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Kinesin 26B modulates M2 polarization of macrophage by activating cancer-associated fibroblasts to aggravate gastric cancer occurrence and metastasis

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World Journal of Gastroenterology 2024年第20期30卷 2689-2708页

作者： Lian-meng Huang Ming-jin Zhang Department of General Surgery The 901st Hospital of PLAHefei 230031Anhui ProvinceChina

BACKGROUND The regulatory effects of KIF26B on gastric cancer(GC)have been confirmed,but the specific mechanism still needs further ***-cancer analysis shows that the KIF26B expression is highly related to immune infiltration of cancerassociated fibroblasts(CAFs),and CAFs promote macrophage M2 polarization and affect cancers’*** To investigate the regulatory functions of KIF26B on immune and metastasis of *** We analyzed genes’mRNA levels by quantitative real-time polymerase chain *** levels of target proteins were detected by immunohistochemistry,ELISA,and Western *** injected AGS cells into nude mice for the establishment of a xenograft tumor model and observed the occurrence and metastasis of *** degree of inflammatory infiltration in pulmonary nodes was observed through hematoxylin-eosin *** and wound healing assays were performed for the evaluation of cell invasion and migration *** formation assay was used for detecting angiogenesis.M2-polarized macrophages were estimated by immunofluorescence and flow *** KIF26B was significantly overexpressed in cells and tissues of GC,and the higher expression of KIF26B was related to GC metastasis and *** to in vivo experiments,KIF26B promoted tumor formation and metastasis of ***26B expression was positively associated with CAFs’degree of ***,CAFs could regulate M2-type polarization of macrophages,affecting GC cells’migration,angiogenesis,invasion,and epithelial-mesenchymal transition *** KIF26B regulated M2 polarization of macrophage through activating CAFs,regulating the occurrence and metastasis of GC.

关键词： metastasis invasion macrophage

Boundary Regularity of Isometries Between Infinitely Flat Complex Domains

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Acta Mathematica Sinica,English Series 2024年第6期40卷 1375-1387页

作者： jin Song LIU Fei tao Hong Yu WANG Academy of Mathematics and Systems Science Chinese Academy of SciencesBeijing 100190P.R.China School of Mathematical Sciences University of Chinese Academy of SciencesBeijing 100049P.R.China Beijing International Center for Mathematical Research Peking UniversityBeijing 100871P.R.China School of Science Beijing University of Posts and TelecommunicationsBeijing 100876P.R.China Key Laboratory of Mathematics and Information Networks(Beijing University of Posts and Telecommunications) Ministry of EducationBeijing 100876P.R.China

In this paper we prove that isometries with respect to the Kobayashi metric between certain domains having boundary points at which the boundary is infinitely flat extend continuously to the *** strategy is to reestab... 详细信息

关键词： Boundary extension Kobayashi metric isometries

GEOSatDB:global civil earth observation satellite semantic database

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Big Earth Data 2024年第3期8卷 522-539页

作者： Ming Lin meng jin Juanzi Li Yuqi Bai Department of Earth System Science Institute for Global Change StudiesMinistry of Education Ecological Field Station for East Asian Migratory BirdsTsinghua UniversityBeijingChina Department of Computer Science and Technology Tsinghua UniversityBeijingChina Tsinghua Urban Institute Tsinghua UniversityBeijingChina

Satellite remote sensing,characterized by extensive coverage,fre-quent revisits,and continuous monitoring,provides essential data support for addressing global *** the past six decades,thousands of Earth observation satellites and sensors have been deployed *** valuable Earth observation assets are contributed independently by various nations and organizations employing diverse *** poses a significant challenge in effectively discovering global Earth observation resources and realizing their full *** this paper,we describe the develop-ment of GEOSatDB,the most complete semantic database of civil Earth observation satellites developed based on a unified ontology model.A similarity matching method is used to integrate satellite information and a prompt strategy is used to extract unstructured sensor *** resulting semantic database contains 127,949 semantic statements for 2,340 remote sensing satellites and 1,021 observation *** global Earth observation capabil-ities of 195 countries worldwide have been analyzed in detail,and a concrete use case along with an associated query demonstration is *** database provides significant value in effectively facilitating the semantic understanding and sharing of Earth observa-tion resources.

