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A novel absorptive thin film for laser welding in optoelectronic device capsulation

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光学精密工程 2005年第4期13卷 492-499页

作者： JIANG Shao-ji jin tao li Wei-duo WANG He-zhou State Key Laboratory of Optoelectronic Materials and Technologies Sun Yat-Sen University Guangzhou 510275 China

A kind of absorptive thin film was designed and used in laser welding of SiO2, Si and liNbO3. This absorptive thin film of three-layer metal-dielectric-metal structure is designed for further reducing the high reflectance of the Nd:YAG laser beam on the surface of the tin layer that is utilized as solder between the transparent parent materials. The actual absorption of laser energy in experiment exceeds 99%. This combination of absorber and solder transformed the laser energy into heat efficiently and decreased the minimum necessary incident laser power transmitting through the transparent parent materials. As a result, the damage of the parent materials, which is suffered from laser transmission, was avoided; On the other hand, mechanical stability of the welded materials had been improved. Experiment had been made to show the difference between welding with and without the absorptive thin film.

关键词：光电子装置封装工艺薄膜激光仪器激光技术

Minimax Theorems Involving Two Functions and Strictly Monotone Transformations of Their Values

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Acta Mathematicae Applicatae Sinica 2006年第4期22卷 607-614页

作者： Cai-yun jin Cao-zong Cheng Yong-tao jin jing li Department of Mathematics Beijing University of Technology Beijing 100022 China

Two two-function minimax theorems are proved. The concavity-convexity conditions of the two functions involve strictly monotone transformations and mixing of the values of the two functions, and are described by the i... 详细信息

关键词： Minimax theorems two functions strictly monotone increasing transformation

Expression of NG2 and platelet-derived growth factor receptor alpha in the developing neonatal rat brain

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Neural Regeneration Research 2017年第11期12卷 1843-1852页

作者： Ping li Heng-xi li Hong-yan Jiang lie Zhu Hai-ying Wu jin-tao li Jiang-hua Lai College of Forensic Science Health Science CenterXi'an Jiaotong UniversityXi'anShaanxi ProvinceChina Department of Anatomy and Histology&Embryology Faculty of Basic Medical SciencesKunming Medical UniversityKunmingYunnan ProvinceChina Department of Plastic Surgery Changzheng HospitalShanghaiChina Department of Emergency and Intensive Care Unit First Affiliated HospitalKunming Medical UniversityKunmingYunnan ProvinceChina Neuroscience Institute Faculty of Basic Medical SciencesKunming Medical UniversityKunmingYunnan ProvinceChina

Platelet-derived growth factor receptor alpha （PDGFRct） is a marker of oligodendrocyte precursor cells in the central nervous system. NG2 is also considered a marker of oligodendrocyte precursor cells. However, whether there are differences in the distribution and morphol- ogy of oligodendrocyte precursor cells labeled by NG2 or PDGFRa in the developing neonatal rat brain remains unclear. In this study, by immunohistochemical staining, NG2 positive （NG2＋） cells were ubiquitous in the molecular layer, external pyramidal layer, internal pyramidal layer, and polymorphic layer of the cerebral cortex, and corpus callosum, external capsule, piriform cortex, and medial septal nucleus. NG2~ cells were stellate or fusiform in shape with long processes that were progressively decreased and shortened over the course of brain development. The distribution and morphology of PDGFRct positive （PDGFRa＋） cells were coincident with NG2＋ cells. The co- localization of NG2 and PDGFRu in the cell bodies and processes of some cells was confirmed by double immunofluorescence labeling. Moreover, cells double-labeled for NG2 and PDGFRa were predominantly in the early postnatal stage of development. The numbers of NG2＋/PDGFRa＋ cells and PDGFRa＋ cells decreased, but the number of NG2＋ cells increased from postnatal days 3 to 14 in the developing brain. In addition, amoeboid microglial cells of the corpus callosum, newborn brain macrophages in the normal developing brain, did not express NG2 or PDGFRu, but NG2 expression was detected in amoeboid microglia after hypoxia. The present results suggest that NG2 and PDGFRct are specific markers of oligodendrocyte precursor cells at different stages during early development. Additionally, the NG2 protein is involved in inflammatory and pathological processes of amoeboid microglial cells.

