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A meta-regression evaluating the effectiveness and prognostic factors of oral phosphodiesterase type 5 inhibitors for the treatment of erectile dysfunction

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Asian Journal of Andrology 2016年第1期18卷 60-65页

作者： jin-Qiu Yuan Chen Mao Zu-Yao Yang Xiao-Hong Fu Samuel Y Wong jin-ling tang Division of Epidemiology School of Public Health and Primary Care The Chinese University of Hang Kong Hang Kong China Shenzhen Municipal Key Laboratory for Health Risk Analysis Shenzhen Research Institute of The Chinese University of Hang Kong Shenzhen 518055 China Department of Community and Family Medicine The Chinese University of Hang Kong Hang Kong China

The effectiveness of phosphodiesterase type 5 inhibitors （PDE5-1s） for erectile dysfunction （ED） varies considerably among trials, but available studies investigating the factors that affect the effectiveness are few and findings are not consistent. A systematic search was performed in PubMed, Cochrane Library, and EMBASE to identify randomized controlled trials comparing PDE5-1s with placebo for the treatment of ED. The methodological quality of included studies was assessed by the Cochrane Collaboration＇s tool for assessing risk of bias. The associations between prespecified study-level factors and effectiveness were tested by a random effects meta-regression model. This study included 93 trials with 26 139 patients. When all PDE5-1s were grouped together, Caucasian ethnicity was associated with 15.636% （95% confidence interval [CI]： 0.858% to 32.579%） increase in risk ratio （RR） for Global Assessment Questionnaire question-1 （GAQ-1）, and 1.473 （95% CI： 0.406 to 2.338） score increase in mean difference （MD） for posttreatment International Index of Erectile Function-Erectile Function domain score （IIEF-EF）, compared to Asian ethnicity. A one-score increase in baseline IIEF-EF was associated with -5.635% （95% CI： -9.120% to -2.017%） reduction in RR for GAQ-1, and -0.229 （95% CI： -0.425 to -0.042） score decrease in MD for posttreatment IIEF-EF. In conclusion, PDE5-1s are more effective in Caucasians than Asians, and in patients with more severe ED.

关键词： erectile dysfunction meta-regression phosphodiesterase type 5 inhibitors systematic review

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The dengue preface to endemic in China's Mainland:the historical largest outbreak by Aedes albopictus in Guangzhou,2014

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Infectious Diseases of Poverty 2017年第1期6卷 1313-1323页

作者： Lei Luo Li-Yun Jiang Xin-Cai Xiao Biao Di Qin-Long jing Sheng-Yong Wang jin-ling tang Ming Wang Xiao-Ping tang Zhi-Cong Yang Guangzhou Center for Disease Control and Prevention Guangzhou 510440People’s Republic of China Department of Epidemiology Medical CollegeJinan UniversityGuangzhou 510632People’s Republic of China Division of Epidemiology The Jockey Club School of Public Health and Primary CareThe Chinese University of Hong KongHong Kong 999077People’s Republic of China Department of Infectious Diseases Guangzhou No.8 People’s HospitalGuangzhou 510060People’s Republic of China

Background:Dengue was regarded as a mild epidemic in China's Mainland transmitted by Aedes ***,the 2014 record-breaking outbreak in Guangzhou could change the *** order to provide an early warning of epidemic trends and provide evidence for prevention and control strategies,we seek to characterize the 2014 outbreak through application of detailed cases and entomological data,as well as phylogenetic analysis of viral envelope(E)***:We used case survey data identified through the Notifiable Infectious Disease Report System,entomological surveillance and population serosurvey,along with laboratory testing for IgM/IgG,NS1,and isolation of viral samples followed by E gene sequencing and phylogenetic analysis to examine the epidemiological and molecular characteristics of the ***:The 2014 dengue outbreak in Guangzhou accounted for nearly 80%of total reported cases that year in China's Mainland;a total of 37,376 cases including 37,340 indigenous cases with incidence rate 2908.3 per million and 36 imported cases were reported in Guangzhou,with 14,055 hospitalized and 5 *** epidemic lasted for 193 days from June 11 to December 21,with the highest incidence observed in domestic workers,the unemployed and *** inapparent infection rate was 18.00%(135/750).In total,96 dengue virus 1(DENV-1)and 11 dengue virus 2(DENV-2)strains were *** analysis indicated that the DENV-1 strains were divided into genotype I and V,similar to the strains isolated in Guangzhou and Dongguan in *** DENV-2 strains isolated were similar to those imported from Thailand on May 11 in 2014 and that imported from Indonesia in ***:The 2014 dengue epidemic was confirmed to be the first co-circulation of DENV-1 and DENV-2 in *** DENV-1 strain was endemic,while the DENV-2 strain was imported,being efficiently transmitted by the Aedes albopictus vector species at levels as high as Aedes aegypti.

