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Abstinence Following a Motivation-Skill-Desensitization-Mental Energy Intervention for Heroin Dependence: A Three-year Follow-up Result of a Randomized Controlled Trial

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Current Medical Science 2019年第3期39卷 472-482页

作者： Jia-yan CHEN jin-cong yu Jie-pin CAO Yang XIAO Hong GU Rui-lin ZHONG Fang DING Zeng-zhen WANG Department of Epidemiology and Biostatistics School of Public Health Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China Psychological Health Education and Counseling Center Zhongnan University of Economics and Law Wuhan 430073China School of Nursing Duke University Durham NC 27710 USA Wuhan Shiwu Research Institute of Science on Modem Psychology Wuhan 430062 China Xiangyang Drug Rehabilitation Center Xiangyang 441100 China

The high rate of relapse among heroin users remains a significant public concern in China. In the present study, we utilized a Motivation-Skill-Desensitization-Mental Energy (MSDE) intervention and evaluated its effects on abstinence and mental health. Eighty-nine male heroin users in a drug rehabilitation center were enrolled in the study. The participants in the MSDE intervention group (n=46) received MSDE intervention, which included motivational interviewing, coping skills training, eye movement desensitization and reprocessing, and mindfulness-based psychotherapy. The participants in the control group (h=43) received a series of lectures on skills training. A significant increase in Contemplation Ladder score (P<0.001) and decreases in scores on the Obsessive Compulsive Drug Use Scale (P<0.001), Beck Depression Inventory (P<0.001), and Aggression Questionnaire (P=O.O33) were found immediately after intervention. Compared to the control group, the MSDE intervention group reported significantly higher abstinence rates (P=0.027) and retention rates (P<0.001) at follow-up. Overall, the MSDE intervention, which uses a combined strategy for relapse prevention, could be a promising approach for preventing relapse among heroin users in China.

关键词： heroin dependence relapse prevention motivational interviewing cognitive therapy eye movement desensitization and reprocessing

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Alzheimer's disease with depressive symptoms: Clinical effect of intermittent theta burst stimulation repetitive transcranial magnetic stimulation

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World Journal of Psychiatry 2024年第8期14卷 1216-1223页

作者： Xin jin Chun-yun Xu jin-Feng Fei yu Fang cong-Hao Sun Department of Psychiatry Huzhou Third Municipal HospitalThe Affiliated Hospital of Huzhou UniversityHuzhou 313000Zhejiang ProvinceChina

BACKGROUND Alzheimer's disease(AD),characterized by the ongoing deterioration of neural function,often presents alongside depressive features and greatly affects the quality of life of individuals living with the *** several treatment methods exist,their efficacy is *** recent years,repetitive transcranial magnetic stimulation(rTMS)utilizing the theta burst stimulation(TBS)mode,specifically the intermittent TBS(iTBS),has demonstrated promising therapeutic potential in the management of neuropsychiatric *** To examine the therapeutic efficacy of iTBS mode of rTMS for treating depressive symptoms in patients with *** This retrospective study enrolled 105 individuals diagnosed with AD with depressive symptoms at Huzhou Third Municipal Hospital,affiliated with Huzhou University,between January 2020 and December *** received standard pharmacological interventions and were categorized into control(n=53)and observation(n=52)groups based on treatment *** observation group received iTBS mode of rTMS,while the control group received pseudo-stimulation.A comparative analysis evaluated psychological well-being,adverse events,and therapeutic at initiation of hospitalization(T0)and 15 days post-treatment(T1).RESULTS At T1,both groups exhibited a marked reduction in self-rating depression scale and Hamilton depression scale scores compared to ***,the observa-tion group showed a more pronounced decrease than the control *** T1,the Mini-mental state examination scores for both groups had increased markedly from their initial T0 ***,the increase was particularly more substantial in the observation group than in the control *** patients in the control group had ineffective treatment effects,while five patients in the observation group experienced the ***,the observation group experienced a substantially reduced incidence of ineffective treatment as compared to th

关键词： Alzheimer's disease Non-persistentθshort array fast pulse mode Depression Clinical efficacy Dementia Repetitive transcranial magnetic stimulation

