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Scoparone inhibits pancreatic cancer through PI3K/Akt signaling pathway

World Journal of Gastrointestinal Oncology 2021年第9期13卷 1164-1183页

作者： Na Li Fan Yang Dong-Yan Liu jin-tao guo Nan Ge Si-Yu Sun Department of Hospice Care Shengjing Hospital of China Medical UniversityShenyang 110022Liaoning ProvinceChina Department of Gastroenterology Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina Medical Research Center Shengjing Hospital of China Medical UniversityBenxi 111700Liaoning ProvinceChina

BACKGROUND Pancreatic cancer is a highly malignant tumor of the gastrointestinal system whose emerging resistance to chemotherapy has necessitated the development of novel antitumor ***,a traditional Chinese medicine monomer with a wide range of pharmacological properties,has attracted considerable attention for its antitumor *** To explore the potential antitumor effect of scoparone on pancreatic cancer and the possible molecular mechanism of *** The target genes of scoparone were determined using both the bioinformatics and multiplatform *** effect of scoparone on pancreatic cancer cell proliferation,migration,invasion,cell cycle,and apoptosis was detected in *** expression of hub genes was tested using quantitative reverse transcription polymerase chain reaction(qRT-PCR),and the molecular mechanism was analyzed using Western *** in vivo effect of scoparone on pancreatic cancer cell proliferation was detected using a xenograft tumor model in nude mice as well as *** The hub genes involved in the suppression of pancreatic cancer by scoparone were obtained by network bioinformatics analyses using publicly available databases and platforms,including SwissTargetPrediction,STITCH,GeneCards,CTD,STRING,WebGestalt,Cytoscape,and Gepia;AKT1 was confirmed using qRT-PCR to be the hub *** Counting Kit-8 assay revealed that the viability of Capan-2 and SW1990 cells was significantly reduced by scoparone treatment exhibiting IC50 values of 225.2μmol/L and 209.1μmol/L,*** healing and transwell assays showed that scoparone inhibited the migration and invasion of pancreatic cancer ***,flow cytometry confirmed that scoparone caused cell cycle arrest and induced *** also increased the expression levels of Bax and cleaved caspase-3,decreased the levels of MMP9 and Bcl-2,and suppressed the phosphorylation of Akt without affecting total PI3K and ***

关键词： Pancreatic cancer Scoparone Akt1 PI3K/Akt signaling pathway Bioinformatics analysis Xenograft tumor

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Circular RNA circ-LDLRAD3 as a biomarker in diagnosis of pancreatic cancer

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World Journal of Gastroenterology 2017年第47期23卷 8345-8354页

作者： Fan Yang Dong-Yan Liu jin-tao guo Nan Ge Ping Zhu Xiang Liu Sheng Wang guo-Xin Wang Si-Yu Sun Endoscopy Center Shengjing Hospital of China Medical University Medical Research Center Shengjing Hospital of China Medical University

AIM To analyze the diagnostic value of a circular RNA(circR NA), circ-LDLRAD3, in pancreatic *** Expression levels of circ-LDLRAD3 were tested in both cells and clinical samples; the latter included 30 paired pancreatic cancer tissues and adjacent non-tumorous tissues, 31 plasma samples from patients with pancreatic cancer, and 31 plasma samples from healthy volunteers. Real-time quantitative reverse transcriptionpolymerase chain reaction(q RT-PCR) was performed to measure expression levels of circ-LDLRAD3 in cells and clinical samples; then, the relationship between clinicopathological factors of patient samples and expression of circ-LDLRAD3 in pancreatic cancer was analyzed. The diagnostic value of circ-LDLRAD3 was verified by receiver operating characteristic(ROC) curve *** Circ-LDLRAD3 was up-regulated in pancreatic cancer cell lines(P < 0.01), pancreatic cancer tissues(P < 0.01), and plasma samples from patients with pancreatic cancer(P < 0.01). High expression of circLDLRAD3 was significantly associated with venous invasion, lymphatic invasion, and metastasis. The area under the ROC curve of circ-LDLRAD3 alone or combination with CA19-9 was 0.67 and 0.87, respectively, with a sensitivity and specificity of 0.5738(alone) and 0.7049(alone), and 0.8033(combination) and 0.9355(combination), *** These data suggest that circ-LDLRAD3 may be a biomarker in the diagnosis of pancreatic cancer.

