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A New Ceramide from the Basidiomycetes Armillaria mellea

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Chinese Chemical Letters 2001年第2期12卷 139-140页

作者： jin ming gao Ze Jun DONG Ji Kai LIU Kunming Institute of Botany Chinese Academy of SciencesKunming 650204 Northwest Sci & Tech.University of Agriculture and Forestry YanglingShaanxi 712100

A new phytosphingosine-type ceramide, armillaramide 1, has been isolated from the fruiting bodies of Basidiomycetes Armillaria mellea (Vahl ex Fr.) Quel. Its structure was established as (2S, 3S. 4R)-2-N-(palmitoyl)-p... 详细信息

关键词： Armillaria mellea basidiomycetes ceramide armillaramide

A New Disaccharide from the Fern Macrothelypteris digophlebia

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Chinese Chemical Letters 2000年第12期11卷 1063-1064页

作者： ming Hua QIU jin ming gao Hu Qi LIU Jian Xi FU Kunming Institute of Botany The Chinese Academy of SciencesKunming 650204 Northwest Sci.&Tech.University of Agriculture and Forestry YanglingShaanxi 712100

A new disaccharide, digobiose 1, was isolated from the rhizomes of Macrothelypteris digophlebia (Bak.) Ching var. elegans (koidz.). Its structure which is very similar with that of sucrose was identified as alpha -D-g... 详细信息

关键词： Digobiose Disaccharide Macrothelypteris digophlebia

CXC CHEMOKINE RECEPTOR 3 MODULATES BLEOMYCIN-INDUCED PULMONARY INJURY VIA INVOLVING INFLAMMATORY PROCESS

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Chinese Medical Sciences Journal 2006年第3期21卷 152-156页

作者： jin-ming gao Bao Lu Zi-jian Guo Department of Respiratory Medicine Peking Union Medical College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730 Ina Sue Perlmutter Laboratory Division of Pulmonary Children＇s Hospital Department of Medicine Harvard Medical School Boston MA 02115

Objeelive To investigate the role of CXC chemokine receptor 3 （ CXCR3 ） in bleomycin-induced lung injury by using CXCR3 gene deficient mice. Methods Sex-, age-, and weight-matched C57BL/6 CXCR3 gene knockout mice and C57BL/6 wide type mice were challenged by injection of bleomycin via trachea. Lung tissue was stained with HE method. Airway resistance was measured. Bronchoalveolar lavage （BAL） was performed using phosphate buffered saline twice, cell number and differentials were counted by Diff-Quick staining. Interleukin （IL）-4, IL-5, IL-12p40, and interfon-~ in BAL fluid and lung homogenate were measured by enzyme-linked immunosorbent assay. Unpaired t test was explored to compare the difference between two groups. Results On day 7 after bleomycin injection via trachea, CXCR3 knockout mice were protected from bleomycininduced lung injury as evidenced by fewer accumulation of inflammatory cells in the airway and lung interstitium compared with their wild type littermates （ P 〈 0. 05 ）. Airway resistance was also lower in CXCR3 knockout mice compared with wild type mice （P 〈 0. 01 ）. Significantly lower level of inflammatory cytokines release, including the altered production of IL-4 and IL-5 both in BAL fluid and lung tissue was seen in CXCR3 knockout mice than in wild type mice （both P 〈0. 05）. Conclusion CXCR3 signaling promotes inflammatory cells recruiting and initiates inflammatory cytokines cascade following endotracheal bleomycin administration, indicating that CXCR3 might be a therapeutic target for pulmonary injury.

