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Prostate-specific Antigen Density Variation Rate as a Potential Guideline Parameter for Second Prostate Cancer Detection Biopsy

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Chinese Medical Journal 2016年第15期129卷 1800-1804页

作者： Gan-Sheng xie jin-Xing Lyv Gang Li Chun-Yin Yan Jian-Quan Hou jin-Xian Pu Xiang Ding Yu-Hua Huang Department of Urology The First Affiliated Hospital of Soochow University Suzhou Jiangsu 215000 China

Background： The diagnostic value of current prostate-specific antigen （PSA） tests is challenged by the poor detection rate of prostate cancer （PCa） in repeat prostate biopsy. In this study, we proposed a novel PSA-related parameter named PSA density variation rate （PSADVR） and designed a clinical trial to evaluate its potential diagnostic value for detecting PCa on a second prostate biopsy. Methods： Data from 184 males who underwent second ultrasound-guided prostate biopsy 6 months after the first biopsy were included in the study. The subjects were divided into PCa and non-PCa groups according to the second biopsy pathological results. Prostate volume, PSA density （PSAD）, free-total PSA ratio, and PSADVR were calculated according to corresponding formulas at the second biopsy. These parameters were compared using t-test or Mann-Whitney U-test between PCa and non-PCa groups, and receiver operating characteristic analysis were used to evaluate their predictability on PCa detection. Results： PCa was detected in 24 patients on the second biopsy. Mean values of PSA, PSAD, and PSADVR were greater in the PCa group than in the non-PCa group （8.39 μg/L vs. 7.16 μg/L, 0.20 vs. 0.16, 14.15% vs. 1.36%, respectively）. PSADVR had the largest area trader the curve, with 0.667 sensitivity and 0.824 specificity when the cutoff was 10%. The PCa detection rate was significantly greater in subjects with PSADVR 〉10% than PSADVR _〈10% （28.6% vs. 6.5%, P 〈 0.001 ）. In addition, PSADVR was the only parameter in this study that showed a significant correlation with mid-to-high-risk PCa （r = 0.63, P = 0.03）. Conclusions： Our results demonstrated that PSADVR improved the PCa detection rate on second biopsies, especially for mid-to-high-risk cancers requiring prompt treatment.

关键词： Prostate-specific Antigen Prostatic Hyperplasia Prostatic Neoplasm Transrectal Ultrasound

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热电热泵低温热水装置的实验研究

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西安交通大学学报 2007年第11期41卷 1338-1341页

作者：谢康山鱼剑琳赵华西安交通大学能源与动力工程学院西安710049

对一台空气源热电热泵低温热水装置在不同工作条件下的性能进行了实验研究.研究结果表明:随着工作电压升高,制热系数减小,但热水加热时间会缩短;在环境温度较低时,随着热水温度的升高,冷端吸热量有可能减少,而在环境温度较高时,冷端吸... 详细信息

对一台空气源热电热泵低温热水装置在不同工作条件下的性能进行了实验研究.研究结果表明:随着工作电压升高,制热系数减小,但热水加热时间会缩短;在环境温度较低时,随着热水温度的升高,冷端吸热量有可能减少,而在环境温度较高时,冷端吸热量随着热水温度的升高而一直增大;环境温度越高,冷端温度也就越高,冷热端温差就越小,制热系数就越大;在电压为117 V、热水温度为35℃、环境温度为30℃时的制热系数为1.68,而环境温度为5℃时的制热系数仅为1.22.此项研究可为热电热泵热水装置的设计和应用提供参考.

关键词：热电热泵热水装置制热系数

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Accuracy of segmented measurement of axial length in ultra-high myopia filled with silicone oil using immersion B-scan ultrasonography

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International Journal of Ophthalmology(English edition) 2022年第5期15卷 793-799页

作者： Qing-Hua Yang Hong-Tao Zhang Xiao-Qi Li Bing Chen zhao-Hui Li Yi-Fei Huang Xin jin Ying Zhang Li-Qiang Wang Senior Department of Ophthalmology the Third Medical Center of PLA General HospitalBeijingChina

