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Perioperative complication incidence and risk factors for retroperitoneal neuroblastoma in children:analysis of 571 patients

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World Journal of Pediatrics 2024年第3期20卷 250-258页

作者： Min He Jia-Bin Cai Xuan Wu Yin-Bing Tang jin-Yan wang Jun-Qin Mao Ji-Jun Chen Li-Feng Zhang Zhong-Hai Guan Jie-Ni Xiong Wan-Xin Peng jin-hu wang Ting Tao Pediatric Cancer Research Center National Clinical Research Center for Child HealthHangzhouChina Department of Surgical Oncology Children's HospitalZhejiang University School of MedicineHangzhouChina Cancer Center Zhejiang UniversityNo.3333 Binsheng RodeHangzhouChina

Background Surgery plays an important role in the treatment of *** complications may impact the course of neuroblastoma *** date,comprehensive analyses of complications and risk factors have been *** Patients with retroperitoneal neuroblastoma undergoing tumor resection were retrospectively analyzed between 2014 and *** data collected included clinical characteristics,operative details,operative complications and postopera-tive *** factors for perioperative complications of retroperitoneal neuroblastoma were *** A total of 571 patients were enrolled in this *** complications were observed in 255(44.7%)*** leakage(28.4%),diarrhea(13.5%),and injury(vascular,nerve and organ;7.5%)were the most frequent *** were three operation-related deaths(0.53%):massive hemorrhage(n=1),biliary tract perforation(n=1)and intestinal necrosis(n=1).The presence of image-defined risk factors(IDRFs)[odds ratio(OR)=2.09,P<0.01],high stage of the International Neuroblastoma Risk Group staging system(INRGSS)(OR=0.454,P=0.04),retroperitoneal lymph node metastasis(OR=2.433,P=0.026),superior mesenteric artery encasement(OR=3.346,P=0.003),and inferior mesenteric artery encasement(OR=2.218,P=0.019)were identified as independent risk factors for perioperative *** Despite the high incidence of perioperative complications,the associated mortality rate was quite ***-perative complications of retroperitoneal neuroblastoma were associated with IDRFs,INRGSS,retroperitoneal lymph node metastasis and vascular *** with high-risk factors should receive more serious attention during surgery but should not discourage the determination to pursue total resection of neuroblastoma.

关键词： Complication Neuroblastoma Risk factors Surgery

Paraplegia after transcatheter artery chemoembolization in a child with clear cell sarcoma of the kidney:A case report

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World Journal of Clinical Cases 2020年第11期8卷 2332-2338页

作者： Jia-Bin Cai Min He Fa-Liang wang Jie-Ni Xiong Jun-Qing Mao Zhong-Hai Guan Lin-Jie Li jin-hu wang Department of Surgical Oncology The Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310053Zhejiang ProvinceChina

BACKGROUND Transcatheter arterial chemoembolization(TACE)is a common treatment for inoperable malignant renal ***,a series of complications may follow the TACE *** cord injury caused by the embolization of intercostal or lumbar arteries is extremely *** SUMMARY We describe a case with quite uncommon spinal cord injury after TACE in a 3-year-old child with clear cell sarcoma of the *** impairment beneath the T10 dermatomes and paraplegia on the day after TACE were found in this ***,sustained paraplegia still existed for more than 2 mo after TACE despite the large dose of steroids and supportive *** We should draw attention to an uncommon complication of paraplegia after TACE treatment in malignant renal *** it is rare,the result is disastrous.

