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Effect of Hot Extrusion on Interfacial Microstructure and Tensile Properties of SiC_p/2009Al Composites Fabricated at Different Hot Pressing Temperatures

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Journal of Materials Science & Technology 2011年第6期27卷 518-524页

作者： peng jin Bolu xiao Quanzhao Wang Zongyi Ma Yue Liu Shu Li Institute of Metal Research Chinese Academy of Sciences Shenyang 110016 China

The effects of hot extrusion on the interfacial microstructures and tensile properties of 15 ***/2009Al composites fabricated at different hot pressing temperatures were *** hot extrusion,the relative density of the composites increased,the SiC particle distribution became more uniform,and the SiC particles tended to align along the extrusion ***,the interface bonding was improved after hot extrusion;however,the extrusion exerted no obvious effect on the interfacial reaction products formed during sintering *** tests indicated that the mechanical properties of the composites were improved significantly after *** revealed that the fracture mechanism of the extruded composites fabricated at the hot pressing temperatures below 540℃ was mainly the interfacial *** the extruded composites fabricated at 560-600℃,the fracture was the matrix ductile fracture and the SiC particle *** the composites were hot pressed at or above 620℃,after extrusion,the fracture mechanism of the composites was the matrix ductile fracture,the interface cracking and the SiC particle fracture.

关键词： Aluminum matrix composite Hot extrusion Microstructure Mechanical properties

Co-delivery of Doxorubicin and Afatinib with pH-responsive Polymeric Nanovesicle for Enhanced Lung Cancer Therapy

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Chinese Journal of Polymer Science 2019年第12期37卷 1224-1233,I0006页

作者： Heng-Ye Gong Yan-Gui Chen Xing-Su Yu Hong xiao jin-peng xiao Yong Wang Xin-Tao Shuai PCFM Lab of Ministry of Education School of Materials Science and EngineeringSun Yat-Sen UniversityGuangzhou 510275China HEC Pharma Co. Ltd.Dongguan 523871China Reproductive Center Guangdong Women’s Health Care CenterGuangzhou 511400China

Drug-resistance and drastic side effects are two major issues of traditional chemotherapy which may result in trail failure even ***-mediated multidrug combination treatment has been proven to be a feasible strategy to overcome these *** the present study,amphipathic block polymer of methoxyl poly(ethylene glycol)-poly(aspartyl(dibutylethylenediamine)-co-phenylalanine)(m PEG-P(Asp(DBA)-co-Phe))was synthesized and self-assembled into p H-responsive polymeric *** vesicle was utilized to co-deliver cancer-associated epidermal growth factor(EGFR)inhibitor of afatinib and DNA-damaging chemotherapeutic doxorubicin hydrochloride(DOX)for enhanced non-small-cell lung cancer(NSCLC)*** evaluated in vitro,the p H-responsive design of nanovesicle resulted in a rapid release of encapsulated drugs into tumor cells and caused enhanced cell *** addition,in vivo therapeutic studies were conducted and the results evidenced that the co-delevery of DOX and afatinib using p H-sensitive nanovector was a promising strategy for NSCLC treatment.

关键词： Nanovesicle Polymeric vector Combination therapy pH-responsive

Association between autoimmune gastritis and gastric polyps:Clinical characteristics and risk factors

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 73-87页

作者： jing-Zheng jin xiao Liang Shu-peng Liu Rui-Lan Wang Qing-Wei Zhang Yu-Feng Shen xiao-Bo Li Division of Gastroenterology and Hepatology Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China Division of Gastroenterology and Hepatology Shanghai Institute of Digestive DiseasesShanghai 200001China Division of Gastroenterology and Hepatology Renji Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200127China Division of Gastroenterology and Hepatology Sichuan Armed Police Corps HospitalLeshan 610041Sichuan ProvinceChina Division of Gastroenterology and Hepatology NHC Key Laboratory of Digestive DiseasesRenji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China Department of Gastroenterology Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai Institute of Digestive DiseasesShanghai 200127China

BACKGROUND The relationship between autoimmune gastritis(AIG)and gastric polyps(GPs)is not well *** To explore the clinical characteristics and risk factors of AIG with GPs in *** This double center retrospective study included 530 patients diagnosed with AIG from July 2019 to July *** collected clinical,biochemical,serological,and demographic data were of each *** regression analyses,both multivariate and univariate,were conducted to pinpoint independent risk factors for GPs in patients with AIG *** operating characteristic curves were utilized to establish the optimal cutoff values,sensitivity,and specificity of these risk factors for predicting GPs in patients with *** Patients with GPs had a higher median age than those without GPs[61(52.25-69)years vs 58(47-66)years,P=0.006].The gastrin-17 levels were significantly elevated in patients with GPs compared with those without GPs[91.9(34.2-138.9)pmol/mL vs 60.9(12.6-98.4)pmol/mL,P<0.001].Additionally,the positive rate of parietal cell antibody(PCA)antibody was higher in these patients than in those without GPs(88.6%vs 73.6%,P<0.001).Multivariate and univariate analyses revealed that PCA positivity[odds ratio(OR)=2.003,P=0.017],pepsinogen II(OR=1.053,P=0.015),and enterochromaffin like cells hyperplasia(OR=3.116,P<0.001)were significant risk factors for GPs,while pepsinogen I was identified as a protective *** PCA positivity and enterochromaffin like cells hyperplasia are significant risk factor for the development of GPs in patients with *** gastrin-17 levels may also play a role in this *** findings suggest potential targets for further research and therapeutic intervention in managing GPs in patients with AIG.