AIM:To evaluate the accuracy of segmented measurement of axial length(AL)in high myopia filled with silicone oil by immersion B-scan ultrasonography(immersion B-scan).METHODS:From June 2016 to June 2020,a total of 67 ultra-high myopia inpatients(67 eyes)who underwent silicone oil removal combined with cataract extraction and intraocular lens(IOL)implantation were retrospectively *** preoperative axial length(AL)of 31 patients with severe cataract were segmented measured using immersion B-scan(B-scan group)and another 36 patients with mild or moderate cataract were measured using IOLMaster 500(IOLMaster group).The post-operative ALs in two groups were both measured using IOLMaster *** IOL power was calculated with Haigis *** differences in ALs between pre-and post-surgery,as well as the postoperative refractive spherical equivalent,absolute refractive error,the prediction deviation of postoperative refraction and best corrected visual acuity(BCVA)were ***:The pre-and post-operative ALs were 30.46±1.63 mm(range 28.09-33.51 mm)and 30.42±1.70 mm(range 28.03-33.90 mm)in B-scan group(t=0.644,P=0.542)and 30.51±1.21 mm(range 28.03-33.90 mm)and 30.43±1.27 mm(range 28.54-33.50 mm)in IOLMaster group(t=1.843,P=0.074),*** months after surgery,BCVA were 0.45±0.13(range 0.3-0.9)and 0.44±0.20(range 0.2-1.0)in B-scan and IOLMaster group respectively(t=0.086,P=0.932).There was no significant difference of the postoperative spherical equivalent(-3.11±0.65 D vs-3.21±0.51 D,t=0.671,P=0.505)and the absolute refractive error(0.589±0.340 vs 0.470±0.245 D,t=1.615,P=0.112)between two *** B-scan group,absolute refractive error within±0.50 D was found in 18 eyes(58.1%),within±1.00 D in 26 eyes(83.9%),and within±1.50 D in 31 eyes(100%).In IOLMaster group,absolute refractive error within±0.50 D was found in 23 eyes(63.9%),within±1.00 D in 34 eyes(94.4%),and within±1.50 D in 36 eyes(Z=0.757,P=0.449).CONCLUSION:The segmented measurement of ALs

关键词： high myopia axial length immersion B-ultrasound IOLMaster silicone oil cataract

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Damage produced on GaN surface by highly charged Krq+irradiation

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Nuclear Science and Techniques 2017年第12期28卷 220-225页

作者： Li-Qing Zhang Chong-Hong Zhang Chao-Liang Xu Heng-Qing Zhang Yi-Tao Yang jin-Yu Li Hui-Ping Liu zhao-Nan Ding Ting-Xing Yan Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China

Surface morphology, compositions, microstructure and optical properties of GaN film irradiated by highly charged Kr^(q+)(q = 23, 15, 11) in two geometries to a fluence of 1×10^(15)kr^(q+)/cm^2 were studied using AFM,XPS, PL, Raman scattering and UV–visible *** AFM observation shows that the irradiated GaN area is a swollen terrace. The swelling rate increased with the charge state(potential energy). For the same charge state,the swelling rate of tilted incidence was greater than that for normal incidence. The XPS measurements reveal that N deficiency, Ga enrichment and Ga–O and Ga dangling bonds generated on the irradiated GaN surface increased with the charge state, and more N was lost for normal incidence than that for tilted incidence. The UV–Vis results show that the transmittance decreased with increasing charge state. For the same charge state, the transmittance for tilted incidence is higher than that for normal *** PL spectra present that, with increasing charge state,the YL band intensity decreased, with a blueshift in its peak position; while the NBE peak intensity increased firstand then reduced, and a blue luminescence band appeared.A rapid quenching of both the YL and the NEB for normal incidence was observed. Raman spectra display that screw dislocations perhaps were produced near the surface for normal incidence.

关键词： GaN Highly charged Krypton ion AFM XPS UV–Vis transmittance spectra PL Raman spectra

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基于rDNA ITS序列的何首乌PCR-RFLP分子鉴别

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华南理工大学学报（自然科学版） 2009年第6期37卷 74-78,83页

作者：郑传进赵树进赵振华呙军华南理工大学生物科学与工程学院广东广州510006 广州军区广州总医院广东广州510010

对何首乌及其常见混淆品的核糖体DNA内转录间隔区（rDNAITS）序列进行了测序分析．结果表明：何首乌与其混淆品毛脉蓼、翼蓼及耳叶牛皮消ITSI区的差异率分别为6．91％、18．10％和42．20％，ITS2区的差异率分别为10．00％、19．40％和43... 详细信息

对何首乌及其常见混淆品的核糖体DNA内转录间隔区（rDNAITS）序列进行了测序分析．结果表明：何首乌与其混淆品毛脉蓼、翼蓼及耳叶牛皮消ITSI区的差异率分别为6．91％、18．10％和42．20％，ITS2区的差异率分别为10．00％、19．40％和43．90％；而何首乌种内各居群间ITS1和ITS2区的差异率分别为0．00％～2．13％和0．00％～1．03％．基于何首乌及其混淆品的rDNAITS序列的差异，找出一个位于ITS2间隔区的何首乌特征性M6I酶切位点，用M6I酶对何首乌rDNAITS序列扩增产物酶切后得到含约531bp和109bp的两片段的聚合酶链反应一限制性片段长度多态性（PCR—RFLP）图谱，而其混淆品的rDNAITS序列扩增产物不能被NsbI酶切，故图谱呈单一条带．利用建立的***方法可以很好地区分何首乌及其混淆品．