关键词： Circular RNA Pancreatic cancer biomarker

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A model for transient diffusion in bidisperse pore structures

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Petroleum Science 2019年第6期16卷 1455-1470页

作者： Wei Sun Sheng-Li Chen Ming-Ri Xu Ya-Qian Wei Ting-Ting Fan Bao-Li Ma jin-tao guo State Key Laboratory of Heavy Oil Processing and Department of Chemical Engineering China University of PetroleumChangpingBeijing 102249People’s Republic of China Daqing Petrochemical Research Center CNPCDaqing 163741HeilongjiangChina

A bidisperse model for transient diffusion and adsorption processes in porous materials is presented in this *** mathematical model is solved by numerical methods based on finite elements combined with the linear driving force approximation.A criterion based on the model to identify the diffusion controlling mechanism(macropore diffusion,micropore diffusion,or both)is *** effects of different adsorption isotherms(linear,Freundlich,or Langmuir)on the concentration profiles and on curves of fractional uptake versus time are *** addition,the influences of model parameters concerning the pore networks on the fractional uptake are studied as well.

关键词： Transient diffusion Adsorption Bidisperse pores Macropore Micropore Linear driving force

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Fluorescence study on the coaggregating tendencies of the cholesterols --the culprits of arteriosclerosis

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Chinese Journal of Chemistry 1994年第3期12卷 277-282页

作者： ZHANG, jin-tao JI, guo-Zhen JIANG, Xi-KuiShanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China Shanghai Institute of Organic Chemistry Chinese Academy of Sciences 354 Fenglin Lu Shanghai 200032 China

The coaggregating tendencies of the culprits of arteriosclerosis, the cholesteryl esters (CE-n's), have been investigated in the 40:60 V/V (Φ= 0.40) dioxane (DX)-H2O system, by using decyl pyrenyl ketone (Py-11) as the fluorescence probe. The fluorescence intensity of Py-11 decreases when coaggregation occurs between CE-n and Py-11, because of the low polarity of the microenviroment of the coaggregates. The order of the coaggregating tendencies obtained from the fluorescence data is in full agreement with that from the kinetic method, i.e., CE-ol, CE-in > CE-12 > CE-8 > CE-18 > CE-0.

关键词： Cholesteryl esters fluorescence probe coaggregating tendency.

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Revealing the role of calcium ion intercalation of hydrated vanadium oxides for aqueous zinc-ion batteries

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Journal of Energy Chemistry 2024年第8期95卷 9-19,I0001页

作者： tao Zhou Xuan Du guo Gao Key Laboratory for Thin Film and Micro Fabrication of the Ministry of Education School of Sensing Science and EngineeringSchool of Electronic Information and Electrical EngineeringShanghai Jiao Tong UniversityShanghai 200240China

Exploring suitable high-capacity V_(2)O_(5)-based cathode materials is essential for the rapid advancement of aqueous zinc ion batteries(ZIBs).However,the typical problem of slow Zn^(2+)diffusion kinetics has severely limited the feasibility of such *** this work,unique hydrated vanadates(CaVO,BaVO)were obtained by intercalation of Ca^(2+)or Ba^(2+)into hydrated vanadium *** the CaVO//Zn and BaVO//Zn batteries systems,the former delivered up to a 489.8 mAh g^(-1)discharge specific capacity at 0.1 A g^(-1).Moreover,the remarkable energy density of 370.07 Wh kg^(-1)and favorable cycling stability yard outperform BaVO,pure V_(2)O_(5),and many reported cathodes of similar ionic intercalation *** addition,pseudocapacitance analysis,galvanostatic intermittent titration(GITT)tests,and Trasatti analysis revealed the high capacitance contribution and Zn^(2+)diffusion coefficient of CaVO,while an in-depth investigation based on EIS elucidated the reasons for the better electrochemical performance of ***,ex-situ XRD,XPS,and TEM tests further demonstrated the Zn^(2+)insertion/extraction and Zn-storage mechanism that occurred during the cycle in the CaVO//Zn battery *** work provides new insights into the intercalation of similar divalent cations in vanadium oxides and offers new solutions for designing cathodes for high-capacity aqueous ZIBs.