关键词： Dengue Co-circulation Dengue virus-1 Dengue virus-2 Endemic disease

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Specific convulsions and brain damage in children hospitalized for Omicron BA.5 infection:an observational study using two cohorts

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World Journal of Pediatrics 2024年第10期20卷 1079-1089页

作者： Yuan-Yuan Pei Hong-Li Wang Gen-Quan Yin Yi Xu Jian-Hao Tan Xin-Hua Liang Hui-Ying Wu Xun-Tao Yin Chun-Xiao Fang Jun-Zheng Peng Zhi-Yuan Wu Yi Sun Run Dang Yu-Feng Liang Hong-Mei tang You-Yi Li Zhong-Xiang Qiao Zhi-Cheng Liang Jian-Ping tang Fan-Sen Zeng Ke-Lu Zheng Yi-Ru Zeng Xiao-Jun Cao Hui-Min Xia Jian-Rui Wei jin-ling tang Si-tang Gong Clinical Data Center Guangzhou Women and Children's Medical CenterGuangzhou Medical UniversityGuangzhou 510623China Department of Gastroenterology Guangzhou Women and Children's Medical CenterGuangzhou Medical UniversityGuangzhou 510623China Department of Internal Medicine Guangzhou Women and Children's Medical CenterGuangzhou Medical UniversityGuangzhou 510623China Department of Infectious Diseases Guangzhou Women and Children's Medical CenterGuangzhou Medical UniversityGuangzhou 510623China Information Department Guangzhou Women and Children's Medical CenterGuangzhou Medical UniversityGuangzhou 510623China School of Pediatrics Guangzhou Medical UniversityGuangzhou 510623China Imaging Department Guangzhou Women and Children's Medical CenterGuangzhou Medical UniversityGuangzhou 510623China Respiratory Department Guangzhou Women and Children's Medical CenterGuangzhou Medical UniversityGuangzhou 510623China Pediatric Intensive Care Unit Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangzhou510623China Neonatal Intensive Care Unit Guangzhou Women and Children's Medical CenterGuangzhou Medical UniversityGuangzhou 510623China Rehabilitation Department Guangzhou Women and Children's Medical CenterGuangzhou Medical UniversityGuangzhou 510623China General Pediatrics Guangzhou Women and Children's Medical CenterGuangzhou Medical UniversityGuangzhou510623China Emergency Department Guangzhou Women and Children's Medical CenterGuangzhou Medical UniversityGuangzhou 510623China Department of Neurology Guangzhou Women and Children's Medical CenterGuangzhou Medical UniversityGuangzhou 510623China Key Laboratory of Structural Birth Defects Research in Guangdong Province Guangzhou Women and Children's Medical CenterGuangzhou Medical UniversityGuangzhou 510623China Cardiovascular Department Guangzhou Women and Children's Medical CenterGuangzhou Medical UniversityGuangzhou 510623China Shenzhen Institute of Advanced Technology Chinese Academy of SciencesShen