关键词：何首乌分子鉴别核糖体DNA内转录间隔区 PCR—RFLP

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Research on Safety and Stability of Regional Power Grids to the Year 2020

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Electricity 2005年第3期16卷 26-31页

作者： Zhou Qinyong zhao Liang Guo Qiang jin Wen China Electric Power Research Institute 不详

The safety and stability study on Northeast, North, East, Northwest and Central China power grids had been carried out, which provided technical supports to planning design of regional power grids. By analyzing safety and stability under severe faults in regional power grids, revealed weaknesses on power grid configurations and measures for preventing from loss of stability were presented. In comparison of various schemes of power system safety and stability among parts of power grids, more than two recommended schemes can be chosen as reference in planning design for regional power grids. Considering the safety and stability control measures necessary for each power grids, it is believed the trunk networks of all power grids can fulfill the third criteria of Guideline for Power System Safety and Stability, while the weakness and predominated hydropower may deteriorate safety and stability of power grids. The power grid shall be regulated in line with the variation of boundary conditions.

关键词： regional power grid safe and stable power grid planning power system

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A Singlet Oxygen Reservoir Based on Poly-Pyridone and Porphyrin Nanoscale Metal-Organic Framework for Cancer Therapy

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CCS Chemistry 2021年第5期3卷 1187-1202页

作者： Bo-Ru xie Chu-Xin Li Yun Yu jin-Yue Zeng Ming-Kang Zhang Xiao-Shuang Wang Xuan Zeng Xian-Zheng Zhang Key Laboratory of Biomedical Polymers of Ministry of Education Department of ChemistryWuhan UniversityWuhan 430072

Here,a methacrylate-modified pyridone derivative(mPYR)was loaded into a porphyrin nanoscale metal-organic framework(porphyrin-nMOF).Then,the loaded mPYR was further polymerized to obtain poly-pyridone(poly-mPYR)to form poly-mPYR loaded porphyrin-nMOF,which is designated as PLP and used as a reservoir of singlet oxygen(^(1)O_(2)).It was found that PLP could quickly capture^(1)O_(2)in vitro and slowly release^(1)O_(2)in vivo to induce cancer cell *** release of^(1)O_(2)was light and oxygen independent,and the entire process did not cause intracellular oxygen *** also displayed good therapeutic effect in the treatment of both solid tumor and lung metastasis *** strategy of oxygenand light-independent^(1)O_(2)treatment presents great potential for treating refractory ***,the form of^(1)O_(2)capturing polymer-loaded nMOF expands the biomedical applications of MOFs and polymers,which can be used as a platform for biomedical applications.

关键词： cancer endoperoxides pyridone derivative metal-organic framework photodynamictherapy

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Albumin-to-alkaline phosphatase ratio: A novel prognostic index of overall survival in cholangiocarcinoma patients after surgery

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World Journal of Gastrointestinal Oncology 2019年第1期11卷 39-47页

作者： Jian-Ping Xiong Jun-Yu Long Wei-Yu Xu jin Bian Han-Chun Huang Yi Bai Yi-Yao Xu Hai-Tao zhao Xin Lu Department of Liver Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical College

AIM To clarify the prognostic significance of preoperative albumin-to-alkaline phosphatase ratio(AAPR) in cholangiocarcinoma(CCA) subjects receiving *** In this retrospective study, we included 303 CCA patients receiving surgery without preoperative therapy between 2002 and 2014. Clinicopathological characteristics(including AAPR) were analyzed to determine predictors of postoperative overall survival and recurrence-free survival(RFS). In addition,univariate and multivariate Cox proportional hazards models were conducted,followed by application of time-dependent receiver operating curves to identify the optimal *** Univariate and multivariate analyses revealed both decreased overall survival[hazard ratio(HR): 2.88, 95%CI: 1.19-5.78] and recurrence-free survival(HR: 2.31,95%CI: 1.40–3.29) in patients with AAPR < 0.41 compared to those with AAPR ≥0.41. The optimal cut-off of AAPR was 0.41. Of the 303 subjects, 253(83.5%) had an AAPR over 0.41. The overall 1-, 3- and 5-year survival rates were 70.2%, 38.0% and 16.5%, respectively in the low(< 0.41) AAPR group, which were significantly lower than those in the high(≥ 0.41) AAPR group(81.7%, 53.9%, and 33.4%,respectively)(P < 0.0001). Large tumor size, multiple tumors, and advanced clinical stage were also identified as significant predictors of poor *** Our outcomes showed that AAPR was a potential valuable prognostic indicator in CCA patients undergoing surgery, which should be further confirmed by prospective studies. Moreover, it is necessary to investigate the mechanisms concerning the correlation of low AAPR with poor post-operative survival in CCA patients.

