检索结果-南通市图书馆

Zinc finger factor ZNF121 is a MYC-interacting protein functionally affecting MYC and cell proliferation in epithelial cells

引用

Journal of Genetics and Genomics 2016年第12期43卷 677-685页

作者： Ang Luoa Xuan Zhanga Liya Fua Zhengmao Zhua jin-tang dong Department of Genetics and Cell Biology Nankai University College of Life Sciences Department of Hematology and Medical Oncology Winship Cancer Institute Emory University School of Medicine

MYC is a potent oncoprotein that modulates multiple cellular processes including proliferation,apoptosis, differentiation, stemness, senescence, and migration. Functioning primarily as a transcriptional factor, MYC interacts with a large number of proteins, and identification and characterization of MYC-interacting proteins are important for understanding how MYC functions. In this study, we used different systems to demonstrate that a novel zinc finger transcription factor, ZNF121, physically interacted with MYC, and the interaction involved their N-terminal regions. Overexpression of ZNF121 increased, while its knockdown decreased, the expression of MYC in multiple epithelial cell lines, and MYC had similar effects on ZNF121 expression. An expression correlation was also detectable in a panel of epithelial cell lines and a cohort of human breast cancer tissues. Functionally, knockdown of ZNF121 in several breast epithelial cell lines attenuated the expressions of MYC and its target genes（e.g., EGR1,CDC2, and nucleolin） and slowed cell proliferation, accompanied by cell cycle arrest in the G1 phase and expression alteration of cell cycle regulators（cyclin D1, p14 and p21）. Analysis of publically available databases showed that ZNF121 expression is up-regulated in human breast cancer, and the up-regulation significantly associates with worse patient survival in the luminal A subtype of breast cancer. These findings establish ZNF121 as a MYC-interacting protein with functional effects on MYC and cell proliferation.

关键词： ZNF121 MYC Cell proliferation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Lack of an Additive Effect between the Deletions of Klf5 and Nkx3-1 in Mouse Prostatic Tumorigenesis

引用

Journal of Genetics and Genomics 2013年第6期40卷 315-318页

作者： Changsheng Xing Xiaoying Fu Xiaodong Sun jin-tang dong Department of Genetics and Cell Biology College of Life SciencesNankai University Department of Hematology and Medical Oncology Emory Winship Cancer InstituteEmory University School of MedicineAtlantaGA 30322USA Department of Pathology Tianjin University of Traditional Chinese Medicine

Prostate cancer is one of the most common *** development and progression of prostate cancer are driven by a series of genetic and epigenetic events including gene amplification that activates oncogenes and chromosomal deletion that inactivates tumor suppressor *** gene amplification occurs in human prostate cancer,gene deletion is more common,

关键词： Lack of an Additive Effect between the Deletions of Klf5 and Nkx3-1 in Mouse Prostatic Tumorigenesis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Implication of snoRNA U50 in human breast cancer

引用

Journal of Genetics and Genomics 2009年第8期36卷 447-454页

作者： Xue-Yuan dong Peng Guo Jeff Boyd Xiaodong Sun Qunna Li Wei Zhou jin-tang dong Department of Hematology and Medical Oncology and Winship Cancer Institute Emory University School of Medicine 1365 Clifton Road Atlanta Georgia 30322 USA Fox Chase Cancer Center 333 Cottman Avenue Philadelphia PA 19111 USA

Deletion of chromosome 6q is frequent in breast cancer, and the deletion often involves a region in 6q 14-q 16. At present, however, the underlying tumor suppressor gene has not been established. Based on a recent study identifying snoRNA U50 as a candidate for the 6q14-16 tumor suppressor gene in prostate cancer, we investigated whether U50 is also involved in breast cancer. PCR-based approaches showed that U50 underwent frequent genomic deletion and transcriptional downregulation in cell lines derived from breast cancer. Mutation screening identified the same 2-bp deletion of U50 as in prostate cancer in both cell lines and primary tumors from breast cancer, and the deletion was both somatic and in germline. Genotyping of a cohort of breast cancer cases and controls for the mutation demonstrated that, while homozygous genotype of the mutation was rare, its heterozygous genotype occurred more frequently in women with breast cancer. Functionally, re-expression of U50 resulted in the inhibition of colony formation in breast cancer cell lines. These results suggest that noncoding snoRNA U50 plays a role in the development and/or progression of breast cancer.