关键词： nerve regeneration NG2 platelet-derived growth factor receptor alpha oligodendrocyte precursor cells amoeboid microglial cells OX-42 hypoxia cerebral cortex corpus callosum neural regeneration

Prevalence of human papillomavirus in esophageal carcinoma in Tangshan,China

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World Journal of Gastroenterology 2015年第10期21卷 2905-2911页

作者： Mohammadreza Mohammadzad Mehryar Shu-Ying li Hong-Wei liu Fan li Fang Zhang Yu-bai Zhou Yi Zeng jin-tao li Beijing Key Laboratory of Environmental and Viral Oncology College of Life Science and Bio-EngineeringBeijing University of Technology Collaborative Innovation Center for Biotherapy West China HospitalSichuan University Department of Pathogenic Biology College of Basic Medicine Hebei United University Key Laboratory of Southwest China Wildlife Resources Conservation Ministry of EducationCollege of Life Sciences China West Normal University National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention and State Key Laboratory for Infectious Disease Prevention and Control

AIM:to study the prevalence of human papillomavirus(HPV) in esophageal carcinoma in tangshan,China,a high-incidence ***:Formalin-fixed,paraffin-embedded tissue specimens from 198 patients who were pathologically diagnosed with esophageal squamous cell carcinoma from 2011 to 2013 were obtained from a pathology department in *** was extracted from all198 specimens to detect HPV by polymerase chain reaction(PCR).β-globin PCR was performed to check the quality of the DNA extraction *** was performed to detect a wide range of HPV types,and type-specific PCR was performed to detect HPV types16 and *** and positive controls were used for HPV 16 and 18 ***:the DNA extraction method in this study appeared to be more effective than other previously reported *** DNA extraction,more than98%of the tissue specimens had an acceptable result in the DNA qualification test(β-globin PCR).the overall prevalence of HPV in tumor tissues by GP6+/GP5+PCR was 79.79%,and the prevalence of HPV types16 and 18 was 40.40%and 47.47%,*** demonstrated the presence of HPV,and direct sequencing confirmed the HPV *** HPVpositive PCR products were checked by DNA sequence analysis using DNAman and compared with the known HPV sequences listed in the basic Local Alignment Search tool database to evaluate the HPV *** analysis confirmed the presence of HPV types 16 ***:DNA of high-risk HPV types 16 and 18is present in esophageal tumors,implicating HPV as a possible etiologic factor for esophageal squamous cell carcinoma.

关键词： Esophageal carcinoma Formalin-fixed,paraffin-embed

Acetylation promotes BCAT2 degradation to suppress BCAA catabolism and pancreatic cancer growth

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Signal Transduction and Targeted Therapy 2020年第1期5卷 1769-1777页

作者： Ming-Zhu Lei Xu-Xu li Ye Zhang jin-tao li Fan Zhang Yi-Ping Wang Miao Yin Jia Qu Qun-Ying Lei Department of Biochemistry and Molecular Biology School of Basic Medical SciencesShanghai Medical CollegeFudan University131 Dong’an RoadShanghai 200032China Cancer Metabolism Laboratory and the Shanghai Key Laboratory of Medical Epigenetics the International Co-laboratory of Medical Epigenetics and MetabolismMinistry of Science and TechnologyInstitutes of Biomedical SciencesShanghai Medical CollegeFudan University131 Dong’an RoadShanghai 200032China Cancer Institute Fudan University Shanghai Cancer Center and Department of OncologyShanghai Medical CollegeFudan University270 Dong’an RoadShanghai 200032China State Key Laboratory of Medical Neurobiology Fudan University131 Dong’an RoadShanghai 200032China

Pancreatic ductal adenocarcinoma(PDAC)is well-known for inefficient early diagnosis,with most patients diagnosed at advanced *** evidence indicates that elevated plasma levels of branched-chain amino acids(BCAAs)are associated with an increased risk of pancreatic ***-chain amino acid transaminase 2(BCAT2)is an important enzyme in BCAA catabolism that reversibly catalyzes the initial step of BCAA degradation to branched-chain ***,we show that BCAT2 is acetylated at lysine 44(K44),an evolutionarily conserved ***2 acetylation leads to its degradation through the ubiquitin–proteasome pathway and is stimulated in response to BCAA ***-responsive element-binding(CREB)-binding protein(CBP)and SIRT4 are the acetyltransferase and deacetylase for BCAT2,*** and SIRT4 bind to BCAT2 and control the K44 acetylation level in response to BCAA *** importantly,the K44R mutant promotes BCAA catabolism,cell proliferation,and pancreatic tumor ***,the data from our study reveal a previously unknown regulatory mechanism of BCAT2 in PDAC and provide a potential therapeutic target for PDAC treatment.