关键词： Aqueous zinc ion batteries Cathode materials Ion pre-intercalation Vanadium oxides Energy storage mechanism

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Endoscopic full-thickness resection using an over-the-scope device:A prospective study

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World Journal of Gastroenterology 2021年第8期27卷 725-736页

作者： jin-tao guo jing-jing Zhang Yu-Fan Wu Ye Liao Yi-Dan Wang Bao-Zhen Zhang Sheng Wang Si-Yu Sun Department of Gastroenterology Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina

BACKGROUND Endoscopic submucosal dissection to treat mucosal and submucosal lesions sometimes results in low rates of microscopically margin-negative(R0)*** full-thickness resection(EFTR)has a high R0 resection rate and allows for the definitive diagnosis and treatment of selected mucosal and submucosal lesions that are not suitable for conventional resection *** To evaluate the efficacy and safety of EFTR using an over-the-scope clip(OTSC).METHODS This prospective,single-center,non-randomized clinical trial was conducted at the endoscopy center of Shengjing Hospital of China Medical *** study included patients aged 18-70 years who had gastric or colorectal submucosal tumors(SMTs)(≤20 mm in diameter)originating from the muscularis propria based on endoscopic ultrasound(EUS)and patients who had early-stage gastric or colorectal cancer(≤20 mm in diameter)based on EUS and computed *** lesions were treated by EFTR combined with an OTSC for wound closure between November 2014 and October *** analyzed patient demographics,lesion features,histopathological diagnoses,R0 resection(negative margins)status,adverse events,and follow-up *** A total of 68 patients(17 men and 51 women)with an average age of 52.0±10.5 years(32-71 years)were enrolled in this study,which included 66 gastric or colorectal SMTs and 2 early-stage colorectal *** mean tumor diameter was 12.6±4.3 *** EFTR procedure was successful in all *** mean EFTR procedure time was 39.6±38.0 *** mean OTSC defect closure time was 5.0±3.8 min,and the success rate of closure for defects was 100%.Histologically complete resection(R0)was achieved in 67(98.5%)***-related adverse events were observed in 11(16.2%)*** average post-procedure length of follow-up was 48.2±15.7 *** was no recurrence during *** EFTR combined with an OTSC is an effective and safe technique for the removal of select sube

关键词： Endoscopic full-thickness resection Over-the-scope clip Early gastric cancer Early colorectal cancer Submucosal tumor Gastrointestinal stromal tumor

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Development characteristics and controlling factors of fractures in lacustrine shale and their geological significance for evaluating shale oil sweet spots in the third member of the Shahejie Formation in the Qikou Sag, Bohai Bay Basin

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Petroleum Science 2024年第2期21卷 791-805页

作者： Xu Zeng tao Yang Jian-Wei Feng Cong-Sheng Bian Ming Guan Wei Liu Bing-Cheng guo jin Dong Research Institute of Petroleum Exploration and Development China National Petroleum CorporationBeijing100083China College of Geosciences China University of Petroleum(Beijing)Beijing102249China Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum(Beijing)Beijing102249China School of Earth Sciences China University of PetroleumQingdao266400ShandongChina

Natural fractures are critical for shale oil and gas enrichment and development. Due to the extremely high heterogeneity of shale, the factors controlling the formation of internal fractures, especially horizontal fractures, remain controversial. In this study, we integrate thin section analysis and microcomputed tomography(CT) data from several lacustrine shale samples from the third member(Es3) of the Shahejie Formation, Qikou Sag, Bohai Bay Basin, to assess the fractures in detail. The goal is to reveal the development characteristics, controlling factors, and geological significance for evaluating sweet spots in a shale oil play. The fractures in the Es3contain high-angle structural and horizontal bed-parallel fractures that are mostly shear and extensional. Various factors influence fracture development,including lithofacies, mineral composition, organic matter content, and the number of laminae. Structural fractures occur predominantly in siltstone, whereas bed-parallel fractures are abundant in laminated shale and layered mudstone. A higher quartz content results in higher shale brittleness, causing fractures, whereas the transformation between clay minerals contributes to the development of bedparallel fractures. Excess pore pressure due to hydrocarbon generation and expulsion during thermal advance can cause the formation of bed-parallel fractures. The density of the bed-parallel and structural fractures increases with the lamina density, and the bed-parallel fractures are more sensitive to the number of laminae. The fractures are critical storage spaces and flow conduits and are indicative of sweet spots. The laminated shale in the Es3with a high organic matter content contains natural fractures and is an organic-rich, liquid-rich, self-sourced shale play. Conversely, the siltstone, massive mudstone, and argillaceous carbonate lithofacies contain lower amounts of organic matter and do not have bed-parallel fractures. However, good reservoirs can form in th