关键词： Albumin-to-alkaline phosphatase ratio Cholangiocarcinoma Prognosis Surgery Survival

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Investigation of the pin-roller metering device and tube effect for wheat seeds and granular fertilizers based on DEM

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International Journal of Agricultural and Biological Engineering 2023年第2期16卷 103-114页

作者： Sugirbay Adilet Kaiyuan zhao Guangyao Liu Nukeshev Sayakhat Jun Chen Guangrui Hu Lingxin Bu Yu Chen Hongling jin Shuo Zhang Zagainov Nikolay Muratkhan Marat College of Mechanical and Electronic Engineering Northwest A&F UniversityXianyang 712100ShaanxiChina College of Water Resources and Architectural Engineering Northwest A&F UniversityXianyang 712100ShaanxiChina Technical Faculty S.Seifullin Kazakh Agrotechnical UniversityAstana 010000Kazakhstan College of Mechatronic Engineering North Minzu UniversityYinchuan 750021China

The metering device is the central part of the seeder discharging granular fertilizers or seeds from the hopper to the colter passing through the *** on the metering device design,the batches of particles are discharged or discharged *** research analyzes existing metering devices,and a new pin-roller metering device is recommended to discharge evenly high doses of granular fertilizers and wheat seeds at low rotation *** objective was to adapt the metering device to precision agriculture so that a little electric motor containing gearbox drives every metering ***,the pin-roller metering device parameters were investigated to apply high doses of granular fertilizers and wheat seeds *** optimal pin positions were determined according to response surface methods(RSM)by simulating the granular fertilizers and wheat seeds'behavior on *** coefficient of variation(CV)and the slip rate(SR)of the particles between the pins were chosen as indicators for evaluating the *** shape of the pin was specified,and then the number of lines,the number of pins in a line,and the pin height were chosen to *** analysis of the simulation results shows the optimal parameters:the number of pins in a line is four,and the number of lines is *** SR of granular fertilizers and wheat seeds were 8%and 2%,*** pin-roller metering device is compared with the six-grooved and twelve-grooved metering *** comparison results show that the pin-roller metering device distributes twice more uniformly than other metering *** CV of the granular fertilizer distribution for six-grooved,twelve-grooved,and pin-roller metering devices was 111.13%,80.74%,and 37%,*** CV of the wheat seed distribution for twelve-grooved and pin-roller metering devices was 96%,and 37%,*** long as the particles interact with the tube,leaving the metering device,the effect of tube type and position is investi

关键词： pin-roller metering device DEM coefficient of variation slippage rate tube

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Hsa_circ_0002137 stabled by LIN28B promotes osteosarcoma cell growth through the hsa-miR-1246/BCL2 axis

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BIOCELL 2022年第3期46卷 699-709页

作者： FEI ZHANG JIANZHONG LAI RONGHAN HE YI SHI KUN XU SHIHAI JIANG TANGzhao LIANG WANYU zhao WEIDA REN LEI ZHU SONG jin KUN WANG Department of Joint and Trauma Surgery The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou510630China Department of Othopaedic Surgery The Eighth Affiliated Hospital of Sun Yat-sen UniversityShenzhen518033China Department of Othopaedic Surgery Dongguan Dongcheng HospitalDongguan523007China Department of Orthopedic The First Affiliated Hospital of Anhui Medical UniversityHefei230022China Key Laboratory for Regenerative Medicine Ministry of EducationCollege of Life Science and TechnologyJinan UniversityGuangzhou510632China Department of Plastic Surgery The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou510630China

Circular RNAs(circRNAs)are a novel class of non-coding RNA that have recently shown to have huge capabilities in the regulation of gene expression at the posttranscriptional *** evidence has indicated that circRNAs could serve as competing endogenous RNAs(ceRNAs)to sponge microRNAs(miRNAs)and suppress functions of targeted ***(OS)is the most common malignant primary bone ***_circ_0002137 is upregulated in ***,the role of hsa_circ_0002137 in OS remains *** miRNA pull-down assay,we showed that cir_0002137 sponged hsa-miR-1246,and BCL2 apoptosis regulator(BCL2)mRNA was a potential target of hsa-miR-1246 in human osteosarcoma(HOS)***,we found that hsa_cir_0002137 could enhance the expression of BCL2 hsa-miR-1246 and promote HOS cell growth through sponging ***,RNA binding protein immunoprecip itation(RIP)assay revealed that lin-28 homolog B(LIN28B)protein associated with hsa_circ_0002137,and LIN28B could increase hsa_circ_0002137 stability and thus accelerate OS cell *** work was the first to study the functions of hsa_circ_0002137,has-miR-1246 and LIN28B in OS,and these results may provide novel therapeutic targets for OS treatment.

关键词： Osteosarcoma hsa_circ_0002137 hsa-miR-1246 Proliferation Apoptosis

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