关键词： Autoimmune gastritis Gastric polyps Neuroendocrine tumor Risk factors Nomogram

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递减候选集正则化子空间追踪算法

控制与决策 2017年第2期32卷 287-292页

作者：田金鹏刘小娟郑国莘上海大学通信与信息工程学院上海200072 上海大学特种光纤与光接入网省部共建重点实验室上海200072

为提高压缩感知子空间追踪算法的信号重建概率及精度,提出一种递减候选集正则化子空间追踪算法.该算法基于Co Sa MP/SP算法并加以改进,将迭代过程分成若干个阶段,在每个阶段均采用类Co Sa MP/SP算法进行迭代计算,但各阶段的候选集原子... 详细信息

为提高压缩感知子空间追踪算法的信号重建概率及精度,提出一种递减候选集正则化子空间追踪算法.该算法基于Co Sa MP/SP算法并加以改进,将迭代过程分成若干个阶段,在每个阶段均采用类Co Sa MP/SP算法进行迭代计算,但各阶段的候选集原子个数依次递减,同时按正则化方法选择新的候选集原子.实验仿真对比结果表明,与同类算法相比,所提出算法能够以更高概率重建信号,在噪声环境下也具有较高的重建精度.

关键词：压缩感知信号重建子空间追踪稀疏表示正则化

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一种变步长稀疏度自适应子空间追踪算法

自动化学报 2016年第10期42卷 1512-1519页

作者：田金鹏刘小娟郑国莘上海大学通信与信息工程学院上海200444 上海大学特种光纤与光接入网重点实验室上海200072

针对压缩感知(Compressive sensing,CS)中未知稀疏度信号的重建问题,本文提出一种变步长稀疏度自适应子空间追踪算法.首先,采用一种匹配测试的方法确定固定步长,然后以该固定步长与变步长方式相结合,通过不同支撑集原子个数下的重建残... 详细信息

针对压缩感知(Compressive sensing,CS)中未知稀疏度信号的重建问题,本文提出一种变步长稀疏度自适应子空间追踪算法.首先,采用一种匹配测试的方法确定固定步长,然后以该固定步长与变步长方式相结合,通过不同支撑集原子个数下的重建残差变化确定信号稀疏度,算法采用子空间追踪方法确定相应支撑集原子,并完成原始信号准确重建.实验结果表明,与同类算法相比,该算法可以更准确重建原始信号,且信号稀疏度值较高时,运算量低于同类算法.

关键词：压缩感知信号重建子空间追踪自适应算法稀疏表示

Microsurgical transverse 2-suture intussusception vasoepididymostomy： effectiveness and rationality

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Chinese Medical Journal 2013年第24期126卷 4670-4673页

作者： ZHANG Hao HUANG Wen-tao RUAN Xing-xing LI Liao-yuan DI jin-ming LIUxiao-peng xiao Heng-jun GAO Xin ZHANG Yan Department of Urology the Third Affiliated Hospital of Sun Yat-sen University Guangzhou Guangdong 510630 China

Background 2-Suture longitudinal vasoepididymostomy shows superiority to transverse technique in an animal study; to date, this has not been consistently confirmed in human body. In the present study, we evaluated the effectiveness of 2-suture transverse intussusception vasoepididymostomy and compared the rationality between transverse and longitudinal techniques. Methods From May 2007 to December 2008, we performed 2-suture transverse vasoepididymostomy in 19 consecutive patients, as described by Marmar with modification. Between March 2009 and January 2010, the internal diameter of the vas lumen and the outer diameter of the epididymal tube were measured using microruler （21 patients and 37 sides）. Results Three patients lost to follow-up. At the first follow-up period （ranged from 10 to 24 months）, the patency rate was 56.3% （9/16） and the natural pregnancy rate was 25% （4/16）. At the second follow-up period （ranged from 46 to 63 months）, the patency rate was 68.8% （11/16）, the natural pregnancy rate was 37.5% （6/16）, respectively, and the take- home baby rate was 31.3% （5/16）. The diameter of the vas lumen and the outer diameter of the epididymal tubule were （0.512±0.046） mm and （0.572±0.051） mm （P 〈0.001）, respectively. Conclusion Transverse 2-suture intussusception vasoepididymostomy is still an effective technique in treating obstructive azoospermia.