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Temporal and Spectral Characteristics of Persistent Emission and Special Bursts of Magnetar SGR J1935+2154 Based on Insight-HXMT

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Research in Astronomy and Astrophysics 2024年第6期24卷 225-233页

作者： Xue-Feng Lu Li-Ming Song Ming-yu Ge Shuang-Nan Zhang jin-Lu Qu Ce Cai cong-Zhan Liu Cheng-Kui Li yu-cong Fu Ying-Chen Xu Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsBeijing 100049China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China College of Physics and Hebei Key Laboratory of Photophysics Research and Application Hebei Normal UniversityShijiazhuang 050024China Department of Astronomy Beijing Normal UniversityBeijing 100875China

In October 2022,the magnetar SGR J1935+2154 entered the active outburst *** the episode,the InsightHXMT satellite carried out a long observation that lasted for 20 *** than 300 bursts were detected,and a certain amount of persistent radiation signals were also *** paper mainly introduces the results of persistent radiation profile folding and period search based on Insight-HXMT *** the same time,the burst phase distribution characteristics,spectral lag results of burst,the spectral characteristics of zero-lag bursts and the time-resolved spectral evolution characteristics of high-flux bursts are *** found that there is no significant delay feature during different energy bands for the bursts of SGR J1935+*** observed zero-lag burst does not have a unique *** time-resolved spectrum of the individual burst has consistent spectral types and spectral parameters at different time periods of the *** also find that the burst number phase distribution and the burst photon phase distribution have the same tendency to concentrate in specific regions of the persistent emission profile.

关键词： radiation mechanisms:general dense matter magnetic fields

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Flexible and multifunctional triboelectric nanogenerator based on liquid metal/polyvinyl alcohol hydrogel for energy harvesting and self-powered wearable human-machine interaction

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Rare Metals 2024年第3期43卷 1186-1196页

作者： Hou-Wang Zhou cong Zhao Ze-yu Zhao Jun-Chen Jiang Hui-Le jin Shun Wang Shuang Pan Min-Yi Xu Yi-Huang Chen Hai-Ming jin Department of Orthopaedics The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhou325027China College of Chemistry and Materials Engineering Wenzhou UniversityWenzhou325035China Dalian Key Laboratory of Marine Micro/Nano Energy and Self-Powered Systems Marine Engineering CollegeDalian Maritime UniversityDalian116026China

Hydrogel-based triboelectric nanoge nerator(TENG)has a promising applied prospect in wearable electronic ***,its low performance,poor stability,insufficient recyclability and inferior self-healing seriously hinder its ***,we report a robust route to a liquid metal(LM)/polyvinyl alcohol(PVA)hydrogel-based TENG(LP-TENG).Owing to the intrinsically liquid feature of conductive LM within the flexible PVA hydrogel,the as-prepared LP-TENG exhibited comprehensiye advantages of adaptability,biocompatibility,outstanding electrical performance,superior stability,recyclability and diverse applications,which were unattainable by traditional ***,the LP-TENG delivered appealing open circuit voltage of 250 V,short circuit current of 4μA and transferred charge of 120 nC with high stability,outperforming most advanced TENG *** LP-TENG was successfully employed for versatile applications with multifunctionality,including human motion detection,handwriting recognition,energy collection,message transmission and human-machine *** work presents significant prospects for crafting advanced materials and devices in the fields of wearable electronics,flexible skin and smart robots.

关键词： Liquid metal Hydrogel Wearable TENG Multifunctionality Human-machine interaction

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Research on the mechanism of the two-dimensional ultrasonic surface burnishing process to enhance the wear resistance for aluminum alloy

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Friction 2024年第3期12卷 490-509页

作者： Zhen-yu ZHOU Qiu-Yang ZHENG yu LI cong DING Guang-Jian PENG Zhong-yu PIAO College of Mechanical Engineering Zhejiang University of TechnologyHangzhou 310023China Key Laboratory of Special Purpose Equipment and Advanced Processing Technology Ministry of Education and Zhejiang ProvinceZhejiang University of TechnologyHangzhou 310014China