关键词： BCAA elevated diagnosis

Synthesis of Red Phosphor CaZrO_(3):Eu^(3+) for White light-Emitting Diodes

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Chinese Physics Letters 2011年第2期28卷 208-211页

作者： li Xu GUAN li AN Jia-Yi jin li-tao YANG Zhi-Ping YANG Yan-Min li Pan-Lai FU Guang-Sheng College of Physics Science and Technology Hebei UniversityBaoding 071002 Tangshan Vocational and Technical College Tangshan 063004

A red-emitting CaZrO_(3):Eu^(3+)phosphor has been prepared by solid state reaction and its luminescent properties are *** crystal structure is investigated by the x-ray *** energy transitions of^(5)Do→^(7)Fj(J=0,1,2,3)in Eu^(3+)ions,the emission spectrum of the phosphor shows a series of narrow bands under near-ultraviolet light and the strongest peak locates at *** emission intensity of Cai-xZrO_(3):xEu^(3+)phosphor will reach the maximum as the molar concentration of Eu^(3+)is 5mol%.

关键词： diffraction narrow ultraviolet

Ethanol extract of Herpetospermum caudigerum Wall ameliorates psoriasis-like skin inflammation and promotes degradation of keratinocyte-derived ICAM-1 and CXCL9

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Journal of Integrative Medicine 2023年第6期21卷 584-592页

作者： Ya Zhong Bo-wen Zhang jin-tao li Xin Zeng Jun-xia Pei Ya-mei Zhang Yi-xi Yang Fu-lun li Yu Deng Qi Zhao Engineering Research Center of Sichuan-Xizang Traditional Medicinal Plant Chengdu UniversityChengdu 610106Sichuan ProvinceChina Institute of Cancer Biology and Drug Discovery Chengdu UniversityChengdu 610106Sichuan ProvinceChina School of Food and Biological Engineering Chengdu UniversityChengdu 610106Sichuan ProvinceChina School of Pharmacy Chengdu UniversityChengdu 610106Sichuan ProvinceChina Key Laboratory of Clinical Genetics Affiliated Hospital of Chengdu UniversityChengdu 610106Sichuan ProvinceChina Department of Dermatology Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China School of Basic Medical Sciences Chengdu UniversityChengdu 610106Sichuan ProvinceChina

Objective:To explore whether the ethanol extract of Herpetospermum caudigerum Wall(EHC),a Xizang medicinal plant traditionally used for treating liver diseases,can improve imiquimod-induced psoriasis-like skin ***:Immunohistochemistry and immunofluorescence staining were used to determine the effects of topical EHC use in vivo on the skin pathology of imiquimod-induced psoriasis in *** protein levels of interferon-γ(IFN-γ),tumor necrosis factor-a(TNF-a),and interleukin-17A(IL-17A)in mouse skin samples were examined using immunohistochemical *** vitro,IFN-γ-induced HaCaT cells with or without EHC treatment were used to evaluate the expression of keratinocyte-derived intercellular cell adhesion molecule-1(ICAM-1)and chemokine CXC ligand 9(CXCL9)using Western blotting and reverse transcription-quantitative polymerase chain *** protein synthesis inhibitor cycloheximide and proteasome inhibitor MG132 were utilized to validate the EHC-mediated mechanism underlying degradation of ICAM-1 and ***:EHC improved inflammation in the imiquimod-induced psoriasis mouse model and reduced the levels of IFN-γ,TNF-a,and IL-17A in psoriatic *** with EHC also suppressed ICAM-1 and CXCL9 in epidermal *** mechanistic studies revealed that EHC suppressed keratinocyte-derived ICAM-1 and CXCL9 by promoting ubiquitin–proteasome-mediated protein degradation rather than transcriptional *** primary compounds including ehletianol C,dehydrodiconiferyl alcohol,herpetrione,herpetin,herpetotriol,herpetetrone and herpetetrol were identified from the EHC using ultra-performance liquid chromatography-quadrupole-time of flight-mass ***:Topical application of EHC ameliorates psoriasis-like skin symptoms and improves the inflammation at the lesion sites.