关键词： Earth observation satellite sensor semantic representation information extraction

New Vacuum Solar Telescope Achieves Narrowband Infrared Solar Imaging Observation at He I 10830 A

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Research in Astronomy and Astrophysics 2024年第5期24卷 76-84页

作者： Wei-Jie meng Fang-Yu Xu Zhen-Yu jin Yunnan Observatories Chinese Academy of SciencesKunming 650011China Yunnan Key Laboratory of Solar Physics and Space Science Kunming 650216China University of Chinese Academy of Sciences Beijing 100049China

The near-infrared imaging channel constitutes a crucial component of the multichannel high-resolution imaging system of the New Vacuum Solar Telescope(NVST). We have successfully achieved high-resolution, narrowband imaging of the chromosphere using He I 10830 A triplet within this channel, which significantly enhances the imaging observation capabilities of NVST. This paper provides a concise overview of the optical system associated with the near-infrared imaging channel, detailing data processing procedures and presenting several observed images. Leveraging a high-resolution image reconstruction algorithm, we were able to generate a narrowband image near the diffraction limit at 10830 A with a temporal resolution of less than 10 s.

关键词： instrumentation detectors-instrumentation high angular resolution-Sun chromosphere-Sun infrared

Characterization of a smog chamber for studying formation of gas-phase products and secondary organic aerosol

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Journal of Environmental Sciences 2024年第2期136卷 570-582页

作者： Qi Yuan Zhuozhi Zhang meng Wang Kin Fai Ho tao Wang Shuncheng Lee Department of Civil and Environmental Engineering The Hong Kong Polytechnic UniversityKowloonHong KongChina School of Public Health and Primary Care The Chinese University of Hong KongShatinHong KongChina

Smog chambers provide a potent approach to explore the secondary organic aerosol formation under varied *** study describes the construction and characterization of a new smog chamber facility for studying the formation mechanisms of gas-phase products and secondary organic aerosol from the photooxidation of volatile organic *** chamber is a 5.4 m^(3) Fluorinated Ethylene Propylene(FEP)Teflon reactor with the potential to perform photooxidation experiments at controlled temperature and relative *** characterizations were conducted for evaluation of stability of environmental parameters,mixing time,background contamination,light intensity,and wall losses of gases and *** photolysis rate of NO_(2)(J_(NO2))ranged from(1.02-3.32)×10^(-3)sec^(-1),comparable to the average J_(NO2)in ambient *** wall loss rates for NO,NO_(2),and O_(3)were 0.47×10^(-4),0.37×10^(-4),and 1.17×10^(-4)min^(-1),while wall loss of toluene was obsoletely found in a 6 hr *** particle number wall loss rates are(0.01-2.46)×10^(-3)min^(-1)for 40-350 nm with an average lifetime of more than one day.A series of toluene photooxidation experiments were carried out in absence of NO_xunder dry *** results of the simulation experiments demonstrated that the chamber is well designed to simulate photolysis progress in the atmosphere.

关键词： Smog chamber Gas-phase oxidation Chamber characterization Chemical mechanism

A biased edge enhancement method for truss-based community search

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Frontiers of Computer Science 2024年第3期18卷 251-253页

作者： Yuqi LI tao meng Zhixiong HE Haiyan LIU Keqin LI School of Computer and Information Engineering Central South University of Forestry and TechnologyChangsha 410082China School of Business Central South University of Forestry and TechnologyChangsha 410082China College of Information Engineering Changsha Medical UniversityChangsha 410219China Department of Computer Science State University of New YorkNew York 12561USA

1 Introduction A related study called community search,whose target is to find dense subgraphs containing the given node,has drawn a growing amount of attention recently[1].To explore the higher-order structure of complex networks,truss-based community search methods[2]have been ***,the truss-based hypergraph constructed from the original graph is frequently fragmented and consists of numerous subgraphs and isolated nodes[3],which boils down to the fact that these methods often pay only attention to the truss connections but ignore the lower-order connectivity of the original graph.