关键词： Complication Chemoembolization Spinal cord injury Clear cell sarcoma of the kidney Pediatric Case report

Cloning and Analyzing of Xenopus Mespo Promoter in Retinoic Acid Regulated Mespo Expression

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Acta Biochimica et Biophysica Sinica 2006年第11期38卷 759-764页

作者： jin-hu wang Xiao-Yan DING* Institute of Biochemistry and Cell Biology,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Graduate School of the Chinese Academy of Sciences,Shanghai 200031,China Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Graduate School of the Chinese Academy of SciencesShanghai 200031 China

During vertebrate embryogenesis,presomitic mesoderm cells enter a segmental program togenerate somite,a process termed ***,a member of the bHLH transcription factor family,plays important roles in this ***,how Mespo expression is regulated remains *** this question,we isolated a genomic DNA sequence containing 4317 bp of Mespo 5’ flanking regionin *** assays show that this upstream sequence has transcription *** assayshows that this genomic contig is sufficient to recapitulate the dynamic stage-and tissue-specific expressionpattern of endogenous Mespo from the gastrula to the tailbud *** further mapped a 326 bp DNAsequence responding to retinoic acid *** results shed light on how Mespo expression is regulated,and suggest that retinoic acid signaling pathways play roles in somitogenesis through regulating Mespo.

关键词： bHLH paraxial presomitic segmental tailbud Xenopus laevis

Unusual presentation of bladder neuroblastoma in a child: A case report

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World Journal of Clinical Cases 2020年第1期8卷 194-199页

作者： Jia-Bin Cai jin-hu wang Min He Fa-Liang wang Jie-Ni Xiong Jun-Qing Mao Min-Ju Li Kun Zhu Jia-Wei Liang Division of Surgical Oncology Department of Pediatric SurgeryChildren’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310053Zhejiang ProvinceChina Department of Pathology Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310053Zhejiang ProvinceChina Department of Radiology Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310053Zhejiang ProvinceChina

BACKGROUND Neuroblastoma is an extracranial malignant tumor in children that is most often located in the adrenal gland and sympathetic ***,we present a rare case of neuroblastoma originating from the urinary *** SUMMARY A 3-year-old girl presented with lower abdominal pain with *** revealed a lower abdominal *** computed tomography scan displayed a solitary mass at the top of the urinary *** levels of neuron-specific enolase and lactate dehydrogenase were *** treated the child with partial cystectomy and six courses of chemotherapy,and the outcome at 4-year follow-up was *** Neuroblastoma should be considered when tumors are located in the urinary bladder,especially in the dome;although this presentation is rare,the prognosis is very good.

关键词： Neuroblastoma Urinary bladder Pelvic neoplasms Prognosis Child Case report

Expression of B7 costimulation molecules by colorectal cancer cells reduces tumorigenicity and induces anti-tumor immunity

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World Journal of Gastroenterology 1999年第2期5卷 59-63页

作者： hu jin Yue, wang Sa, Zhu Jian Gao, ZHOU Guo hua and SUN Qu Bing

AIM To study the tumorigenicity of colorectal cancer cells transfected with B7 gene and the anti-tumor immunity induced by B7 gene modified colorectal cancer *** B7 gene was transfected into mouse colon cancer cell line CMT93. The transfectants were selected in DMEM containing 800 mg/ L G418, and B7 molecules were detected by immunohistochemistry. Experiments in vivo include: ① 5×106 B7+ CMT93 cells were inoculated into the back of C57BL/ 6 mice subcutaneously to determine their tumorigenicity (n=4). As control, wild type CMT93 cells were inoculated the same as the experimental group (n=3). ② The mice primed by B7+ CMT93 cells whose tumors vanished were rechallenged with wild type CMT93 to observe the immune protection of these mice against the wild type CMT93 (n=4). Non-primed 4 native mice inoculated with wild type CMT93 were used as control. With in vitro cytotoxicity assay, the mice were immunized with B7+ CMT93 or the wild type CMT93 by intraperitoneal injection (n=4×2). The spleen cells and the abdominal cavity infiltrating lymphocytes were obtained and cultured for two days. Cytotoxicity of these cells against the B7 gene modified or wild type CMT93 was detected by MTT *** B7 high expression clones were obtained after the transfection of the B7 gene into CMT93 cells by electroporation. Immunohistochemistry results showed mainly membrance staining and partly cytoplasm staining in B7 gene transfected CMT93 cells. In vivo experiments: ① After the inoculation of the B7+ CMT93 cells into the back of C57BL/ 6 mice, they lost their tumorigenicity greatly (P＜0.01). All the small tumors growing in the early period in the experimental group vanished in one month, and the tumors in control group grew progressively. ② No tumors were found in all 4 mice primed by B7+ CMT93 cells after they were rechallenged with wild type CMT93. In the control group all mice had grown tumors (P＜0.05). In vitro cytotoxicity assay, the CTLs induced by B7+ CMT93 had a hig