关键词： Psoriasis Herpetospermum caudigerum wall Cytokines Degradation

Sodium chloride exacerbates dextran sulfate sodiuminduced colitis by tuning proinflammatory and antiinflammatory lamina propria mononuclear cells through p38/MAPK pathway in mice

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World Journal of Gastroenterology 2018年第16期24卷 1779-1794页

作者： Hong-Xia Guo Nan Ye Ping Yan Min-Yue Qiu Ji Zhang Zi-Gang Shen Hai-Yang He Zhi-Qiang Tian Hong-li li jin-tao li Department of Microbiology Third Military Medical University Army Medical University Institute of Tropical Medicine Third Military Medical University Army Medical University Department of Obstetrics and Gynecology Southwest Hospital Third Military Medical University Army Medical University Institute of Immunology Third Military Medical University Army Medical University Department of Histology and Embryology College of Basic Medicine Third Military Medical University Army Medical University

AIM To investigate the influence of high salt on dextran sulfate sodium(DSS)-induced colitis in mice and explore the underlying mechanisms of this *** DSS and NaC l were used to establish the proinflammatory animal model. We evaluated the colitis severity. Flow cytometry was employed for detecting the frequencies of Th1, macrophages and Tregs in spleen, mesenteric lymph node and lamina propria. The important role of macrophages in the promotion of DSS-induced colitis by NaCl was evaluated by depleting macrophages with clodronate liposomes. Activated peritoneal macrophages and lamina propria mononuclear cells(LPMCs) were stimulated with NaCl, and proteins were detected by western blotting. Cytokines and inflammation genes were analyzed by enzyme-linked immunosorbent assay and RT-PCR, *** The study findings indicate that NaC l up-regulates the frequencies of CD11b^+ macrophages and CD4^+IFN-γ^+IL-17^+ T cells in lamina propria in DSS-treated mice. CD3^+CD4^+CD25^+Foxp^3+ T cells, which can secrete high levels of IL-10 and TGF-β, increase through feedback in NaCl-and DSS-treated mice. Furthermore, clodronate liposomes pretreatment significantly alleviated DSSinduced colitis, indicating that macrophages play a vital role in NaCl proinflammatory activity. NaCl aggravates peritoneal macrophage inflammation by promoting the expressions of interleukin(IL)-1, IL-6 and mouse inducible nitric oxide synthase. Specifically, high NaCl concentrations promote p38 phosphorylation in lipopolysaccharide-and IFN-γ-activated LPMCs mediated by SGK1. CONCLUSION Proinflammatory macrophages may play an essential role in the onset and development of NaCl-promoted inflammation in DSS-induced colitis. The underlining mechanism involves up-regulation of the p38/MAPK axis.

关键词： inflammatory bowel disease macrophage NaCl CD4^+IFN-γ^+IL-17^+T cell p38/MAPK

Diet high in branched-chain amino acid promotes PDAC development by USP1-mediated BCAT2 stabilization

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National Science Review 2022年第5期9卷 119-128页

作者： jin-tao li Kai-Yue li Ying Su Yuan Shen Ming-Zhu Lei Fan Zhang Miao Yin Zheng-Jun Chen Wen-Yu Wen Wei-Guo Hu Dan Su Jia Qu Qun-Ying Lei Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences Cancer Institutes Key Laboratory of Breast Cancer in ShanghaiShanghai Key Laboratory of Medical EpigeneticsInternational Co-Laboratory of Medical Epigenetics and MetabolismMinistry of Science and Technology Shanghai Medical College Fudan University State Key Laboratory of Cell Biology Shanghai Institute of Biochemistry and Cell Biology Center for Excellence in Molecular Cell ScienceChinese Academy of Sciences Cancer Research Institute Zhejiang Cancer Hospital and Key Laboratory Diagnosis and Treatment Technology on Thoracic Oncology of Zhejiang Province Department of Oncology Shanghai Medical College Fudan University State Key Laboratory of Medical Neurobiology Fudan University

BCAT2-mediated branched-chain amino acid(BCAA) catabolism is critical for pancreatic ductal adenocarcinoma(PDAC) development,especially at an early ***,whether a high-BCAA diet promotes PDAC development in vivo,and the underlying mechanism of BCAT2 upregulation,remain ***,we find that a high-BCAA diet promotes pancreatic intraepithelial neoplasia(PanIN)progression in LSL-KrasG12 D/+; Pdx1-Cre(KC) ***,we screened with an available deubiquitylase library which contains 31 members of USP family and identified that USP1 deubiquitylates BCAT2 at the K229 ***,BCAA increases USP1 protein at the translational level via the GCN2-eIF2α pathway both in vitro and in *** importantly,USP1 inhibition recedes cell proliferation and clone formation in PDAC cells and attenuates pancreas tumor growth in an orthotopic transplanted mice ***,a positive correlation between USP1 and BCAT2 is found in KC;LSL-KrasG12D/+;p53flox/+;Pdx1-Cre mice and clinical ***,a therapeutic targeting USP1-BCAT2-BCAA metabolic axis could be considered as a rational strategy for treatment of PDAC and precisive dietary intervention of BCAA has potentially translational significance.

关键词： USP1 deubiquitylation BCAT2 PanIN PDAC