Background SARS-CoV-2 continues to mutate over time,and reports on children infected with Omicron BA.5 are *** aimed to analyze the specific symptoms of Omicron-infected children and to improve patient *** We selected 315 consecutively hospitalized children with Omicron BA.5 and 16,744 non-Omicron-infected febrile children visiting the fever clinic at our hospital between December 8 and 30,*** convulsions and body temperatures were compared between the two *** analyzed potential associations between convulsions and vaccination,and additionally evaluated the brain damage among severe Omicron-infected *** Convulsion rates(97.5%vs.4.3%,P<0.001)and frequencies(median:2.0 vs.1.6,P<0.001)significantly differed between Omicron-infected and non-Omicron-infected febrile *** body temperatures of Omicron-infected children were significantly higher during convulsions than when they were not convulsing and those of non-Omicron-infected febrile children during convulsions(median:39.5 vs.38.2 and 38.6℃,both P<0.001).In the three Omicron-subgroups,the temperature during convulsions was proportional to the percentage of patients and significantly differed(P<0.001),while not in the three non-Omicron-subgroups(P=0.244).The convulsion frequency was lower in the 55 vaccinated children compared to the 260 non-vaccinated children(average:1.8 vs.2.1,P<0.001).The vaccination dose and convulsion frequency in Omicron-infected children were significantly correlated(P<0.001).Fifteen of the 112 severe Omicron cases had brain *** Omicron-infected children experience higher body temperatures and frequencies during convulsions than those of non-Omicron-infected febrile *** additionally found evidence of brain damage caused by infection with omicron *** and prompt fever reduction may relieve symptoms.

关键词： Body temperature Brain damage:Children:Convulsion Omicron BA.5.Vaccination

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Vector meson's spin alignments in high energy reactions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 5-20页

作者： jin-Hui Chen Zuo-tang Liang Yu-Gang Ma Xin-Li Sheng Qun Wang Key Laboratory of Nuclear Physics and Ion-beam Application (MoE) Institute of Modern PhysicsFudan University Institute of Frontier and Interdisciplinary Science Key Laboratory of Particle Physics and Particle Irradiation (MOE)Shandong University INFN-Firenze Department of Modern Physics University of Science and Technology of China School of Mechanics and Physics Anhui University of Science and Technology

The global spin alignment of vector mesons has been observed by the STAR collaboration at the Relativistic Heavy Ion Collider （RHIC） at Brookhaven National Laboratory （BNL）.It provides a unique opportunity to probe the correlation between the polarized quark and antiquark in the strongly coupled quark-gluon plasma （sQGP） produced in relativistic heavy ion collisions,opening a new window to explore the properties of s *** addition,spin alignments of vector mesons have also been observed in other high-energy particle collisions such as e+e-annihilations at high energies where hadron production is dominated by quark fragmentation *** results obtained are quite different from those obtained in heavy ion collisions where quark coalescence/combination mechanism dominates suggesting strong dependence on hadronization *** comprehensive studies in different hadronization processes are *** this article,we present a brief review of theoretical and experimental advances in the study of vector meson’s spin alignments in a variety of high-energy particle collisions,with emphasis on hadronization mechanisms.

关键词： vector meson spin alignment global polarization relativistic heavy ion collisions fragmentation

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Comparing the incidence of major cardiovascular events and severe microvascular complications in patients with type 2 diabetes mellitus:A systematic review and meta-analysis

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World Journal of Meta-Analysis 2020年第5期8卷 400-410页

作者： Ying-Ying Zhu Zu-Yao Yang Ping Li Xin-Ying Huang Xue-Hong Zhang Li-Nong Ji jin-ling tang Division of Epidemiology The Jockey Club School of Public Health and Primary CareThe Chinese University of Hong KongHong KongChina Channing Division of Network Medicine Department of MedicineBrigham and Women's Hospital and Harvard Medical SchoolBostonMA 02115United States Department of Endocrinology and Metabolism Peking University People's HospitalPeking University Diabetes CentreBeijing 100044China