关键词： colorectal neoplasms B7 gene gene expression immunohistochemistry

Neoadjuvant transcatheter arterial chemoembolization and systemic chemotherapy for the treatment of undifferentiated embryonal sarcoma of the liver in children

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World Journal of Clinical Cases 2022年第19期10卷 6437-6445页

作者： Min He Jia-Bin Cai Can Lai Jun-Qing Mao Jie-Ni Xiong Zhong-Hai Guan Lin-Jie Li Qiang Shu Mei-Dan Ying jin-hu wang Department of Surgical Oncology The Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052Zhejiang ProvinceChina Department of Radiology The Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052Zhejiang ProvinceChina Cancer Center Zhejiang UniversityHangzhou 310058Zhejiang ProvinceChina

BACKGROUND Undifferentiated embryonal sarcoma of the liver(UESL)is a rare and aggressive mesenchymal tumor in ***,we describe our experience in neoadjuvant therapy(NAT)and subsequent surgery for the treatment of UESL in *** To evaluate the efficacy of NAT and explore a new choice for successful operation of UESL in *** We retrospectively analyzed six patients newly diagnosed with unresectable UESL who received NAT and then surgery at our center between January 2004 and December *** tumor was considered unresectable if it involved a large part of both lobes of the liver or had invaded the main hepatic vessels or inferior vena *** NAT included preoperative transcatheter arterial chemoembol ization(TACE)and systemic *** patients were 4 boys and 2 girls with a mean age of 7 *** longest tumor at presentation ranged from 8.6 to 14.8 cm(mean,12 cm).Extrahepatic metastases were present in 2 *** systemic chemotherapy was administered 3 wk after *** resection was performed 3 wk after one or two cycles of *** patients received systemic chemotherapy after *** All patients successfully underwent NAT and complete *** tumor volumes decreased by 18.2%–68.7%,with a mean decrease of 36%after 1 cycle of NAT(t=3.524,P=0.017).According to the Response Evaluation Criteria In Solid Tumors criteria,4 patients had a partial response and underwent surgery,while 2 had stable disease and received another cycle of NAT before *** tumor necrosis was seen on pathological examination of the surgical specimen:>90%necrosis in two,>50%necrosis in three,and 25%necrosis in 1,with an average of 71.8%.Post-NAT complications included fever,nausea and vomiting,and mild bone marrow *** alanine transaminase levels occurred in all patients,which returned to normal within 7–10 d after *** cardiac or renal toxicity,severe hepatic dysfunction,bleeding and nontarget e

关键词： Undifferentiated embryonal sarcoma of the liver Unresectable Neoadjuvant therapy Transcatheter arterial chemoembolization Systemic chemotherapy

Standards of care for Kasabach-Merritt phenomenon in China

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World Journal of Pediatrics 2021年第2期17卷 123-130页