关键词： graph. truss connectivity

The potential of herbal drugs to treat heart failure:The roles of Sirt1/AMPK

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Journal of Pharmaceutical Analysis 2024年第2期14卷 157-176页

作者： tao Zhang Lei Xu Xiaowei Guo Honglin tao Yue Liu Xianfeng Liu Yi Zhang Xianli meng State Key Laboratory of Southwestern Chinese Medicine Resources Innovative Institute of Chinese Medicine and PharmacyChengdu University of Traditional Chinese MedicineChengdu611137China College of Pharmacy Chengdu University of Traditional Chinese MedicineChengdu611137China School of Ethnic Medicine Chengdu University of Traditional Chinese MedicineChengdu611137China Meishan Hospital of Chengdu University of Traditional Chinese Medicine MeishanSichuan620032China

Heart failure(HF)is a highly morbid syndrome that seriously affects the physical and mental health of patients and generates an enormous socio-economic *** addition to cardiac myocyte oxidative stress and apoptosis,which are considered mechanisms for the development of HF,alterations in cardiac energy metabolism and pathological autophagy also contribute to cardiac abnormalities and ultimately *** information regulator 1(Sirt1)and adenosine monophosphate-activated protein kinase(AMPK)are nicotinamide adenine dinucleotide(NAD+)-dependent deacetylases and phosphorylated kinases,*** play similar roles in regulating some pathological processes of the heart through regulating targets such as peroxisome proliferator-activated receptorγcoactivator 1α(PGC-1α),protein 38 mitogen-activated protein kinase(p38 MAPK),peroxisome proliferator-activated receptors(PPARs),and mammalian target of rapamycin(mTOR).We summarized the synergistic effects of Sirt1 and AMPK in the heart,and listed the traditional Chinese medicine(TCM)that exhibit cardioprotective properties by modulating the Sirt1/AMPK pathway,to provide a basis for the development of Sirt1/AMPK activators or inhibitors for the treatment of HF and other cardiovascular diseases(CVDs).

关键词： Heart failure Silent information regulator 1 Adenosine monophosphate-activated protein kinase Traditional Chinese medicine

A Finite-Time Convergent Analysis of Continuous Action Iterated Dilemma

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IEEE/CAA Journal of Automatica Sinica 2024年第2期11卷 563-565页

作者： Zhen Wang Xiaoyue jin tao Zhang Dengxiu Yu Northwestern Polytechnical University

Dear Editor,In this letter, a finite-time convergent analysis of continuous action iterated dilemma(CAID) is proposed. In traditional evolutionary game theory, the strategy of the player is binary(cooperation or defec... 详细信息

关键词： lemma letter convergent

Effectiveness of colonoscopy,immune fecal occult blood testing,and risk-graded screening strategies in colorectal cancer screening

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2270-2280页

作者： Ming Xu jing-Yi Yang tao meng Department of Colorectal Surgery Qilu Hospital(Qingdao)Cheeloo College of MedicineQingdao 266000Shandong ProvinceChina Department of Gastrointestinal Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina

BACKGROUND Colorectal cancer(CRC)is one of the most common malignant tumors,and early screening is crucial to improving the survival rate of *** combination of colonoscopy and immune fecal occult blood detection has garnered significant attention as a novel method for CRC *** and fecal occult blood tests,when combined,can improve screening accuracy and early detection rates,thereby facilitating early intervention and ***,certain risks and costs accompany it,making the establishment of a risk classification model crucial for accurate classification and management of screened *** To evaluate the feasibility and effectiveness of colonoscopy,immune fecal occult blood test(FIT),and risk-graded screening strategies in CRC *** Based on the randomized controlled trial of CRC screening in the population conducted by our hospital May 2020 to May 2023,participants who met the requirements were randomly assigned to a colonoscopy group,an FIT group,or a graded screening group at a ratio of 1:2:2(after risk assessment,the high-risk group received colonoscopy,the low-risk group received an FIT test,and the FITpositive group received colonoscopy).The three groups received CRC screening with different protocols,among which the colonoscopy group only received baseline screening,and the FIT group and the graded screening group received annual follow-up screening based on baseline *** primary outcome was the detection rate of advanced tumors,including CRC and advanced *** population participation rate,advanced tumor detection rate,and colonoscopy load of the three screening programs were *** A total of 19373 subjects who met the inclusion and exclusion criteria were enrolled,including 8082 males(41.7%)and 11291 females(58.3%).The mean age was 60.05±6.5 *** them,3883 patients were enrolled in the colonoscopy group,7793 in the FIT group,and 7697 in the graded screening *** rounds

关键词： Colorectal tumor Immune fecal occult blood testing Colonoscopy Hierarchical screening Risk assessment