关键词： Fractures Development characteristics Controlling factors Shale oil Sweet spot

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TCF10 Liquid Helium System

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近代物理研究所和兰州重离子加速器实验室年报：英文版 2007年第1期 171-172页

作者： jin tao guo Xiaohong Man Kaidi

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Endoscopic fenestration in the diagnosis and treatment of delayed anastomotic submucosal abscess:A case report and review of literature

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World Journal of Clinical Cases 2020年第23期8卷 6086-6094页

作者： Bao-Zhen Zhang Yi-Dan Wang Ye Liao jing-jing Zhang Yu-Fan Wu Xiao-Lin Sun Si-Yu Sun jin-tao guo Department of Gastroenterology Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina Department of Endoscopy Center Liaoyang Liaohua HospitalLiaoyang 111000Liaoning ProvinceChina

BACKGROUND Abscess formation is one of the complications after radical resection of rectal cancer;cases with delayed postoperative anastomotic abscess are ***,we report a rare case of postoperative anastomotic abscess with a submucosal neoplasm appearing after rectal ***,the patient was diagnosed and treated by endoscopic *** addition,we review the literature on the appearance of an abscess as a complication after rectal cancer *** SUMMARY A 57-year-old man with a history of rectal malignancy resection complained of a smooth protuberance near the anastomotic *** ultrasonography revealed a hypoechoic structure originating from the muscularis propria,and a submucosal tumor was *** patient was subsequently referred to our hospital and underwent pelvic contrast-enhanced computed tomography,which revealed no thickening or strengthening of the anastomotic *** order to clarify the origin of the lesion and obtain the pathology,endoscopic fenestration was *** endoscopic procedure,a definitive diagnosis of delayed anastomotic submucosal abscess was *** patient achieved good recovery and prognosis after the complete clearance of *** Endoscopic fenestration may be safe and effective for the diagnosis/treatment of delayed intestinal smooth protuberance after rectal cancer surgery.

关键词： Anastomotic stoma Rectal cancer Submucosal tumor Endoscopic fenestration Delayed postoperative abscess Case report

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Multi-Objective Multi-Variable Large-Size Fan Aerodynamic Optimization by Using Multi-Model Ensemble Optimization Algorithm

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Journal of Thermal Science 2024年第3期33卷 914-930页

作者： XIONG jin guo Penghua LI jingyin School of Energy and Power Engineering Xi’an Jiaotong UniversityXi’an710049China

The constrained multi-objective multi-variable optimization of fans usually needs a great deal of computational fluid dynamics(CFD)calculations and is *** this study,a new multi-model ensemble optimization algorithm is proposed to tackle such an expensive optimization *** multi-variable and multi-objective optimization are conducted with a new flexible multi-objective infill *** addition,the search direction is determined by the multi-model ensemble assisted evolutionary algorithm and the feature extraction by the principal component analysis is used to reduce the dimension of optimization ***,the proposed algorithm and other two optimization algorithms which prevail in fan optimizations were compared by using test *** the same number of objective function evaluations,the proposed algorithm shows a fast convergency rate on finding the optimal objective function ***,this algorithm was used to optimize the rotor and stator blades of a large axial fan,with the efficiencies as the objectives at three flow rates,the high,the design and the low flow ***-two variables were included in the optimization *** results show that compared with the prototype fan,the total pressure efficiencies of the optimized fan at the high,the design and the low flow rate were increased by 3.35%,3.07%and 2.89%,respectively,after CFD simulations for 500 fan candidates with the constraint for the design *** optimization results validate the effectiveness and feasibility of the proposed algorithm.

关键词： multi-objective optimization surrogate-assisted evolutionary algorithm axial fan computational fluid dynamics aerodynamic optimization

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