BACKGROUND Type 2 diabetes mellitus(T2DM)causes both macrovascular and microvascular ***,currently,selection of glycemic measures and their thresholds to diagnose T2DM,and efficacy outcomes in evaluation of anti-diabetic drugs is predominantly informed by the relation of T2DM to microvascular *** can be severely mistaken on T2DM by neglecting macrovascular complications which are generally more severe,if they also occur more commonly than microvascular *** To compare the incidence of major cardiovascular events(MACEs)and severe microvascular complications(SMICs)in T2DM *** MEDLINE,EMBASE,and Cochrane Central Register of Controlled Trials were searched from inception to September *** studies or trials of T2DM patients aged 18 years or older that reported incidence of both MACEs and SMICs were *** were defined as nonfatal myocardial infarction and stroke,and cardiovascular death,while SMICs included serious retinopathy,nephropathy and diabetic *** relative risk(RR)was estimated as the incidence of MACEs divided by that of SMICs in same patients and combined with meta-analysis in a random-effect *** Twelve studies with a total of 16 cohorts and 387376 patients were included,and the combined RR was 2.02(95%CI:1.46–2.79).The higher incidence of MACEs remained in various subgroup and sensitivity *** Patients with T2DM are much more likely to develop MACEs than *** taking more serious consequences and relatively higher incidence into consideration,macrovascular complications deserve more emphasis in developing the diagnostic criteria of T2DM and in evaluating the efficacy of antidiabetic drugs.

关键词： Diabetes mellitus Diabetic complications Cardiovascular disease Diabetic retinopathy Diagnostic criteria Anti-diabetic drugs

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Distinct MLT asymmetry of auroral kilometric radiation observed by the FAST satellite

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Earth and Planetary Physics 2025年第1期9卷 188-193页

作者： JiaWen tang Sai Zhang FuLiang Xiao HongMing Yang Si Liu YiHua He Chang Yang YuYue jin ZhouKun Deng Ping Li Archie James Johnston School of Physics and Electronic Sciences Changsha University of Science and TechnologyChangsha 410114China Hunan Province Higher Education Key Laboratory of Modeling and Monitoring on the Near-Earth Electromagnetic Environments Changsha University of Science and TechnologyChangsha 410114China School of Electrical and Information Engineering Changsha University of Science and TechnologyChangsha 410114China

Auroral Kilometric Radiation (AKR) is a common radio emission,which can contribute to the magnetosphere-ionosphereatmosphere co u *** emissions have been observed in all magnetic planet magnetospheres of the solar *** this study,using observations from the FAST satellite from 30 August 1996 to 9 September 2001,the distribution of AKR in altitude=500-4500 km and invariant latitude (|ILAT|)=60°-80°has been analyzed.63045 AKR samples have been identified with~48%(52%) samples on the dayside (nightside).Of considerable interest,there is a distinct MLT asymmetry with the high occurrence rate in MLT=05-08 and 18-22(02-05 and 12-17) in the northern (southern) *** distinct MLT asymmetry is associated with the direction of Bxof the interplaneta ry magnetic *** addition,the occurrence rate on the nightside clearly increases as the AE^(*) index *** study further enriches the information and understanding of AKR in the magnetosphere as well as other similar radio emissions.

关键词： asymmetry auroral kilometric radiation interplanetary magnetic field

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Aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders:progress of experimental models based on disease pathogenesis

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Neural Regeneration Research 2025年第2期20卷 354-365页

作者： Li Xu Huiming Xu Changyong tang Department of Neurology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Neuromyelitis optica spectrum disorders are neuroinflammatory demyelinating disorders that lead to permanent visual loss and motor *** date,no effective treatment exists as the exact causative mechanism remains ***,experimental models of neuromyelitis optica spectrum disorders are essential for exploring its pathogenesis and in screening for therapeutic *** most patients with neuromyelitis optica spectrum disorders are seropositive for IgG autoantibodies against aquaporin-4,which is highly expressed on the membrane of astrocyte endfeet,most current experimental models are based on aquaporin-4-IgG that initially targets *** experimental models have successfully simulated many pathological features of neuromyelitis optica spectrum disorders,such as aquaporin-4 loss,astrocytopathy,granulocyte and macrophage infiltration,complement activation,demyelination,and neuronal loss;however,they do not fully capture the pathological process of human neuromyelitis optica spectrum *** this review,we summarize the currently known pathogenic mechanisms and the development of associated experimental models in vitro,ex vivo,and in vivo for neuromyelitis optica spectrum disorders,suggest potential pathogenic mechanisms for further investigation,and provide guidance on experimental model *** addition,this review summarizes the latest information on pathologies and therapies for neuromyelitis optica spectrum disorders based on experimental models of aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders,offering further therapeutic targets and a theoretical basis for clinical trials.