关键词： snoRNA U50 tumor suppressor gene breast cancer

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Estrogen-estrogen receptor signaling suppresses the transcription of ERRF in breast cancer cells

引用

Journal of Genetics and Genomics 2016年第9期43卷 565-567页

作者： Ang Luo Dan Su Xuan Zhang Leilei Qi Liya Fu jin-tang dong Department of Genetics and Cell Biology Nankai University College of Life Sciences Department of Hematology and Medical Oncology Winship Cancer Institute Emory University School of Medicine

The estrogen receptor （ER）-related factor （ERRF） was previously reported as a novel modulator of breast cancer （Suet al., 2012）. Its expression was upregulated in breast cancer, and increased ERRF expression was significantly associated with ER and/or progesterone receptor （PR） positivity and human epidermal growth factor receptor 2 （HER2） negativity （Suet al., 2012）. In addition, ERRF was necessary for ER-positive breast cancer cells to form tumors in nude mice （Suet al., 2012）. Unexpectedly,

关键词： ERE Estrogen-estrogen receptor signaling suppresses the transcription of ERRF in breast cancer cells

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Recent advancement of sonogenetics:A promising noninvasive cellular manipulation by ultrasound

引用

Genes & Diseases 2024年第5期11卷 163-182页

作者： jin tang Mingxuan Feng dong Wang Liang Zhang Ke Yang Pediatric Research Institute Children’s Hospital of Chongqing Medical UniversityNational Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChina International Science and Technology Cooperation Base of Child Development and Critical DisordersChongqing Engineering Research Center of Stem Cell TherapyChongqing 400014China Department of Ultrasound The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Tongji Medical College Huazhong University of Science and TechnologyWuhanHubei 430074China

Recent advancements in biomedical research have underscored the importance of noninvasive cellular manipulation ***,a method that uses genetic engineering to produce ultrasound-sensitive proteins in target cells,is gaining prominence along with optogenetics,electrogenetics,and *** stimulation with ultrasound,these proteins trigger a cascade of cellular activities and *** traditional ultrasound modalities,sonogenetics offers enhanced spatial selectivity,improving precision and safety in disease *** technology broadens the scope of non-surgical interventions across a wide range of clinical research and therapeutic applications,including neuromodulation,oncologic treatments,stem cell therapy,and *** current literature predominantly emphasizes ultrasonic neuromodulation,this review offers a comprehensive exploration of *** discuss ultrasound properties,the specific ultrasound-sensitive proteins employed in sonogenetics,and the technique’s potential in managing conditions such as neurological disorders,cancer,and ophthalmic diseases,and in stem cell *** objective is to stimulate fresh perspectives for further research in this promising field.

关键词： Mechanosensitive channel Neuromodulation Sonogenetics Ultrasound Ultrasound-sensitive protein

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Additive Effect of Zfhx3/Atbf1 and Pten Deletion on Mouse Prostatic Tumorigenesis

引用

Journal of Genetics and Genomics 2015年第7期42卷 373-382页

作者： Xiaodong Sun Changsheng Xing Xiaoying Fu Jie Li Baotong Zhang Henry F.Frierson Jr. jin-tang dong Winship Cancer Institute Department of Hematology and Medical OncologyEmory University School of Medicine Department of Pathology Tianjin University of Traditional Chinese Medicine Department of Pathology University of Virginia Health System