作者： Wei Yao Ke-Lei Li Zhong-Ping Qin Kai Li Jia-Wei Zheng Xin-Dong Fan Lin Ma De-Kai Zhou Xue-Jian Liu Li Wei Li Li Mao-Zhong Tai jin-hu wang Yi Ji Lin Zhou Hai-jin huang Xiao-Yun Gao Zhi-Jian huang Song Gu He-Ying Yang Department of Pediatric Surgery Children's Hospital of Fudan UniversityShanghai 201102China Special Department of Vascular Anomalies Tumor Hospital of Linyi CityLinyi 276001China Department of Oral and Maxillofacial Surgery Shanghai Ninth People’s HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineShanghai 200011.China Department of Intervention Therapy Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China Department of Dermatology Beijing Children's Hospital Affiliated to Capital Medical UniversityBeijing 100045China Department of Infantile Hemangioma Gastrointestinal and Neonatal SurgeryChildren's Hospital of Chongqing Medical UniversityChongqing 400014China Department of Oncology People’s Hospital of Linyi Economic Development ZoneLinyi 276023China Department of Pediatric Surgery Children’s HospitalZhejiang University School of MedicineHangzhou 310003China Department of Pediatric Surgery West China HospitalSichuan UniversityChendu 610041China Department of Pediatric Surgery People’s Hospital of Xinjiang Uygur Autonomous RegionUrumchi 830001China Department of Pediatric Surgery First Affiliated Hospital of Gannan Medical UniversityGanzhou 341000China Department of Pediatric Surgery Fujian Provincial HospitalFuzhou 350001China Department of Pediatric Surgery Children's Hospital of Soochow UniversitySuzhou 215025China Department of Pediatric Surgery Shanghai Children's Medical CenterShanghai Jiao Tong University School of MedicineShanghai 200127China Department of Pediatric Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China

Kasabach-Merritt phenomenon(KMP)is a rare disease that is characterized by severe thrombocytopenia and consumptive coagulation dysfunction caused by kaposiform hemangioendothelioma or tufted *** condition primarily occurs in infants and young children,usually with acute onset and rapid *** review article introduced standardized recommendations for the pathogenesis,clinical manifestation,diagnostic methods and treatment process of KMP in China,which can be used as a reference for clinical practice.

关键词： Kasabach-Merritt phenomenon Kaposiform hemangioendothelioma Tufted hemangioma

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从天命到命运:王安石命论之演进

南昌大学学报（人文社会科学版） 2014年第1期45卷 34-39页

作者：胡金旺宜宾学院历史与哲学研究所四川宜宾644000

王安石的命论大致经历了三个阶段的发展历程。第一个阶段主要是从天命的角度来阐述自己对性与命的看法;第二个阶段是对第一个阶段性命论的深化,具体阐述如何才能做到天人之道相合,从而达到"通乎命"或"正命"的状态;第三个阶段是从命既有... 详细信息

王安石的命论大致经历了三个阶段的发展历程。第一个阶段主要是从天命的角度来阐述自己对性与命的看法;第二个阶段是对第一个阶段性命论的深化,具体阐述如何才能做到天人之道相合,从而达到"通乎命"或"正命"的状态;第三个阶段是从命既有天命又有命运的含义提出了"莫非命矣"的看法,主张要实现对命的自我超越,进而将全副的精力用于人事。所以,王安石命论总的倾向是充满积极进取的精神,而绝非学界所认为的其命论带有消极悲观的情绪。

关键词：王安石天命命命运人事

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唐君毅九境中的辩证法及其与黑格尔的差异

广西师范大学学报（哲学社会科学版） 2017年第3期53卷 19-24页

作者：胡金旺宜宾学院四川思想家研究中心四川宜宾644000

唐君毅对九境体相用的辩证关系的阐述从形式与方法上借鉴了黑格尔正反合的辩证法,但是实质不同。主体在九境中的转进并非按照体相用的顺序次第进行,而是要在当下进入合适的境界。唐君毅与黑格尔辩证法不同之处在于前者认为事物之间的主... 详细信息

唐君毅对九境体相用的辩证关系的阐述从形式与方法上借鉴了黑格尔正反合的辩证法,但是实质不同。主体在九境中的转进并非按照体相用的顺序次第进行,而是要在当下进入合适的境界。唐君毅与黑格尔辩证法不同之处在于前者认为事物之间的主要关系不是矛盾,而是隐显,这种关系正是虚灵明觉心的体现。因而,万物内部以统一和谐的德性为主。这种哲学建构是对西方文化认知理性造成事物之间为紧张关系的纠偏,有其深刻的时代隐忧。

关键词：唐君毅九境辩证法隐显认知理性道德理性

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