyze the risk factors of the recurrence. Results： Univariate analysis showed that there was a significant difference in the postoperative treatment （the percentage of patients who received postoperative treatment in non-recurrence group and recurrence group, 23.9% vs. 40.0%, x2=4.729, P = 0.030） and ovarian preservation （the percentage of patients who received surgery of ovarian preservation in non-recurrence group and recurrence group. 25.0 % vs. 44.4%, x2 = 19.462, P 〈 0.001 ） between the nonrecurrence group and the recurrence group. There was no correlation between recurrence and the following factors including patient＇s age, menarche age, gravidity, parity, CA125 level, ovarian lesions, menopausal status, combined benign gynecological conditions （such as myoma and adenomyoma） and endometrial abnormalities, and surgical approach or surgical staging （all P 〉 0.05）. Multivariate analysis indicated t

关键词： Ovarian Endometriosis Recurrence Risk Factor

Pathogenetic gene changes of eutopic endometrium in patients with ovarian endometriosis

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Chinese Medical Journal 2019年第9期132卷 1107-1109页

作者： Ling Li Qian Chen Qing-Bo Fan Shu Wang Hong-Hui Shi Lan Zhu Da-Wei Sun jin-hua leng jing-He Lang Department of Gynecology and Obstetrics Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China

To the Editor:Endometriosis refers to the endometrial tissue (interstitial substance and gland) with growth function occurring in the uterine lining of uterine cavity and the places outside *** often leads to pain,infertility,nodules or masses and other symptoms and signs,and thus,brings a heavy burden on individuals and *** blood reflux theory,immune theory,inflammatory theory,hormone theory,etc.,cannot fully elucidate the pathogenesis of endometriosis.

关键词： Editor gland substance

Clinical Manifestations of Adenomyosis Patients with or without Coexisting Endometriosis

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Chinese Medical Journal 2018年第20期131卷 2495-2498页

作者： Yun-Wei Li Yu-Ting Liu Shu Wang Hong-Hui Shi Qing-Bo Fan Lan Zhu jin-hua leng Da-Wei Sun Jian Sun jing-He Lang Department of Gynecology and Obstetrics Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China Department of Pathology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China

To the Editor： Uterine adenomyosis （AM） is caused by the ectopic growth of endometrial glands and stroma in the myometrium of the uterus, accompanied by hyperplasia and hypertrophy of the surrounding smooth muscle ...

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