The phosphatase and tensin homolog （PTEN） and the zinc finger homeobox 3 （ZFHX3）/AT-motif binding factor 1 （ATBF1） genes have been established as tumor suppressor genes in prostate cancer by their frequent deletions and mutations in human prostate cancer and by the formation of mouse prostatic intraepithelial neoplasia （mPIN） or tumor by their deletions in mouse prostates. However, whether ZFHX3/ATBF1 deletion together with PTEN deletion facilitates prostatic tumorigenesis is unknown. In this study, we simultaneously deleted both genes in mouse prostatic epithelia and performed histological and molecular analyses. While deletion of one Pten allele alone caused low-grade （LG） mPIN as previously reported, concurrent deletion of Zfhx3/Atbfl promoted the progression to high-grade （HG） mPIN or early carcinoma. ZJhx3/Atbfl and Pten deletions together increased cell proliferation, disrupted the smooth muscle layer between epithelium and stroma, and increased the number of apoptotic cells. Deletion of both genes also accelerated the activation of Akt and Erkl/2 oncoproteins. These results suggest an additive effect of ZFHX3/ATBF1 and PTEN deletions on the development and progression of prostate neoplasia.

关键词： ZFHX3 ATBFI PTEN Prostate cancer mPIN

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Programmable repulsive potential for tight-binding from Chen-Möbius inversion theorem

引用

Science China(Physics,Mechanics & Astronomy) 2024年第1期67卷 71-83页

作者： Jian-Gao Li jin-Kun tang Hong-Quan Song Gotthard Seifert dong-Bo Zhang College of Nuclear Science and Technology Beijing Normal UniversityBeijing 100875China Department of Physics Beijing Normal UniversityBeijing 100875China College of Physics and Telecommunication Engineering Zhoukou Normal UniversityZhoukou 466001China Theoretische Chemie Technische Universität DresdenDresden D-01062Germany

An accurate total energy calculation is essential in materials *** date,many tight-binding(TB)approaches based on parameterized hopping can produce electronic structures comparable to those obtained using first-principles ***,TB approaches still have limited applicability for determining material properties derived from the total *** is,the predictive power of the TB total energy is impaired by an inaccurate evaluation of the repulsive *** complexity associated with the parametrization of TB repulsive potentials is the weak link in this *** this study,we propose a new method for obtaining the pairwise TB repulsive potential for crystalline materials by employing the Chen-Möbius inversion *** show that the TB-based phonon dispersions,calculated using the resulting repulsive potential,compare well with those obtained by first-principles calculations for various systems,including covalent and ionic bulk materials and twodimensional *** present approach only requires the first-principles total energy and TB electronic band energy as input and does not involve any *** striking feature enables us to generate repulsive potentials programmatically.

关键词： tight binding first-principles calculation total energy repulsive potential phonon dispersion

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frequent Mutation of rs13281615 and Its Association with PVT1 Expression and Cell Proliferation in Breast Cancer

引用

Journal of Genetics and Genomics 2014年第4期41卷 187-195页

作者： Zhiqian Zhang Zhengmao Zhu Baotong Zhang Weidong Li Xin Li Xiao Wu Lijuan Wang Liya Fu Li Fu jin-tang dong Department of Genetics and Cell Biology Nankai University College of Life Sciences Key Laboratory of Breast Cancer Research Department of Breast Cancer Pathology and Research LaboratoryCancer Hospital of Tianjin Medical University Department of Hematology and Medical Oncology Emory University School of MedicineEmory Winship Cancer Institute