关键词： aquaporin-4 experimental model neuromyelitis optica spectrum disorder pathogenesis

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Industrial Control Anomaly Detection Based on Distributed Linear Deep Learning

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Computers, Materials & Continua 2025年第1期82卷 1129-1150页

作者： Shijie tang Yong Ding Huiyong Wang School of Computer Science and Information Security Guilin University of Electronic TechnologyGuilin541004China School of Electronic Engineering and Automation Guilin University of Electronic TechnologyGuilin541004China Guangxi Engineering Research Center of Industrial Internet Security and Blockchain Guilin University of Electronic TechnologyGuilin541004China Institute of Cyberspace Technology HKCT Institute for Higher EducationHong Kong999077China School of Mathematics&Computing Science Guilin University of Electronic TechnologyGuilin541004China

As more and more devices in Cyber-Physical Systems(CPS)are connected to the Internet,physical components such as programmable logic controller(PLC),sensors,and actuators are facing greater risks of network attacks,and fast and accurate attack detection techniques are *** key problem in distinguishing between normal and abnormal sequences is to model sequential changes in a large and diverse field of time *** address this issue,we propose an anomaly detection method based on distributed deep *** method uses a bilateral filtering algorithm for sequential sequences to remove noise in the time series,which can maintain the edge of discrete *** use a distributed linear deep learning model to establish a sequential prediction model and adjust the threshold for anomaly detection based on the prediction error of the validation *** method can not only detect abnormal attacks but also locate the sensors that cause *** conducted experiments on the Secure Water Treatment(SWAT)and Water Distribution(WADI)public *** experimental results show that our method is superior to the baseline method in identifying the types of attacks and detecting efficiency.

关键词： Anomaly detection CPS deep learning MLP(multi-layer perceptron)

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Soluble epoxide hydrolase:a next-generation drug target for Alzheimer's disease and related dementias

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Neural Regeneration Research 2025年第9期20卷 2585-2586页

作者： Andrew Gregory Chengyun tang Fan Fan Department of Physiology Medical College of GeorgiaAugusta UniversityAugustaGAUSA

Alzheimer's disease(AD)and Alzheimer's diseaserelated dementias(ADRD)represent a significant public health challenge,with projections indicating a substantial increase in affected individuals due to the aging global *** the World Health Organization,AD/ADRD has affected more than 55 million individuals worldwide,with an additional 10 million cases diagnosed each year.

关键词： Alzheimer population drug

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产出导向下师范教育课程的逆向审视与创新发展——基于S市新入职教师的调查

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东北师大学报（哲学社会科学版） 2025年第1期 81-90页

作者：杨进唐燕东北师范大学教育学部吉林长春130024

当下我国师范教育改革进入了以产出导向为改革理念的新阶段,即以师范生的学习结果和能力表现来评价师范教育培养质量。本研究突破在师范教育阶段内讨论师范生水平的局限,采用问卷调查和访谈调查法,以毕业后任教1个月的新教师为研究对象... 详细信息

当下我国师范教育改革进入了以产出导向为改革理念的新阶段,即以师范生的学习结果和能力表现来评价师范教育培养质量。本研究突破在师范教育阶段内讨论师范生水平的局限,采用问卷调查和访谈调查法,以毕业后任教1个月的新教师为研究对象,通过新教师自评和老教师他评的对比,呈现师范毕业生的职业能力水平与存在的主要问题。再结合新教师在真实教育情境中的适应性和对在学阶段所接受的师范教育课程的满意度评价,逆向审视师范教育课程存在的问题。以“服务终端”的理念进行课程设置、嵌入前沿属性优化课程教学、数字技术支持“具身拟态”提高实训效果、创设“人人交往”机会消解人机互动带来的沟通弱化等,以推动师范教育的课程改革。

关键词：师范教育课程产出导向教育新入职教师

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