The gradient nanostructure is machined on the aluminum(Al)alloy by the two-dimensional ultrasonic surface burnishing process(2D-USBP).The mechanism of why the gradient nanostructure enhances wear resistance is *** mechanical properties and microstructure characterization for the gradient nanostructure are performed by operating a nanoindenter,transmission electron microscopy(TEM),and electron backscattered diffraction(EBSD).Dry wear tests are performed on the samples before and after machining to evaluate the wear resistance and *** effect of the gradient nanostructure on the wear resistance is explored by developing the crystal plasticity(CP)finite element and molecular dynamics(MD)*** characterization results show that the 2D-USBP sample prepared a gradient structure of~600μm thick on the aluminum surface,increasing the surface hardness from 1.13 to 1.71 GPa and reducing the elastic modulus from 78.84 to 70.14 *** optimization of the surface microstructure and the increase of the mechanical properties effectively enhance the wear resistance of the sample,with 41.20%,39.07%,and 54.58% of the wear scar areas for the 2D-USBP treated samples to the original samples under 5,10,and 15 N loads,*** gradient nanostructure hinders the slip of dislocations inside the sample during the wear process and reduces the size and scope of plastic deformation;meanwhile,the resistance to deformation,adhesion,and crack initiation and propagation of the sample surface is improved,resulting in enhanced wear resistance.

关键词： structural superlubricity lattice registry elastic deformation strained solitons crystal plasticity molecular dynamics simulations

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Social Robot Detection Method with Improved Graph Neural Networks

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Computers, Materials & Continua 2024年第2期78卷 1773-1795页

作者： Zhenhua yu Liangxue Bai Ou Ye Xuya cong Institute of Systems Security and Control College of Computer Science and TechnologyXi’an University of Science and TechnologyXi’an710054China

Social robot accounts controlled by artificial intelligence or humans are active in social networks,bringing negative impacts to network security and social *** social robot detection methods based on graph neural networks suffer from the problem of many social network nodes and complex relationships,which makes it difficult to accurately describe the difference between the topological relations of nodes,resulting in low detection accuracy of social *** paper proposes a social robot detection method with the use of an improved neural ***,social relationship subgraphs are constructed by leveraging the user’s social network to disentangle intricate social relationships ***,a linear modulated graph attention residual network model is devised to extract the node and network topology features of the social relation subgraph,thereby generating comprehensive social relation subgraph features,and the feature-wise linear modulation module of the model can better learn the differences between the ***,user text content and behavioral gene sequences are extracted to construct social behavioral features combined with the social relationship subgraph ***,social robots can be more accurately identified by combining user behavioral and relationship *** carrying out experimental studies based on the publicly available datasets TwiBot-20 and Cresci-15,the suggested method’s detection accuracies can achieve 86.73%and 97.86%,*** with the existing mainstream approaches,the accuracy of the proposed method is 2.2%and 1.35%higher on the two *** results show that the method proposed in this paper can effectively detect social robots and maintain a healthy ecological environment of social networks.

关键词： Social robot detection social relationship subgraph graph attention network feature linear modulation behavioral gene sequences

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Deterministic learning-based neural output-feedback control for a class of nonlinear sampled-data systems

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Science China(Information Sciences) 2024年第09期67卷 164-183页

作者： yu ZENG Fukai ZHANG Tianrui CHEN cong WANG School of Automation Science and Engineering South China University of Technology School of Control Science and Engineering Shandong University

This study investigates the deterministic learning(DL)-based output-feedback neural control for a class of nonlinear sampled-data systems with prescribed performance(PP). Specifically, first, a sampleddata observer is employed to estimate the unavailable system states for the Euler discretization model of the transformed system dynamics. Then, based on the observations and backstepping method, a discrete neural network(NN) controller is constructed to ensure system stability and achieve the desired tracking performance. The noncausal problem encountered during the controller deduction process is resolved using a command filter. Moreover, the regression characteristics of the NN input signals are demonstrated with the observed states. This ensures that the radial basis function NN, based on DL theory, meets the partial persistent excitation condition. Subsequently, a class of discrete linear time-varying systems is proven to be exponentially stable, achieving partial convergence of neural weights to their optimal/actual values. Consequently, accurate modeling of unknown closed-loop dynamics is achieved along the system trajectory from the output-feedback control. Finally, a knowledge-based controller is developed using the modeling *** controller not only enhances the control performance but also ensures the PP of the tracking error. The effectiveness of the scheme is illustrated through simulation results.