关键词： obstructive azoospermia vasoepididymostomy transverse, longitudinal

Interleukin-17A facilitates tumor progression via upregulating programmed death ligand-1 expression in hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 176-198页

作者： Zhong-Xia Yang Li-Ting Zhang xiao-Jun Liu Xue-Bin peng xiao-Rong Mao The First School of Clinical Medicine Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Infectious Diseases The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Radiotherapy Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)is an inflammation-associated tumor with a dismal *** has become an important treatment strategy for HCC,as immunity is closely related to inflammation in the tumor *** regulates the expression of programmed death ligand-1(PD-L1)in the immunosuppressive tumor microenvironment and affects im-munotherapy ***-17A(IL-17A)is involved in the remodeling of the tumor microenvironment and plays a protumor or antitumor role in different *** hypothesized that IL-17A participates in tumor progression by affe-cting the level of immune checkpoint molecules in *** upregulation of PD-L1 expression in HCC cells by IL-17A was assessed by reverse transcription PCR,western blotting,and flow *** studies were conducted with gene knockout models and pathway *** function of IL-17A in immune evasion was explored through coculture of T cells and HCC *** effects of IL-17A on the malignant biological behaviors of HCC cells were evaluated in vitro,and the antitumor effects of an IL-17A inhibitor and its synergistic effects with a PD-L1 inhibitor were studied in *** IL-17A upregulated PD-L1 expression in HCC cells in a dose-dependent manner,whereas IL-17A receptor knockout or treatment with a small mothers against decapentaplegic 2 inhibitor diminished the PD-L1 expression induced by ***-17A enhanced the survival of HCC cells in the coculture ***-17A increased the viability,G2/M ratio,and migration of HCC cells and decreased the apoptotic *** D1,VEGF,MMP9,and Bcl-1 expression increased after IL-17A treatment,whereas BAX expression *** combination of IL-17A and PD-L1 inhibitors showed synergistic antitumor efficacy and increased cluster of differentiation 8+T lymphocyte infiltration in an HCC mouse *** IL-17A upregulates PD-L1 expression via the IL-17A receptor/phosphorylation-small mothers against

关键词： Interleukin-17A Programmed death ligand-1 Interleukin-17A receptor Small mothers against decapentaplegic 2 Hepatocellular carcinoma Immunotherapy

Clinicopathological Features of Non-familial Colorectal Cancer with High-frequency Microsatellite Instability

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Chinese Medical Sciences Journal 2010年第4期25卷 228-232页

作者： peng jin xiao-ming Meng Jian-qiu Sheng Zi-tao Wu Lei Fu He-juan An Ying Han Shi-rong Li Department of Gastroenterology The Military General Hospital of Beijing Beijing 100700 China

Objective To explore the clinicopathological features of non-familial colorectal cancer with high-frequency microsatellite instability (MSI-H). Methods One hundred and fifty patients with colorectal cancer who had no family history were enrolled in this study from June 2006 to June 2008. Five standard microsatellite loci including BAT25, BAT26, D2S123, D5S346, and D17S250 were amplified with immunofluorescent polymerase chain reaction. The patient information including age, sex, and tumor location was recorded. Pathological features including differentiation, mucinous differentiation, histological heterogeneity, and Crohn's-like reaction were observed under light microscope. The presence of tumor-infiltrating lymphocytes (TLs, CD4+ and CD8+) was detected by means of immunohistochemistry. A regression equation was obtained by stepwise logistic regression analysis to evaluate the relationship between MSI-H phenotype in colorectal cancer ands pathological features. Results MSI-H phenotype occurred in 13.33% of the 150 patients with non-familial colorectal cancer. Poor differentiation, histological heterogeneity, Crohn's-like reaction, and presence of TLs were found to be independent factors to identify MSI-H non-familial colorectal cancer. Logistic regression equation showed an overall sensitivity of 70.0%, specificity of 99.2%, and accuracy of 95.3% in identifying MSI-H non-familial colorectal cancer. Conclusion MSI-H non-familial colorectal cancer manifests specific pathological features, which may be relied upon for effective identification of that disease.

关键词： colorectal cancer microsatellite instability phenotype clinical pathology

Preliminary Design of a System for Picking up Audio-Signals From Bubble Detectors GAO Si-ze1,NI Bang-fa,ZHANG Gui-ying,xiao Cai-jin,LIU Cun-xiong, CHEN Zhe1,NIE peng,LIU Chao1,ZHAO Chang-jun (*** of Physics Science and Engineering Technology,Guang

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Preliminary Design of a System for Picking up Audio-Signals ...