关键词： chemokine receptor bleomycin lung injury inflammation

The chemical structures and biological activities of indole diterpenoids

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Natural Products and Bioprospecting 2023年第1期13卷 756-778页

作者： jingwen Niu Jianzhao Qi Pengchao Wang Chengwei Liu jin-ming gao Key Laboratory for Enzyme and Enzyme-Like Material Engineering of Heilongjiang College of Life ScienceNortheast Forestry UniversityHarbin 150040HeilongjiangChina Shaanxi Key Laboratory of Natural Products and Chemical Biology College of Chemistry and PharmacyNorthwest A&F UniversityYangling 712100ShaanxiChina

Indole diterpenoids(IDTs)are an essential class of structurally diverse fungal secondary metabolites,that generally appear to be restricted to a limited number of fungi,such as Penicillium,Aspergillus,Claviceps,and Epichloe species,*** compounds share a typical core structure consisting of a cyclic diterpene skeleton of geranylgeranyl diphos-phate(GGPP)and an indole ring moiety derived from indole-3-glycerol phosphate(IGP).3-geranylgeranylindole(3-GGI)is the common precursor of all *** this basis,it is modified by cyclization,oxidation,and prenylation to generate a large class of compounds with complex *** compounds exhibit antibacterial,anti-insect,and ion channel inhibitory *** summarized 204 compounds of IDTs discovered from various fungi over the past 50 years,these compounds were reclassified,and their biological activities were *** review will help to understand the structural diversity of IDTs and provide help for their physiological activities.

关键词： Indole diterpenoids Structural classification Physiological activity Fungus

Rufoolivacin B,a novel polyketide pigment from the fruiting bodies of the fungus Cortinarius rufo-olivaceus(basidiomycetes)

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Chinese Chemical Letters 2009年第11期20卷 1324-1326页

作者： An Ling Zhang Jian Chun Qin ming Sheng Bai jin ming gao Ya Mei Zhang Sheng Xiang Yang Hartmut Laatsch College of Science Northwest A & F University Yangling Shaanxi 712100 China Department of Orgnic Chemistry University of Gottingen Tammannstrasse 2 D-3 7077 Gottingen Germany College of Life Sciences Northwest A & F University Yangling Shaanxi 712100 China Center for Experiments & Education Technology Linyi Normal University Linyi Shandong 276005 China

A novel polyketide pigment （1） with the 4＇,10-coupled linkage between 1-naphthalenol and 1,4-anthraquinone, named rufoolivacin B together with the known analog rufoolivacin （2）, has been isolated from the fruiting bodies of the Chinese toadstool Cortinarius rufo-olivaceus （basidiomycetes）. Their structures were characterized by means of analysis of spectroscopic methods, including 2D-NMR experiments and HR-ESI-MS.

关键词： Anthraquinone Polyketide Basidiomycetes Cortinarius rufo-olivaceus Fungal pigment Rufoolivacin B

Structurally Diverse Sesquiterpenoids with Anti-neuroinflammatory Activity from the Endolichenic Fungus Cryptomarasmius aucubae

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Natural Products and Bioprospecting 2021年第3期11卷 325-332页

作者： Yi-Jie Zhai Jian-Nan Li Yu-Qi gao Lin-Lin gao Da-Cheng Wang Wen-Bo Han jin-ming gao Shaanxi Key Laboratory of Natural Products and Chemical Biology College of Chemistry and PharmacyNorthwest A&F UniversityYanglingShaanxi 712100People’s Republic of China

Two new sterpurane sesquiterpenoids named sterpurol D(1)and sterpurol E(2),and one skeletally new sesquiterpene,cryptomaraone(3),bearing a 5,6-fused bicyclic ring system,along with five known ones,sterpurol A(4),sterpurol B(5),paneolilludinic Acid(6),murolane-2α,9β-diol-3-ene(7)and(-)-10,11-dihydroxyfarnesol(8)were isolated from an endolichenic fungus Cryptomarasmius *** structures of the new compounds were elucidated by analysis of NMR spectroscopic spectra and HRESIMS *** absolute configurations of 1 and 2 were established by spectroscopic data analysis and comparison of specific optical rotation,as well as the biosynthetic ***,compounds 1,2,4-6,and 8 showed significant nitric oxide(NO)production inhibition in Lipopolysaccharide(LPS)-induced BV-2 microglial cells with the IC50 values ranging from 9.06 to 14.81μM.