关键词： deterministic learning neural networks adaptive neural control predefined performance nonlinear sampled-data systems

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Fecal microbiota transplantation for irritable bowel syndrome:Current evidence and perspectives

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World Journal of Gastroenterology 2024年第16期30卷 2179-2183页

作者： cong Dai yu-Hong Huang Min Jiang Department of Gastroenterology First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina

In this editorial we comment on the article published in the recent issue of the World journal of *** focus specifically on the mechanisms underlying the effects of fecal microbiota transplantation(FMT)for irritable bowel syndrome(IBS),the factors which affect the outcomes of FMT in IBS patients,and *** has emerged as a efficacious intervention for clostridium difficile infection and holds promise as a therapeutic modality for *** utilization of FMT in the treatment of IBS has undergone scrutiny in numerous randomized controlled trials,yielding divergent *** current frontier in this field seeks to elucidate these variations,underscore the existing knowledge gaps that necessitate exploration,and provide a guideline for successful FMT implementation in IBS *** the same time,the application of FMT as a treatment for IBS confronts several challenges.

关键词： Fecal microbiota transplantation Irritable bowel syndrome Microbiota Randomized controlled trial Meta-analysis

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Fuzzing:Progress,Challenges,and Perspectives

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Computers, Materials & Continua 2024年第1期78卷 1-29页

作者： Zhenhua yu Zhengqi Liu Xuya cong Xiaobo Li Li Yin Institute of Systems Security and Control College of Computer Science and TechnologyXi'an University of Science and TechnologyXi'an710054China School of Mathematics and Information Science Baoji University of Arts and SciencesBaoji721013China Institute of Systems Engineering Macao University of Science and TechnologyTaipaMacaoChina

As one of the most effective techniques for finding software vulnerabilities,fuzzing has become a hot topic in software *** feeds potentially syntactically or semantically malformed test data to a target program to mine vulnerabilities and crash the *** recent years,considerable efforts have been dedicated by researchers and practitioners towards improving fuzzing,so there aremore and more methods and forms,whichmake it difficult to have a comprehensive understanding of the *** paper conducts a thorough survey of fuzzing,focusing on its general process,classification,common application scenarios,and some state-of-the-art techniques that have been introduced to improve its ***,this paper puts forward key research challenges and proposes possible future research directions that may provide new insights for researchers.

关键词： Fuzzing vulnerability software testing software security

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Oral peptide therapeutics for diabetes treatment: State-of-the-art and future perspectives

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2006-2025页

作者： Bingwen Ding Zhu Zhu cong Guo Jiaxin Li Yong Gan Miaorong yu State Key Laboratory of Drug Research and Center of Pharmaceutics Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China School of Pharmacy Henan UniversityKaifeng 475004China NMPA Key Laboratory for Quality Research and Evaluation of Pharmaceutical Excipients National Institutes for Food and Drug ControlBeijing 100050China

Diabetes,characterized by hyperglycemia,is a major cause of death and disability ***,such as insulin and glucagon-like peptide-1(GLP-1)analogs,have shown promise as treatments for diabetes due to their ability to mimic or enhance insulin's actions in the *** to subcutaneous injection,oral administration of anti-diabetic peptides is a preferred ***,biological barriers significantly reduce the efficacy of oral peptide *** advancements in drug delivery systems and formulation techniques have greatly improved the oral delivery of peptide therapeutics and their efficacy in treating *** review will highlight(1)the benefits of oral anti-diabetic peptide therapeutics;(2)the biological barriers for oral peptide delivery,including pH and enzyme degradation,intestinal mucosa barrier,and biodistribution barrier;(3)the delivery platforms to overcome these biological ***,the review will discuss the prospects in this *** information provided in this review will serve as a valuable guide for future developments in oral anti-diabetic peptide therapeutics.

关键词： Oral peptides Diabetes Delivery platforms Insulin Glucagon-like peptide-1 Biodistribution Biological barriers Targeted delivery

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