Endoscopic full-thickness resection using an over-the-scope device:A prospective study

作     者：Jin-Tao Guo Jing-Jing Zhang Yu-Fan Wu Ye Liao Yi-Dan Wang Bao-Zhen Zhang Sheng Wang Si-Yu Sun 

作者机构：Department of GastroenterologyShengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2021年第27卷第8期

页      面：725-736页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：National Natural Science Foundation of China,No.81900601 Innovative Talent Support Program of Liaoning Province,No.LR2019073 Outstanding Scientific Fund of Shengjing Hospital,No.201701 and No.201702 

主　　题：Endoscopic full-thickness resection Over-the-scope clip Early gastric cancer Early colorectal cancer Submucosal tumor Gastrointestinal stromal tumor 

摘      要：BACKGROUND Endoscopic submucosal dissection to treat mucosal and submucosal lesions sometimes results in low rates of microscopically margin-negative(R0)*** full-thickness resection(EFTR)has a high R0 resection rate and allows for the definitive diagnosis and treatment of selected mucosal and submucosal lesions that are not suitable for conventional resection *** To evaluate the efficacy and safety of EFTR using an over-the-scope clip(OTSC).METHODS This prospective,single-center,non-randomized clinical trial was conducted at the endoscopy center of Shengjing Hospital of China Medical *** study included patients aged 18-70 years who had gastric or colorectal submucosal tumors(SMTs)(≤20 mm in diameter)originating from the muscularis propria based on endoscopic ultrasound(EUS)and patients who had early-stage gastric or colorectal cancer(≤20 mm in diameter)based on EUS and computed *** lesions were treated by EFTR combined with an OTSC for wound closure between November 2014 and October *** analyzed patient demographics,lesion features,histopathological diagnoses,R0 resection(negative margins)status,adverse events,and follow-up *** A total of 68 patients(17 men and 51 women)with an average age of 52.0±10.5 years(32-71 years)were enrolled in this study,which included 66 gastric or colorectal SMTs and 2 early-stage colorectal *** mean tumor diameter was 12.6±4.3 *** EFTR procedure was successful in all *** mean EFTR procedure time was 39.6±38.0 *** mean OTSC defect closure time was 5.0±3.8 min,and the success rate of closure for defects was 100%.Histologically complete resection(R0)was achieved in 67(98.5%)***-related adverse events were observed in 11(16.2%)*** average post-procedure length of follow-up was 48.2±15.7 *** was no recurrence during *** EFTR combined with an OTSC is an effective and safe technique for the removal of select sube