The q24 band of chromosome 8 （8q24） is frequently amplified in human cancers including breast cancer, and several SNPs （single nucleotide polymorphisms） at 8q24, including rs13281615, have been identified for their association with cancer risks. These SNPs are in a ＂gene desert＂ region, and their functions in cancer development remain to be illustrated, although several of the SNPs appear to influence the genes in the ＂desert＂ in a long-range manner, including the v-myc avian myelocytomatosis viral oncogene homolog （MYC） and the non- protein coding plasmacytoma variant translocation 1 （PVT1）, both of which have been implicated in human cancers. In the current study, we examined rs13281615 for its potential role in breast cancer using normal and cancer tissues from 121 Chinese women with breast cancer. In addition to confirming the association of the GG genotype of rs 13281615 with breast cancer risk, we found that germline GG genotype was significantly associated with estrogen receptor （ER） positivity, higher tumor grade and higher proliferation index. We also found frequent somatic mutations （22/121 or 18.2%） of this SNP in breast cancer. Interestingly, the majority of the mutations （17/22 or 77%） involved a G→ A change, resulting in a decrease in the number of cancers with the GG risk genotype and subsequent loss of GG association with higher tumor grade and proliferation index in cancers. Furthermore, PVT1 expression was increased in cancers, and the increase was associated with the GG genotype of rs13281615. These results suggest that the GG genotype of SNP rs13281615 plays a role in breast cancer likely by influencing PVT1 expression, and that during oncogenesis, ＂protective＂ mutations could occur.

关键词： rs13281615 Mutation PVT1 Breast cancer

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Homovalent doping: An efficient strategy of the enhanced TiNb2O7 anode for lithium-ion batteries

引用

Green Energy & Environment 2024年第8期9卷 1257-1266页

作者： Xiaohe jin Yirui Deng Han Tian Miaomiao Zhou Wenhao tang Huiyou dong Xinquan Zhang Ruiping Liu Department of Materials Science and Engineering China University of Mining & Technology (Beijing) Department of Materials Science and Engineering China University of Mining&Technology (Beijing)

The low energy density,unsatisfied cycling performance,potential safety issue and slow charging kinetics of the commercial lithium-ion batteries restrained their further application in the fields of fast charging and long-haul electric *** TiNb2O7（TNO） with the theoretical capacity of 387 mAh g-1has been proposed as a high-capacity anode materials to replace *** this work,homovalent doping strategy was used to enhance the electrochemical performance of Ti Nb2O7（TNO） by employing Zr to partial substitute Ti through solvothermal *** doping of Zr4+ions can enlarge the lattice structure without changing the chemical valence of the original elements,refine and homogenize the grains,improve the electrical conductivity,and accelerate the ion diffusion kinetics,and finally enhance the cycle and rate ***,Z0.05-TNO shows initial discharge capacity of as high as 312.2 mAh g-1at 1 C and 244.8 mAh g-1at 10 C,and still maintains a high specific capacity of 171.3 mAh g-1after 800 cycles at 10 *** study provides a new strategy for high-performance fastcharging energy storage electrodes.

关键词： Homovalent doping Zr 4+ TiNb 2 O 7 Microsphere Lithium-ion batteries

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

A Least-squares-based Iterative Method with Better Convergence for PF/OPF in Integrated Transmission and Distribution Networks

引用

CSEE Journal of Power and Energy Systems 2024年第3期10卷 953-962页

作者： Kunjie tang Shufeng dong Yonghua Song College of Electrical Engineering Zhejiang UniversityHangzhou 310027China State Key Laboratory of Internet of Things for Smart City and Department of Electrical and Computer Engineering University of MacaoMacao SARChina IEEE

The limitations of the conventional master-slavesplitting(MSS)method,which is commonly applied to power flow and optimal power flow in integrated transmission and distribution(I-T&D)networks,are first *** that the MSS method suffers from a slow convergence rate or even divergence under some circumstances,a least-squares-based iterative(LSI)method is *** with the MSS method,the LSI method modifies the iterative variables in each iteration by solving a least-squares problem with the information in previous iterations.A practical implementation and a parameter tuning strategy for the LSI method are ***,a LSI-PF method is proposed to solve I-T&D power flow and a LSIheterogeneous decomposition(LSI-HGD)method is proposed to solve optimal power *** experiments demonstrate that the proposed LSI-PF and LSI-HGD methods can achieve the same accuracy as the benchmark ***,these LSI methods,with appropriate settings,significantly enhance the convergence and efficiency of conventional ***,in some cases,where conventional methods diverge,these LSI methods can still converge.

关键词： Fixed-point theory integrated transmission and distribution networks least-squares-based iterative method master-slave-splitting method optimal power flow power flow

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：