关键词： Endolichenic fungus Cryptomarasmius aucubae Sesquiterpenes Anti-neuroinflammatory activity

The alkynyl-containing compounds from mushrooms and their biological activities

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Natural Products and Bioprospecting 2023年第1期13卷 138-158页

作者： Ji-shuang Qi Yingce Duan Zhao-chen Li jin-ming gao Jianzhao Qi Chengwei Liu Key Laboratory for Enzyme and Enzyme-Like Material Engineering of Heilongjiang College of Life ScienceNortheast Forestry UniversityHarbin 150040China Shaanxi Key Laboratory of Natural Products&Chemical Biology College of Chemistry&PharmacyNorthwest A&F UniversityYangling 712100China

Mushrooms have been utilized by humans for thousands of years due to their medicinal and nutritional *** are a crucial natural source of bioactive secondary metabolites,and recent advancements have led to the isolation of several alkynyl-containing compounds with potential medicinal *** their relatively low abundance,naturally occurring alkynyl compounds have attracted considerable attention due to their high *** studies have shown that alkynyl compounds exhibit significant biological and pharmacological activities,including antitumor,antibacterial,antifungal,insecticidal,phototoxic,HIV-inhibitory,and immunosuppressive *** review systematically compiles 213 alkynyl-containing bioactive compounds isolated from mushrooms since 1947 and summarizes their diverse biological activities,focusing mainly on cytotoxicity and anticancer *** review serves as a detailed and comprehensive reference for the chemical structures and bioactivity of alkynyl-containing secondary metabolites from ***,it provides theoretical support for the development of chemical constituents containing alkynyl compounds in mushrooms based on academic research and theory.

关键词： Mushroom Alkynyl compounds Bioactivity Chemical structures

Effect of multiple coulomb scattering on the beam tests of silicon pixel detectors

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Nuclear Science and Techniques 2024年第4期35卷 200-207页

作者： Lan-Kun Li ming-Yi Dong Ze gao Liang-Cheng-Long jin Shu-Jun Zhao School of Physics and Microelectronics Zhengzhou UniversityZhengzhou 450001China State Key Laboratory of Particle Detection and Electronics(Institute of High Energy Physics CAS)Beijing 100049China University of Chinese Academy of Science Beijing 100049China University of South China Hengyang 421001China

In the research and development of new silicon pixel detectors,a collimated monoenergetic charged-particle test beam equipped with a high-resolution pixel-beam telescope is crucial for prototype verification and performance *** the beam energy is low,the effect of multiple Coulomb scattering on the measured resolution of the Device Under Test(DUT)must be considered to accurately evaluate the performance of the pixel chips and *** study aimed to investigate the effect of multiple Coulomb scattering on the measured resolution,particularly at low beam *** were conducted using Allpix^(2) to study the effects of multiple Coulomb scattering under different beam energies,material budgets,and telescope *** simulations also provided the minimum energy at which the effect of multiple Coulomb scattering could be *** with the results of a five-layer detector system tested with an electron beam at DESY,the simulation results were consistent with the beam test results,confirming the reliability of the simulations.

关键词： Silicon Pixel Detectors Beam Telescope Multiple Coulomb Scattering Spatial Resolution

C_(Ar)-Br bond cleavage via cooperative EnT/NHC catalysis: mild access to indolines

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Science China Chemistry 2024年第3期67卷 922-927页

作者： Yi-Xiong Dong Cao-Bo Li ming-Lei jin Zhong-Hua gao Song Ye Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Molecular Recognition and FunctionCAS Research/Education Center for Excellence in Molecular SciencesInstitute of ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

The cooperative visible-light mediated and NHC-catalyzed dearomative arylation-acylation of N-(2-bromobenzoyl)indoles with aldehydes was developed, affording the corresponding highly functionalized polycyclic indolines in moderate to good yields with exclusive diastereoselectivities. Mechanism investigations support the activation of CAr-Br bond via visible-light mediated energy transfer(EnT) and the following single-electron-transfer(SET) with Breslow intermediate under NHC catalysis to give key aryl radical and ketyl radical. This protocol demonstrates the cleavage of CAr-Br bond under mild cooperative EnT/NHC catalysis.

关键词： energy transfer N-heterocyclic carbenes photocatalysis aryl radicals indolines